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A. APPOINTMENT AND CONTACT DETAILS Surname: Heraclides First Name: Alexandros Middle Name: Academic Title: Specialty: E-mail: Assistant Professor of Epidemiology and Public Health Epidemiology heraclides.a@unic.ac.cy Phone: 22471964 B. EMPLOYMENT HISTORY ( current to oldest) including your affiliation with the University of Nicosia Medical School Position/Title Employer 2014 current Assistant Professor of Epidemiology and Public Health (Full-Time) 2014 current Visiting Scientist (Genetic Epidemiology and Population ) 2012 2014 Fellow and Faculty Associate 2012 2014 Lecturer (Part-Time) in Epidemiology and Methods 2011 2014 Lecturer (Part-Time) in Epidemiology, Medical Statistics, Methods, Environmental Health, and Nutrition 2010 2011 er (Geneenvironment interactions) 2010 2012 Fellow (Type 2 diabetes prediction) University of Nicosia Medical School and the Cyprus School of Molecular Medicine European University Cyprus University of Nicosia Molecular Epidemiology Group, German Institute of Human Nutrition (DIfE), Germany Epidemiology Unit, Steno Diabetes Center, Denmark 2009 2010 Associate MRC Unit for Lifelong Health and Aging, UK; University of Wageningen, The Netherlands

C. EDUCATIONAL BACKGROUND 1. University or equivalent Name of University/ Academic Institution Degree Obtained 2006 2009 University College London (UCL) PhD Epidemiology and Public Health 2005 2006 UCL / London School of Hygiene & Tropical Medicine MSc Social Epidemiology 2003 2004 King s College London MSc Nutrition 2000 2003 University of Bedfordshire BSc (Hons) Biology 2. Other Formal Training Awarding Institution Certificates or Diplomas Obtained 2017 2017 Centre for the Advancement of and Development in Educational Technology (CARDET) 2011 2011 Clinical Centre, Lund University, Sweden Designing & Delivering Successful Training Programs - Train the Trainer Training on Genetic and Molecular Epidemiology D. RESEARCH PROGRAMMES (e.g Academic Lead/Group Member, er, Assistant er) Up to 10 most important and 5 of the most recent Programme/Title Sponsor Role 1 10/2017 current Personality traits in relation to meal regularity, metabolic rate and BMI 2 05/2016 current Investigation of evolutionary mechanisms of vitamin D deficiency in the Cypriot population: identification of genetic and phenotypic determinants 3 04/2016 current Epidemiological investigation for identifying non-genetic factors associated with Multiple Sclerosis among Cypriot adults University of Nicosia University of Nicosia, University of Surrey Newcastle University, Cyprus Institute of PhD supervisor (third) (MD supervisor)

4 02/2015 current Dietary glycaemic index in relation to cognitive function in the 1946 British birth cohort 5 06/2014 current Elucidating the ancestry of Cypriots through population genetics and genetic genealogy) 6 06/2013 current Epidemiology of Parkinson s Disease in Cyprus with a special emphasis on gene-environment interactions MRC Unit for Lifelong Health and Ageing at University College London, Durham University (PhD supervisor) 7 06/2012 current Epidemiology and geographical clustering of monogenic neurological conditions in Cyprus: a population genetics approach 8 01/2010 09/2016 Gene-environment interactions in relation to type 2 diabetes: the InterAct study InterAct Consortium, German Institute of Human Nutrition er 9 05/2011 05/2012 The role of chromosomal telomere length for predicting disease risk in epidemiological studies 10 12/2010 12/2011 Prediction of diabetes using traditional and novel risk factors in the Whitehall II study 11 07/2009 10/2011 Investigation of the effect of dairy product intake on cardiometabolic disease Lund University Steno Diabetes Center, Denmark MRC Unit for Lifelong Health and Ageing at UCL, Wageningen University, Steno Diabetes Center Fellow Associate, Fellow E. ADVISORY SERVICES (Memberships of Councils/ Publishing Committees) Name of Advisory Services Role 1 01/2017 current Cyprus Ministry of Health National Committee on the Promotion of Vaccinations in the Public Committee Member (Epidemiology advisor)

F. AWARDS/INTERNATIONAL DISTINCTIONS Date Award/Distinction Awarding Body 1 11/2011 Genes, lifestyle and their role in cardiometabolic disease (awarded best ENLP Newsletter article of 2011) European Nutrition Leadership Platform G. PUBLICATIONS- Up to 10 most important and 5 of the most recent Date Published Publication 1 11/2017 Demetriou CA, Heraclides A, Salafori C, Tanteles GA, Christodoulou K, Christou Y, Zamba- Papanicolaou E. Epidemiology of Huntington Disease in Cyprus: A 20-Year Retrospective Study. Clin Genet. 2017 Nov 6. doi: 10.1111/cge.13168. [Epub ahead of print] 2 07/2017 Georgiou A, Demetriou CA, Heraclides A, Christou YP, Leonidou E, Loukaides P, Yiasoumi E, Panagiotou D, Manoli P, Thomson P, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Mitochondrial superclusters influence age of onset of Parkinson's disease in a gender specific manner in the Cypriot population: A case-control study. PLoS One. 2017 Sep 6;12(9):e0183444. 3 06/2017 Heraclides A, Bashiardes E, Fernández-Domínguez E, Chimonas M, Christofi V, King J, Budowle B, Manoli P, Cariolou MA. Y-chromosomal analysis of Greek Cypriots reveals a primarily common pre-ottoman paternal ancestry with Turkish Cypriots. PlosOne 12(6): e0179474. 4 12/2016 Heraclides A, Meidtner K, Buijsse B, van der Schouw YT, et al. Investigation of gene diet interactions in the incretin system and risk of type 2 diabetes: the EPIC-InterAct study. Diabetologia, 2016; 59: 2613 21 5 10/2016 Varda E, Demetriou CA, Heraclides A, Christou YP, Zamba-Papanicolaou E. Quality of Life of Cypriot Patients Suffering with Huntington s Disease. PLOS Currents Huntington Disease. 2016 Oct 25. Ed. 1. 6 07/2013 Heraclides A, Jensen TM, Rasmussen SS, Eugen-Olsen J, Haugaard SB, Borch-Johnsen K, Sandbæk A, Lauritzen T, Witte DR. The association between the immune marker soluble urokinase plasminogen activator receptor (supar) and incident diabetes is modified by smoking and body weight status among people with impaired glucose regulation. Diabetologia, 2013; 56: 1542-6 7 10/2012 Heraclides A, Mishra G, Hardy R, Geleijnse M, Black S, Prynne C, Kuh D, Soedamah-Muthu S. Dairy Intake, blood pressure and incident hypertension in a general British population: the 1946 birth cohort. Eur Jour Nutr 2012 ;51:583-91 8 05/2011 Heraclides A, Chandola T, Witte DR, Brunner EJ. Work Stress, Obesity and the Risk of Type 2 Diabetes: Gender-Specific Bidirectional Effect in the Whitehall II Study. Obesity 2012; 20:428-433

9 10/2009 Heraclides A, Chandola T, Witte DR, Brunner EJ. Psychosocial stress at work doubles the risk of type 2 diabetes in middle-aged women: Evidence from the Whitehall II study. Diabetes Care, 2009; 32: 2230-5 10 04/2008 Heraclides A, Witte D, Brunner EJ. The association between father s social class and adult obesity is not explained by educational attainment and an unhealthy lifestyle in adulthood Eur J Epidemiol, 2008; 23:573-79