Ludwig Presence at 2016 ASCO Annual Meeting

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Ludwig Scientist(s) Affiliation(s) Session and Presentation Time Location Track Session Type/Title Presentation and/or Abstract Title Friday, June 3, 2016 Luisa Lina Villa Ludwig Sao Paulo 1:00pm - 3:15pm 1:40pm - 2:00pm S100bc Gynecological Cancer, International, Head and Neck Cancer Extended Education Session: Global Oncology Session: HPV-Associated Malignancies HPV Screening, Prevention and Vaccination Saturday, June 4, 2016 Jedd Wolchok Ludwig MSK 8:00am - 9:30am 8:36am - 8:48am Hall D1 Special Sessions Symposium: The View Beyond Single- Agent Checkpoint Blockade Perils and Promise of Combination Therapy, abstracts #100, #101 Peter Gibbs Ludwig Melbourne 8:00am - 11:30am Board 273 Gastrointestinal (Colorectal) Cancer Abstract #3576: Immune profile and survival outcomes in stage 2 colon cancer

Luis Diaz Ludwig John Hopkins 8:00am - 11:30am Board 328b Gastrointestinal (Colorectal) Cancer Abstract TPS3639: KEYNOTE- 177: first-line, open-label, randomized, phase 3 study of pembrolizumab versus investigator-choice chemotherapy for mismatch repair-deficient or microsatellite instability-high metastatic colorectal carcinoma Hui Gan, Andrew Park (presenter), Mary Macri, Aileen Ryan, Toni Ricciardi, Ralph Venhaus Ludwig Melbourne, Ludwig New York 1:00pm - 4:30pm Board 266a Central Nervous System Tumors Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 (durvalumab) in patients with glioblastoma (GBM) Stephen Hodi Ludwig Harvard 1:00pm - 4:30pm. Poster Discussion Session 4:45pm- 6:00pm Board 123. Poster Discussion Session E354b Melanoma/Skin Cancers Abstract #9518: Overall survival in patients with adavanced melanoma (MEL) who discontinued treatment with nivolumab (NIVO) plus ipilimumab (IPI) due to toxicity in a phase II trial (CheckMate 069)

Luis Diaz Ludwig Johns Hopkins 1:15pm - 2:45pm 1:55pm - 2:15pm S100a Clinical Trials, Tumor Biology, Value, Special Sessions Education Session: ASCO/American Association for Cancer Research (AACR) Joint Session: The Next Frontier of Genomics in the Clinic and Clinical Trials Potential of Liquid Biopsies in Precision Medicine Luis Diaz Ludwig Johns Hopkins 1:15pm - 4:15pm 2:15pm - 2:27pm Hall B1 Oral Abstract Session Programmed death-1 blockade in mismatch repair deficient cancer independent of tumor histology, abstract #3003 Sunday, June 5, 2016 Michael Postow Ludwig MSK 8:00am - 11:30am Board 395 Abstract #3073: Peripheral blood T cell subset phenotype analysis in melanoma patients treated with combination nivolumab + ipilimumab compared to ipilimumab alone

Crystal Mackall Ludwig Stanford 8:00am - 11:30am Board 362 Abstract #3040: Cytokine release syndrome (CRS) in patients treated with NY-ESO- 1c259 TCR Crystal Mackall Ludwig Stanford 8:00am - 11:30am Board 420a Abstract TPS3101: Autologous genetically engineered NY- ESO-1c259T in HLA-A*02:01, HLA*02:05 and HLA*02:06 positive patients with NY-ESO- 1 expressing tumors Jonathan Cebon Ludwig Melbourne 4:45pm - 6:00pm 5:03pm - 5:15pm Hall B1 Poster Discussion Session: T-Cell Stimulation: Step It Up Abstracts #3016, #3017, #3018

Monday, June 6, 2016 Maximilian Diehn Ludwig Stanford 8:00am - 9:15am 8:00am - 8:20am E253B Lung Cancer Meet the Professor Session Stereotactic Body Radiation Therapy for Early-Stage Disease Levi Garraway Ludwig Harvard 8:00am - 9:15am S504 Special Sessions Education Session: NCI Blue Ribbon Panel Listens: Submit Panelist Your Ideas for the National Cancer Moonshot Initiative Jedd Wolchok Ludwig MSK 9:45am - 11:00am 9:45am - 10:05am E253B Melanoma/Skin Cancers, therapeutics and Translational Research, Tumor Biology Meet the Professor Session Melanoma : Where Do We Go From Here? Levi Garraway Ludwig Harvard 9:45am - 11:15am 9:45am - 9:57am: Hall D1 Special Sessions Symposium: Actionable Mutations Redefined Introduction

Jeanne Tie Ludwig Melbourne 11:30am - 1:00pm 12:18pm - 12:30pm Hall D2 Gastrointestinal (Colorectal) Cancer Symposium: The Clone Wars The potential of circulating tumor DNA (ctdna) to reshape the design of clinical trials testing adjuvant therapy in patients with early stage cancers, abstract #3511 (169716) Jedd Wolchok Ludwig MSK 1:15pm - 4:15pm 2:39pm - 2:51pm Arie Crown Theater Melanoma/Skin Cancers Oral Abstract Session Updated results from a phase III trial of nivolumab (NIVO) combined with ipilimumab (IPI) in treatment-naïve patients (pts) with advanced melanoma (MEL) (CheckMate 067), abstract #9505 Tuesday, June 7, 2016 Ash Alizadeh (session discussant), David Kurtz (abstract presenter) Ludwig Stanford 8:00am - 9:30am 8:36am - 8:48am E354b Hematologic Malignancies - Lymphoma and Chronixc Lymphocytic Leukemia Symposium: Integrating New Diagnostics in Lymphoid Malignancies How Best to Define Proliferation in Mantle Cell Lymphoma, abstract #7510