Total NRS 0 NRS 1 NRS 2 NRS 3 NRS 4 NRS 5 NRS 6 NRS 7 NRS 8 NRS 9 NRS 10

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Table 1: Frequencies of worst pain intensity scores (Numeric Rating Scale, NRS 0-10) of 179 surgical procedures. Frequencies of patients with pain intensities higher than NRS 6 and 8. Total 50199 3056 3090 5032 6455 6176 7721 5070 4614 5250 2033 1702 18669 8985 6.1% 6.2% 10.0% 12.9% 12.3% 15.4% 10.1% 9.2% 10.5% 4.0% 3.4% 37.2% 17.9% 1. Open reduction (calcaneus) 90 0 1 5 4 11 8 9 12 18 8 14 61 40 0.0% 1.1% 5.6% 4.4% 12.2% 8.9% 10.0% 13.3% 20.0% 8.9% 15.6% 67.8% 44.5% 2. Spinal fusion, dorsal (1-2 segments) 126 1 2 8 5 13 6 15 19 32 11 14 91 57 0.8% 1.6% 6.3% 4.0% 10.3% 4.8% 11.9% 15.1% 25.4% 8.7% 11.1% 72.2% 45.2% 3. Spinal fusion, dorsal (3 or more segments) 40 1 0 1 3 5 5 2 5 6 9 3 25 18 2.5% 0.0% 2.5% 7.5% 12.5% 12.5% 5.0% 12.5% 15.0% 22.5% 7.5% 62.5% 45.0% 4. Myomectomy (open) 36 0 3 1 2 1 1 6 5 12 4 1 28 17 0.0% 8.3% 2.8% 5.6% 2.8% 2.8% 16.7% 13.9% 33.3% 11.1% 2.8% 77.8% 47.2% 5. Proctocolectomy (open) 14 0 0 0 3 2 0 0 4 3 1 1 9 5 0.0% 0.0% 0.0% 21.4% 14.3% 0.0% 0.0% 28.6% 21.4% 7.1% 7.1% 64.2% 35.6% 6. Vertebra body replacement and complex spinal reconstruction 37 1 2 3 1 4 2 4 9 9 0 2 24 11 (e.g. scoliosis) 2.7% 5.4% 8.1% 2.7% 10.8% 5.4% 10.8% 24.3% 24.3%.0% 5.4% 64.8% 29.7% 7. Arthrodesis (foot joint) 77 0 3 3 5 5 15 8 11 14 6 7 46 27 0.0% 3.9% 3.9% 6.5% 6.5% 19.5% 10.4% 14.3% 18.2% 7.8% 9.1% 59.8% 35.1% 8. Arthodesis (metacarpophalangeal, interphalangeal joints) 112 0 3 5 10 14 14 12 16 20 5 13 66 38 0.0% 2.7% 4.5% 8.9% 12.5% 12.5% 10.7% 14.3% 17.9% 4.5% 11.6% 59.0% 34.0% 9. Caesarean section 818 3 16 42 57 91 107 106 125 148 72 51 502 271 0.4% 2.0% 5.1% 7.0% 11.1% 13.1% 13.0% 15.3% 18.1% 8.8% 6.2% 61.4% 33.1% 10. Open reduction (acetabulum and head of femur with internal 31 1 2 0 5 2 3 3 2 5 2 6 18 13 fixation) 3.2% 6.5% 0.0% 16.1% 6.5% 9.7% 9.7% 6.5% 16.1% 6.5% 19.4% 58.2% 42.0% 11. Hand resection arthroplasty 78 1 2 3 4 5 18 8 12 14 6 5 45 25 1.3% 2.6% 3.8% 5.1% 6.4% 23.1% 10.3% 15.4% 17.9% 7.7% 6.4% 57.7% 32.0% 12. Shoulder joint replacement 79 5 0 1 5 6 18 9 5 13 13 4 44 30 6.3% 0.0% 1.3% 6.3% 7.6% 22.8% 11.4% 6.3% 16.5% 16.5% 5.1% 55.8% 38.1% 13. Arthrodesis (ankle joint) 124 3 6 3 7 19 15 11 13 26 7 14 71 47 2.4% 4.8% 2.4% 5.6% 15.3% 12.1% 8.9% 10.5% 21.0% 5.6% 11.3% 57.3% 37.9% 14. Pancreatectomy (partial - Whipple) 18 0 0 0 1 1 6 2 5 2 1 0 10 3 0.0% 0.0% 0.0% 5.6% 5.6% 33.3% 11.1% 27.8% 11.1% 5.6% 0.0% 55.6% 16.7% 15. Open refixation and reconstruction (w or w/o plastic) (knee 148 4 1 8 8 12 23 22 25 28 9 8 92 45 ligaments) 2.7%.7% 5.4% 5.4% 8.1% 15.5% 14.9% 16.9% 18.9% 6.1% 5.4% 62.2% 30.4% 16. Open reduction (tibia shaft) 49 1 1 3 3 4 7 9 6 8 1 6 30 15 2.0% 2.0% 6.1% 6.1% 8.2% 14.3% 18.4% 12.2% 16.3% 2.0% 12.2% 61.1% 30.5% 17. Open reduction (patella) 55 0 2 1 7 7 8 6 7 7 5 5 30 17 0.0% 3.6% 1.8% 12.7% 12.7% 14.5% 10.9% 12.7% 12.7% 9.1% 9.1% 54.5% 30.9% 18. Open reduction (proximal radius) 76 0 0 4 11 8 11 8 10 14 5 5 42 24 0.0% 0.0% 5.3% 14.5% 10.5% 14.5% 10.5% 13.2% 18.4% 6.6% 6.6% 55.3% 31.6% 19. Appendectomy (open) 227 0 4 10 20 24 40 32 32 38 19 8 129 65 0.0% 1.8% 4.4% 8.8% 10.6% 17.6% 14.1% 14.1% 16.7% 8.4% 3.5% 56.8% 28.6% 20. Open reduction (proximal tibia) 141 3 2 6 12 17 20 23 15 21 10 12 81 43 2.1% 1.4% 4.3% 8.5% 12.1% 14.2% 16.3% 10.6% 14.9% 7.1% 8.5% 57.4% 30.5% 21. Open reconstruction (shoulder joint ligaments) 633 8 19 44 59 45 100 79 74 102 59 44 358 205 1.3% 3.0% 7.0% 9.3% 7.1% 15.8% 12.5% 11.7% 16.1% 9.3% 7.0% 56.6% 32.4% 22. Partial shoulder joint replacement (humerus) 113 5 6 5 4 10 18 14 9 21 15 6 65 42 4.4% 5.3% 4.4% 3.5% 8.8% 15.9% 12.4% 8.0% 18.6% 13.3% 5.3% 57.6% 37.2% 23. Hemorrhoids (plastic reconstruction) 67 2 1 4 5 5 12 9 7 12 7 3 38 22 3.0% 1.5% 6.0% 7.5% 7.5% 17.9% 13.4% 10.4% 17.9% 10.4% 4.5% 56.6% 32.8% 24. Tonsillectomy 402 0 6 22 30 40 79 43 83 63 32 4 225 99 0.0% 1.5% 5.5% 7.5% 10.0% 19.7% 10.7% 20.6% 15.7% 8.0% 1.0% 56.0% 24.7% 25. Cholecystectomy (open) 335 4 5 9 36 45 61 49 31 53 18 24 175 95 1.2% 1.5% 2.7% 10.7% 13.4% 18.2% 14.6% 9.3% 15.8% 5.4% 7.2% 52.3% 28.4% 26. Kidney transplantation 43 2 0 3 5 4 7 5 2 5 6 4 22 15 4.7% 0.0% 7.0% 11.6% 9.3% 16.3% 11.6% 4.7% 11.6% 14.0% 9.3% 51.2% 34.9% 27. Hysterectomy (subtotal) (open) 19 0 0 3 2 3 1 1 1 5 2 1 10 8 0.0% 0.0% 15.8% 10.5% 15.8% 5.3% 5.3% 5.3% 26.3% 10.5% 5.3% 52.7% 42.1% 28. Vertical sleeve gastrectomy for biliopancreatic diversion with 15 0 0 1 2 0 3 4 1 4 0 0 9 4 duodenal switch (open) 0.0% 0.0% 6.7% 13.3%.0% 20.0% 26.7% 6.7% 26.7% 0.0% 0.0% 60.1% 26.7% 29. Incisional hernia repair, with alloplastic material (lap) 132 0 4 9 18 16 15 19 14 19 8 10 70 37 0.0% 3.0% 6.8% 13.6% 12.1% 11.4% 14.4% 10.6% 14.4% 6.1% 7.6% 53.1% 28.1% 30. Open reduction (pelvic rim and ring) 127 8 2 9 12 13 17 10 17 16 15 8 66 39 6.3% 1.6% 7.1% 9.4% 10.2% 13.4% 7.9% 13.4% 12.6% 11.8% 6.3% 52.0% 30.7% 31. Oophorectomy and salpingo-oophorectomy (open) 21 1 1 1 1 4 2 3 2 2 2 2 11 6 4.8% 4.8% 4.8% 4.8% 19.0% 9.5% 14.3% 9.5% 9.5% 9.5% 9.5% 52.3% 28.5% 1

32. Arthrodesis (toe joint) 33. Open reduction (distal humerus) 34. Open reduction (distal fibula) 35. Small bowel resection (open) 36. Arthroscopic surgery (knee ligaments) 37. Vertical sleeve gastrectomy for biliopancreatic diversion with duodenal switch (lap) 38. Arthroscopic surgery (hip joint) 39. Arthroscopic revision (wrist joint) 40. Open reduction (distal femur) 41. Splenectomy (open) 42. Open reduction (fibula shaft) 43. Closed reduction with internal fixation (fibula) 44. Open reduction (distal tibia) 45. Breast augmentation 46. Knee joint replacement (revision, exchange, removal) 47. Appendectomy (lap) 48. Open reduction (distal radius) 49. Open reduction (metatarsal bone) 50. Open reduction (clavicle) 51. Incisional hernia repair, with alloplastic material (open) 52. Sternotomy (cardiac surgery) 53. Knee joint replacement 54. Open reconstruction (ankle joint ligaments) 55. Arthroscopic surgery (shoulder ligaments) 56. Open reduction (humerus shaft) 57. Extrauterine pregnancy (lap) 58. Closed reduction with internal fixation (tibia) 59. Implantation or exchange of an adjustable gastric band (lap) 60. Open reduction (femur shaft) 61. Closed reduction with internal fixation (clavicle) 62. Pancreatectomy (partial - w or w/o resection of duodenum) 63. Lower leg amputation 70 2 3 8 6 7 5 6 13 12 2 6 39 20 2.9% 4.3% 11.4% 8.6% 10.0% 7.1% 8.6% 18.6% 17.1% 2.9% 8.6% 55.8% 28.6% 55 2 2 5 6 3 7 6 6 11 6 1 30 18 3.6% 3.6% 9.1% 10.9% 5.5% 12.7% 10.9% 10.9% 20.0% 10.9% 1.8% 54.5% 32.7% 677 19 17 53 75 80 88 73 90 91 54 37 345 182 2.8% 2.5% 7.8% 11.1% 11.8% 13.0% 10.8% 13.3% 13.4% 8.0% 5.5% 51.0% 26.9% 49 1 2 4 6 6 5 5 7 9 1 3 25 13 2.0% 4.1% 8.2% 12.2% 12.2% 10.2% 10.2% 14.3% 18.4% 2.0% 6.1% 51.0% 26.5% 633 14 40 39 71 53 91 88 84 87 46 20 325 153 2.2% 6.3% 6.2% 11.2% 8.4% 14.4% 13.9% 13.3% 13.7% 7.3% 3.2% 51.4% 24.2% 164 2 4 10 19 19 26 30 29 18 3 4 84 25 1.2% 2.4% 6.1% 11.6% 11.6% 15.9% 18.3% 17.7% 11.0% 1.8% 2.4% 51.2% 15.2% 27 0 3 3 1 2 4 3 7 2 0 2 14 4 0.0% 11.1% 11.1% 3.7% 7.4% 14.8% 11.1% 25.9% 7.4% 0.0% 7.4% 51.8% 14.8% 32 3 0 4 3 2 3 5 5 5 2 0 17 7 9.4% 0.0% 12.5% 9.4% 6.3% 9.4% 15.6% 15.6% 15.6% 6.3% 0.0% 53.1% 21.9% 29 3 0 5 1 4 1 6 2 4 1 2 15 7 10.3% 0.0% 17.2% 3.4% 13.8% 3.4% 20.7% 6.9% 13.8% 3.4% 6.9% 51.7% 24.1% 18 1 1 1 0 2 4 1 3 4 0 1 9 5 5.6% 5.6% 5.6% 0.0% 11.1% 22.2% 5.6% 16.7% 22.2% 0.0% 5.6% 50.1% 27.8% 20 2 0 2 3 2 1 1 3 5 0 1 10 6 10.0% 0.0% 10.0% 15.0% 10.0% 5.0% 5.0% 15.0% 25.0% 0.0% 5.0% 50.0% 30.0% 28 0 4 1 5 3 1 1 8 2 3 0 14 5 0.0% 14.3% 3.6% 17.9% 10.7% 3.6% 3.6% 28.6% 7.1% 10.7% 0.0% 50.0% 17.8% 355 7 9 25 35 39 66 34 34 52 29 25 174 106 2.0% 2.5% 7.0% 9.9% 11.0% 18.6% 9.6% 9.6% 14.6% 8.2% 7.0% 49.0% 29.8% 37 2 1 3 2 6 6 2 4 4 4 3 17 11 5.4% 2.7% 8.1% 5.4% 16.2% 16.2% 5.4% 10.8% 10.8% 10.8% 8.1% 45.9% 29.7% 351 18 15 20 30 45 53 40 31 59 19 21 170 99 5.1% 4.3% 5.7% 8.5% 12.8% 15.1% 11.4% 8.8% 16.8% 5.4% 6.0% 48.4% 28.2% 1198 16 44 68 146 134 197 188 168 163 43 31 593 237 1.3% 3.7% 5.7% 12.2% 11.2% 16.4% 15.7% 14.0% 13.6% 3.6% 2.6% 49.5% 19.8% 996 33 39 65 101 120 163 137 111 124 58 45 475 227 3.3% 3.9% 6.5% 10.1% 12.0% 16.4% 13.8% 11.1% 12.4% 5.8% 4.5% 47.6% 22.7% 103 5 2 7 10 16 15 10 16 11 5 6 48 22 4.9% 1.9% 6.8% 9.7% 15.5% 14.6% 9.7% 15.5% 10.7% 4.9% 5.8% 46.6% 21.4% 240 4 9 19 29 27 41 26 29 36 13 7 111 56 1.7% 3.8% 7.9% 12.1% 11.3% 17.1% 10.8% 12.1% 15.0% 5.4% 2.9% 46.2% 23.3% 413 15 19 30 39 46 69 57 40 57 18 23 195 98 3.6% 4.6% 7.3% 9.4% 11.1% 16.7% 13.8% 9.7% 13.8% 4.4% 5.6% 47.3% 23.8% 134 6 5 9 9 19 25 15 12 26 2 6 61 34 4.5% 3.7% 6.7% 6.7% 14.2% 18.7% 11.2% 9.0% 19.4% 1.5% 4.5% 45.6% 25.4% 4439 300 181 297 408 442 735 467 416 634 275 284 2076 1193 6.8% 4.1% 6.7% 9.2% 10.0% 16.6% 10.5% 9.4% 14.3% 6.2% 6.4% 46.8% 26.9% 77 2 1 9 8 5 15 13 8 11 2 3 37 16 2.6% 1.3% 11.7% 10.4% 6.5% 19.5% 16.9% 10.4% 14.3% 2.6% 3.9% 48.1% 20.8% 1083 56 51 77 119 111 161 112 130 149 68 49 508 266 5.2% 4.7% 7.1% 11.0% 10.2% 14.9% 10.3% 12.0% 13.8% 6.3% 4.5% 46.9% 24.6% 46 1 1 4 5 5 10 9 2 5 1 3 20 9 2.2% 2.2% 8.7% 10.9% 10.9% 21.7% 19.6% 4.3% 10.9% 2.2% 6.5% 43.5% 19.6% 34 1 1 1 3 5 10 4 4 2 3 0 13 5 2.9% 2.9% 2.9% 8.8% 14.7% 29.4% 11.8% 11.8% 5.9% 8.8% 0.0% 38.3% 14.7% 182 9 6 11 22 24 30 17 21 26 10 6 80 42 4.9% 3.3% 6.0% 12.1% 13.2% 16.5% 9.3% 11.5% 14.3% 5.5% 3.3% 43.9% 23.1% 25 1 1 2 2 1 7 2 6 2 0 1 11 3 4.0% 4.0% 8.0% 8.0% 4.0% 28.0% 8.0% 24.0% 8.0%.0% 4.0% 44.0% 12.0% 73 4 1 5 5 11 18 4 13 7 2 3 29 12 5.5% 1.4% 6.8% 6.8% 15.1% 24.7% 5.5% 17.8% 9.6% 2.7% 4.1% 39.7% 16.4% 298 7 9 20 39 35 65 38 27 33 17 8 123 58 2.3% 3.0% 6.7% 13.1% 11.7% 21.8% 12.8% 9.1% 11.1% 5.7% 2.7% 41.4% 19.5% 43 5 1 1 5 8 2 4 5 8 1 3 21 12 11.6% 2.3% 2.3% 11.6% 18.6% 4.7% 9.3% 11.6% 18.6% 2.3% 7.0% 48.8% 27.9% 61 4 1 5 8 7 10 8 4 5 6 3 26 14 6.6% 1.6% 8.2% 13.1% 11.5% 16.4% 13.1% 6.6% 8.2% 9.8% 4.9% 42.6% 22.9% 2

64. Open reduction (proximal humerus) 65. Sigmoidectomy (open) 66. Surgical correction procedures (metatarsus and toes) 67. Thoracoscopic lung resection (atypical, segmental, lobar pneumonectomy) 68. Spinal fusion, ventral (1-2 segments) 69. Closed reduction with internal fixation (humerus) 70. Closed reduction with internal fixation (radius) 71. Open reduction (metacarpal bone) 72. Incisional hernia repair, with reconstruction 73. Sigmoidectomy (lap) 74. Open reduction (carpal bones) 75. Hysterectomy (open, vaginal) 76. Oophorectomy and salpingo-oophorectomy (lap) 77. Liver resection (atypical), w or w/o cholecystectomy (open) 78. Myomectomy (lap, vaginal laparoscopically assisted) 79. Open reduction (ulnar shaft) 80. Open reduction (proximal ulna) 81. Hip joint replacement (revision, exchange, removal) 82. Hip joint replacement 83. Incisional hernia repair, without reconstruction 84. Removal of osteosynthetic material (ulnar) 85. Enterostomy as independent procedure, double barrel and end enterostomy 86. Removal of osteosynthesis material (femur without femoral neck) 87. Resection of rectum with sphincter preservation (open) 88. Reduction mammoplasty 89. Epigastric hernia repair (lap) 90. Spinal canal decompression (2 segments) 91. Laminectomy, hemilaminectomy (cervical, ventral, 1-2 segments) 92. Right hemicolectomy (open) 93. Femoral hernia repair (open) 94. Cholecystectomy (lap) 95. Closed reduction with internal fixation (metacarpal bones) 402 17 10 40 40 53 79 39 42 47 16 19 163 82 4.2% 2.5% 10.0% 10.0% 13.2% 19.7% 9.7% 10.4% 11.7% 4.0% 4.7% 40.5% 20.4% 119 7 4 9 12 10 26 18 9 13 6 5 51 24 5.9% 3.4% 7.6% 10.1% 8.4% 21.8% 15.1% 7.6% 10.9% 5.0% 4.2% 42.8% 20.1% 209 17 10 17 19 22 23 23 26 34 10 8 101 52 8.1% 4.8% 8.1% 9.1% 10.5% 11.0% 11.0% 12.4% 16.3% 4.8% 3.8% 48.3% 24.9% 60 2 3 8 8 5 7 4 9 8 4 2 27 14 3.3% 5.0% 13.3% 13.3% 8.3% 11.7% 6.7% 15.0% 13.3% 6.7% 3.3% 45.0% 23.3% 95 6 5 11 8 8 15 8 14 10 6 4 42 20 6.3% 5.3% 11.6% 8.4% 8.4% 15.8% 8.4% 14.7% 10.5% 6.3% 4.2% 44.1% 21.0% 126 5 9 12 9 17 25 9 12 17 7 4 49 28 4.0% 7.1% 9.5% 7.1% 13.5% 19.8% 7.1% 9.5% 13.5% 5.6% 3.2% 38.9% 22.3% 117 2 9 12 14 13 21 12 12 11 4 7 46 22 1.7% 7.7% 10.3% 12.0% 11.1% 17.9% 10.3% 10.3% 9.4% 3.4% 6.0% 39.4% 18.8% 95 2 5 12 15 10 11 8 12 12 5 3 40 20 2.1% 5.3% 12.6% 15.8% 10.5% 11.6% 8.4% 12.6% 12.6% 5.3% 3.2% 42.1% 21.1% 158 2 6 17 15 19 41 23 11 16 4 4 58 24 1.3% 3.8% 10.8% 9.5% 12.0% 25.9% 14.6% 7.0% 10.1% 2.5% 2.5% 36.7% 15.1% 127 6 8 16 12 12 17 14 12 22 5 3 56 30 4.7% 6.3% 12.6% 9.4% 9.4% 13.4% 11.0% 9.4% 17.3% 3.9% 2.4% 44.0% 23.6% 50 0 3 5 8 6 8 8 4 5 1 2 20 8 0.0% 6.0% 10.0% 16.0% 12.0% 16.0% 16.0% 8.0% 10.0% 2.0% 4.0% 40.0% 16.0% 2401 82 130 242 295 324 400 252 208 270 120 78 928 468 3.4% 5.4% 10.1% 12.3% 13.5% 16.7% 10.5% 8.7% 11.2% 5.0% 3.2% 38.6% 19.4% 52 0 4 4 8 8 9 4 5 8 1 1 19 10 0.0% 7.7% 7.7% 15.4% 15.4% 17.3% 7.7% 9.6% 15.4% 1.9% 1.9% 36.5% 19.2% 51 3 4 2 8 5 6 7 5 9 1 1 23 11 5.9% 7.8% 3.9% 15.7% 9.8% 11.8% 13.7% 9.8% 17.6% 2.0% 2.0% 45.1% 21.6% 56 2 3 6 5 6 12 7 7 3 5 0 22 8 3.6% 5.4% 10.7% 8.9% 10.7% 21.4% 12.5% 12.5% 5.4% 8.9% 0.0% 39.3% 14.3% 26 0 0 5 1 5 5 4 4 1 1 0 10 2 0.0% 0.0% 19.2% 3.8% 19.2% 19.2% 15.4% 15.4% 3.8% 3.8% 0.0% 38.4% 7.6% 107 5 6 8 10 23 17 9 9 11 4 5 38 20 4.7% 5.6% 7.5% 9.3% 21.5% 15.9% 8.4% 8.4% 10.3% 3.7% 4.7% 35.5% 18.7% 411 24 21 41 50 50 65 35 40 54 14 17 160 85 5.8% 5.1% 10.0% 12.2% 12.2% 15.8% 8.5% 9.7% 13.1% 3.4% 4.1% 38.8% 20.6% 4208 256 197 367 483 541 734 429 432 452 164 153 1630 769 6.1% 4.7% 8.7% 11.5% 12.9% 17.4% 10.2% 10.3% 10.7% 3.9% 3.6% 38.7% 18.2% 66 4 1 6 8 9 13 8 8 5 2 2 25 9 6.1% 1.5% 9.1% 12.1% 13.6% 19.7% 12.1% 12.1% 7.6% 3.0% 3.0% 37.8% 13.6% 55 2 3 8 5 7 9 7 3 6 2 3 21 11 3.6% 5.5% 14.5% 9.1% 12.7% 16.4% 12.7% 5.5% 10.9% 3.6% 5.5% 38.2% 20.0% 86 2 1 5 10 18 26 7 9 5 3 0 24 8 2.3% 1.2% 5.8% 11.6% 20.9% 30.2% 8.1% 10.5% 5.8% 3.5% 0.0% 27.9% 9.3% 193 8 11 19 26 24 36 18 16 16 11 8 69 35 4.1% 5.7% 9.8% 13.5% 12.4% 18.7% 9.3% 8.3% 8.3% 5.7% 4.1% 35.7% 18.1% 182 5 8 22 22 25 40 18 11 19 5 7 60 31 2.7% 4.4% 12.1% 12.1% 13.7% 22.0% 9.9% 6.0% 10.4% 2.7% 3.8% 32.8% 16.9% 146 4 11 16 22 17 18 14 15 22 5 2 58 29 2.7% 7.5% 11.0% 15.1% 11.6% 12.3% 9.6% 10.3% 15.1% 3.4% 1.4% 39.8% 19.9% 13 0 2 1 0 0 4 4 2 0 0 0 6 0 0.0% 15.4% 7.7% 0.0% 0.0% 30.8% 30.8% 15.4% 0.0% 0.0% 0.0% 46.2% 0.0% 167 10 6 18 18 25 29 21 9 20 4 7 61 31 6.0% 3.6% 10.8% 10.8% 15.0% 17.4% 12.6% 5.4% 12.0% 2.4% 4.2% 36.6% 18.6% 88 2 5 7 14 14 16 8 9 9 1 3 30 13 2.3% 5.7% 8.0% 15.9% 15.9% 18.2% 9.1% 10.2% 10.2% 1.1% 3.4% 34.0% 14.7% 163 11 7 18 23 20 22 14 14 20 8 6 62 34 6.7% 4.3% 11.0% 14.1% 12.3% 13.5% 8.6% 8.6% 12.3% 4.9% 3.7% 38.1% 20.9% 79 3 1 9 14 12 14 6 6 8 5 1 26 14 3.8% 1.3% 11.4% 17.7% 15.2% 17.7% 7.6% 7.6% 10.1% 6.3% 1.3% 32.9% 17.7% 4460 149 225 406 635 661 775 527 420 406 146 110 1609 662 3.3% 5.0% 9.1% 14.2% 14.8% 17.4% 11.8% 9.4% 9.1% 3.3% 2.5% 36.1% 14.9% 36 0 2 6 2 6 7 5 4 3 0 1 13 4 0.0% 5.6% 16.7% 5.6% 16.7% 19.4% 13.9% 11.1% 8.3% 0.0% 2.8% 36.1% 11.1% 3

96. Resection of rectum with sphincter preservation (lap) 97. Hemorrhoids. excision (e.g. Milligan-Morgan) 98. Fallopian tube (insufflation. chromopertubation) (lap) 99. Closed reduction with internal fixation (femur - neck of femur) 100. Arthroscopic surgery (shoulder joint) 101. Shunt or bypass - femoral and popliteal artery (femoro-pop. femoro-crural. femoro-femoral) 102. Liver resection (anatomical). w or w/o cholecystectomy (segmental. bisegmental. hemihepatectomy) 103. Arthroscopic surgery (knee) (excl. ligaments and meniscus) 104. Open reduction (proximal femur) 105. Open reduction (finger) 106. Hemorrhoids (stapler procedure) 107. Nephrectomy (open) 108. Liver resection (atypical). w or w/o cholecystectomy (lap) 109. Left hemicolectomy (open) 110. Umbilical hernia repair (lap) 111. Arthroscopic surgery (ankle joint) 112. Spinal canal decompression (1 segment) 113. Open reduction (radius shaft) 114. Removal of osteosynthetic material (tibia w or w/o fibula) 115. Trans-femoral amputation 116. Laminectomy. hemilaminectomy (lumbar. 1-2 segments) 117. Epigastric hernia repair (open) 118. Open lung resection (atypical. segmental. lobar pneumonectomy) 119. Right hemicolectomy (lap) 120. Gastrectomy (total or subtotal) 121. Hysterectomy (subtotal) (lap) 122. Submucosal resection und plastic reconstruction of nasal septum 123. Inguinal hernia repair (w or w/o mesh) (open) 124. Fundoplication (lap) 125. Removal of osteosynthetic material (fibula) 126. Surgical wound debridement 127. Thyroid (total. hemi. partial resection) 151 9 4 10 20 32 23 15 12 21 3 2 53 26 6.0% 2.6% 6.6% 13.2% 21.2% 15.2% 9.9% 7.9% 13.9% 2.0% 1.3% 35.0% 17.2% 143 11 9 10 22 18 16 10 17 22 4 4 57 30 7.7% 6.3% 7.0% 15.4% 12.6% 11.2% 7.0% 11.9% 15.4% 2.8% 2.8% 39.9% 21.0% 23 0 1 1 4 5 5 2 3 2 0 0 7 2 0.0% 4.3% 4.3% 17.4% 21.7% 21.7% 8.7% 13.0% 8.7%.0% 0.0% 30.4% 8.7% 59 5 0 5 10 8 8 10 6 4 0 3 23 7 8.5%.0% 8.5% 16.9% 13.6% 13.6% 16.9% 10.2% 6.8% 0.0% 5.1% 39.0% 11.9% 96 8 6 9 13 9 16 6 8 14 4 3 35 21 8.3% 6.3% 9.4% 13.5% 9.4% 16.7% 6.3% 8.3% 14.6% 4.2% 3.1% 36.5% 21.9% 248 20 12 20 38 31 38 35 15 17 6 16 89 39 8.1% 4.8% 8.1% 15.3% 12.5% 15.3% 14.1% 6.0% 6.9% 2.4% 6.5% 35.9% 15.8% 62 4 5 2 6 7 16 11 5 5 0 1 22 6 6.5% 8.1% 3.2% 9.7% 11.3% 25.8% 17.7% 8.1% 8.1%.0% 1.6% 35.5% 9.7% 1001 41 81 107 141 124 149 107 83 109 34 25 358 168 4.1% 8.1% 10.7% 14.1% 12.4% 14.9% 10.7% 8.3% 10.9% 3.4% 2.5% 35.8% 16.8% 108 5 5 6 18 17 25 10 11 5 4 2 32 11 4.6% 4.6% 5.6% 16.7% 15.7% 23.1% 9.3% 10.2% 4.6% 3.7% 1.9% 29.7% 10.2% 69 2 8 6 13 5 10 5 7 10 1 2 25 13 2.9% 11.6% 8.7% 18.8% 7.2% 14.5% 7.2% 10.1% 14.5% 1.4% 2.9% 36.1% 18.8% 130 4 14 19 14 12 21 16 7 12 5 6 46 23 3.1% 10.8% 14.6% 10.8% 9.2% 16.2% 12.3% 5.4% 9.2% 3.8% 4.6% 35.3% 17.6% 158 25 7 12 16 15 22 16 10 19 9 7 61 35 15.8% 4.4% 7.6% 10.1% 9.5% 13.9% 10.1% 6.3% 12.0% 5.7% 4.4% 38.5% 22.1% 40 1 2 7 4 4 11 4 3 2 2 0 11 4 2.5% 5.0% 17.5% 10.0% 10.0% 27.5% 10.0% 7.5% 5.0% 5.0% 0.0% 27.5% 10.0% 53 3 3 5 7 10 6 3 6 6 0 4 19 10 5.7% 5.7% 9.4% 13.2% 18.9% 11.3% 5.7% 11.3% 11.3%.0% 7.5% 35.8% 18.8% 22 0 1 3 3 5 4 0 1 4 1 0 6 5 0.0% 4.5% 13.6% 13.6% 22.7% 18.2%.0% 4.5% 18.2% 4.5% 0.0% 27.2% 22.7% 79 8 5 8 13 6 6 2 10 14 7 0 33 21 10.1% 6.3% 10.1% 16.5% 7.6% 7.6% 2.5% 12.7% 17.7% 8.9% 0.0% 41.8% 26.6% 407 12 20 50 58 64 59 41 43 36 9 15 144 60 2.9% 4.9% 12.3% 14.3% 15.7% 14.5% 10.1% 10.6% 8.8% 2.2% 3.7% 35.4% 14.7% 29 0 2 3 4 6 5 1 3 5 0 0 9 5 0.0% 6.9% 10.3% 13.8% 20.7% 17.2% 3.4% 10.3% 17.2%.0% 0.0% 30.9% 17.2% 397 10 28 40 65 58 59 47 32 39 12 7 137 58 2.5% 7.1% 10.1% 16.4% 14.6% 14.9% 11.8% 8.1% 9.8% 3.0% 1.8% 34.5% 14.6% 53 7 2 4 3 12 6 7 2 3 4 3 19 10 13.2% 3.8% 7.5% 5.7% 22.6% 11.3% 13.2% 3.8% 5.7% 7.5% 5.7% 35.9% 18.9% 867 45 46 108 144 113 137 61 69 78 35 31 274 144 5.2% 5.3% 12.5% 16.6% 13.0% 15.8% 7.0% 8.0% 9.0% 4.0% 3.6% 31.6% 16.6% 125 7 3 12 22 21 21 13 11 11 2 2 39 15 5.6% 2.4% 9.6% 17.6% 16.8% 16.8% 10.4% 8.8% 8.8% 1.6% 1.6% 31.2% 12.0% 80 5 10 12 11 8 4 7 4 9 3 7 30 19 6.3% 12.5% 15.0% 13.8% 10.0% 5.0% 8.8% 5.0% 11.3% 3.8% 8.8% 37.7% 23.9% 15 1 0 2 2 5 1 1 0 2 0 1 4 3 6.7% 0.0% 13.3% 13.3% 33.3% 6.7% 6.7%.0% 13.3% 0.0% 6.7% 26.7% 20.0% 98 7 2 12 16 13 20 8 7 8 1 4 28 13 7.1% 2.0% 12.2% 16.3% 13.3% 20.4% 8.2% 7.1% 8.2% 1.0% 4.1% 28.6% 13.3% 106 2 6 10 20 18 19 9 13 8 1 0 31 9 1.9% 5.7% 9.4% 18.9% 17.0% 17.9% 8.5% 12.3% 7.5% 0.9% 0.0% 29.2% 8.4% 388 31 32 43 50 45 51 39 33 36 19 9 136 64 8.0% 8.2% 11.1% 12.9% 11.6% 13.1% 10.1% 8.5% 9.3% 4.9% 2.3% 35.1% 16.5% 941 41 57 120 171 127 136 91 81 73 25 19 289 117 4.4% 6.1% 12.8% 18.2% 13.5% 14.5% 9.7% 8.6% 7.8% 2.7% 2.0% 30.8% 12.5% 153 8 11 15 23 26 23 13 17 12 4 1 47 17 5.2% 7.2% 9.8% 15.0% 17.0% 15.0% 8.5% 11.1% 7.8% 2.6% 0.7% 30.7% 11.1% 150 6 17 14 24 16 25 16 11 17 3 1 48 21 4.0% 11.3% 9.3% 16.0% 10.7% 16.7% 10.7% 7.3% 11.3% 2.0%.7% 32.0% 14.0% 618 53 43 78 78 87 83 48 57 52 18 21 196 91 8.6% 7.0% 12.6% 12.6% 14.1% 13.4% 7.8% 9.2% 8.4% 2.9% 3.4% 31.7% 14.7% 2362 91 164 295 402 347 401 224 203 166 41 28 662 235 3.9% 6.9% 12.5% 17.0% 14.7% 17.0% 9.5% 8.6% 7.0% 1.7% 1.2% 28.0% 9.9% 4

128. Nephrectomy (lap) 129. Hand tendon repair 130. Umbilical hernia repair (open) 131. Orchidectomy 132. Removal/reconstruction of teeth 133. Resection of rectum without sphincter preservation 134. Breast reconstruction (muscle or skin flap) 135. Reduction of facial bone fractures 136. Adrenal glands surgery (open) 137. Rhinoplasty 138. Female pelvic floor reconstruction 139. Adrenal glands surgery (lap) 140. Inguinal hernia repair (w or w/o mesh) (endoscopic) 141. Radical prostatectomy (lap) 142. Cystectomie (total) (urinary bladder) 143. Pleurodesis (thoracoscopic) 144. Removal of osteosynthetic material (radius) 145. Anal fistula closure 146. Mastectomy w or w/o axillary lymphadenectomy (with or without prothesis) 147. Kidney stone removal (nephrostomy. ureterrenoscopic. lithotripsy) 148. Paranasal sinus surgery (several sinuses) 149. Vulva (incision. Bartholins gland. local excision) 150. Inguinal hernia repair (w or w/o mesh) (lap) 151. Pilonidal sinus surgery 152. Excision of solitary lymph nodes or lymphatic vessels (inguinal) (open) 153. Endarterectomy (femoral arteries) 154. Removal of osteosynthetic material (clavicle) 155. Middle and inner ear surgery 156. Creation of AV-fistula (e.g. Cimino-shunt) 157. Extended excision of diseased cutaneous and subcutaneous tissue 158. Transmetatarsal amputation 159. Toe amputation 34 0 1 7 4 10 5 3 0 3 0 1 7 4 0.0% 2.9% 20.6% 11.8% 29.4% 14.7% 8.8% 0.0% 8.8% 0.0% 2.9% 20.5% 11.7% 192 17 14 23 29 21 29 23 13 8 7 8 59 23 8.9% 7.3% 12.0% 15.1% 10.9% 15.1% 12.0% 6.8% 4.2% 3.6% 4.2% 30.8% 12.0% 378 17 23 55 65 48 65 43 29 19 11 3 105 33 4.5% 6.1% 14.6% 17.2% 12.7% 17.2% 11.4% 7.7% 5.0% 2.9% 0.8% 27.8% 8.7% 74 6 6 11 10 5 16 5 6 6 0 3 20 9 8.1% 8.1% 14.9% 13.5% 6.8% 21.6% 6.8% 8.1% 8.1% 0.0% 4.1% 27.1% 12.2% 37 3 4 8 1 4 3 5 5 3 1 0 14 4 8.1% 10.8% 21.6% 2.7% 10.8% 8.1% 13.5% 13.5% 8.1% 2.7% 0.0% 37.8% 10.8% 47 4 1 9 7 8 5 4 3 3 3 0 13 6 8.5% 2.1% 19.1% 14.9% 17.0% 10.6% 8.5% 6.4% 6.4% 6.4% 0.0% 27.7% 12.8% 11 1 2 1 0 2 1 2 1 0 1 0 4 1 9.1% 18.2% 9.1%.0% 18.2% 9.1% 18.2% 9.1% 0.0% 9.1% 0.0% 36.4% 9.1% 578 45 60 78 98 72 75 58 36 44 7 5 150 56 7.8% 10.4% 13.5% 17.0% 12.5% 13.0% 10.0% 6.2% 7.6% 1.2% 0.9% 25.9% 9.7% 22 4 1 3 2 3 3 1 1 4 0 0 6 4 18.2% 4.5% 13.6% 9.1% 13.6% 13.6% 4.5% 4.5% 18.2% 0.0% 0.0% 27.2% 18.2% 70 5 12 7 9 9 8 7 7 5 0 1 20 6 7.1% 17.1% 10.0% 12.9% 12.9% 11.4% 10.0% 10.0% 7.1% 0.0% 1.4% 28.5% 8.5% 293 35 27 39 41 31 50 23 17 15 7 8 70 30 11.9% 9.2% 13.3% 14.0% 10.6% 17.1% 7.8% 5.8% 5.1% 2.4% 2.7% 23.8% 10.2% 17 0 2 4 2 3 3 2 0 0 1 0 3 1 0.0% 11.8% 23.5% 11.8% 17.6% 17.6% 11.8% 0.0% 0.0% 5.9% 0.0% 17.7% 5.9% 836 43 76 135 163 144 111 62 37 51 9 5 164 65 5.1% 9.1% 16.1% 19.5% 17.2% 13.3% 7.4% 4.4% 6.1% 1.1% 0.6% 19.6% 7.8% 33 2 4 3 7 7 6 2 1 0 0 1 4 1 6.1% 12.1% 9.1% 21.2% 21.2% 18.2% 6.1% 3.0% 0.0% 0.0% 3.0% 12.1% 3.0% 26 1 3 2 7 2 2 1 0 3 4 1 9 8 3.8% 11.5% 7.7% 26.9% 7.7% 7.7% 3.8% 0.0% 11.5% 15.4% 3.8% 34.5% 30.7% 24 2 2 2 6 2 3 2 3 1 0 1 7 2 8.3% 8.3% 8.3% 25.0% 8.3% 12.5% 8.3% 12.5% 4.2% 0.0% 4.2% 29.2% 8.4% 147 8 13 28 30 14 11 12 13 10 2 6 43 18 5.4% 8.8% 19.0% 20.4% 9.5% 7.5% 8.2% 8.8% 6.8% 1.4% 4.1% 29.3% 12.3% 305 26 43 39 52 30 32 25 21 27 6 4 83 37 8.5% 14.1% 12.8% 17.0% 9.8% 10.5% 8.2% 6.9% 8.9% 2.0% 1.3% 27.3% 12.2% 451 33 53 64 77 67 60 20 24 33 15 5 97 53 7.3% 11.8% 14.2% 17.1% 14.9% 13.3% 4.4% 5.3% 7.3% 3.3% 1.1% 21.4% 11.7% 88 17 11 11 8 6 9 6 6 7 2 5 26 14 19.3% 12.5% 12.5% 9.1% 6.8% 10.2% 6.8% 6.8% 8.0% 2.3% 5.7% 29.6% 16.0% 178 26 24 19 22 16 19 14 20 13 2 3 52 18 14.6% 13.5% 10.7% 12.4% 9.0% 10.7% 7.9% 11.2% 7.3% 1.1% 1.7% 29.2% 10.1% 36 1 5 7 7 5 4 3 0 2 1 1 7 4 2.8% 13.9% 19.4% 19.4% 13.9% 11.1% 8.3%.0% 5.6% 2.8% 2.8% 19.5% 11.2% 924 61 83 157 170 139 137 73 52 35 11 6 177 52 6.6% 9.0% 17.0% 18.4% 15.0% 14.8% 7.9% 5.6% 3.8% 1.2%.6% 19.1% 5.6% 248 27 32 38 45 26 22 18 21 9 6 4 58 19 10.9% 12.9% 15.3% 18.1% 10.5% 8.9% 7.3% 8.5% 3.6% 2.4% 1.6% 23.4% 7.6% 31 3 3 6 5 5 4 1 2 1 0 1 5 2 9.7% 9.7% 19.4% 16.1% 16.1% 12.9% 3.2% 6.5% 3.2% 0.0% 3.2% 16.1% 6.4% 95 13 7 13 19 15 9 9 5 2 2 1 19 5 13.7% 7.4% 13.7% 20.0% 15.8% 9.5% 9.5% 5.3% 2.1% 2.1% 1.1% 20.1% 5.3% 90 5 19 13 15 10 9 8 5 4 1 1 19 6 5.6% 21.1% 14.4% 16.7% 11.1% 10.0% 8.9% 5.6% 4.4% 1.1% 1.1% 21.1% 6.6% 184 28 21 25 35 16 21 8 13 12 3 2 38 17 15.2% 11.4% 13.6% 19.0% 8.7% 11.4% 4.3% 7.1% 6.5% 1.6% 1.1% 20.6% 9.2% 72 13 12 8 6 7 8 5 8 3 1 1 18 5 18.1% 16.7% 11.1% 8.3% 9.7% 11.1% 6.9% 11.1% 4.2% 1.4% 1.4% 25.0% 7.0% 199 43 21 18 33 19 25 6 14 11 6 3 40 20 21.6% 10.6% 9.0% 16.6% 9.5% 12.6% 3.0% 7.0% 5.5% 3.0% 1.5% 20.0% 10.0% 59 11 9 7 7 7 5 2 3 7 1 0 13 8 18.6% 15.3% 11.9% 11.9% 11.9% 8.5% 3.4% 5.1% 11.9% 1.7% 0.0% 22.1% 13.6% 183 43 18 26 22 11 21 12 11 9 4 6 42 19 23.5% 9.8% 14.2% 12.0% 6.0% 11.5% 6.6% 6.0% 4.9% 2.2% 3.3% 23.0% 10.4% 5

160. Breast conservation surgery, w or w/o axillary lymphadenectomy (segment or quadrant resection) 161. Submandibular gland surgery 162. Transvaginal sling suspension of bladder neck 163. Radical prostatectomy (open) 164. Varicose veins surgery (ligation, excision, stripping) 165. Excision of solitary lymph nodes or lymphatic vessels (axillary) 166. Breast conservation surgery, w or w/o axillary lymphadenectomy (local, cone, ductal or lump resections) 167. Parotidectomy 168. Carotid endarterectomy 169. Metatarsophalangeal amputation 170. Testicular hydrocele surgery 171. Widening of ureter (stent, dilatation, incision) (transurethral) 172. Eye surgery 173. Skull surgery (trepanation, craniotomy, stereotactic surgery, meninges, CSF shunts, intracranial blood vessels) 174. Cervical conization 175. Transurethral resection of bladder 176. Transurethral resection of prostate 177. Prepuce surgery 178. Urethra, transurethral incision 179. Excision of solitary lymph nodes or lymphatic vessels (cervical) 542 49 77 79 111 81 70 33 20 15 4 3 75 22 9.0% 14.2% 14.6% 20.5% 14.9% 12.9% 6.1% 3.7% 2.8% 0.7% 0.6% 13.9% 4.1% 30 3 5 4 7 3 2 4 1 1 0 0 6 1 10.0% 16.7% 13.3% 23.3% 10.0% 6.7% 13.3% 3.3% 3.3% 0.0% 0.0% 19.9% 3.3% 277 46 39 39 42 23 43 18 7 12 6 2 45 20 16.6% 14.1% 14.1% 15.2% 8.3% 15.5% 6.5% 2.5% 4.3% 2.2% 0.7% 16.2% 7.2% 266 50 28 43 38 28 32 19 12 10 3 3 47 16 18.8% 10.5% 16.2% 14.3% 10.5% 12.0% 7.1% 4.5% 3.8% 1.1% 1.1% 17.6% 6.0% 307 36 54 62 41 37 30 17 10 11 5 4 47 20 11.7% 17.6% 20.2% 13.4% 12.1% 9.8% 5.5% 3.3% 3.6% 1.6% 1.3% 15.3% 6.5% 57 5 7 12 13 7 9 2 0 1 1 0 4 2 8.8% 12.3% 21.1% 22.8% 12.3% 15.8% 3.5% 0.0% 1.8% 1.8% 0.0% 7.1% 3.6% 664 63 110 141 124 88 57 32 21 19 6 3 81 28 9.5% 16.6% 21.2% 18.7% 13.3% 8.6% 4.8% 3.2% 2.9% 0.9% 0.5% 12.3% 4.3% 33 5 7 4 5 4 3 2 0 3 0 0 5 3 15.2% 21.2% 12.1% 15.2% 12.1% 9.1% 6.1% 0.0% 9.1% 0.0% 0.0% 15.2% 9.1% 160 26 17 31 30 22 18 6 5 5 0 0 16 5 16.3% 10.6% 19.4% 18.8% 13.8% 11.3% 3.8% 3.1% 3.1% 0.0% 0.0% 10.0% 3.1% 35 10 4 5 3 2 4 2 1 0 1 3 7 4 28.6% 11.4% 14.3% 8.6% 5.7% 11.4% 5.7% 2.9% 0.0% 2.9% 8.6% 20.1% 11.5% 71 7 15 15 7 12 4 5 0 3 2 1 11 6 9.9% 21.1% 21.1% 9.9% 16.9% 5.6% 7.0% 0.0% 4.2% 2.8% 1.4% 15.4% 8.4% 102 26 18 16 12 5 5 9 2 5 1 3 20 9 25.5% 17.6% 15.7% 11.8% 4.9% 4.9% 8.8% 2.0% 4.9% 1.0% 2.9% 19.6% 8.8% 100 32 14 14 8 4 9 7 3 5 1 3 19 9 32.0% 14.0% 14.0% 8.0% 4.0% 9.0% 7.0% 3.0% 5.0% 1.0% 3.0% 19.0% 9.0% 80 20 6 15 13 9 8 2 5 2 0 0 9 2 25.0% 7.5% 18.8% 16.3% 11.3% 10.0% 2.5% 6.3% 2.5% 0.0% 0.0% 11.3% 2.5% 56 13 9 11 6 3 6 2 2 4 0 0 8 4 23.2% 16.1% 19.6% 10.7% 5.4% 10.7% 3.6% 3.6% 7.1% 0.0% 0.0% 14.3% 7.1% 590 177 82 96 67 42 56 25 21 17 5 2 70 24 30.0% 13.9% 16.3% 11.4% 7.1% 9.5% 4.2% 3.6% 2.9% 0.8% 0.3% 11.8% 4.0% 572 173 67 98 82 54 38 22 15 15 4 4 60 23 30.2% 11.7% 17.1% 14.3% 9.4% 6.6% 3.8% 2.6% 2.6% 0.7% 0.7% 10.4% 4.0% 20 5 3 4 2 2 3 0 1 0 0 0 1 0 25.0% 15.0% 20.0% 5.0% 10.0% 15.0% 0.0% 5.0% 0.0% 0.0% 0.0% 5.0% 0.0% 137 50 17 19 16 6 11 7 3 4 1 3 18 8 36.5% 12.4% 13.9% 11.7% 4.4% 8.0% 5.1% 2.2% 2.9% 0.7% 2.2% 13.1% 5.8% 31 8 6 5 3 6 0 0 2 1 0 0 3 1 25.8% 19.4% 16.1% 9.7% 19.4% 0.0% 0.0% 6.5% 3.2% 0.0% 0.0% 9.7% 3.2% NRS = numeric rating score w = with w/o = without AV = arterio-venous CSF = cerebrospinal fluid 6