doublo-s 2nd Generation HIFU For Intenal Purpose

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2nd Generation HIFU doublo-s 0120 9F SICOX TOWER, 513-14 SANGDAEWON-DONG, JOONGWON-GU, SUNGNAM, 462-120, KOREA TEL. 82-31-698-4900 FAX. 82-31-777-9713 www.hironic.com

C O N T E N T S 1. Technology Evolution 003 2. HIFU 009 3. doublo-s 015 4. Video, Before / After Picture 015

01 Technology Evolution

Technology Evolution from Lasers 2010 RF 4 Muscle

Differences Laser & IPL Advantages - Selectivity: Energy is only applied to Hemoglobin, Melanin, and water. - Safety: Safety has been proved for 30 years through its theoretical background and technology. Disadvantages - It is hard to apply to dark skin and deliver the energy into deep dermis & subcutaneous fat. RF (Radio Frequency) Fractional Laser Advantages Disadvantages Advantages - It can deliver the energy into deep dermis. - It generates stable and high thermal energy. - Non selectivity. - It is hard to transfer the energy into SMAS layer. - Partial, selective treatment is possible and shortening downtime. - Effective for various scar. 5 Disadvantages - The side effects, such as PIH or erythema happens. - It is hard to deliver the energy into deep dermis.

HIFU(High Intensity Focused Ultrasound) HIFU Advantages - Treatment up to SMAS layer creating Focal Zone - No damage to the Epidermis and without downtime Disadvantages - Need knowledge on nerve and blood systems. - Need consumables like HIFU cartridge 6

02 HIFU

HIFU(High Intensity Focused Ultrasound) H i g h I n t e n s i t y F o c u s e d Ultrasonic surgical unit, HIFU 8 HIFU is an equipment to treat various cancers like liver cancer, uterine cancer, and breast cancer through thermal energy which created in the focal point of supersonic wave collected through ultrasound transducer.

Medical Equipment Utilizing HIFU 9 Chinese Video Photographing Combined HIFU Cancer Operational Equipment American Prostate Cancer, Uterus Cancer HIFU Operational Equipment

Principles of HIFU Emit High Intensity Focuse d Ultrasound (HIFU) Induce Vibration among the tissue particles in the target area Generate Thermal Energy caused by friction 10 Coagulation Zone (Denaturation(60~70 C))

Principles of HIFU Energy C oagulation 2.6mm 1.4mm Focus Area High Electricity 7.5MHz Concentrated Ultrasound Schlieren Video Image (W.M. White et al, 2008) Histology of energy deposited in human cadaver skin tissue (H.J. Laubach et al, 2008) 11 What is Schlieren? Refracted Light by the change of density based on Frequency Makes visible pattern of wave

03 doublo-s

The strength of doublo-s doublo-s treatment gives a collagen remodeling and SMAS contraction in single treatment. 13 M7 3.0mm / D4, D7 4.5mm

Molecular Mechanism of ImmediateCollagen shrinkage* Tropocollagen molecule 60~70 C (Time + Heat dependent Denaturation) a.heat-labile Intermolecular alpha cross-links destroyed. 14 Immediate Shrinkage b. Intramolecular beta cross-links preserved.

What is target of doublo-s? 15 Superficial Dermis Deep Dermis Subcutaneous Tissue Fascia Muscle 1 2 3 4 Convey HIFU(High Intensity Focused Ultrasound) deeply into the the Skin fractionally, Cause thermal damage to the deep Tissues such as Dermis, border between Dermis and Subcutaneous layer, Subcutaneous fat Fibro tissue, SMAS and Fascia. Through a few months recovering period from wound, skin tightening happens gradually.

Configuration of doublo-s Handpiece 3 Types of Cartridges LCD Screen Cart (excluded) Control Unit 16

LCD Screen LCD Screen Adopt LCD Screen to display picture or movie file for operating of doublo-s 17

HIFU Control System HIFU Control System for operation 18 HIFU Control Syste m

User Friendly Interface 19 MEMORY selection screen More precise and longer treatment term > Speedy treatment thanks to the preset parameter > Optimum environment for patient > User s option for adjustment > Confirmation of presets in single screen

Optimum 3 Different Cartridges Based on treatment area, provision of 3 different Cartridge M7 D4 D7 Frequency 7.0MHz 4.0MHz 7.0MHz Focal Distance from Surface 3.0mm 4.5mm 4.5mm 20

Exclusive Cart Exclusive Cart provision of space for Consumables > Ergonomic Design, Movability 21

Strong Point of doublo-s 1 2 Collagen remodeling and SMAS contraction in single treatment Reasonable price of unit and its consumables 22 3 More precise and longer treatment term

Expectation in Selection of doublo-s Reasonable equipment and its consumable price. Application of reasonable treatment fee. 23 Increase of Increase of sat isfaction on cost Differentiation patients. effectiveness. with other hospitals.

The Perfect Reasons for Choosing doublo-s 1. Safety double! 2. Profit double! 24 2nd Generation HIFU

Specification 25 Energy type Power Cartridge Spacing Length Electrical Requirement s Weight Dimensions M7 D4 D7 HIFU 0.2 ~ 2J/cm 2 (0.05 Step) 7.0 MHz, 3.0 mm 4.0 MHz, 4.5 mm 7.0 MHz, 4.5 mm 0.5-10 mm (0.5 ~ 2 : 0.1mm/Step), (2 ~ 10 : 0.5mm/Step) 5.0-25 mm (1.0mm/Step) AC 100-240 V, 50/60 Hz Main body : 18.6Kg, Cart : 28.0kg 400 X 455 X 460 ( W X D X H) (Cart excluded)

04 Video, Before/After Pictures

BEFORE AFTER AFTER Global market leader Hironic doublo-s Before & After <After 10 months> 27

BEFORE AFTER Global market leader Hironic doublo-s Before & After 28 Effective to jaw and it looks sharp

BEFORE AFTER Global market leader Hironic doublo-s Before & After 29 *Female aged early 50s / Full face 2 pass *Parameter D4 : Cheek 1.0J (spacing 1.7) Mandible/ Submental 0.9J(spacing1.6) M7 : Cheek 0.45J(spacing1.2)

BEFORE AFTER Global market leader Hironic doublo-s Before & After <A Month later> 30 *Male aged mid 30s / Full face 2 pass *Parameter D4 : Cheek 1.0J (spacing 1.7) Mandible/ Submental 0.9J(spacing1.5) M7 : Cheek 0.45J(spacing1.2)

doublo-s Before & After Treatment Non-Treatment 31 Test

doublo-s Before & After Treatment Non-Treatment 32 Half Half

BEFORE AFTER Global market leader Hironic doublo-s Before & After <A Month later> E F O R E B AFTER 33

THANK YOU. WE WILL BE YOUR SUCCESSFUL BUSINESS PARTNER!! If you have any questions, pls don t hesitate to contact us at Tel. 82-31-698-4900 export@hironic.com Thank you for your attention!! 9F SICOX TOWER, 513-14 SANGDAEWON-DONG, JOONGWON-GU, SUNG NAM, 462-120, KOREA TEL. 82-31-698-4900 FAX. 82-31-777-9713 www. hironic.com