Regional Update EW 41 Influenza (October 25, h GMT; 12 h EST)

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Regional Update EW 41 Influenza (October 2, 21-17 h GMT; 12 h EST) The information contained within this update is obtained from data provided by Ministries of Health of Member States and National Influenza Centers through reports sent to Pan American Health Organization (PAHO) or updates on their web pages. Epidemiologic influenza update North America In Canada 1, in epidemiological week (EW) 41, influenza activity increased slightly but remained relatively low. The influenza-like illness (ILI) consultation rate remained similar to previous weeks and was still within expected levels for this time of year. The percentage of positive samples during EW 41 (less than 1%) increased compared to the previous weeks and was higher than what is usually observed during this time of the year but much lower than what was observed in 29. Of the positive influenza specimens, approximately, one third were influenza A/H3N2 and two thirds were reported as unsubtyped influenza A. Low levels of other respiratory viruses continued to be reported. In Mexico, the predominant respiratory virus is the influenza A, especially the influenza A/H3. In the United States, 2 in EW 41, the proportion of outpatient consultations for ILI continued to remain below the national baseline. All the sub-national surveillance regions reported the proportion of ILI to be below their region-specific baselines. The proportion of deaths attributed to pneumonia and influenza remained below the epidemic threshold. No influenza -associated pediatric deaths were reported this week. During EW 41, influenza activity remained low 3.6% of samples tested were positive for influenza (influenza A 29 H1N1, influenza A/H3 and influenza B). Caribbean Cuba and Jamaica reported that the predominant respiratory virus circulating was the influenza A/H3. In EW 41, nationally, Dominican Republic 3 reported fewer cases of acute respiratory infection (ARI) as compared with average values of the period 24-28; however, in the capital city, the number of ILI consultations increased in two sentinel hospitals. The most affected age group was the children less than 1 year old. The respiratory syncytial virus (RSV) was the predominant virus during EW 41. No influenza viruses were isolated since EW 36. Central America During the EWs 4-41, the predominant circulating virus in El Salvador, Honduras and Nicaragua was the influenza B. Panama reported exclusive circulation of RSV and parainfluenza virus in the last two EWs. South America Andean Bolivia reported the circulation of influenza pandemic A (H1N1) 29 (predominant in the west of Bolivia), influenza A/H3 (predominant in the east of Bolivia), with a less percentage of Influenza B. South America Southern Cone In Argentina 4, nationally, ILI activity decreased from EW 33 to EW 39, remaining below the epidemic threshold. However, at the regional level, the ILI activity remained high in the north-western region of the country, especially in the provinces of Jujuy and Salta, where ILI activity increased from EW 3-39, crossing above the epidemic threshold. The predominant virus in the north-western regions of Argentina was the influenza A/H3. Low levels of parainfluenza virus and adenovirus were also reported. 1

In Chile, nationally, after 6 weeks of increasing, influenza-like illness (ILI) activity decreased during the last four epidemiological weeks (EW 38-41); however it still remained well above the epidemic threshold. At the regional level, ILI activity remained high in the central and southern part of the country (Maule, Bio Bio and Los Lagos), but decreased in all of them as compared to the previous weeks. This EW, the proportion of emergency services consultations for respiratory illness, out of the total number of consultations, decreased in children and adults, as compared to the last week. The number of severe acute respiratory infection (SARI) cases, associated to influenza, kept on decreasing since the EW 33 to EW 41, most of them because of influenza A/H3 infection. During the EW 41, the predominant respiratory virus was the RSV, after an 8- week period of influenza A/H3 predominance. In EW 4, Paraguay 6 reported a national decrease of 6.2% in ILI outpatient consultations as compared to the previous EW. Regionally, the southern regions of Misiones and Caazapa reported increasing ILI consultations (higher than % as compared to the previous week). SARI activity remained similar in the last EW. Paraguay reported similar circulation of pandemic influenza A (H1N1) 29 and influenza B during the last 1 EW; however, influenza A/H3 has been increasing. In Uruguay 7, during the last seven EWs, the proportion of SARI cases, out of the total number of hospitalizations showed a decreasing trend, remaining in less than 2%. The proportion of SARI hospitalized in intensive care units among all ICU admissions decreased between EW 38 and EW 41 (from ~% to 2,%). The proportion of SARI deaths among all deaths remained low as compared to the winter season. Viral circulation The information below is based on reports from National Influenza Centers and influenza laboratories from the Region. Americas Region (FluNet data) This graph includes data from countries who reported to FluNet: Argentina, Brazil, Canada, Chile, Colombia, Costa Rica, Cuba, El Salvador, French Guiana, Guatemala, Honduras, Jamaica, Martinique, Mexico, Panama, Paraguay, Peru and The United States. 2

North America Canada 3 3 Mexico 21, as reported to PAHO 9 8 2 2 1 1 7 6 4 3 2 1 Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B United States 3

Caribbean 12 Cuba 21 as reported to PAHO 7 1 6 8 6 4 2 4 3 2 1 RSV Adenovirus Parainfluenza Flu A (not subty Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B Dominican Republic 21 as reported to PAHO Number of Cases 3 3 2 2 1 1 7 6 4 3 2 1 Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B 3 Jamaica 21 as reported to PAHO 2 2 1 1 Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B 4

Central America El Salvador (FluNet data) Honduras (FluNet data) Nicaragua Panama 18 Nicaragua 21, as reported to PAHO 8% Panama 21, as reported to PAHO 16 7% 7 6% Número de Muestras Positivas 14 12 1 8 6 4 6% % 4% 3% 2% % Positivos Número de Muestras Positivas 6 4 3 2 1 % 4% 3% 2% 1% % Positivos 2 1% % Semana Epidemiológica % Semana Epidemiológica Adenovirus RSV Parainfluenza Influenza B Influenza A/H3 Influenza A/H1 A not subtypeable A not subtyped A (H1N1) 29 Adenovirus RSV Parainfluenza Influenza B Influenza A/H3 Influenza A/H1 A not subtypeable A not subtyped A (H1N1) 29

South America - Andean Bolivia 14 Bolivia (La Paz - INLASA) 21 as reported to PAHO 7 14 Bolivia (Santa Cruz - CENETROP) 21, as reported to PAHO 8 12 6 12 7 1 8 6 4 2 4 3 2 1 1 8 6 4 2 6 4 3 2 1 Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B South America Southern Cone Argentina Casos 14 12 1 8 6 4 2 Corredor Endémico Semanal de 21 Enfermedad Tipo Influenza (ETI). Argentina Históricos de años: 2 a 29 Semanas Exito Seguridad Alerta Casos Nuevos Fuente: SNVS - C2 16 14 12 1 8 6 4 2 Argentina 21 Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B 4 4 3 3 2 2 1 1 6

Paraguay 4 4 3 Paraguay 21 as reported to PAHO 6% % Number of cases 3 2 2 1 1 4% 3% 2% 1% % Adenovirus RSV Parainfluenza Influenza B Influenza A/ H3 Influenza A/ H1 A not subtypable A not subtyped Inf A H1N1 29 % Positivos Uruguay Proportion of SARI hospitalizations, SARI hospitalizations in ICU, and SARI deaths 4 Uruguay* Distribution of respiratory viruses under SARI surveillance by EW 21 4 4 4 3 3 3 2 2 1 1 3 2 2 1 1 Flu A Seasonal (H3) Flu H1N1 (pandemic) Flu B Chile Datos de FluNet Distribution of influenza viruses under surveillance by EW 21 7

WHO Influenza update - 2 October 21 2 October 21 - Summary: Influenza activity in the temperate regions of the Southern Hemisphere is continuing to decline. In most of the temperate regions of the Northern Hemisphere the level of activity is still low. Influenza virus A(H3N2) continues to be the most frequently detected virus world wide. Most of the influenza A(H3N2) viruses are A/Perth/16/29-like,which is the virus strain included in the seasonal vaccines for the Northern and Southern Hemispheres. http://www.who.int/csr/disease/influenza/21_1_2_gip_surveillance/en/index.html 1 FluWatch Report. EW 41. http://www.phac-aspc.gc.ca/fluwatch/ 2 Surveillance Summary. Week 41. Centers for Disease Control and Prevention 3 Informe de Verificación de alerta de brote de IRA. 21 de octubre de 21 4 Argentina. Informe de vigilancia de enfermedad tipo influenza. 21 de octubre de 21 Chile. Informe de situación. SE 41. www.pandemia.cl 6 Paraguay. Boletín Epidemiológico semanal SE 42 7 Uruguay. Vigilancia de IRAG. https://trantor.msp.gub.uy/epidemiologia/servlet/iraggrafmenu 8