Summer 2015 Research Opportunity

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Summer 2015 Research Opportunity Conduct research during the summer of 2015 (June 1-August 6) under the direction of a Vanderbilt scientist (stipend provided, approximately $1,800/month) Laboratory-based, clinical or translational research in kidney disease or hypertension (no research experience required) Career advice, clinical and research seminars and discussions Completed Application Deadline is February 19th, 2015 (Program is limited to 10 students) For more information and registration details visit: http://www.mc.vanderbilt.edu/mkpdc/events/2015/internship/ Nancy Lightsey, Program Administrator SRTP-KD Division of Nephrology and Hypertension Vanderbilt University Medical Center 1161 21 st Avenue South Medical Center North S-3223 Email: nancy.lightsey@vanderbilt.edu Nashville, TN 37232-2372 Phone: (615) 322-3146 Fax: (615) 343-9391

Division of Nephrology & Hypertension The Division of Nephrology & Hypertension at Vanderbilt University conducts a broad range of NIH funded, cutting edge basic science and human and patient-oriented research. Ranked in the top 10 Nephrology Divisions (US News and World Report ) and in an elite group of top NIH funded Nephrology Divisions. Our goal is to advance and acquire new knowledge that will advance our understanding of kidney biology and the pathogenesis and treatment of renal disease and hypertension. Over 60 clinical and research faculty, 19 NIH funded laboratories with over 25,000 sq. ft. of office and research space, and more than $15.1 million in annual external research funding. Human and patient-oriented research conducted at the Clinical Research and Nephrology Clinical Trials Centers. Close ties between the Vanderbilt Division of Nephrology and world renowned research in the Division of Clinical Pharmacology and the Centers for Matrix Biology, Developmental Biology and Stem Cell Biology.

Organization of the Course Dates You will spend a total of 10 weeks over the summer of 2015. Core curriculum is June 2 nd July 31 st but, you must be able to attend Orientation on June 1 st and to complete the 9-week core curriculum in order to be eligible. You are also expected to present your research at the National Summer Research Symposium at the end of the summer (August 5 th and August 6 th ). Orientation Will be on June 1 st, 2015. Students should arrive prior to this date and be ready to start the program on June 1 st. Daily Meetings from June 2 nd July 31 st (Core Curriculum) Monday: Nephrology seminar (Clinical topic) Tuesday: Diabetes seminar Wednesday: Nephrology seminar (Basic science related to the clinical topic) Thursday: Diabetes seminar Friday: Work in Progress - informal discussions about your project and the preparation of posters for the final Symposium at the end of the summer. Clinical Rotations We will also coordinate for all of the students to have some clinical exposure by attending renal clinics or wards at Vanderbilt over the course of the summer. National Summer Research Symposium at Vanderbilt (August 6 th & August 7 th ) Attend and present your research poster at the National Summer Research Symposium that is being jointly organized with the Diabetes Center at Vanderbilt.

Preceptors Khaled Abdel-Kader, M.D., M.S., Assistant Professor of Nephrology Dr. Abdel-Kader's research interests include quality of life in chronic kidney disease (CKD), quality of care of non-dialysis dependent CKD, health information technology including electronic health records (EHR) and clinical decision support systems (CDSS), and predictive modeling. Gautam (Jay) Bhave, M.D., Ph.D., Assistant Professor of Nephrology Dr. Bhave is interested in the assembly and function of basement membranes and extracellular matrix particularly in renal disease. His group utilizes cell culture systems, molecular biology, biochemistry, mass spectrometry, and mouse genetics to answer questions of interest. Kelly Birdwell, M.D., M.S.C.I., Assistant Professor of Nephrology Dr. Birdwell's research interests focus on metabolic changes and cardiovascular complications in kidney transplant recipients, and the impact of immunosuppression pharmacogenomics on these risks. Rich Breyer, Ph.D., Professor of Nephrology Dr. Breyer s lab studies eicosanoid signaling in the kidney and vasculature. Page 1 of 3 Nancy J. Brown, M.D., Professor and Chair of Medicine Dr. Brown s research focuses on the mechanisms of end organ damage in hypertension and the pathophysiology of cardiovascular disease in renal failure. Mark de Caestecker, M.D., Ph.D., Associate Professor of Nephrology. Dr. de Caestecker is Director of the Medical Student Research Training Program (Basic Science Research). His lab studies renal development and renal regenerative therapies. Kerri Cavanaugh, M.D., M.H.S., Assistant Professor of Nephrology Dr. Cavanaugh is Co-Director of the Medical Student Research Training Program (Clinical. Research). Her research interests focus on the impact of psychosocial and behavioral factors in kidney disease care. Peter Clark, M.D., Associate Professor of Urologic Surgery Dr. Clark is Co-Director of the Vanderbilt Center for Benign Urologic Disease and Residency Program Director in Urology. His research focuses on MAPK and canonical Wnt signaling in renal epithelial neoplasms. Douglass B. Clayton, M.D., Assistant Professor of Pediatric Urology Dr. Clayton focuses his research on the role of ischemia and reperfusion injury in bladder diseases.

Preceptors William Fissell, M.D., Professor of Nephrology Dr. Fissell s research focuses on Technology Development for End-Stage Renal Disease and Detailed Analysis of therapeutic strategy in AKI.. Agnes Fogo, M.D., Professor and Director, Renal Pathology Dr. Fogo an expert on human and experimental renal pathology, with many years of experience studying the effects of chronic renal injury models in rodents.. Al George, M.D., Professor and Chief of Genetic Medicine Dr. George studies the molecular genetics of ion transporters. Leslie Gewin, M.D., Instructor of Nephrology Dr. Gewin s research investigates the role of growth factors in renal injury and fibrosis. Page 2 of 3 Volker H. Haase, M.D., Associate Professor of Nephrology Dr. Haase studies the molecular machinery that senses cellular oxygen levels and its role in renal physiology and pathophysiology. Ray Harris, M.D., Professor and Chief of Nephrology Dr. Harris is Director of the O Brien Kidney Disease Center. His research interests focus on the role of growth factors and eicosanoids in renal physiology and pathophysiology. David Harrison, Professor and Chief of Clinical Pharmacology Dr. Harrison is the Director of the Vanderbilt Vascular Biology Center. His laboratory studies the role of inflammation and immunity in hypertension. Adriana Hung, M.D., M.P.H., Assistant Professor of Nephrology Dr. Hung studies metabolic disorders of chronic kidney disease with focus on vascular inflammation, insulin resistance, endothelial dysfunction and oxidative stress; and how these derangements are linked to cardiovascular risk and kidney disease progression. Alp Ikizler, M.D., Professor of Nephrology Dr. Ikizler s research focuses on the translational/metabolism physiology in kidney disease. Deborah P. Jones, M.D., Professor of Pediatric Nephrology Dr. Jones is the fellowship training program director in pediatric nephrology. Her research interests include: the acute and chronic effects of cancer therapy on the kidney, factors which predict poor outcome in children with glomerular disease and cardiovascular alterations among children with chronic kidney disease and hypertension.

Preceptors Valentina Kon, M.D., Professor of Pediatric Nephrology Dr. Kon is investigating the mechanisms underlying CKD-associated dysfunctions of lipid handling and inflammatory functions in atherosclerotic heart disease. Matt Luther, M.D., M.S.C.I., Assistant Professor of Clinical Pharmacology Dr. Luther studies the effects of the renin/angiotensin/aldosterone system on glucose metabolism and vascular function, utilizing clinical studies and model systems. John Oates, M.D., Professor of Clinical Pharmacology Dr. Oates laboratory studies the role of eicosanoids in vascular disease and therapy. Page 3 of 3 Ambra Pozzi, Ph.D., Professor of Nephrology Dr. Pozzi is the Associate Director of the O Brien Kidney Disease Center. Her research interests focus on the role collagen binding receptors in renal physiology and pathophysiology Heidi Schaefer, M.D., Associate Professor of Nephrology Dr. Schaefer is a transplant nephrologist whose research interests including living donation and medical issues related to kidney transplant recipients. Edward Siew, M.D., M.S.C.I., Assistant Professor of Medicine Dr. Siew s research interests include the translational and clinical study of Acute Kidney Injury. Specifically, he has a research program centered around validating novel biomarkers for the diagnosis and prognosis of AKI as well as examining the processes of care patients experience following an AKI event. Takamune Takahashi, M.D., Ph.D., Associate Professor of Nephrology Dr. Takahashi studies the molecular controls of renal vascular development and the pathogenic mechanisms of diabetic vascular injury. Jens Titze, M.D., Associate Professor of Clinical Pharmacology Dr. Titze s research uses both experimental rodent models and human studies to evaluate renal and extra-renal control of electrolyte and water homeostasis by immune cells. Matthew H. Wilson, M.D., Ph.D., Associate Professor of Nephrology Dr. Wilson s research interests focuses on developing cell and gene therapies for kidney diseases. Roy Zent, M.D., Ph.D., Professor of Nephrology Dr. Zent s research focuses on understanding the role of cell-matrix interaction in renal development as well as performing structure/function analysis of the matrix receptors integrins.

Application Student Research Training Program In Kidney Disease 2015 Complete Application Deadline is February 19 th, 2015 Program notifications will be sent out in mid-march 2015. The Vanderbilt Student Research Training (SRTP-KD) is sponsored by the National Institutes of Health and allows medical students to conduct research under the direction of an established scientist in the areas of Nephrology and/or Hypertension at Vanderbilt University during the summer between the first and second year, or second and third year of medical school. You are expected to work on your research for 8-10 weeks and must participate in the National Symposium at Vanderbilt on August 6 & 7, 2014. http://www.mc.vanderbilt.edu/mkpdc/events/2015/internship/ The application link is: https://redcap.vanderbilt.edu/surveys/?s=mapykn9kmn Please submit your completed application by February 19 th, 2015. For questions please contact: Nancy Lightsey Phone: 615-322-3146 Program Administrator, SRTP-KD Fax: 615-343-9391 1161 21 st Avenue South nancy.lightsey@vanderbilt.edu MCN S-3223 Nashville, TN 37232