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Scientific programme THURSDAY, 17 OCTOBER 2013 09:00 10:30 (VIENA HALL) 09:00 09:05 Precongress course: New discoveries in molecular targeted therapy 2013 Coordinator University of Medicine and Pharmacy Iuliu Hațieganu Cluj-Napoca Introducere 09:05 10:00 Clasificarea țintelor moleculare, update. Ce este deja autorizat FDA, EMA/ ANM? Dr. R. Curcă 10:00 10:15 Celulele stem tumorale în cancerul colorectal un nou marker? Dr. S. Șușman 10.15 10.30 Rolul de biomarker al miarn în cancerul colorectal Dr. O. Bălăcescu 10:30 10:45 Coffee break 10:45 12:30 (VIENA HALL) 10:45 11:00 Precongress course: New discoveries in molecular targeted therapy 2013 Coordinator University of Medicine and Pharmacy Iuliu Hațieganu Cluj-Napoca Celulele tumorale circulante în cancerul colorectal posibilități de detecție și implicații prognostice și predictive Dr. R. Buiga 11:00 11:15 Inflamazomii și evaluarea profilului molecular al cancerelor Dr. Ioana Berindan Neagoe

11:15 11:30 Markeri oncoimunologici și posibilități de imunomodulare în cancerul colorectal Dr. N. Miron 11:30 11:50 Oncoimunologie From bench to bedside Bristol Myers Squibb Session 11:50-12:20 Actualități în terapia moleculară țintită a tumorilor digestive 12:20 13:10 Lunch 13:10 15:25 (VIENA HALL) 13:10 13:55 Precongress course: New discoveries in molecular targeted therapy 2013 Coordinator University of Medicine and Pharmacy Iuliu Hațieganu Cluj-Napoca Actualități în terapia personalizată a cancerelor bronhopulmonare 13:55 14:40 Interacțiunea tumoră-gazdă o nouă țintă pentru tratamentul personalizat al cancerului mamar? Dr. A. Eniu 14:40 15:10 Actualități în terapia personalizată a altor tumori solide 15:10 15:25 Take home messages 15:30 15:50 (ATENA HALL) Eli Lilly Symposium Alimta (pemetrexed) - Innovative aspects in the management of advanced and metastatic non-small cell lung cancer

15:50 16:10 Coffee break 16:10 17:30 (ATENA HALL) 16:10 16:20 Resident afternoon Moderators: Prof. Dr. Viorica Nagy, Dr. O. Coza University of Medicine and Pharmacy Iuliu Hațieganu Cluj-Napoca Treatment results in nasopharyngeal carcinoma, the experience of the Oncology Institute Prof. Dr. I Chiricuță Cluj-Napoca Dr. Cristian Turdeanu 16:20 16:30 Comparison of three different types of target volume (PTV) delineation on postoperative conformal radiotherapy for primary brain tumors Dr. Raluca Stăhiescu 16:30 16:40 Neo-adjuvant chemotherapy in locally advanced cervical cancer Dr. Adina Nemes 16:40 16:50 Cancer Institute Ion Chiricuță experience in neoadjuvant and adjuvant treatment in breast cancer patients Dr. Andreea-Mirabela Patrulescu 16:50 17:00 Second radiotherapy treatment in recurrent brain tumors Dr. Silviu Halașag 17:00 17:10 Can amputation be avoided in early ano-rectal adenocarcinomas? Dr. Istvan Peter László 17:10 17:20 Brachytherapy for head and neck cancers the IOC experience Dr. Anamaria Sipos 17:20 17:30 Stage I testicular seminoma: results of survival and risk factors for relapse Dr. Nicoleta Zenovia Antone

17:30 17:50 17:50 18:10 18:10 18:30 18:30 18:50 Vifor Pharma Symposium Intravenous iron and hematopoietic response: from clinical studies to clinical practice Teva Pharmaceuticals Symposium Episodic pain in oncology pacients Dr. R. Curca Sandoz Pharma Symposium Impact of chemotherapy-induced anaemia in cancer patients Merck Sharp&Dohme (MSD) Symposium Aprepitant proven efficacy for the prevention of chemotherapy-induced nausea and vomiting (CINV) Dr. Larisa Ciule 18:50 19:10 19:30 22:00 AstraZeneca Symposium Therapeutic options after PSA progression following initial hormonal therapy in advanced prostate cancer WELCOME RECEPTION Grand Hotel Napoca

FRIDAY, 18 OCTOBER 2013 08:45 09:00 (ATENA HALL) Opening Ceremony Prof. Dr. A. Irimie Rector of the University of Medicine and Pharmacy Iuliu Hațieganu Cluj-Napoca Assoc. Prof. Dr. Anca Bojan Medical Director of the Institute of Oncology Ion Chiricuță Cluj-Napoca Dr. O. Coza RSRMO President 09:00 10:20 09:00 09:20 Epidemiology Session Moderators: Assoc. Prof. Dr. Anca Bojan, Dr. F. Nicula Incidence of tyroid cancer in Cluj County, 1998-2009 Dr. Ofelia Șuteu University of Medicine and Pharmacy Iuliu Hațieganu Cluj- Napoca 09:20 09:40 Cancer surveillance in North-Western region of Romania. Recent trends in major cancers incidence and mortality Dr. Daniela Coza Institute of Oncology Ion Chiricuță Cluj-Napoca 09:40 10:00 The Oncology Institute "Prof. Dr. Ion Chiricuță" Cancer prevention and control Department report on cancer control activities Dr. F. Nicula Institute of Oncology Ion Chiricuță Cluj-Napoca 10:00 10:20 Significance of circulating tumor cells in cancer therapy management Dr. R. Buiga Potcoava Institute of Oncology Ion Chiricuță Cluj-Napoca 10:20 10:40 Coffee break 10:40 12:30 (ATENA HALL) 10:40 11:10 Diagnosis & New Technologies Session Moderators: Prof. Dr. Anca Grosu, Prof. Dr. Viorica Nagy Biological Imaging for Radiation Treatment Planning Prof. Dr. Anca Grosu University Medical Center Freiburg, Germany

11:10 11:30 Predictive assays in clinical oncology Dr. Ioana Brie Institute of Oncology Ion Chiricuță Cluj-Napoca 11:30 11:50 Modern oncologic imaging Dr. C. Popița Institute of Oncology Ion Chiricuță Cluj-Napoca 11:50 12:05 Digital Breast Tomosynthesis in Breast Cancer Diagnosis and Screening Dr. Carmen Lisencu Institute of Oncology Ion Chiricuță Cluj-Napoca 12:05 12:20 Development of a joint platform for research publishing in non-english speaking countries - presentation of "Reports of Practical Oncology and Radiotherapy Journal" Prof. Dr. J. Malicki Greater Poland Cancer Center, Poznan, Poland 12:20 13:20 Lunch 12:20 12:50 Poster Session (I) 13:20 15:20 (ATENA HALL) 13:20 13:50 Treatment Session (I) Moderators: Prof. Dr. R. Pötter, Dr. O. Coza Current concepts and clinical evidence in image guided adaptive brachytherapy of cervical cancer Prof. Dr. R. Pötter Department of Radiotherapy, Comprehensive Cancer Centre, General Hospital Vienna, Medical University of Vienna, Austria 13:50 14:20 Is SBRT the future of RT? Prof. Dr. F. Guedea Catalan Institute of Oncology, University of Barcelona, Barcelona, Spain 14:20 14:50 Presenting European Guidelines on a risk assessment and analysis of adverse events and near misses in radiotherapy Prof. Dr. J. Malicki Greater Poland Cancer Center, Poznan, Poland 14:50 15:20 Survival scores in palliative radiotherapy Prof. Dr. D. Rades University Hospital Schleswig-Holstein, Campus Lübeck, Germany

15:20 16:00 Session with AstraZeneca support Place of hormonal therapy in advanced breast cancer Place of hormonal therapy in early breast cancer management Dr. A. Eniu (Romania) Place of hormonal therapy in advanced breast cancer management Dr. Bellet Meritxell (Spain) 16:00 16:20 Coffee break 16:00 16:20 Poster Session (II) 16:20 17:10 (ATENA HALL) 17:10 17:30 17:30 17:50 18:00 19:30 Janssen Symposium Moderator: Enhancing Hormonal Therapies and Enzimatic Mechanism of Action in metastatic Castration Resistant Prostate Cancer with focus on Abiraterone Prof. Dirk Schrijvers Medische Oncologie Antwerpen, Belgium Amgen Symposium Optimizing chemotherapy in breast cancer patients: dealing with toxicity Dr. A. Eniu, Dr. M. Dediu GlaxoSmithKline (GSK) Symposium New evidence, new standards? Redefining treatment selection in mrcc Dr. Larisa Ciule The Annual 23rd RSRMO Congress Meeting - 2013 Annual Report - election for RSRMO Board of Directors 2014-2016 20:00 23:00 Dinner

SATURDAY, 19 OCTOBER 2013 09:00 10:20 (ATENA HALL) 09:00 09:20 Treatment Session (II) Moderators: Assoc. Prof. Dr. Anca Bojan, Dr. O. Coza Myeloma management in the era of novel agents Assoc. Prof. Dr. Anca Bojan Institute of Oncology Ion Chiricuță Cluj-Napoca 09:20 09:40 Neadjuvant chemotherapy in the treatment of cervical cancer advances and controversies Prof. Dr. Viorica Nagy University of Medicine and Pharmacy Iuliu Hațieganu Cluj- Napoca 09:40 10:00 TNF sirna as modulators of apoptosis and angiogenesis, in cell migration and invasion in Triple Negative Breast Cancer Cells (TNBC) Dr. Ioana Berindan Neagoe Institute of Oncology Ion Chiricuță Cluj-Napoca 10:00 10:20 Local experience in the clinical set-up of ultrasound-guided brachytherapy in cervix cancer Dr. Claudia Ordeanu Institute of Oncology Ion Chiricuță Cluj-Napoca 10:20 10:40 Risk factors and long term survival in germ cell tumors stage I Dr. Cristina Ligia Cebotaru Institute of Oncology Ion Chiricuță Cluj-Napoca 09:00 10:40 (VIENA HALL) Course for Oncology Nurses Coordinator Dr. Claudia Ordeanu Institute of Oncology Ion Chiricuță Cluj- Napoca Sesiunea I 09:00 09:05 Moderatori: Dr. Claudia Ordeanu, Dr. Elisabeta Ciuleanu Deschiderea oficială 09:05 09:25 Complicațiile și tratamentul radioterapiei pelvisului Dr. Claudia Ordeanu

09:25 09:45 Tratamentul mucozitei radice Dr. Elisabeta Ciuleanu 09:45 10:05 Tratamentul antialgic la bolnavii oncologici As. Univ. Dr. Claudia Burz 10:05 10:25 Urgențe oncologice Roulul asistentei medicale Dr. Gh. Hogea 10:25 11:00 Pauză cafea (pentru sesiunea asistentelor) 10:40 11:00 Coffee break 11:00 12:40 (ATENA HALL) 11:00 11:30 Treatment Session (III) Moderators: Prof. Dr. C. Chiricuță, Assoc. Prof. Dr. A. C. Rancea Should be the immediate silicone breast implantation in breast cancer patients postponed after performing the external beam radiotherapy? Prof. Dr. C. Chiricuță Amethyst Radiotherapy Center, Otopeni 11:30 11:50 Update on breast reconstruction techniques and indications - Surgeon point of view. Dr. A. Martin Medestet Center Cluj-Napoca 11:50 12:10 Radiotherapy and breast reconstruction timing and clinical outcomes - Radiation oncologist point of view. Dr. Daniela Martin Institute of Oncology Ion Chiricuță Cluj-Napoca 12:10 12:25 Physicist point of view Phys. D. Dordai Institute of Oncology Ion Chiricuță Cluj-Napoca 12:2 12:40 The treatment planning using VMAT for immediate implant breast cancer surgery Phys. R. Popa Amethyst Radiotherapy Center, Otopeni, Romania

11:00 12:40 (VIENA HALL) Course for Oncology Nurses Coordinator Dr. Claudia Ordeanu Institute of Oncology Ion Chiricuță Cluj- Napoca Sesiunea II 11:00 11:20 Moderatori: Prof. Dr. Viorica Nagy, Șef Lucr. Dr. C. Căinap Tratamentul neutropeniei Șef Lucr. Dr. C. Căinap 11:20 11:40 Tratamentul anemiei Indicații actuale Dr. Cristina Cebotaru 11:40 12:10 Ghiduri practice O schimbare în practica curentă As. Univ. Dr. Z. Fekete 12:10 12:40 Trialurile clinice Ce trebuie să știm despre ele Dr. A. Eniu 12:40 13:00 (ATENA HALL) CONCLUSIONS Congress closure

Poster Session (I) Friday, October 18 (12:20 12:50*) 1. Microrna-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of Serpini-1, PDCD4 and PTEN Dr. Ciprian Tomuleasa 2. Human bile contains Microrna-Laden exosomes that can be used for cholangiocarcinoma diagnosis Dr. Ciprian Tomuleasa 3. Microrna-126 mediates the interaction of cancer associated fibroblasts with malignant cells in primary liver cancers Dr. Ciprian Tomuleasa 4. Metformin plus PIAF combination chemotherapy for hepatocellular carcinoma Mr. Bobe Petrushev 5. Metformin plus Sorafenib a novel combined therapy that highly impacts glioblastoma stem-like cells resistant to temozolomide Miss Mihaela Aldea 6. Implication of antiangiogenic inhibitors in triple negative breast cancer Dr. Cornelia Braicu 7. Pilot study for the targeted sequencing of acute myeloid leukemia-associated genes using the GS junior platform Dr. Ciprian Tomuleasa 8. The influence of 5-Fluorouracil and Oxaliplatin on the inflammatory cytokines and receptors on colorectal cancer cell line COLO320 Miss Valentina Pileczki 9. Cerebral metastases-preoperative diagnostic, possible or not? Dr. Stanca Mihaela Ples 10. Controverses in pathological bone fracture of the spine Dr. Stanca Mihaela Ples 11. Superior vena cava syndrome in patients with small-cell lung cancer Miss Teodora Alexa 12. Rapidarc technique in cranio-spinal irradiation Mr. Aurel Chiș Poster Session (II) Friday, October 18 (16:00 16:20*) 1. Follow-up in operated and non-operated low grade gliomas Dr. Stanca Mihaela Ples 2. Port-a-Cath chemotherapy administration system at Medisprof Oncology Day Clinic Dr. Adrian Udrea 3. Primary hepatoma versus liver metastases in liver cirrhosis Dr. Corina-Georgiana Mintoiu

4. Whole body magnetic resonance investigation Dr. Mariana Marusteri 5. The incidence of cancer in liver cirrhosis Dr. Corina Georgiana Mintoiu 6. Effectiveness of chemotherapy in elderly patients with metastatic lung cancer in clinical practice Dr. Eva Maria Postolache 7. Maintenance therapy results in stage IV lung adenocarcinoma Dr. Eva Maria Postolache 8. Changes in the plasma levels of TGF-BETA-2 and GDF-15 in response to radiotherapy in breast cancer patients Dr. Boglárka Schilling-Tóth *Fiecare prezentare ale alocate câte 3 minute.