Pr oducts List Ludger Ltd Culham Science Centre Oxford OX14 3EB United Kingdom

Pr oducts List 2018 Ludger Ltd Culham Science Centre Oxford OX14 3EB United Kingdom Email: lily.wang@ludger.com cindy.li@ludger.com www.ludger.com www.ludgersh.com

Enzymes for Glycan Release E-PNG01 PNGase F (Peptide N Glycosidase F) 0.3 Unit / 60 µl E-rPNG01 Recombinant PNGase F 0.3 Unit / 60 µl E-PNG05 PNGase F (Peptide N Glycosidase F) 1 Unit / 200 µl E-EF01 Endoglycosidase F1 1 Unit / 60 µl E-EF02 Endoglycosidase F2 0.3 Unit / 60 µl E-EF03 Endoglycosidase F3 0.33 Unit / 60 µl E-EH02 Endoglycosidase H 0.3 Unit / 60 µl E-G001 O-glycosidase 75 munit / 60 µl E-XBG01 Endo-Beta-Galactosidase 0.9 Unit / 60 µl KE-DG01 Enzymatic CarboRelease Kit KE-DGMX Enzymatic DeGlycoMx Kit LZ-CER-HM-KIT Ceramide glycanase kit LZ-ACASE-KIT Sialate O-acetylesterase kit LZ-rPNGaseF-KIT Recombinant PNGase F enzyme 150 μl Kits for Chemical Glycan Release Total number of samples Cat. No. Item (including standards) LL-HYDRAZ-A2 Ludger Liberate Hydrazinolysis Kit 12 LL-ORELA-A2 Ludger Liberate Orela Kit 12 LL-MR-A2 Ludger Liberate Membrane Release kit 96 Release and Labelling of mono and sialic acids Total number of samples Cat. No. Item (including standards) LT-KDMB-A1 DMB Sialic Acid Release & Labeling Kit 22 LT-MONO-96 Monosaccharide Release & Labeling Kit 96 Glycan Labelling Kits Total number of samples Cat. No. Item (including standards) LT-KAB-A2 2-AB Glycan Labeling Kit up to 30 LT-KAA-A2 2-AA Glycan Labeling Kit up to 30 LT-KAB-VP24 2-AB Glycan Labeling Kit, 2PB reductant 24 LT-KAA-VP24 2-AA Glycan Labeling Kit, 2PB reductant 24 LT-KAB-VP96 2-AB Glycan Labeling Kit, 2PB reductant 96 LT-KPROC-VP24 Procainamide Glycan Labeling Kit, 2PB reductant 24 LT-KPROC-24 Procainamide Glycan Labeling Kit, sodium 24 cyanoborohydride reductant LT-VTAG-24 Glycopeptide Labeling and Enrichment Kit 24 LT-PERMET-96 Permethylation Kit 96 LT-KAPTS-VP96 APTS Glycan Labeling Kit, 2PB reductant 96 Enquire for details Page 2

Clean Up /Quantity LC-A-24 LudgerClean A cartridges 24 cartridges LC-CEX-A6 LudgerClean CEX cartridges 6 cartridges LC-EB10-A6 LudgerClean EB10 Cartridges 6 cartridges LC-S-A6 LudgerClean S Cartridges 6 cartridges LC-T1-A6 LudgerClean T1 Cartridges* 6 cartridges LC-PBM-96 LudgerClean Protein Binding Membrane Plate 1 x 96 well plate LC-PROC-96 LudgerClean Plate for Procainamide Glycan Clean Up 1 x 96 well plate LC-PERMET-96 LudgerClean Plate for pre-permethylation Clean Up 1 x 96 well plate Vacuum Manifold System * discounts apply when ordering multiple packs of T1 cartridges. Please enquire for details. LC-VAC-MANIFOLD-KIT Vacuum manifold in 96 plate format 1 LC-VAC-TRAP-KIT Vacuum trap kit 1 LP-COLLPLATE-2ML-96 Collection Plate Pack 5 per pack LP-COLLPLATE-LID-96 Collection Plate Lid Pack 5 per pack LP-HOLDER-96 Cartridge Holder 1 LP-PLUG-96 Plug pack 12 strips of 8 plugs Chromatography Columns and Buffers LS-N1-4.6x10 LudgerSep N1 amide Guard Column 4.6 x 10 mm, 5 µm LS-N1-4.6x250 LudgerSep N1 amide HPLC Column 4.6 x 250 mm, 5 µm LS-N2-4.6x150 LudgerSep N2 amide HPLC Column 4.6 x 150mm, 3 µm LS-N2-2.0x150 LudgerSep N2 amide HPLC Column 2.0 x 150 mm, 3 µm LS-N-BUFFX40 LudgerSep N Buffer x40 Concentrate 50ml, makes 2 litres buffer LS-C2-4.6x50 LudgerSep C2 anion exchange HPLC Column 4.6 x 50 mm LS-C2-4.6x150 LudgerSep C2 anion exchange HPLC Column 4.6 x 150 mm LS-C3-7.5x75 LudgerSep C3 anion exchange HPLC Column 7.5 x 75 mm LS-C-BUFFX4 LudgerSep C Buffer x4 Concentrate 50ml, makes 250 ml buffer LS-R1-4.6x150 LudgerSep R1 HPLC Column 4.6 x 150 mm LS-R2-4.6x150 LudgerSep R2 HPLC Column 4.6 x 150 mm LS-UR2-2.1x50 LudgerSep ur2 UHPLC Column - monosaccharide 2.1 x 50 mm LS-UR2-2.1x100 LudgerSep ur2 UHPLC Column sialic acid 2.1 x 100 mm LS-R-BPTX10 LudgerSep R BPT solvent x10 Concentrate 50ml, makes 500ml solvent Exoglycosidases E-AM01 Alpha-(1-2,3,6)-mannosidase 0.6 Unit / 60 µl E-AM02 Alpha-(1,6) core mannosidase 0.6 Unit / 60 µl E-AG01 Alpha-(1-3,6)-galactosidase 30 U/mg / 400 U/ml E-BG02 Beta-(1-3,4,6)-galactosidase 0.5 Unit / 200 µl E-BG07 Beta-(1-4)-galactosidase 180 munit / 60 µl Page 3

E-F134 Alpha-(1-3,4)-fucosidase 30 munit / 60 µl E-GL01 Beta-N-acetylglucosaminidase 2.4 Unit / 60 µl E-S001 Sialidase Au Alpha-(2-3,6,8,9) 0.3 Unit / 60 µl E-S005 Sialidase Cp Alpha-(2-3,6) 900 mu/60 μl E-S007 Sialidase Sp Alpha-(2-3) 300 mu/60 μl Ludger Standards Native N-Glycans list price, GBP A4 Family Glycans CN-NA4-20U NA4 Glycan (A4G4) 20 µg CN-NA4-10U NA4 Glycan (A4G4) 10 µg CN-NGA4-20U NGA4 Glycan (A4) 20 µg CN-NGA4-10U NGA4 Glycan (A4) 10 µg A3 Family Glycans CN-A3-20U A3 Glycan (A3G3S3) 20 µg CN-A3-10U A3 Glycan (A3G3S3) 10 µg CN-NA3-20U NA3 Glycan (A3G3) 20 µg CN-NA3-10U NA3 Glycan (A3G3) 10 µg CN-NGA3-20U NGA3 Glycan (A3) 20 µg CN-NGA3-10U NGA3 Glycan (A3) 10 µg A2F Family Glycans CN-A2F-20U A2F Glycan (FA2G2S2, G2FS2) 20 µg CN-A2F-10U A2F Glycan (FA2G2S2, G2FS2) 10 µg CN-A1F-20U A1F Glycan (FA2G2S1, G2FS1) 20 µg CN-A1F-10U A1F Glycan (FA2G2S1, G2FS1) 10 µg CN-NA2F-20U NA2F Glycan (FA2G2, G2F) 20 µg CN-NA2F-10U NA2F Glycan (FA2G2, G2F) 10 µg CN-NGA2F-20U NGA2F Glycan (FA2, G0F) 20 µg CN-NGA2F-10U NGA2F Glycan (FA2, G0F) 10 µg CN-FA2G1-20U FA2G1 Glycan (G1F) 20 µg CN-FA2G1-10U FA2G1 Glycan (G1F) 10 µg A2 Family Glycans CN-A2-20U A2 Glycan (A2G2S2, G2S2) 20 µg CN-A2-10U A2 Glycan (A2G2S2, G2S2) 10 µg CN-A1-20U A1 Glycan (A2G2S1, G2S1) 20 µg CN-A1-10U A1 Glycan (A2G2S1, G2S1) 10 µg CN-NA2-20U NA2 Glycan (A2G2, G2) 20 µg CN-NA2-10U NA2 Glycan (A2G2, G2) 10 µg CN-A2G1-20U A2G1 Glycan (G1) 20 µg CN-NGA2-20U NGA2 Glycan (A2, G0) 20 µg CN-NGA2-10U NGA2 Glycan (A2, G0) 10 µg Page 4

Oligomannose Glycans CN-MAN9-20U Man-9 Glycan 20 µg CN-MAN9-10U Man-9 Glycan 10 µg CN-MAN8-20U Man-8 Glycan 20 µg CN-MAN8-10U Man-8 Glycan 10 µg CN-MAN7-20U Man-7 Glycan 20 µg CN-MAN7-10U Man-7 Glycan 10 µg CN-MAN6-20U Man-6 Glycan 20 µg CN-MAN6-10U Man-6 Glycan 10 µg CN-MAN5-20U Man-5 Glycan 20 µg CN-MAN5-10U Man-5 Glycan 10 µg CN-M3N2-20U M3N2 (Man-3) Glycan 20 µg CN-M3N2-10U M3N2 (Man-3) Glycan 10 µg N-Glycan libraries CLIBN-IGG-01 IgG N glycan library 25 µg CLIBN-FETUIN-01 Fetuin N glycan library Approx. 7.5 µg SA-MAB4 MAb 4 Glycan Reference Panel 10 µg Hybrid Family Glycans - Product discontinued CN-HYBRID-20U Hybrid Glycan - discontinued 20 µg -- CN-HYBRID-10U Hybrid Glycan - discontinued 10 µg -- Native O-Glycans SA-CORE1 Galactose-ß-(1-3)-GalNAc Glycan, O-linked 20 µg CLIBO-FETUIN-01 Fetuin O glycan library Released from 30 µg fetuin Permethylated N-Glycan standards CPM-IGG-01 N-glycan IgG library, permethylated 20 MS runs CPM-C13-IGG-01 N-glycan IgG library, permethylated with heavy (13C) 20 MS runs methyl iodide 2-AB Labeled N-Glycans, 100pmol A4 Family Glycans CAB-NA4-01 NA4 Glycan (A4G4), 2-AB Labeled 100 pmol CAB-NGA4-01 NGA4 Glycan (A4), 2-AB Labeled 100 pmol Page 5

A3 Family Glycans CAB-A3-01 A3 Glycan (A3G3S3), 2-AB Labeled 100 pmol CAB-NA3-01 NA3 Glycan (A3G3), 2-AB Labeled 100 pmol CAB-NGA3-01 NGA3 Glycan (A3), 2-AB Labeled 100 pmol A2F Family Glycans CAB-A2F-01 A2F Glycan (FA2G2S2, G2FS2), 2-AB Labeled 100 pmol CAB-A1F-01 A1F Glycan (FA2G2S1, G2FS1), 2-AB Labeled 100 pmol CAB-NA2F-01 NA2F Glycan (FA2G2, G2F), 2-AB Labeled 100 pmol CAB-NGA2F-01 NGA2F Glycan (FA2, G0F), 2-AB Labeled 100 pmol CAB-FA2G1-01 FA2G1 Glycan (G1F), 2-AB Labeled 100 pmol CAB-FA2B-01 FA2B Glycan (G0B), 2-AB Labeled 100 pmol CAB-FA2BG1-01 FA2BG1 Glycan (G1B), 2-AB Labeled 100 pmol A2 Family Glycans CAB-A2-01 A2 Glycan (A2G2S2, G2S2), 2-AB Labeled 100 pmol CAB-A1-01 A1 Glycan (A2G2S1, G2S1), 2-AB Labeled 100 pmol CAB-NA2-01 NA2 Glycan (A2G2, G2), 2-AB Labeled 100 pmol CAB-A2G1-01 A2G1 Glycan (G1), 2-AB Labeled 100 pmol CAB-NGA2-01 NGA2 Glycan (A2, G0), 2-AB Labeled 100 pmol Oligomannose Glycans CAB-MAN9-01 Man-9 Glycan, 2-AB Labeled 100 pmol CAB-MAN8-01 Man-8 Glycan, 2-AB Labeled 100 pmol CAB-MAN7-01 Man-7 Glycan, 2-AB Labeled 100 pmol CAB-MAN6-01 Man-6 Glycan, 2-AB Labeled 100 pmol CAB-MAN5-01 Man-5 Glycan, 2-AB Labeled 100 pmol CAB-M3N2-01 M3N2 (Man-3) Glycan, 2-AB Labeled 100 pmol Glycan Library CAB-IGG-01 IgG N glycan library, 2-AB Labeled 200 pmol HPLC Calibration Standard CAB-GHP-30 2-AB Labeled Glucose Homopolymer Ladder 30 runs Other CAB-ALPHA-GAL-01 Gal alpha 1-3 Gal beta 1-4 GlcNAc, 2-AB Labeled 100 pmol Hybrid Family Glycans - Product discontinued CAB-HYBRID-01 Hybrid Glycan (Man5BA1), 2-AB Labeled - discontinued 100 pmol -- Page 6

2-AB Labeled O-Glycans Cat. No. Item Quantity CAB-C1-01 2AB labeled core 1 O- glycan, C1 100 pmol CAB-C1S(3)1-01 2AB labeled sialylated core 1 O glycan, C1S(3)1 100 pmol CAB-C1S(3)1-02 2AB labeled sialylated core 1 O glycan, C1S(3)1 50 pmol CAB-C2S(3,3)2-01 2AB labeled di-sialylated core 2 O glycan, C2S(3,3)2 100 pmol CAB-C2S(3,3)2-02 2AB labeled di-sialylated core 2 O glycan, C2S(3,3)2 50 pmol -- Product discontinued at the 50pmol size, available only by special request CAB-C1S(3,6)2-01 2AB labeled di-sialylated core 1 O glycan, C1S(3,6)2 100 pmol 2-AA Labeled N-Glycans, 100pmol A4 Family Glycans CAA-NA4-01 NA4 Glycan (A4G4), 2-AA Labeled 100 pmol CAA-NGA4-01 NGA4 Glycan (A4), 2-AA Labeled 100 pmol A3 Family Glycans CAA-A3-01 A3 Glycan (A3G3S3), 2-AA Labeled 100 pmol CAA-NA3-01 NA3 Glycan (A3G3), 2-AA Labeled 100 pmol CAA-NGA3-01 NGA3 Glycan (A3), 2-AA Labeled 100 pmol A2F Family Glycans CAA-A2F-01 A2F Glycan (FA2G2S2, G2FS2), 2-AA Labeled 100 pmol CAA-A1F-01 A1F Glycan (FA2G2S1, G2FS1), 2-AA Labeled 100 pmol CAA-NA2F-01 NA2F Glycan (FA2G2, G2F), 2-AA Labeled 100 pmol CAA-FA2G1-01 FA2G1 Glycan (G1F), 2-AA Labeled 100 pmol CAA-NGA2F-01 NGA2F Glycan (FA2, G0F), 2-AA Labeled 100 pmol CAA-FA2B-01 FA2B Glycan (G0B), 2-AA Labeled 100 pmol CAA-FA2BG1-01 FA2BG1 Glycan (G1B), 2-AA Labeled 100 pmol A2 Family Glycans CAA-A2-01 A2 Glycan (A2G2S2, G2S2), 2-AA Labeled 100 pmol CAA-A1-01 A1 Glycan (A2G2S1, G2S1), 2-AA Labeled 100 pmol CAA-NA2-01 NA2 Glycan (A2G2, G2), 2-AA Labeled 100 pmol CAA-A2G1-01 A2G1 Glycan (G1), 2AA Labeled 100 pmol CAA-NGA2-01 NGA2 Glycan (A2, G0), 2-AA Labeled 100 pmol Oligomannose Glycans CAA-MAN9-01 Man-9 Glycan, 2-AA Labeled 100 pmol CAA-MAN8-01 Man-8 Glycan, 2-AA Labeled 100 pmol CAA-MAN7-01 Man-7 Glycan, 2-AA Labeled 100 pmol CAA-MAN6-01 Man-6 Glycan, 2-AA Labeled 100 pmol CAA-MAN5-01 Man-5 Glycan, 2-AA Labeled 100 pmol CAA-M3N2-01 M3N2 (Man-3) Glycan, 2-AA Labeled 100 pmol Page 7

HPLC Calibration Standard CAA-GHP-30 2-AA Labeled Glucose Homopolymer Ladder 30 runs Other CAA-ALPHAGAL-01 Gal alpha 1-3 Gal beta 1-4 GlcNAc, 2-AA Labeled 100 pmol Hybrid Family Glycans - Product discontinued CAA-HYBRID-01 Hybrid Glycan (Man5BA1), 2-AA Labeled - discontinued 100 pmol -- APTS Labeled N-Glycans CAPTS-A2F-01 A2F Glycan (FA2G2S2, G2FS2), APTS Labeled 20 pmol CAPTS-A1F-01 A1F Glycan (FA2G2S1, G2FS1), APTS Labeled 20 pmol CAPTS-NA2F-01 NA2F Glycan (FA2G2, G2F), APTS Labeled 20 pmol CAPTS-FA2G1-01 FA2G1 Glycan (G1F), APTS Labeled 20 pmol CAPTS-NGA2F-01 NGA2F Glycan (FA2, G0F), APTS Labeled 20 pmol CAPTS-A2-01 A2 Glycan (A2G2S2, G2S2), APTS Labeled 20 pmol CAPTS-A1-01 A1 Glycan (A2G2S1, G2S1), APTS Labeled 20 pmol CAPTS-NA2-01 NA2 Glycan (A2G2, G2), APTS Labeled 20 pmol CAPTS-NGA2-01 NGA2 Glycan (A2, G0), APTS Labeled 20 pmol CAPTS-MAN5-01 Man-5 Glycan, APTS Labeled 20 pmol CAPTS-IGG-01 IgG N-glycan library, APTS labeled 10 pmol Procainamide Labeled N-Glycans CPROC-A3-01 A3 Glycan (A3G3S3), Procainamide Labeled 20 pmol CPROC-NA3-01 NA3 Glycan (A3G3), Procainamide Labeled 20 pmol CPROC-A1F-01 A1F Glycan (FA2G2S1, G2FS1), Procainamide Labeled 20 pmol CPROC-FA2G1-01 FA2G1 Glycan (G1F), Procainamide Labeled 20 pmol CPROC-NA2-01 NA2 Glycan (A2G2S1, G2S1), Procainamide Labeled 20 pmol CPROC-NGA2-01 NGA2 Glycan (A2), Procainamide Labeled 20 pmol CPROC-MAN5-01 Man-5 Glycan, Procainamide Labeled 20 pmol CPROC-MAN6-01 Man-6 Glycan, Procainamide Labeled 20 pmol CPROC-MAN7-01 Man-7 Glycan, Procainamide Labeled 20 pmol CPROC-MAN8-01 Man-8 Glycan, Procainamide Labeled 20 pmol CPROC-MAN9-01 Man-9 Glycan, Procainamide Labeled 20 pmol CPROC-IGG-02 IgG N-glycan library, Procainamide Labeled 50 pmol CPROC-GHP-30 HPLC Calibration Standard Glucose Homopolymer Ladder, Procainamide Labeled Page 8

Glycan Libraries CLIBN-FETUIN-01 Fetuin N glycan library Approx. 7.5 µg CLIBO-FETUIN-01 Fetuin O glycan library Released from 30 µg fetuin CLIBN-IGG-01 IgG N glycan library 25 µg CAB-IGG-01 IgG N glycan library, 2-AB Labeled 200 pmol CPROC-IGG-02 IgG N-glycan library, Procainamide Labeled 50 pmol CAPTS-IGG-01 IgG N-glycan library, APTS Labeled 10 pmol CPM-IGG-01 N-glycan IgG library, permethylated 20 MS runs CPM-C13-IGG-01 N-glycan IgG library, permethylated with heavy (13C) 20 MS runs methyl iodide SA-MAB4 MAb 4 Glycan Reference Panel 10 µg Monosaccharide and Sialic Acid standards CM-NEU-AC-01 N-acetylneuraminic acid quantitative standard 1nmol CM-NEUAC-100 N-acetylneuraminic acid quantitative standard 100nmol CM-NEU-GC-01 N-glycolyneuraminic acid quantitative standard 1nmol CM-NEUGC-100 N-glycolyneuraminic acid quantitative standard 100nmol CM-NEU5,9AC2-01 N-acetylneuraminic acid qualitative standard >800pmol CM-MONOMIX-10X3 Mix of six monosaccharide quantitative standards 10nmols of each, pack of 3 (glucosamine, galactosamine, galactose, mannose, glucose(dextrose) and fucose) CM-SRP-01 Sialic acid reference panel approx 0.125 nmol CM-XYLOSE-100 Xylose quantitative standard 100nmols Glycoprotein and Glycopeptide Standards GCP-FET-05 Fetuin glycoprotein standard 500 µg GCP-FET-250U Fetuin glycoprotein standard 250 µg GCP-FET-50U-X4 Fetuin glycoprotein standard 4 x 50 µg GCP-IGG-50U IgG glycoprotein standard 50 µg GCP-IGG-100U IgG glycoprotein standard 100 µg Quantitative standards BQ-CN-MAN8-10U BioQuant quantitative Man-8 standard 10 µg BQ-GPEP-A2G2S2-10U BioQuant A2G2S2 glycopeptide standard 3.49 nmol BQ-CHITOTRIOSE-01 BioQuant chitotriose standard 5 nmol BQ-CAB-CHI-01 BioQuant chitotriose standard, 2-AB Labeled 100 pmol BQ-CAA-CHI-01 BioQuant chitotriose standard, 2-AA Labeled 100 pmol Page 9

CM-NEU-AC-01 N-acetylneuraminic acid quantitative standard 1nmol CM-NEU-GC-01 N-glycolyneuraminic acid quantitative standard 1nmol CM-MONOMIX-10X3 Mix of six monosaccharide quantitative standards 10nmols of each, pack of 3 (glucosamine, galactosamine, galactose, mannose, glucose(dextrose) and fucose) CM-XYLOSE-100 Xylose quantitative standard 100nmols Some of components of the LL-MR-A2 & LL-HYDRAZ-A2 kits are shipped separately by FedEx as they are classed as dangerous goods items. The delivery charge will be based on the shipping costs for dangerous goods & will be dependent on the delivery location. This cost will be advised if a quotation is requested or at the order acknowledgment stage. Page 10