ANATOMY AND PHYSIOLOGY OF NEURONS AP Biology Chapter 48
Objectives Describe the different types of neurons Describe the structure and function of dendrites, axons, a synapse, types of ion channels, and neurotransmitters. Describe resting potential and the sequence of events that occur during an action potential.
Overview The human brain contains an estimated 10 11 (100 billion) neurons. Each neuron may communicate with thousands of other neurons in complex information-processing circuits. Results of brain imaging and other research methods show that groups of neurons function in specialized circuits dedicated to different tasks.
Structural Organization of the Nervous System Central nervous system (CNS) brain and spinal cord Responsible for integration of sensory input and associating stimuli with appropriate motor output Peripheral nervous system (PNS) network of nerves extending into different parts of the body that carry sensory input to the CNS and motor output away from the CNA
Nervous systems consist of circuits of neurons and supporting cells All animals except sponges (Phylum Porifera) have a nervous system What distinguishes nervous systems of different animal groups is how neurons are organized into circuits
Organization of Nervous Systems: Cnidarians The simplest animals with nervous systems, the cnidarians, have neurons arranged in nerve nets
Echinoderms Sea stars have a nerve net in each arm connected by radial nerves to a central nerve ring What is the difference?
Platyhelmenthyes Relatively simple cephalized animals, such as flatworms, have a central nervous system (CNS) What changed?
Annelids and Arthropods Annelids and arthropods have segmentally arranged clusters of neurons called ganglia These ganglia connect to the CNS and make up a peripheral nervous system (PNS) Change?
Mollusks Nervous systems in mollusks correlate with lifestyles Sessile mollusks have simple systems, whereas more complex mollusks have more sophisticated systems Why?
Vertebrates In vertebrates, the central nervous system consists of a brain and dorsal spinal cord The PNS connects to the CNS What has been selected for?
Information Processing Nervous systems process information in three stages:
Information Processing Sensory neurons pick up and transmit information from sensors that detect external stimuli (light, heat, touch) and internal conditions (blood pressure, muscle tension). Interneurons, in the CNS, integrate the sensory input Motor output leaves the CNS via motor neurons, which communicate with effector cells (muscle or endocrine cells). Effector cells carry out the body s response to a stimulus.
Reflexes The stages of sensory input, integration, and motor output are easy to study in the simple nerve circuits that produce reflexes, the body s automatic responses to stimuli.
Neuron Structure Most of a neuron s organelles are in the cell body Most neurons have dendrites, highly branched extensions that receive signals from other neurons The axon is typically a much longer extension that transmits signals to other cells at synapses Many axons are covered with a myelin sheath Which speeds up transmission
Neurons have a wide variety of shapes that reflect input and output interactions
LE 48-6 Neurons have a wide variety of shapes that reflect input and output interactions Dendrites Axon Cell body Sensory neuron Interneurons Motor neuron
NEURON STRUCTURE POGIL
Ion pumps and ion channels maintain the resting potential of a neuron Across its plasma membrane, every cell has a voltage difference called a membrane potential The cell s inside is negative relative to the outside
The Resting Potential Resting potential is the membrane potential of a neuron that is not transmitting signals Resting potential depends on ionic gradients across the plasma membrane Concentration of Na + is higher in the extracellular fluid than in the cytosol The opposite is true for K + Animation: Resting Potential
LE 48-10 CYTOSOL EXTRACELLULAR FLUID Plasma membrane
NEURON FUNCTION POGIL #s 1-6
Gated Ion Channels Gated ion channels open or close in response to one of three stimuli: Stretch-gated ion channels open when the membrane is mechanically deformed Ligand-gated ion channels open or close when a specific chemical binds to the channel Voltage-gated ion channels respond to a change in membrane potential
NEURON FUNCTION POGIL #s 7-9
Action potentials are the signals conducted by axons If a cell has gated ion channels, its membrane potential may change in response to stimuli that open or close those channels Action potential: rapid change in the membrane potential of an excitable cell, caused by stimulus-triggered selective opening and closing of gated ion channels. Once generated, the impulse travels rapidly down the axon away from the cell body and toward the axon terminals.
Production of Action Potentials Depolarizations are usually graded only up to a certain membrane voltage, called the threshold A stimulus strong enough to produce depolarization that reaches the threshold triggers a response called an action potential
Action Potential An action potential is a brief all-ornone depolarization of a neuron s plasma membrane It carries information along axons
Action Potential Voltage-gated Na + and K + channels are involved in producing an action potential When a stimulus depolarizes the membrane, Na + channels open, allowing Na + to diffuse into the cell As the action potential subsides, K + channels open, and K + flows out of the cell
Conduction of Action Potentials An action potential can travel long distances by regenerating itself along the axon At the site where the action potential is generated, an electrical current depolarizes the neighboring region of the axon membrane
LE 48-14C Axon Action potential Na + An action potential is generated as Na + flows inward across the membrane at one location. K + Action potential Na + K + The depolarization of the action potential spreads to the neighboring region of the membrane, re-initiating the action potential there. To the left of this region, the membrane is repolarizing as K + flows outward. K + Action potential Na + K + The depolarization-repolarization process is repeated in the next region of the membrane. In this way, local currents of ions across the plasma membrane cause the action potential to be propagated along the length of the axon.
Conduction Speed The speed of an action potential increases with the axon s diameter In vertebrates, axons are myelinated, also causing an action potential s speed to increase
LE 48-15 Schwann cell Depolarized region (node of Ranvier) Cell body Myelin sheath Axon
NEURON FUNCTION POGIL #s 10-15
Four Phases of an Action Potential Resting state: no channels are open Depolarizing phase: membrane briefly reverses polarity Cell interior becomes positive to the exterior Repolarizing phase: returns membrane to its resting level Hyperpolarized phase: refractory period
Depolarization phase Na + activation gates open allowing an influx of Na + Potassium gates remain closed Interior of the cell becomes more positive charged than the exterior
Repolarization phase Returns membrane to its resting level Gates close sodium channels and opens potassium channels The inside of the cell becomes more negative compared to the outside of the cell
Hyperpolarization phase Membrane potential is temporarily more negative than the resting state Sodium channels remain closed by potassium channels remain open Refractory period occurs during this phase Neuron is insensitive to depolarizing stimuli This limits the maximum rate at which action potentials can be stimulated in a neuron.
LE 48-13_5 Membrane potential (mv) Na + Na + Na + Na + K + Rising phase of the action potential K + Falling phase of the action potential Na + Na + +50 Action potential 0 Depolarization K + 50 100 Threshold Resting potential Time Na + Na + Extracellular fluid Na + Potassium channel Activation gates Plasma membrane K + Cytosol Sodium channel K + Inactivation gate Undershoot Resting state
NEURON FUNCTION POGIL #s 16-20
Neurons communicate with other cells at synapses In an electrical synapse, current flows directly from one cell to another via a gap junction The vast majority of synapses are chemical synapses In a chemical synapse, a presynaptic neuron releases chemical neurotransmitters stored in the synaptic terminal
LE 48-17 Presynaptic cell Postsynaptic cell Synaptic vesicles containing neurotransmitter Presynaptic membrane Na + K + Neurotransmitter Postsynaptic membrane Voltage-gated Ca 2+ channel Ca 2+ Postsynaptic membrane Ligandgated ion channel Synaptic cleft Ligand-gated ion channels When an action potential reaches a terminal, the final result is release of neurotransmitters into the synaptic cleft
Synaptic Transmission Synaptic transmission involves binding of neurotransmitters to ligand-gated ion channels Neurotransmitter binding causes ion channels to open, generating a new postsynaptic potential After release, the neurotransmitter diffuses out of the synaptic cleft It may be taken up by surrounding cells (reuptake) and/or degraded by enzymes
Neurotransmitters The same neurotransmitter can produce different effects in different types of cells
Generation of Postsynaptic Potentials Direct synaptic transmission involves binding of neurotransmitters to ligandgated ion channels in the postsynaptic cell Neurotransmitter binding causes ion channels to open, generating a postsynaptic potential
Postsynaptic Potentials Excitatory postsynaptic potentials (EPSPs) are depolarizations that bring the membrane potential toward threshold This is what you modeled Inhibitory postsynaptic potentials (IPSPs) are hyperpolarizations that move the membrane potential farther from threshold
Model 1: Action Potential The model will incorporate the sodium-potassium pump previously created. The model must include: Ligand gated channel (and a ligand) Voltage gated Na+ channel Voltage gated K+ channels
Model 2: Synaptic Transmission This model will use pipe cleaners for the vesicles. Only the neurotransmitters will interact with the ligand gates of Model 1. Model 2 must include: Ca2+ Channels and Ca2+ Neurotransmitter Vesicles and NTs
Neuron Modeling Model 1 must include: Ligand gated channel (and a ligand/nt) Voltage gated Na+ channel Voltage gated K+ channels Model 2 must include: Ca2+ Channels and Ca2+ Neurotransmitter Vesicles and NTs NTs will go to the ligand gates of Model 1
Neuron Quiz Tomorrow Sodium-Potassium pump and establishment of Resting Potential Anatomy of a neuron and types of neurons Action Potential! (the whole thing) Membrane Potential Graph Synaptic Transmission, neurotransmitters and reuptake Myelin (just know what it does) IPSP and EPSP
NEURON REVIEW KAHOOT