HIV Update. Under the direction of: Peter F. Weller, MD, MACP Douglas S. Krakower, MD Simi Padival, MD

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JUNE 1-3, 2017 Fenway Health, Boston, Massachusetts, USA TWENTY-FIRST ANNUAL MEETING HIV Update Contemporary Issues in Management HEALTH CARE PROFESSIONALS CAN RELY ON THIS PROGRAM FOR THE LATEST UPDATES AND ADVANCES IN THE DIAGNOSIS AND MANAGEMENT OF THE HIV-INFECTED PATIENT OUR EXPERT FACULTY, RECOGNIZED AS LEADERS IN CLINICAL PRACTICE AND MEDICAL EDUCATION, WILL ENRICH YOUR KNOWLEDGE IN ALL FIELDS OF HIV MANAGEMENT. TOPICS INCLUDE: Opportunistic infections HIV vaccines Perinatal transmission PrEP/PEP HIV/HCV coinfection Integrating addiction treatment into HIV care HPV-related complications Adherence to lifelong antiretroviral regimens New therapeutic regimens Sexual health HIV and transplantation Management of non-aids-defining malignancies, reproductive issues, and renal, endocrine, cardiovascular and liver diseases Under the direction of: Peter F. Weller, MD, MACP Douglas S. Krakower, MD Simi Padival, MD Earn up to: 19 AMA PRA Category 1 Credits 4.50 Risk Management Credits 18.83 Continuing Nurse Education Hours

Course Information 1. Registration: At registration you received your name badge and a printed syllabus. 2. Name Badges: Please remember to wear your name badge at all times during the course. 3. Course Materials: Our presenters have provided you with a variety of educational materials, which may include PowerPoint slides or an outline and references. Please refer to the online syllabus for larger images. All materials can be accessed online at: www.meetingsyllabus.com/hiv Password: hiv2017 NOTE: DUE TO COPYRIGHT RESTRICTIONS, SOME SLIDES, IMAGES AND/OR PRESENTATIONS MAY NOT BE AVAILABLE ON THE WEBSITE. UPDATED SLIDES MAY BE POSTED TO THIS WEBSITE AT THE END OF EACH DAY. THE PRESENTATIONS WILL REMAIN ONLINE FOR SIX MONTHS. 4. Internet Access: Complimentary Wi-Fi is available in the meeting space. To access, select: Network: Password: Fenway Health Guest Access ansin1340 5. Breakfast and Refreshment Breaks: Complimentary continental breakfast and refreshment breaks will be served daily. Please consult the schedule of events for breakfast and break times. We will make an announcement 5 minutes before the end of each break and ask that you begin returning to the meeting room in order to remain on schedule. 6. Lunch: Lunch is on your own. A list of local suggestions can be found in the appendix. 7. Restrooms: Restrooms are located on your left as you exit the auditorium, just passed the coat-check room. Additional restrooms are available on the 9 th floor (one floor down) and can be accessed by the stairs to the left of the coat-check area. 8. Accreditation: designates this educational activity for a maximum of 19 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. Certificates can be obtained immediately upon completion of the online course evaluation. Questions can be directed to ceprograms@hms.harvard.edu. 9. AAFP Credit: This Live activity has been reviewed and is acceptable for up to 18.5 Prescribed credit(s) by the American Academy of Family Physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 10. Risk Management. This activity meets the criteria of the Massachusetts Board of Registration in Medicine for 4.5 Credits of Risk Management Study. Please check with your individual state licensing board requirements before claiming risk management credit(s).

11. Nursing Credit: The Association of Nurses in AIDS Care will provide 18.83 continuing nurse education hours. The Association of Nurses in AIDS Care is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation To obtain credit, please: Sign in daily. Return the blue nursing participant attestation form to the registration desk at the conclusion of the course. Complete the online course evaluation form. Certificates will be emailed to you within 30 days. 12. Evaluations: HMS-DCE utilizes an electronic course evaluation system. To link to access the system can be found on the gold bookmarks. Once you complete the evaluation you will be redirected to the CME Certificate website where you will be able to save and print your certificate. We not only read and review every evaluation, but also provide specific comments made about topics and speakers to the appropriate people. 13. Disclosures: Please refer to the front of the syllabus for acknowledgements and faculty disclosures. 14. Audience Response System: Some of our speakers have incorporated polling questions into their presentations to allow you to anonymously test your knowledge. You may respond to an active poll using any device that is connected to the internet at www.pollev.com/cme2017 You can also respond by text. To join, text CME2017 to 22333. 15. Cell Phones and Electronic Devices: As a courtesy to one another, we kindly request that all cell phones and electronic devices be placed in the silent mode or powered off. 16. Recording: This course is not being recorded. No recording devices or cameras are permitted in the meeting room. 17. Security: We recommend that you write your name on your syllabus and be sure to keep them with you at all times. Unfortunately, we are not be able to replace these items if they are lost or stolen. We also encourage you not to leave any personal belongings in the meeting room. Fenway Health is not responsible for any lost or stolen items. 18. Help. Can t access the presentation materials online? We are happy to help. Please contact Agri Meetings at info@agrimeetings.com for further assistance. Thank you for joining us!

Faculty

Course Directors Peter F. Weller, MD, MACP William Bosworth Castle Professor of Medicine Professor of Immunology and Infectious Diseases Harvard T.H. Chan School of Public Health Chief, Infectious Diseases Division Chief, Allergy and Inflammation Division Vice Chair for Research, Department of Medicine Douglas S. Krakower, MD Staff Physician, Division of Infectious Diseases Simi Padival, MD Instructor in Medicine Staff Physician, Division of Infectious Diseases Guest Faculty Jennifer Delmonte, RN, BSN Registered Nurse, Prevention and Screening Fenway Health Katherine Hsu, MD, MPH, FAAP Associate Professor of Pediatrics Boston University School of Medicine Attending Physician, Pediatric Infectious Diseases Boston Medical Center Medical Director, Division of STD Prevention and HIV/AIDS Surveillance Massachusetts Department of Public Health Meg Sullivan, MD Boston University School of Medicine Director, HIV Clinical Programs, Section of Infectious Diseases Boston Medical Center Alexander Y. Walley, MD, MSc Associate Professor of Medicine Boston University School of Medicine Director, Addiction Medicine Fellowship Program Clinical Addiction Research and Education Unit Boston Medical Center

- Faculty Barbra M. Blair, MD Instructor in Medicine Director, Medical Education for Transplant Infectious Diseases and Immunocompromised Host Program Stephen L. Boswell, MD President and Chief Executive Officer Fenway Health Timothy Cavanaugh, MD Co-Medical Director, Transgender Health Program Fenway Health David A. Cohen, MD, ECNU Instructor in Medicine Co-Director, BIDMC Academy of Medical Educators Attending Physician, Division of Endocrinology Esther E. Freeman, MD, PhD Assistant Professor of Dermatology Massachusetts General Hospital Alex Gonzalez, MD, MPH Instructor in Medicine Staff Physician Medical Director Fenway Health Camilla S. Graham, MD, MPH Staff Physician, Division of Infectious Diseases

Melanie P. Hoenig, MD Associate Professor of Medicine Staff Physician Arthur Y. Kim, MD Director, Viral Hepatitis Clinic, Department of Infectious Diseases Massachusetts General Hospital Kenneth H. Mayer, MD Professor of Medicine Professor, Department of Global Health and Population Harvard School of Public Health Director of HIV Prevention Research Infectious Disease Attending Medical Research Director and Co-Chair The Fenway Institute Shibani S. Mukerji, MD, PhD Instructor in Neurology Assistant in Neurology Massachusetts General Hospital Ami G. Multani, MD Instructor in Medicine Attending Physician, Division of General Medicine and Infectious Diseases Director, High Resolution Anoscopy Fenway Health Ruvandhi Nathavitharana, MD, MPH Clinical and Research Fellow, Division of Infectious Diseases Christopher F. Rowley, MD, MPH Research Associate, Department of Immunology and Infectious Diseases Harvard School of Public Health Attending Physician, Division of Infectious Diseases

Roger L. Shapiro, MD, MPH Associate Professor of Medicine Associate Professor of Immunology and Infectious Diseases Harvard T.H. Chan School of Public Health Division of Infectious Diseases Wendy Stead, MD Program Director, Infectious Diseases Fellowship Staff Physician, Division of Infectious Diseases Kathryn E. Stephenson, MD, MPH Staff Physician, Division of Infectious Diseases Center for Virology and Vaccine Research Virginia A. Triant, MD, MPH Massachusetts General Hospital Robin Wigmore, MD Instructor in Medicine Attending Physician, Division of General Medicine and Infectious Diseases David S. Yassa, MD Instructor in Medicine Staff Physician, Division of Infectious Diseases

Schedule

Thursday, June 1, 2017 7:15am 8:00am Registration and Continental Breakfast 8:00am 8:15am Introduction and Welcome Stephen L. Boswell, MD 8:15am 9:00am History of the HIV Pandemic Kenneth H. Mayer, MD 9:00am 9:45am Primary Care, Including Recognizing and Robin Wigmore, MD Testing for Primary HIV Infection 9:45am 10:00am Question-and-Answer Session Robin Wigmore, MD Kenneth H. Mayer, MD 10:00am 10:20am Refreshment Break Preventing HIV Transmission 10:20am 10:50am HIV Vaccines: Progress to Date and Kathryn E. Stephenson, MD, MPH Future Innovations* 10:50am 11:20am Perinatal Transmission Best Practices Roger L. Shapiro, MD, MPH for Care, Prevention and Early Interventions* 11:20am 12:00pm PrEP and PEP: Enhancing the Benefit* Douglas S. Krakower, MD 12:00pm 12:15pm Question-and-Answer Session Kathryn E. Stephenson, MD, MPH Roger L. Shapiro, MD, MPH Douglas S. Krakower, MD 12:15pm 1:15pm Lunch (on your own) HIV, TB and Mental Health Issues 1:15pm 1:45pm Clinical Issues in the Management of Ruvandhi Nathavitharana, MD, MPH TB and HIV Coinfection 1:45pm 2:15pm Integrating Addiction Treatment into Alexander Y. Walley, MD, MSc HIV Care 2:15pm 2:25pm Question-and-Answer Session Ruvandhi Nathavitharana, MD, MPH Alexander Y. Walley, MD, MSc 2:25pm 2:45pm Refreshment Break Complications of HIV and Other Infections 2:45pm 3:30pm Dermatological Diseases Associated Esther E. Freeman, MD, PhD with HIV: Lessons from a Dermatologist 3:30pm 4:05pm HPV Related Complications in People Ami G. Multani, MD with HIV

Thursday, June 1, 2017 (continued) 4:05pm 4:15pm Question-and-Answer Session Esther E. Freeman, MD, PhD Ami G. Multani, MD 4:15pm 4:40pm HIV Neurology: Addressing Challenges Shibani S. Mukerji, MD, PhD 4:40pm 5:05pm Opportunistic Infections: Guidelines David S. Yassa, MD for Prevention and Treatment 5:05pm 5:15pm Question-and-Answer Session Shibani S. Mukerji, MD, PhD David S. Yassa, MD

Friday, June 2, 2017 7:30am 8:00am Continental Breakfast Special Lecture 8:00am 8:35am Endocrine Issues in HIV: Personalized David A. Cohen, MD, ECNU Therapy Antiretroviral Therapy 8:35am 9:20am Starting an Initial Antiretroviral Regimen: Wendy Stead, MD Take HAART! It s Not as Hard as It Used To Be* 9:20am 10:05am New Therapeutic Agents and When to Christopher F. Rowley, MD, MPH Switch Antiretroviral Regimens* 10:05am 10:20am Refreshment Break 10:20am 11:15am Challenging Cases in HIV Management Wendy Stead, MD Christopher F. Rowley, MD, MPH Viral Hepatitis 11:15am 11:45m Hepatitis B Camilla S. Graham, MD, MPH 11:45am 12:15pm Management and Diagnosis of Liver Arthur Y. Kim, MD Disease 12:15pm 12:30pm Question and Answer Session Camilla S. Graham, MD, MPH Arthur Y. Kim, MD 12:30pm 1:30pm Lunch (on your own) 1:30pm 2:10pm HCV: Here and Now in 2017 Simi Padival, MD 2:10pm 3:05pm Clinical Cases and Applications Arthur Y. Kim, MD Managing HIV and HCV Simi Padival, MD 3:05pm 3:25pm Refreshment Break Sexual Health and HIV 3:25pm 4:00pm HIV Reproductive Health: Conception Meg Sullivan, MD Options for Serodiscordant Couples* 4:00pm 4:30pm Transgender Health Timothy Cavanaugh, MD 4:30pm 5:00pm Sexual Health: How to Communicate Douglas S. Krakower, MD with Our Patients: Difficult Conversations Jennifer Delmonte, RN, BSN

Friday, June 2, 2017 (continued) 5:00pm 515pm Question-and-Answer Session Meg Sullivan, MD Timothy Cavanaugh, MD Jennifer Delmonte, RN, BSN Douglas S. Krakower, MD

Saturday, June 3, 2017 7:30am 8:00am Continental Breakfast Special Lecture 8:00am 8:30am Strategies for Linkage to and Alex Gonzalez, MD, MPH Engagement in HIV Care Complications and Co morbidities 8:30am 9:10am Renal Manifestations of HIV: Melanie P. Hoenig, MD Recommendation for Optimal Care 9:10am 9:40am HIV and Transplantation in 2017 Barbra M. Blair MD 9:40am 10:00am Refreshment Break 10:00am 10:30am Cardiovascular Disease: How to Virginia A. Triant, MD, MPH Optimize Treatment Outcomes 10:30am 10:45am Question-and-Answer Session Barbra M. Blair MD Virginia A. Triant, MD, MPH 10:45am 11:40am Management of Sexually Transmitted Katherine Hsu, MD, MPH, FAAP Infections in HIV Infected and At Risk Patients* 11:40am 12:00pm Closing Remarks *Qualifies for Risk Management Credits