Key Words Aneurysms Aortic disease Atherosclerosis Heart surgery Elderly

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70 : Outcome of Aortic Arch Surgery in Patients Aged 70 Years or Older: Axillary Artery Cannulation and Selective Cerebral Perfusion Supports Yasuhisa Takao Tetsuro Fumihiro Kunihiro Masataka Kazue Kiyoshige SHIMAZAKI, MD WATANABE, MD UCHIDA, MD TAKEDA, MD UESHO, MD KOSHIKA, MD NAKASHIMA, MD INUI, MD Abstract Objectives. Axillary artery cannulation, selective cerebral perfusion and replacement of the ascending and arch aorta with an elephant trunk were evaluated to reduce cerebral complications in aortic arch surgery in patients with aortic aneurysm or aortic dissection involving the aortic arch. Methods and Results. A total of 45 patients 8 with acute A type aortic dissection and 7 with chronic aortic aneurysm involving the aortic arch aged 70 9 mean age 74 years underwent total aortic arch replacement from March 996 to May 00. There were three operative deaths in patients with acute A type aortic dissection caused by massive cerebral infarction, bleeding and myocardial infarction, and one hospital death of sepsis. Overall in-hospital mortality was 8.9% 6.7% in A type dissection and.7% in chronic aneurysm. Operative complications included mediastinitis in four patients 9%, left recurrent laryngeal nerve palsy in eight 8%, and cerebral infarction in four 9%. Three of the patients with cerebral infarction had associated dissection-related cerebral ischemia before surgery. One patient died, and two needed a walking stick. Twelve of 8 patients 67% with acute A type aortic dissection and 6 of 7 96% with chronic aortic aneurysm were discharged on foot. Conclusions. Axillary artery cannulation, selective cerebral perfusion and replacement of the ascending and arch aorta with an elephant trunk provided satisfactory operative results in elderly patients aged 70 years or older, especially in patients with chronic aortic aneurysm involving the aortic arch. J Cardiol 00 Jan ; 4 : 7 Key Words Aneurysms Aortic disease Atherosclerosis Heart surgery Elderly : 990 9585 The Second Department of Surgery, Yamagata University School of Medicine, Yamagata Address for correspondence : SHIMAZAKI Y, MD, The Second Department of Surgery, Yamagata University School of Medicine, Iida-nisi, Yamagata, Yamagata 990 9585 Manuscript received September 8, 00 ; accepted October 4, 00 7

8, 996 00 5 80 70 45 80 9 0% A 8 B 6 70 9 74 Table A 5.5cm A A 4 0 Table 7 9 7 Table 997 7 Table Characteristics of the patients Disease Acute A type aortic dissection Chronic aortic diseases Chronic aortic dissection True aortic aneurysms No. of patients 8 6 Age at operation yr 7 9 70 84 7 8 Total 45 70 9 mean 74 Table Preoperative complications Complications related to acute A type aortic dissection Shock Cardiac tamponade 4 Aortic regurgitation 0 Cerebral infarction Limb ischemia including decreased pressure 5 Myocardial infarction Complications in 7 patients with chronic aortic aneurysms Hypertension 9 Myocardial infarction 7 Cerebral infarction Aortic regurgitation Aortic stenosis Left recurrent laryngeal nerve palsy 5 4 0ml/kg/min 5 :.4 l 8 C 8 C 5ml/kg/min

70 9 5ml/kg/min elephant trunk Elephant trunk4 Hemashield 4.4 l A K 6 C 0 elephant trunk 9% open distal 0 C 5 C 8 C 5 C 4 Table A 6gelatin-resorcinol- Table Concomitant procedures Coronary artery bypass grafting 4 Aortic root replacement Aortic valve replacement Mitral valve replacement Axillo-femoral bypass Table 4 In-hospital deaths Operative deaths Hospital deaths Total 4 8.9% formalin GRF 75 0 04 50 4 C A 6.7% 9 GRF Table 4.% 4 9% 8 9%4 4

0 Table 5 Patients discharged on foot Acute A type aortic dissection 67% Chronic aortic aneurysms 6 96% Total 8 84% 4 9% A 40 A A 9 A 4 4 9 7 8 84% A 8 67% 7 6 96% Table 5 6 % GRF A A 6.7% A 70 International Registry of Acute Aortic Dissection 6 70 7.5% 7 7.7%, 4 A A 8 4

70.7% 9 4,5 8 A GRF GRF A 9 A 6 quality of life A

: 70 : 996 00 5 70 A 8 7 45 70 9 74 A 8.9% A 6.7%.7% 4 9% 8 8%4 9% A A 8 67% 7 6 96% 8 84% : A J Cardiol 00 Jan; 4 : 7 Okita Y, Takamoto S, Ando M, Morota Y, Kawashima Y : Surgical strategies in managing organ malperfusion as a complication of aortic dissection. Eur J Cardiothorac Surg 995; 9 : 4 47 : : 00; : 66 68 : 00; 55: 5 9 4 Baribeau YR, Westbrook BM, Charlesworth DC, Maloney CT : Arterial inflow via an axillary artery graft for the severely atheromatous aorta. Ann Thorac Surg 998; 66 : 7 5 Tanaka H, Kazui T, Sato H, Inoue N, Yamada O, Komatsu S: Experimental study on the optimum flow rate and pressure for selective cerebral perfusion. Ann Thorac Surg 995; 59 : 65 657 6 Mehta RH, Suzuki T, Hagan PG, Bossone E, Gilon D, Llovet A, Maroto LC, Cooper JV, Smith DE, Armstrong WF, Nienaber CA, Eagle KA, for the International Registry of Acute Aortic Dissection IRAD Investigators : Predicting death in patients with acute type A aortic dissection. Circulation 00; 05: 00 06 7 Kawahito K, Adachi H, Yamaguchi A, Ino T : Early and late surgical outcomes of acute type A aortic dissection in patients aged 75 years and older. Ann Thorac Surg 000 ; 70: 455 459 8 Svensson LG, Crawford ES : Aortic dissection. in Cardiovascular and Vascular Disease of the Aorta ed by Svensson LG, Crawford ES. Saunders, London, 977 ; pp 4 8 9 Ueda T, Shimizu H, Ito T, Kashima I, Hashizume K, Iino Y, Kawada S : Cerebral complications associated with selective perfusion of the aortic arch. Ann Thorac Surg 000; 70 : 47 477 0 Okita Y, Ando M, Minatoya K, Kitamura S, Takamoto S, Nakajima N: Predictive factors for mortality and cerebral complications in arteriosclerotic aneurysm of the aortic arch. Ann Thorac Surg 999; 67 :7 78 Stowe CL, Baertlein MA, Wierman MD, Rucker M, Ebra G: Surgical management of ascending and aortic arch disease : Refined techniques with improved results. Ann Thorac Surg 998; 66 : 88 95 Moon MR, Sundt TM : Influence of retrograde cerebral perfusion during aortic arch procedures. Ann Thorac Surg 00; 74 : 46 4 Sabik JF, Lytle BW, McCarthy PM, Cosgrove DM : Axillary artery : An alternative site of arterial cannulation for patients with extensive aortic and peripheral vascular disease. J Thorac Cardiovasc Surg 995; 09: 885 89 4 Kazui T, Washiyama N, Muhammad BAH, Terada H, Yamashita K, Takanami N, Tamiya Y: Extended total arch replacement for acute type A aortic dissection: Experience with seventy patients. J Thorac Cardiovasc Surg 000 ; 9: 558 565 5 : : 00 ; 55: 4 6 : 9 Stanford A