Teacher s Profile 1. PERSONAL DETAILS: Name : Dr.(Mrs.) Akalpita Umesh Arvindekar Date of Birth : 11/04/1959 Sex : Female Marital Status : Married Languages known : Engligh, Marathi, Hindi, Kannada Postal Address : 1151, Aruna Residency, Sykes Extension, 416 001 E. mail : auarvindekar@rediffmail.com Website : - Web : - Phone : 0231-2609153(office) Mobile : 09762746409 Fax : 0231-2692333 (Univ) 2. EDUCATIONAL QUALIFICATION: 1
Degree Subjects Name of Institution Year Class Examination Passed Board/ University Year of passing Grade/ Class S.S.C. General Mysore Board 1974 1 st class B.Sc. Chemistry Bot. Zoology Karnatka University, Dharwar M.Sc. Biochemistry Karnataka University Dharwar Ph.D. Biochemistry Shivaji University, Kolhapur 1979 1 st class 1981 1 st class 1 st rank 1996 CSIR / NET Life Sciences Life Science 1989 TITLE OF Ph. D. THESIS: Biochemistry of cell wall α glucans in Saccharomyces ceriviseae 3. SCHOLARSHIPS AND ACHIEVEMENTS National Merit Scholarship holder for post graduate studies. Worked as JRF from 1983-84 at Biochemistry Department of Manasgangotri Mysore Awarded NET CSIR JRF in 1989 4. RESEARCH AREA OF INTERESTS Earlier worked on yeast cell wall glucans and fermentation technology Working on evaluation of Ayurvedic plant components in treatment of Diabetes. Studies include isolation and identification of bioactives, mechanism of drug action through in vivo and in vitro studies. Working on alpha glucosidase inhibitors, insulin secretagogues, insulin mimetics, protein glycation inhibitors, glycogen phosphorylase inhibitors, GLUT 2 and SGLT2 inhibition in treatment of diabetes mellitus 2
5. TEACHING EXPERIENCE: 25 years of teaching experience Degree Awarded Ph.D. Students N o. Name Research Topic Year Current position 1. Mr. Santosh Sankh (2006) Study of fermentation parameters: A project towards optimization of ethanol production in Saccharomyces cerevisiae Currently working as Senior Scientist Reliance Life Sciences, Navi Mumbai 2. Mr Ashok Dattatray Chougale (2008) Study of hypoglycemic activity and insulin like action of plant components in treatment of diabetes mellitus Currently working as Assistant Professor in Biochemistry at New College, Kolhapur 3. Ms. Varsha Adhikrao Ghadyale (2009) Study of effect of medicinal plants on gastric uptake of glucose and non-specific glycosylation of proteins Currently working as Assistant Professor at Gogate Joglekar College, Ratnagiri 4. Ms. Preeti Prakash Aklujkar (2010) Role of cell wall bound glycogen in Saccharomyces cerevisiae and optimization of ethanol production Planning to start her own private enterprise 5. Mr. Swapnil Balasaheb Patil (2013) Study of insulin secretagogue action and antidiabetic activity of plant components in treatment of diabetes mellitus Working as Post Doc in Stem Cells in diabetic foot therapy at Galaway University, Ireland 6. Mr. Chaitanya Ramesh Kulkarni (2012) Study of plant components having insulin sensitizer action and antihyperglycemic activity in treatment of diabetes mellitus Working as Senior Scientific Officer at Pranav Agro Products, Sangli 7. Ms. Vandana Ramchandra Dongare (2012) 3
Isolation and identification of active component from Foeniculum vulgare having antidiabetic Activity Working as Lecturer at Birnale College of Pharmacy, Sangli 8. Mr. Shreehari Subhash Taklikar (2013) Study of some medicinal plants in treatment of diabetes mellitus Working as Research Officer at Phytopharma, Kolhapur 9. Mr. Shrimant Nivasrao Panaskar (2013) Study of antidiabetic activity of some medicinal plants Working as Production Manager at Preventine Life, Mumbai 10. Madhav M. Joglekar (2014) Role of plant components in nonspecific glycation inhibition and in prevention of secondary complications in diabetes mellitus Working as R & D Manager at Wockhardt Pharma, Aurangabad Research students working N o Name Research topic Working since 1.Tanaji A. More (2012) Study of plant components having insulin mimetic and non specific protein glycation inhibitory activity optimising antidiabetic treatment using combinatorial drug therapy 2.Ashwini D. Jagdale (2012) Antidiabetic effect of some plant component and study of their role in inhibition of non specific glycation and aldose reductase enzyme 3.Snehalata P.Kamble (2013) Effect of plant components on intestinal alpha glucosidase, GLUT, SGLT transporters in treatment of diabetes mellitus 4. Megha L.nalawade (2013) Study of metabolic changes during prediabetes and prevention of progression to diabetes using plant components 5.Laxman N. Bavkar (2013) Evaluation of plant components as inhibitors of non specific protein glycation in prevention of secondary complications in diabetes mellitus 4
6. FIELD OF EXERTISE Diabetes Animal studies, in vivo and in vitro studies Bioprospecting Isolation and identification of bioactives Evaluation of mechanism of drug action Clinical studies in Diabetes 7. REVIEWER OF THE INTERNATIONAL JOURNALS J. of Inst Brew. Analytical Biochemistry J. of enz. Inhibition and medicinal chemistry Food Res. International ECAM Food Biochemistry Plant Foods for Human Nutrition Food Chemistry Natural Products Research Pharmaceutical Biology BMC Complementary and Alternative medicine Food and Chemical Toxicology Food Biophysics European Food Research and Technology Applied Microbiology and Biotechnology Food Science and Technology 8. TECHNICAL AND ANALYTICAL SKILLS: TLC, Column chromatography, HPLC, HPTLC, Animal studies (diabetes induction and evaluation of diabetic status), Enzyme assays, islet studies Spectrofluorimetry studies, Western blot, etc 9. FUNDED PROJECTS. Research Projects in Progress/ Completed Title of Project/Scheme Funding agency Funds received Year Worked as 5
1. Study of non specific protein glycation inhibitors from plant UGC 14.87 lakhs 2013-16 Principal sources in treatment of diabetes Investigator mellitus 2. Establishing a Resource Centre RGSTC 100.90 lakhs 2014-17 Principal for Studies on Ayurvedic medicines (Govt. of Maharashtra) Investigator in treatment of diabetes mellitus 10. WORKSHOPS AND SEMINARS ATTENDEDAND ORGANIZED 1. Poster presented on Antihyperglycemic and antioxidant effect of transanethole in the treatment of Diabetes mellitus. Ashwini D. Jagdale, Tanaji A. More, Madhav M. Joglekar, Vandana R. Dongre, and Akalpita U. Arvindekar* Challenges and Opportunities in Life Sciences Feb 08 09, 2013Department of Biochemistry, Shivaji University, Kolhapur, Maharashtra 2. Poster presented on Antidiabetic activity of linalool in treatment of diabetes mellitus Tanaji More, Ashwini Jagdale, Madhav M. Joglekar, and Akalpita U. Arvindekar* Challenges and Opportunities in Life Sciences Feb 08 09, 2013 Department of Biochemistry, Shivaji University, Kolhapur, Maharashtra 3. International symposium on Proteomics Beyond IDs and 4 th Annual Meeting of Proteomics Society (INDIA) held from 22-24 November, 2012 at CSIR National Chemical Laboratory, Pune 4. Paper presented entitled, nonenzymatic protein glycation inhibition by Piper nigrum pet ether extract M. M. Joglekar, C. R. Kulkarni, S. N. Panaskar, Dr. A. U. Arvindekar, Inernational conference on natural products and biomedical technology (ICNPBT - 2011) held during 10-12 January, in the department of Biochemistry and Biotechnology, Annamalai University (TN-India). 5. Paper presented entitled, Insulin secretagogue, alpha-glucosidase inhibitory and antioxidant activity of Myristica malabarica in treatment of diabetes mellitus. S. B. Patil, S. S. Taklikar, S. N. Panaskar, Dr. A. U. Arvindekar at Inernational conference on natural products and biomedical technology (ICNPBT-2011) held during 10-12 January, in the department of Biochemistry and Biotechnology, Annamalai University (TN-India). 6. Poster presented on Rat hepatic glycogen phosphorylase inhibitory activity and antioxidant property of Caryophyllus aromaticusin treatment of Diabetes mellitus C.R. Kulkarni, S. B. Patil, S. S. Taklikar, V. A. Ghadyale and A. U. Arvindekar at National Symposium on Recent Trends in Life Sciences (RTLS- 2011) on the 4 th and 5 th of March, 2011, organized by Department of Biochemistry, Shivaji University, Kolhapur 6
7. Poster presented on Inhibition of alpha glucosidase and antioxidant activity by Swertia chirata methanolic extract S. N. Panaskar, S.S. Taklikar, C. R. Kulkarni and A.U. Arvindekar National Symposium on Recent Trends in Life Sciences (RTLS- 2011) on the 4 th and 5 th of March, 2011, organized by Department of Biochemistry, Shivaji University, Kolhapur 8. Paper presented entitled, Inhibition of rat hepatic glycogen phosphorylase activity by Cinnamomum zeylanicum,- a novel therapy in the treatment of Diabetes mellitus, C.R. Kulkarni, S. B. Patil, M. M. Joglekar, Dr. A. U. Arvindekar at oral competition at XXXIII Conference of Indian Botanical Society and International Symposium on the New Horizons of Botany dated on 10 th to 12 th November, 2010 organized by Department of Botany, Shivaji University, Kolhapur (MS-India). 9. Poster presented entitled, Anti-Hyperglycemic Activity of Myristica malabarica in Treatment of Diabetes Mellitus. S. B. Patil, S. S. Taklikar, C. R. Kulkarni, Dr. A. U. Arvindekar at Poster competition at XXXIII Conference of Indian Botanical Society and International Symposium on the New Horizons of Botany dated on 10 th to 12 th November, 2010 organized by Department of Botany, Shivaji University, Kolhapur (MS-India). 10. Poster presented entitled, Anti-Hyperglycemic Activity of Aegle marmelos corrrea fruit extract in streptozotocin induced diabetic rats: Histopathological perspective S. S. Taklikar, S. N. Panaskar, S. B. Patil, Dr. A. U. Arvindekar at Poster competition at XXXIII Conference of Indian Botanical Society and International Symposium on the New Horizons of Botany dated on 10 th to 12 th November, 2010 organized by Department of Botany, Shivaji University, Kolhapur 11. RESEARCH PUBLICATIONS (PUBLISHED) International 1. Gycogen a covalently linked component of the cell wall in Saccharomyces cerevisiae (2002) Arvindekar A. U. and Patil N. B. Yeast, 19, 131-139. Imapct factor 2.3 2. Availability of substratum enhances ethanol production in Saccharomyces cerevisiae (2004) Sankh S. N. & Arvindekar A. U. Biotechnology Letters, 26, 1821 1824. Impact factor 1.6 3. A Simplified Method for the Isolation and Estimation of Cell Wall Bound Glycogen in Saccharomyces cerevisiae (2008) Sankh S. N., Aklujkar P.P., & Arvindekar A. U Journal of Institute of Brewing Volume 114 (3) 205-208, 2008. Impact factor 1.3 4. Optimization of Alloxan is essential to induce stable diabetes for prolonged period, (2007) Chougale A. D., Panaskar, S. N., Gurao P. M., & Arvindekar A. U., Asian Journal of Biochemistry, 2, (6) 402-408. 7
5. Alpha glucosidase inhibition by stem extract of Tinospora cordifolia (2009) Ashok D. Chougale, Varsha A. Ghadyale, Shrimant N. Panaskar and Akalpita U. Arvindekar, Journal of Enzyme Inhibition and Medicinal Chemistry 24(4) 998 1001. Impact factor 1.5 6. Insulin Secretagogue, Alpha-glucosidase and Antioxidant Activity of Some Selected Spices in Streptozotocin-induced Diabetic Rats, (2011) Swapnil Balasaheb Patil, Varsha Adhikrao Ghadyale, Shreehari Subhash Taklikar, Chaitanya Ramesh, Kulkarni, & Akalpita Umesh Arvindekar Plant Foods for Human Nutrition, 66:85 90. Impact factor 2.5 7. Study of Two Pools of Glycogen in Saccharomyces cerevisiae and their Role in Fermentation Performance, (2011) Preetee S. Deshpande, Santosh N. Sankh and Akalpita U. Arvindekar* Journal of Institute of Brewing 117(1), 113 119. Impact factor 1.2 8. Effective Control of Postprandial Glucose Level through Inhibition of Intestinal Alpha Glucosidase by cymbopogon martinii (Roxb.) (2011) Varsha Ghadyale, Shrihari Takalikar, Vivek Haldavnekar, and Akalpita Arvindekar Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 372909, 6 pages doi:10.1155/2012/372909 Impact factor 4.7 9. Improvement of Ethanol Production Using Saccharomyces cerevisiae by Enhancement of Biomass and Nutrient Supplementation (2011) Santosh N. Sankh & Preetee S. Deshpande & Akalpita U. Arvindekar Applied Biochemistry and Biotechnology 164:1237 1245, Impact factor 1.9 10. Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats (2011) Chaitanya R. Kulkarni, Madhav M. Joglekar, Swapnil B. Patil, Dr. Akalpita U. Arvindekar* Pharmaceutical Biology. DOI: 10.3109/13880209.2011.604677 Impact factor 0.98. 11. Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. Fruits (2012)Vandana Dongare, Chaitanya Kulkarni, Manish Kondawar, Chandrakant Magdum,Vivek Haldavnekar, Akalpita Arvindekar, Food Chemistry 132(2012) 385 390 Impact factor 3.5 12. Insulinotropic and b-cell protective action of cuminaldehyde,cuminol and an inhibitor isolated from Cuminum cyminum instreptozotocin-induced diabetic rats. (2013) Swapnil B. Patil, Shreehari S. Takalikar, Madhav M. Joglekar, Vivek S. Haldavnekarand Akalpita U. Arvindekar, British Journal of Nutrition, doi:10.1017/s0007114513000627 Impact Factor 3.1 13. Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocininduced diabetic rats anddemonstration of limonene as a potent antiglycating agent, (2013), Shrimant N. Panaskar, Madhav M. Joglekar, Shreehari S. Taklikar, Vivek S. Haldavnekar and Akalpita U.Arvindekar, Journal of Pharmacy and Pharmacology, doi: 10.1111/jphp.12044 Imapct Factor 2.1 14 Antidiabetic activity of Kalanchoe pinnata in streptozotocin induced diabetic rats by glucose independent insulin secretagogue action (2013) Swapnil B. Patil, Vandana R. Dongare, 8
Chaitanya R. Kulkarni, Madhav M. Joglekar, and Akalpita U. Arvindekar, Pharmaceutical Biology, DOI: 10.3109/13880209.2013.794364 15. A novel mechanism for antiglycative action of limonene through stabilization of protein Conformation (2013) Madhav M. Joglekar,a Shrimant N. Panaskar,a Ashok D. Chougale,b Mahesh J. Kulkarnib and Akalpita U. Arvindekar*, Molecular Biosystems 9; 2463-72 Impact Factor 3.3 16. Inhibition of advanced glycation end product formation by cymene A common food constituent (2013) Madhav M. Joglekar, Shrimant N. Panaskar, Akalpita U. Arvindekar*Journal of Functional Foods (2013), http://dx.doi.org/10.1016/j.jff.2013.09.024 Impact factor 2.5 National 1.Treatment of Diabetes mellitus using Ayurvedic preparation X-14, Chougale A. D., Haldavnekar V.S. & Arvindekar A. U,(2006) Ayucon 1, 84 89. 2. Hypoglycemic effect of Foeniculum vulgare Mill. Fruit on dexamethasone induced insulin resistant rats (2010) Dongare V. R., Arvindekar A. U., Magdum C. S. Research Journal of Pharmacognosy and Phytochemistry, 2 (02) 163-165. 9