University of Groningen Vascular Endothelial Growth Factor, diagnostic and therapeutic aspects Kusumanto, Yoka Hadiani IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2006 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Kusumanto, Y. H. (2006). Vascular Endothelial Growth Factor, diagnostic and therapeutic aspects Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
Vascular Endothelial Growth Factor, diagnostic and therapeutic aspects Yoka H. Kusumanto
Financial support by the Dutch Diabetes Research Foundation (Diabetes Fonds Nederland) and the Netherlands Heart Foundation (Nederlandse Hartstichting) for the publication of this thesis is gratefully acknowledged. Financial support by the Stichting Werkgroep Interne Oncologie and the University of Groningen for the publication of this thesis is gratefully acknowledged. Additional financial support for the publication of this thesis was kindly provided by, Bristol-Myers Squibb B.V., Novartis Pharma B.V., Boehringer Ingelheim B.V., Merck Sharp & Dohme B.V. and Pfizer B.V. CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN HAAG Kusumanto, Y.H. Vascular Endothelial Growth Factor, diagnostic and therapeutic aspects Proefschrift Groningen. Met literatuuropgave en samenvatting in het Nederlands ISBN: 90-367-2588-7 Copyright 2006 Y.H. Kusumanto, Groningen, the Netherlands Cover & layout: E.J. Giltay and Y.H. Kusumanto, photograph M. Pattimahu Printed by de Regenboog, Groningen
Vascular Endothelial Growth Factor, diagnostic and therapeutic aspects Proefschrift Ter verkrijging van het doctoraat in de Medische Wetenschappen op gezag van de Rector Magnificus, dr. F. Zwarts in het openbaar te verdedigen op woensdag 28 juni 2006 om 14:45 uur door Yoka Hadiani Kusumanto geboren op 21 oktober 1967 te Bandung, Indonesië
Promotor: Copromotores: Beoordelingscommissie: Prof. Dr. N.H. Mulder Dr. G.A.P. Hospers, Dr. A.J. Smit Prof. Dr. R.O.B. Gans, Prof. Dr. B.H.R. Wolffenbuttel, Prof. Dr. J.H. van Bockel
Paranimfen: P.J. Perik, A. Vrieze
CONTENTS Chapter 1 Preview 9 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Therapeutic angiogenesis with Vascular Endothelial Growth Factor in peripheral and coronary artery disease: a review Int J Cardiovasc Intervent 2003;5:27-34 Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating Vascular Endothelial Growth Factor Angiogenesis 2003;6:283-287 A review on pro- and anti-angiogenic factors as targets of clinical intervention Pharmacological Research 2006;53:89-103 Circulating vascular endothelial growth factor during the normal menstrual cycle Anticancer Res 2004;24:4237-4241 Systemic VEGF levels after coronary artery bypass graft surgery reflects the extend of inflammatory response Acute Cardiac Care: accepted for publication Circulating Vascular Endothelial Growth Factor levels in advanced stage cancer patients compared to normal controls and diabetes mellitus patients with critical ischaemia Submitted for publication 15 31 41 71 81 91
Chapter 8 Chapter 9 Chapter 10 Skin capillary permeability in the diabetic foot with critical limb ischaemia: the effects of a phvegf 165 Submitted for publication The treatment with intra-muscular Vascular Endothelial Growth Factor gene compared to placebo for patients with diabetes mellitus and critical limb ischemia, a double blind randomized trial Human Gene Therapy: accepted for publication Improvement of In-Vivo Transfer of Plasmid DNA in Muscle: Comparison of Electroporation versus Ultrasound Submitted for publication 101 117 135 Chapter 11 Synopsis 147 Chapter 12 Samenvatting en toekomstperspectieven in het Nederlands 157 Dankwoord 169