Click http://www.guidechem.com/cas-232/23261-20-3.html for suppliers of this product Galactitol,1,2:5,6-dianhydro- (cas 23261-20-3) MSDS MSDS : Galactitol, 1,25,6-dianhydro- CAS : 23261-20-3 SYNONYMS : * DAD * DAG * Dianhydrodulcitol * 1,2-5,6-Dianhydro-dulcitol * Dianhydrogalactitol * 1,2:5,6-Dianhydrogalactitol * 1,2:5,6-Diepoxydulcitol * Dulcitoldiepoxide * NSC 132313 Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers [ Galactitol, 1,25,6-dianhydro- 23261-20-3 ] *** CHEMICAL IDENTIFICATION *** RTECS NUMBER CHEMICAL NAME : LW5320000 : Galactitol, 1,2:5,6-dianhydro- CAS REGISTRY NUMBER : 23261-20-3 LAST UPDATED : 199703 DATA ITEMS CITED : 20 MOLECULAR FORMULA : C6-H10-O4 MOLECULAR WEIGHT : 146.16 WISWESSER LINE NOTATION : T3OTJ BYQYQ- BT3OTJ COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * DAD * DAG * Dianhydrodulcitol * 1,2-5,6-Dianhydro-dulcitol * Dianhydrogalactitol * 1,2:5,6-Dianhydrogalactitol * 1,2:5,6-Diepoxydulcitol * Dulcitoldiepoxide
* NSC 132313 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** : Oral : 14 mg/kg : 11 mg/kg : 16 mg/kg
: Oral : 7899 ug/kg Details of toxic effects not reported other than lethal dose value NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 : 15 mg/kg : Subcutaneous : 16500 ug/kg Details of toxic effects not reported other than lethal dose value NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 : 21 mg/kg
: LDLo - Lowest published lethal dose : Mammal - dog : 16 mg/kg Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1585,1976 : Rodent - rabbit : 14 gm/kg Details of toxic effects not reported other than lethal dose value ** OTHER MULTIPLE DOSE TOXICITY DATA ** : TDLo - Lowest published toxic dose : Mammal - dog : 20 mg/kg/5d-i Blood - agranulocytosis Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60(10),1585,1976 : TDLo - Lowest published toxic dose : Primate - monkey : 20 mg/kg/5d-i
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60(10),1585,1976 : TDLo - Lowest published toxic dose : Rodent - rabbit : 87500 ug/kg/70d-i Blood - changes in bone marrow (not otherwise specified) ** MUTATION DATA ** : Mutation in microorganisms : Bacteria - Salmonella typhimurium : 100 ug/plate CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1-1980- Volume(issue)/page/year: 3,333,1982 : DNA adduct : 264 umol/kg 26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress in Research and Clinical Application, 7th Proceedings of the International Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3 vols., Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year: 2,31,1972 : Mutation test systems - not otherwise specified
: 7500 ug/kg ABBPAP Acta Biochimica et Biophysica Academiae Scientiarum Hungaricae. (Kultura, POB 149, H-1389 Budapest, Hungary) V.1-1966- Volume(issue)/page/year: 16,151,1981 : DNA inhibition Ascites tumor : 5 mg/l CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1-1969- Volume(issue)/page/year: 22,99,1978 : DNA inhibition : 5 mg/kg NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-1957- Volume(issue)/page/year: 31,667,1984 : Sister chromatid exchange : Rodent - hamster Cells - not otherwise specified : 50 ug/l CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1-1941- Volume(issue)/page/year: 43,4530,1983 : DNA damage : Bird - chicken Leukocyte : 30 mmol/l TELEAY Tetrahedron Letters. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) 1959- Volume(issue)/page/year: (29),2477,1975 : DNA inhibition : Rodent - rabbit Bone marrow : 136 umol/l BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-1958- Volume(issue)/page/year:
25,1705,1976 *** END OF RECORD ***