University of Groningen Vascular function in chronic end-organ damage Ulu, Nadir IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2009 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Ulu, N. (2009). Vascular function in chronic end-organ damage: pharmacological characterization of vasomotor function in systemic vasculature Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018
The research described in this dissertation was financially supported by grants from the Groningen University Institute for Drug Exploration (GUIDE) and Institut de Recherches Internationales Servier (IRIS). The author gratefully acknowledges the financial support for printing of this dissertation by: The University of Groningen, The Faculty of Medical Sciences, Groningen University Institute for Drug Exploration (GUIDE), Novartis Pharma B.V., AstraZeneca B.V., Schering-Plough Nederland, Pfizer B.V., Servier Nederland Farma B.V. and Boehringer Ingelheim B.V. ISBN: 978-90-367-3983-2 (printed version) ISBN: 978-90-367-3984-9 (digital version) Cover design: Elif Ergur and Nadir Ulu Layout design: Nadir Ulu Printed by: Hacettepe University Hospitals Publishing House, Ankara, Turkey Copyright 2009 by Nadir Ulu All rights reserved. No part of this publication may be reproduced or transmitted in any form or by means without permission of the author.
RIJKSUNIVERSITEIT GRONINGEN VASCULAR FUNCTION IN CHRONIC END-ORGAN DAMAGE Pharmacological Characterization Of Vasomotor Function In Systemic Vasculature Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op maandag 26 oktober 2009 om 16:15 uur door Nadir Ulu geboren op 22 maart 1977 te Malatya, Turkije
Promotores : Prof. Dr. R.H. Henning Prof. Dr. W.H. van Gilst Copromotores : Dr. H. Buikema Dr. R.G. Schoemaker Beoordelingscommissie : Prof. Dr. D. de Zeeuw Prof. Dr. A.H.J. Danser Prof. Dr. H. Gurdal
IN MEMORIAM Prof. Dr. M. O uz GÜÇ 02 August 1960 03 June 2009 I was at his bedside when he died he asked me to read a poem for him about the sun and the sea about the greatness of humanity Nazim Hikmet Ran
Paranimfen: Zeynep Burcu Gokmen Alex C. Kluppel
CONTENTS Chapter 1 General introduction and aim of the thesis 11 PART 1 Chapter 2 VASCULAR RELAXATION FUNCTION Vascular dysfunction in adriamycin nephrosis; different effects of adriamycin exposure and nephrosis Nephrol Dial Transplant 2008; 23:1854-60 25 Chapter 3 Generalized peripheral vascular dysfunction co-incides with the development of hypertension associated-kidney disease in the fawn-hooded hypertensive rat Nephrol Dial Transplant; (under revision) 45 Chapter 4 Proteinuria associated endothelial dysfunction is strain dependent Am J Nephrol 2009; 30:209-17 65 Chapter 5 Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure J Cardiovasc Pharmacol 2009; 53:9-17 87 PART 2 Chapter 6 VASCULAR CONTRACTILE FUNCTION α1-adrenoceptor induced contraction of rat aorta vascular smooth muscle cell involves transactivation of EGF receptor FASEB Journal 2009; 23:775.12 (Abstract) 115 Chapter 7 Effects of chronic DPP-IV inhibition on vascular function in Zucker Diabetic Fatty rats 137 Chapter 8 Effects of chronic EGFR inhibition on vascular contractile function in a rat model of kidney I/R injury 157 Chapter 9 Summary and conclusions 171 Samenvatting 187 Özet 197 Acknowledgements 207