THURSDAY, OCTOBER 27 TH, 2016 FRIDAY, OCTOBER 28 TH, 2016 18:00 Welcome Dinner (Renaissance Hotel) Introduction Topic Speaker 07:30 08:00 Registration/Light breakfast 08:00 08:15 Welcome to IBCN Meeting Goebell/Kamat 08:15 08:20 Welcome to Bochum Brüning/Pesch Pipeline Topic Chair: Goebell 08:20 08:40 BMS: Immuno-oncologic approaches to TBA bladder 08:40 08:50 Discussion Pipeline Topic Chair: Kamat 08:50 09:10 Roche: Atezolizumab Clinical Legrand Development in NMIBC 09:10 09:20 Discussion Targeting novel Topic Chair: Kamat pathways 09:20 09:27 Oncofetal glycan, chemoresistance Daugaard (**Travel Award**) 09:27 09:34 HER2 and EGFR amplification and Eriksson expression 09:34 09:41 Chick embryo chorioallantoic membrane Skowron assay 09:41 09:48 Inhibition of protein kinase D as a Agarwal therapy for bladder 09:48 10:03 Discussion 10:03 10:10 Systemic therapy for urachal carcinoma Szarvas 10:10 10:17 Understanding of therapy resistance to Nawroth CDK4/6 inhibitors 10:17 10:24 Intratumoral anti-ctla4 administration Mangsbo 10:24 10:31 IMvigor 210 first line atezolizumab Necchi cisplatin ineligible 10:31 10:50 Discussion
FRIDAY, OCTOBER 28 TH, 2016 Break 10:50 11:05 Pipeline Topic Chair: Black 11:05 11:25 H3 Biomedicine: Evasion of immunosurveillance by genomic Korpal alterations of PPARg/RXRa 11:25 11:35 Discussion Virus Therapy Topic Chair: Nawroth 11:35 11:55 The multi-faceted mechanism of tumor Rommelaere suppression by oncolytic parvoviruses 11:55 12:10 Virotherapy plus PD-L1 inhibition Holm 12:10 12:25 AdIFN for BCG unresponsive NMIBC Dinney 12:25 12:45 Discussion Lunch Break 12:45 13:30 Pipeline Topic Chair: Kamat 13:30 13:50 TARIS Technology Update in Urothelial Cutie Carcinoma 13:50 14:00 Discussion Diagnosis & Risk Stratification Topic Chair: Schmitz- Dräger 14:00 14:15 Label-free imaging of bladder : Klaus Gerwer towards automated differential diagnostics 14:15 14:20 Discussion 14:20 14:27 Tele-cystoscopy Krupski 14:27 14:34 Diagnostic algorithms for asymptomatic Kuckuck microhematuria 14:34 14:41 UroFollow Biobank Johnen 14:41 14:50 Discussion 14:50 14:57 T1 substaging van Rhijn 14:57 15:04 Pathologic risk stratification of T1 Hansel bladder 15:04 15:10 Discussion 15:10 15:17 CTC pilot study Culp
15:17 15:24 ctdna in metastatic bladder carcinoma Todenhöfer 15:24 15:30 Discussion Industry meets Topic IBCN 15:30 Breakout groups Chair: Schmitz- Dräger Adjourn 16:30 Reconvene for Dinner 18:30 17:45 Bus transfer from Renaissance Hotel 18:30 Tour of Heinrichshütte (Museum) 20:00 Dinner at Heinrichs https://www.lwl.org/industriemuseum/standorte/henrichs huette-hattingen/english 2230 Return bus transfer to Renaissance Hotel SATURDAY, OCTOBER 29 TH, 2016 Business Topic Meeting 08:00-09:00 IBCN Business Meeting with light breakfast (breakfast also available for those not attending the meeting) Speaker: Goebell/ Kamat Keynote Lecture Topic Chair: Black 09:00 09:30 Animal Models of Bladder Cancer Cory Abate-Shen 09:30 09:40 Discussion Potpourri Topic Chair: Goebell 09:40 09:47 Phase I trial of rbcg Rentsch 09:47 09:54 Treatment of oligometastatic bladder Navai 09:54 10:01 Collaborative Effort in Bladder Sarcoma Luz Research 10:01 10:08 IBCN recommendations for MIBC followup Kamat
10:08 10:20 Discussion 10:20 10:27 Uncovering the TWEAK/Fn14 cytokinereceptor Sanchez-Carbayo axis in bladder 10:27 10:34 CD4+ expansion after BCG Bivalacqua 10:34 10:41 Myeloid derived suppressor cells Grivas (**Travel Award**) 10:41 10:50 Discussion Break 10:50 11:05 Molecular Topic Chair: Black Subtyping 11:05 11:17 Molecular subtyping of advanced bladder Sjödahl 11:17 11:29 TCGA Update Lerner 11:29 11:41 Molecular subtypes and response to McConkey immune therapy in NMIBC 11:41 11:53 Response to neoadjuvant chemotherapy Seiler in MIBC is dependent on molecular subtypes 11:53 12:10 Discussion 12:10 12:22 Subtype specific bladder mouse models Kim 12:22 12:34 Validation of 12 gene progression score Dyrskjot in NMIBC 12:34 12:46 Molecular subtypes in micropapillary Guo urothelial carcinoma 12:46 12:58 Forerunner genes - basa to luminal Czerniak differentiation checkpoint 12:58 13:15 Discussion Lunch Break 13:15 14:00 Urine Topic Chair: Zwarthoff Biomarkers 14:00 14:07 Urinary gene expression test Mengual 14:07 14:14 Epigenetic markers in tissue and urine Smit 14:14 14:21 Hypermethylation of 4 gene panel for van Kessel prediction of progression of NMIBC 14:21 14:28 Urine proteomic biomarker panel Vlahou 14:28 14:35 Survivin and UBC Rapide for Gleichenhagen
detection of bladder 14:35 14:50 Discussion Chromatin Topic Remodeling 14:50 15:10 Functional analysis of chromatin remodeling genes 15:10 15:17 Chromatin remodeling gene mutations and T-cell infiltration 15:17 15:32 Genome-wide RNAi screen identifies novel ploidy-control genes that associate with recurrent mutations in human Discussion Chair: Nawroth Schulz Sfakianos Günes Wrap-Up & Closing Remarks 16:00 Kamat and Goebell