Delivering on the Promise: CPRIT s Impact September 8, 2018 Presented By: Wayne Roberts Chief Executive Officer
The Promise In 2007 Texans voted overwhelming for a constitutional amendment creating CPRIT to: Attract, create and expand research capabilities in higher education. Attract, create and expand the capabilities of private entities and create high quality new jobs. Expedite innovation in research and enhance the potential of breakthroughs in preventions and cures. 2
TODAY S MOMENTUM Creating and Sustaining Texas Cancer Fighting Ecosystem 3
Creating a Cancer Fighting Ecosystem Awards to 101 Organizations in 27 cities $2.15 B 35 Academic Research Institutions 36 Community and other Organizations 30 Companies August 2018 4
Creating a Cancer Fighting Ecosystem 159 CPRIT Scholar Awards $467.9 M Cassian Yee The University of Texas MD Anderson Cancer Center Gail Eckhart Dell Medical School The University of Texas at Austin Kevin Pruitt Texas Tech University Health Sciences Center August 2018 5
Creating a Cancer Fighting Ecosystem Houston is loading up on superstar cancer scientists, bankrolled in part by a generously funded state program that's transforming Texas into the nation's center of research on the deadly disease. UCSD loses 3 star scientists to Rice University The Battle for Biomedical Supremacy Much of the frenzy has been driven by the outsize role of Texas. 6
Creating a Cancer Fighting Ecosystem Core Facility Awards 43 Core Facilities at 16 Academic Institutions $187.7 M August 2018 7
Creating a Cancer Fighting Ecosystem Peter Houghton, PhD Primary Investigator - Texas Pediatric Patient Derived Xenograft Core (PDX Core) Spurred statewide collaboration with researchers from over 200 labs to address genetic diversity of childhood cancer in Texas Coordinated efforts between UT Health San Antonio and UT Southwestern to develop and characterize new PDX models from children, focusing on Hispanic and underserved groups Spurred industry partners to focus on pediatric cancer therapeutics at several drug companies and many smaller biotech companies 8
Creating a Cancer Fighting Ecosystem 4 NCI Designated Cancer Centers NCI Designated Comprehensive Cancer Centers NCI Designated Cancer Center August 2018 9
Expanding Capabilities and Expediting Innovation Centers of Excellence Catalyzed by CPRIT Nicolaou Research Accelerator collaboration with AbbVie SU2C Immunology Dream Team & Parker Institute Center NIH Proteogenomic Translational Research Centers NCI Kidney Cancer SPORE 10
Creating a Cancer Fighting Ecosystem James Brugarolas, MD, PhD Director of the Kidney Cancer Program and Brugarolas Labs Recipient of 6 CPRIT Academic Research grants exceeding $5.5 million CPRIT seeded an NCI Specialized Program of Research Excellence (SPORE) award of $11 million, one of two in the nation for kidney cancer Patient survival rates double national benchmarks for stage IV patients Only program to develop a new drug for kidney cancer going from gene discovery to clinical trials Developing a promising first in class treatment for kidney cancer with Peloton Therapeutics 11
Creating a Cancer Fighting Ecosystem 30 CPRIT Funded Companies, 11 Relocations 12
Creating a Cancer Fighting Ecosystem Location of CPRIT funded companies Korysso Therapeutics, Inc. 13
Texas-Company Academic Institution Collaborations Korysso Therapeutics, Inc. August 2018 14
Companies in Active Clinical Trials Preclinical Phase 1 Clinical Trials Phase 2 Clinical Trials August 2018 15
Creating a Cancer Fighting Ecosystem Anticipating growth in the Texas life sciences industry due to CPRIT s presence Companies Expand in Texas Switzerland-based global company with more than 50 facilities worldwide opens Lonza Houston, Inc. A major provider of product and services to laboratory and production customers, expands its regional center in Texas. 16
Economic Benefits Follow-On Funding $1.6 B Additional Non-state Funding $ 380.4 M CPRIT Company Awards As of August 2018 17
Creating a Cancer Fighting Ecosystem Prevention Projects: Serving Texans from all 254 Counties 209 Projects $223.1 M awarded As of August 2018 18
TODAY S MOMENTUM Providing Life Extending Results 19
Providing Life Extending Results 4.7 Million Prevention Services 2.3 M Education & Training for public and professionals 2.4 M Clinical services: übreast, cervical, colorectal cancer screenings & diagnostics ühepatitis B & C screening ühpv & Hepatitis B vaccinations ütobacco cessation counseling and treatment ügenetic testing üsurvivor programs and services August 2018 20
Providing Life Extending Results Screening Outcomes as of August 2018 1,185,141 screenings/ diagnostics 353,949 people never before screened 13,277 Precursors detected 3,364 cancers detected August 2018 21
Providing Life Extending Results I was told about the CPRIT grant, available for women just like me with no job and no insurance. When told I had breast cancer, I was so relieved the grant money was there. Being a single mother of a special needs son, I was so thankful this cancer was spotted early. Thank you for allowing this true blessing to be available to the patients of the Texas Panhandle and surrounding areas. - Martha Patient of Dr. Rakhshanda Rahman Access to Breast and Cervical Care for West Texas 22
Economic Benefits of Prevention Detecting and treating cancer earlier reduces physical, emotional and financial burdens Every $1 spent through CPRIT for screening/prevention Every $1 spent on screening/prevention $24.04 savings in treatment and economic benefits $1.81 savings in direct health spending Source: The Perryman Group, November 2017 23
Providing Life Extending Results CPRIT clinical studies Interventional 83 studies 6,594 patients Observational 25 studies 6,724 patients August 2018 24
Providing Life Extending Results DNAtrix Announces First Pediatric Patient Treated with Oncolytic Virus DNX-2401 - December 2017 The CPRIT grant has accelerated DNAtrix s efforts to pursue clinical development of our lead oncolytic virus for glioblastoma. This grant has enabled us to initiate a Phase 2 clinical trial in collaboration with Merck to evaluate DNX-2401 with KEYTRUDA for patients with recurrent glioblastoma. - Dr. Frank Tufaro, CEO 25
TODAY S MOMENTUM Economic Benefits Outpacing CPRIT s Expenses 26
2017 Annual Economic Benefits Annual employment due to CPRIT > 10,000 jobs Total Expenditures $1.35 Billion Retail Sales $186 Million State & Local Tax Receipts $57.2 Million Personal Income $489 Million Gross Product $705 Million Overall effects of CPRIT extend beyond the initial stimulus & business activity throughout the supply chain Source: The Perryman Group, November 2017 27
Economic Benefits Follow-On Funding $2.58 Billion Additional Non-state $1.93 Funding Billion Academic and Company Awards As of August 2018 28
THE PATH FORWARD 29
The Path Forward $2.839 B = Available to Award $2.152 B = 1,317 Grants Awarded $677 M = Remaining 30
Projected Grant Funds Available Millions $300 $250 $280 $280 $164 M General Revenue Ask $197 $197 $200 Funding $150 $100 $50 $- 0 0 2018 2019 2020 2021 2022 2023 Fiscal Year 31
The Path Forward 32
Questions? www.cprit.state.tx.us PO Box 12097 Austin Texas 78711 (512) 463-3190 Academic Research Program James Willson, MD Chief Scientific Officer Wayne R. Roberts Chief Executive Officer Product Development Research Program Michael Lang Chief Product Development Officer Prevention Program Rebecca Garcia, PhD Chief Prevention and Communications Officer Legal Kristen Doyle Deputy Executive Officer and General Counsel Operations Heidi McConnell Chief Operating Officer Compliance Vince Burgess Chief Compliance Officer 33