Curriculum Vitae WASANA PRATCHAYASAKUL, Ph.D.

Curriculum Vitae WASANA PRATCHAYASAKUL, Ph.D. Office Address: Cardiac Electrophysiology Research and Training Center (CERT) Department of Physiology, Faculty of Medicine Chiang Mai University, 110 Intrawaroros Road, Muang District, Chiang Mai 50200 Thailand Phone: 66-53-945-329 Fax: 66-53-945-368 E-mail: wpratcha@med.cmu.ac.th EDUCATION 1996 High school degree from Dara Academy, Chiang Mai, Thailand 2000 B.Sc.(Nursing and Midwifery), Chiang Mai University, Chiang Mai Thailand 2005 M.Sc.(Physiology), Chiang Mai University, Chiang Mai Thailand 2011 Ph.D.(Physiology), Chiang Mai University, Chiang Mai Thailand HONORS AND AWARDS 1997 Outstanding Academic Achievement Award, Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand 1999 Outstanding Academic Achievement Award, Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand 2000-2001 Scholarship from the Graduate School, Chiang Mai University, Chiang Mai, Thailand

2 2006 Fellowship from IBRO-ISN Neuroscience School @ NUS, National University of Singapore, Singapore 2008-2011 Scholarship from the Royal Golden Jubilee Ph.D. program (RGJ-Ph.D.), Thailand Research Fund under the Office of the Prime Minister, the Royal Thai Government, Thailand 2010 Outstanding oral presentation by Ph.D. student, the 39 th Annual Scientific Meeting of the Physiology Society of Thailand, Chonburi, Thailand 2011 Outstanding oral presentation, the 2 nd Faculty of Medicine, CMU. Research Award, Chiang Mai, Thailand 2012 Outstanding oral presentation, RGJ-Ph.D. Congress XIII, Chonburi, Thailand PROFESSIONAL APPOINTMENT 2005 Research Associate, Cardiac Electrophysiology Research and Training Center, Department of Physiology Faculty of Medicine (Dr. Siriporn Chattipakorn, mentor) 2005-present 2005-present Staff, Cardiac Electrophysiology Research and Training Center (CERT), School of Medicine, Chiang Mai University, Chiang Mai, Thailand Instructor, Department of Physiology, Chiang Mai University, Chiang Mai, Thailand PROFESSIONAL LICENSE 2000 Present Nurse, Thailand. ORGANIZATIONS AND PARTICIPATION 2006 Present Thai Physiological Society 2007 Present Society for Neuroscience 2007 Present The Endocrine Society

3 PRESENTATIONS AT NATIONAL MEETINGS August 2004 May 2006 May 2008 April 2009 May 2010 4 th National Symposium on Graduate Research, Chiang Mai Thailand 35 th Annual Scientific Meeting of the Physiology Society of Thailand, Chiang Mai, Thailand 37 th Annual Scientific Meeting of the Physiology Society of Thailand, Chonburi, Thailand 38 th Annual Scientific Meeting of the Physiology Society of Thailand, Petchaboon, Thailand 39 th Annual Scientific Meeting of the Physiology Society of Thailand, Chonburi, Thailand PRESENTATIONS AT INTERNATIONAL MEETINGS March 2006 July 2006 November 2007 September 2010 November 2010 November 2011 April 2012 June 2013 Collegium Internationale Neuro-Psychopharmacologicum (CINP) Asia Pacific Regional Meeting, Pattaya, Thailand 29 th Annual Meeting of the Japan Neuroscience Society, Kyoto, Japan Neuroscience 2007, San Diego, California, USA RGJ seminar series LXXIV From Basic Biomedical Research to Sustainable Development, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Neuroscience 2010, San Diego, California, USA Neuroscience 2011, Washington DC, USA RGJ Ph.D. Congress XIII, Chonburi, Thailand Endo 2013, San Francisco, California, USA RESEARCH GRANT SUPPORT 04/2012-10/2013 Faculty of Medicine Endowment Fund, Chiang Mai University, Chiang Mai, Thailand. Effect of Anti-Diabetic Drugs: Vildagliptin in rats with

4 neuronal insulin resistance induced by 12-week high fat diet consumption (PI). 01/2013-12/2013 Chiang Mai University Young Researcher Fund, Chiang Mai, Thailand. Effects of estrogen administration on neuronal insulin resistance in long term high-fat fed ovariectomized rats (PI). 06/2013-06/2015 The Thailand Research Fund (TRF) Grant (น กว จ ยร นใหม สกว.). Effects of the combined estrogen deprivation with obesity induced by high-fat diet consumption on neuronal insulin resistance, synaptic plasticity, cognition, brain oxidative stress and brain mitochondrial function (PI). PREVIOUS GRANT SUPPORT 07/2005-06/2008 The Thailand Research Fund (TRF) Grant (เมธ ว จ ย สกว.). Inhibition of cholinesterase activity in circulation and hippocampus in vivo following administration of Tabernaemontana divaricata extract (Co-PI). 04/2008-11/2009 Faculty of Medicine Endowment Fund, Chiang Mai University, Chiang Mai, Thailand. Changes in nitric oxide synthase expression in hippocampus of rats with insulin resistance induced by high-fat diet (PI). 05/2008-04/2011 The Thailand Research Fund (TRF) Grant (เมธ ว จ ย สกว.). Effects of longterm high-fat diet on hippocampal synaptic plasticity in rats (Co-PI). 10/2009-09/2010 National Research Council of Thailand. The alteration of neuronal insulin receptor signaling and the promotion of amyloidosis in the rat brain following chronic high-fat diets ingestion (Co-PI). 06/2010-12/2012 Faculty of Medicine Endowment Fund, Chiang Mai University, Chiang Mai, Thailand. Effect of rosiglitazone on hippocampal long term depression, brain insulin system dysfunction and amyloidosis in long term high-fat diets feeding rat (Co-PI). RESEARCH FIELDS OF INTEREST 1. Neurophysiology 2. Neuroendocrinology PEER REVIEWED ARTICLES 1. Pongchaidecha A, Pratchayasakul W, Khansuwan U. Dietary Fat and Training Enhance Utilization of Intramuscular Triacylglycerol during Exercise. Thai Journal of Physiological Science 2006; 19: 6-29.

5 2. Chattipakorn S, Pongpanparadorn A, Pratchayasakul W, Anchalee Pongchaidacha A, Ingkaninan K, Chattipakorn N. Tabernaemontana Divaricata extract inhibits cholinesterase activity in rat. Journal of Ethnopharmacology 2007; 110: 61-68. 3. Pratchayasakul W, Pongchaidacha A, Chattipakorn N, Chattipakorn S. Ethnobotany & ethnophamacology Tabernaemontana divaricata. Indian Journal of Medical Research 2008; 127: 317-333. 4. Pratchayasakul W, Pongruangporn M, Chattipakorn N, Chattipakorn S. Roles of curcumin in preventing pathogenesis of Alzheimer s disease. Current Topics in Nutraceutical Research 2009; 7: 11-26. 5. Pratchayasakul W, Pongchaidacha A, Chattipakorn N, Chattipakorn S. Reversible acetylcholinesterase inhibitory effect of Tabernamontana divaricata extract on synaptic transmission in rat CA1 hippocampus. Indian Journal of Medical Research 2010; 131: 409-415. 6. Pratchayasakul W, Kerdphoo S, Petsophonsakul P, Pongchaidecha A, Chattipakorn N, Chattipakorn S. Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone. Life Science 2011; 88: 619-627. 7. Pratchayasakul W, Chattipakorn N, Chattipakorn S. Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders. Life Science 2011; 89:702-707. 8. Pramojanee SN, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. Low-dose dental irradiation decreases oxidative stress in osteoblastic MC3T3-E1 cells without any changes in cell viability, cellular proliferation and cellular apoptosis. Archives of oral biology 2011; 57: 252-6. 9. Pipatpiboon N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. PPARγ agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets. Endocrinology 2012;153: 329-38. 10. Pipatpiboon N, Pintana H, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. European Journal Neuroscience. 2013;37:839-49. 11. Pintana H, Apaijai N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats. Life Science. 2012; 91:409-14. PEER REVIEWED ABSTRACTS

6 1. Pratchayasakul W, Chattipakorn N, Chattipakorn S. Estrogen ameliorates brain insulin resistance only in obese female rats, but not in ovariectomized obese rats. Endocrine Review 2013: 34: MON-149 CONFERENCE SHORT PAPERS AND ABSTRACTS 1. Pratchayasakul W, Pongchaidecha A, Wongmekiat O, Khansuwan U. Impact of dietary fat proportion on the endurance capacity in trained rats. Proceeding to the 33 th Annual Scientific Meeting of the Physiology Society of Thailand, Rayong, Thailand, 2004; 1: 28. 2. Pratchayasakul W, Pongchaidecha A, Wongmekiat O, Khansuwan U. Influence of dietary fat proportion on tissue substrate utilization in trained rats. Proceeding to the 4 th National Symposium on Graduate Research, Chiang Mai Thailand, 2004; 1: 219. 3. Pongpanparadorn A, Pratchayasakul W, Pongchaidacha A, Chattipakorn N, Chattipakorn S. Inhibition of neuronal cholinesterase activity in normal rats by single dose administration of Tabernaemontana divaricata extracts. Chiang Mai Medical Bulletin 2005: 44; 2. 4. Chattipakorn S, Pongpanparadorn A, Pratchayasakul W, Pongchaidacha A, Ingkaninan K, Chattipakorn N. Tabernaemontana divaricata extract inhibits cholinesterase activity in rat brains. Proceeding to Collegium Internationale Neuro-Psychopharmacologicum (CINP) Asia Pacific Regional Meeting, Pattaya, Thailand, 2006: 1; 109. 5. Pratchayasakul W, Pongchaidacha A, Ingkaninan K, Chattipakorn N, Chattipakorn S. Tabernaemontana divaricata acts as the short-acting AChE inhibitors in rat model. Proceeding to the 35 th Annual Scientific Meeting of the Physiology Society of Thailand, Chiang Mai, Thailand. 2006. 6. Pratchayasakul W, Pongchaidacha A, Ingkaninan K, Chattipakorn N, Chattipakorn S. Tabernaemontana divaricata acts as the short-acting AChE inhibitors in rats. Neuroscience Research 2006: 55; s101. 7. Chattipakorn S, Pongpanparadorn A, Pratchayasakul W, Pongchaidacha A, Ingkaninan K, Chattipakorn N. Tabernaemontana divaricata extract (TDE) inhibits rats cortical AChE activity and enhances neuronal activity. Neuroscience Research 2006: 55, s101. 8. Pratchayasakul W, Pongchaidacha A, Chattipakorn N, Chattipakorn S. Novel reversible acetylcholinesterase inhibitor effect of Tabernamontana divaricata extract on synaptic transmission in rat CA1 hippocampus.neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007

7 9. Pongchaidacha A, Pratchayasakul W, Chattipakorn N, Chattipakorn S. Effect of nitroglycerin on the animal model of temporomandibular pain.neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007 10. Chattipakorn S, Pratchayasakul W, Pongchaidacha A, Chattipakorn N. High-fat diets induce neuronal and peripheral insulin resistance and decreases nnos expression in CA1 hippocampal neurons. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. 11. Pratchayasakul W, Pongchaidacha A, Chattipakorn N, Chattipakorn S. The effect of Tabernamontana divaricata extract on synaptic transmission in rat CA1 hippocampus. the 37 th Annual Scientific Meeting of the Physiology Society of Thailand, Chonburi, Thailand, 2008. 12. Pratchayasakul W, Pongchaidacha A, Petsophonsakul P, Chattipakorn N, Chattipakorn S. Effects of long term high fat feeding on the function of neuronal insulin receptor in the rats brain. the 38 th Annual Scientific Meeting of the Physiology Society of Thailand, Petchaboon, Thailand, 2009. 13. Chattipakorn S, Pratchayasakul W, Petsophonsakul P, Pongchaidecha A, Chattipakorn N. The prolonged high-fat dietary impairs functional neuronal insulin sensitivity in hippocampus. International Conference on Alzheimer s disease, Vienna, Austria, 2009. 14. Pratchayasakul W, Pongchaidacha A, Petsophonsakul P, Chattipakorn N, Chattipakorn S. The defect of neuronal function of insulin receptor in rat s hippocampus following 12-week high-fat consumption. the 39 th Annual Scientific Meeting of the Physiology Society of Thailand, Chonburi, Thailand, 2010. 15. Pratchayasakul W, Pongchaidacha A, Petsophonsakul P, Kerdphoo S, Chattipakorn N, Chattipakorn S. The defect of neuronal function of insulin receptor in rat s hippocampus following 12-week high-fat consumption. RGJ seminar series LXXIV From Basic Biomedical Research to Sustainable Development, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 2010 16. Pratchayasakul W, Kerdphoo S, Chattipakorn N, Chattipakorn S. Effect of estrogen administration on insulin receptor function in long term high fat-fed male and female rats. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. 17. Pratchayasakul W, Chattipakorn N, Chattipakorn S. Effect of estrogen administration on insulin receptor function in long term high fat-fed ovariectomized rats. Neuroscience Meeting Planner. Washington DC: Society for Neuroscience, 2011. 18. Pipatpiboon N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. Rosiglitazone improves neuronal insulin resistance and neuronal insulin signaling in obese rats induced with high-fat diets. Neuroscience Meeting Planner. Washington DC: Society for Neuroscience, 2011.

8 19. Pratchayasakul W, Chattipakorn N, Chattipakorn SC. Effect of estrogen on neuronal insulin receptor function in long term high fat-fed rats. RGJ Ph.D. Congress XIII, Chonburi, Thailand.