University of Groningen Symptomatic and asymptomatic airway hyperresponsiveness Jansen, Desiree IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 1999 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Jansen, D. F. (1999). Symptomatic and asymptomatic airway hyperresponsiveness: epidemiological and pathological studies s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
SYMPTOMATIC AND ASYMPTOMATIC AIRWAY HYPERRESPONSIVENESS epidemiological and pathological studies
1999 Jansen, D.F. Symptomatic and asymptomatic airway hyperresponsiveness: epidemiological and pathological studies Thesis Groningen - with references - with summary in Dutch ISBN 90-367-1126-6 Copyright by D.F. Jansen. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without written permission from the author. All research described in this thesis was financially supported by the Netherlands Asthma Foundation (grant 93.66). The printing of this study was financially supported by: Stichting Astma Bestrijding, Faculty of Medicine University of Groningen, Merck Sharp & Dohme B.V. (MSD), Yamanouchi Europe B.V., Groningen University Institute for Drug Exploration (GUIDE), Boehringer Ingelheim B.V., Byk Nederland B.V., GlaxoWellcome B.V., Pharmachemie B.V. Cover: Metamorfose, Carla Nederbragt This document was printed by Stichting C. Regenboog
RIJKSUNIVERSITEIT GRONINGEN SYMPTOMATIC AND ASYMPTOMATIC AIRWAY HYPERRESPONSIVENESS epidemiological and pathological studies PROEFSCHRIFT ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. D.F.J. Bosscher, in het openbaar te verdedigen op maandag 1 november 1999 om 16.00 uur door Désirée Frederique Jansen geboren op 12 juli 1969 te Hengelo (O)
Promotores: Prof. Dr. D.S. Postma Prof. Dr. W. Timens Co-Promotor: Dr. H.C.J. Rijcken Referent: Dr. J. Kraan
Voor Henk & mijn ouders
Promotiecommissie: Prof. Dr. E. Duiverman Prof. Dr. J.H.J.M. van Krieken Prof. S.T. Weiss MD MS Paranimfen: Henk van de Beek Peter Verheggen
CONTENTS Chapter 1 General introduction 1 Chapter 2 (A)symptomatic bronchial hyperresponsiveness and asthma Respir. Med. 1997; 91: 121-134. 13 Chapter 3 The relationship of skin test positivity, high serum total IgE levels, and peripheral blood eosinophilia to symptomatic and asymptomatic airway hyperresponsiveness Am.J.Respir.Crit.Care Med. 1999; 159: 924-931. 33 Chapter 4 Smoking, and airway hyperresponsiveness especially in the presence of blood eosinophilia increase the risk to develop respiratory symptoms; A 25 year follow-up study in the general adult population Am.J.Respir.Crit.Care Med. 1999; 160: 259-264. 51 Chapter 5 Maximally attained FEV 1 and preceding decline in FEV 1 determine airway hyperresponsiveness in adult life, whereas the actual FEV 1 level determines the coexistence of respiratory symptoms in adults 65 Chapter 6 Airway inflammation in symptomatic and asymptomatic subjects with and without airway hyperresponsiveness 83 Chapter 6a Airway epithelium in symptomatic and asymptomatic subjects with and without airway hyperresponsiveness 101 Chapter 7 Summary, general discussion, conclusions, and perspectives 113 List of abbreviations 129 Nederlandse samenvatting 131 Dankwoord 146