15 Aprile 2015 - Firenze La cognizione sociale Chiara Cerami Divisione di Neuroscienze, Istituto Scientifico San Raffaele e Università Vita-Salute San Raffaele, Milano, Italy
Theoretical Background
Social Intelligence/Cognition is a complex domain It is the sum of those processes needed to perceive, understand and infer other s emotion and mental states that allow individuals of the same species (conspecifics) to interact with one another Prerequisites: Observation of other s behavior Prediction of other s behavior Appropriate Response Main Subcomponents: Emotion recognition Theory of Mind Empathy Different facets of the same ability
Social Intelligence/Cognition is a dynamic cognitive skill
Empathy is a key component of human emotional experience and social interaction. It comprises the ability to share the affective states both of our closest ones and complete strangers and to predict and understand their feelings, motivations, and actions Shamay-Tsoory et al., 2011
Melloni et al., 2013
PAIN FOR SELF, LOVED-ONE AND STRANGER Melloni et al., 2013
Theory of Mind (ToM) refers to the abilities to attribute mental states to others and to predict, describe, and explain behaviour on the basis of such mental states Poletti et al., 2012
Social cognition disorders in neurodegenerative conditions
Articles on the topic ToM in neurodegenerative diseases between 2000 and 2013
AD bvftd Poletti et al., 2012
19 AD, 12 AD and 16 HC bvftd impaired in all ToM tasks (cognitive and affective ToM as well as control question) AD impaired in more complex tasks (second order false belief and control questions)
In preparation
amci vs. HC no significant difference AD and bvftd overall impairments In preparation 12 AD, 20 bvftd, 15 prodromal AD bvftd specific impairment in the balance between EA and CI conditions (α SET-EA )
Schoeter et al., 2014
Schoeter et al., 2014
Seeley WW, Neuroscientist 2011
From Research to Practice
Index: Memory Attention Executive Functions Language Perceptual and Visuo-Spatial Functions Neglect Praxic abilities Logics and Intelligence Numbers and Calculation Complex assessment batteries Reading the Mind in the Eye (Serafin, 2004) Social Cognition Assessment (Prior, 2009) Social cognition??
EMOTION RECOGNITION ToM and EMPATHY Elamin et al., JNNP 2012
Ekman-60 Faces Test 60 stimuli eliciting the 6 basic emotions (i.e., happy, fear, anger, disgust, sad, surprise) global (0-60) and single emotion (0-10) scores Preliminary trial Italian normative data (132 sbj; 20-89 y age and 3-23 y education) Story-based Empathy Task 18 cartoon-strips depicting intention and emotion attribution plus a control condition of causal inferences global (0-18) and single emotion (0-6) scores Preliminary trial Italian normative data (136 sbj; 20-76 y age and 3-23 y education) Dodich et al., submitted
C.M., 82-year-old female; behavioural changes (irritability, apathy, disinhibition, inappropriate, bizzarre and impulsive behaviours) and episodic memory impairments from 10 years; MMSE 21/30; CDR 1 FDG-PET SPM t-map FWE-corrected (P.F. vs. 112 HC)
FDG-PET metabolic and neuropsychological profiles of the autoimmune limbic encephalitis Dodich et al., in preparation Brain MR images FLAIR Raw Score Adjusted Score Cut-off Mini Mental State Examination 25 24.97 24 Behavioral Changes Neuropsychiatric Inventory 33 - - Frontal Behavioral Inventory 16-27 Memory Digit Span Forward 6 5.96 3.50 Digit Span Backward 3 3.10 2.65 Corsi block-tapping Test 3 3.07 3.50 FCSRT immediate free recall 10 8.02 19.59 FCSRT immediate total recall 29-35 FCSRT delayed free recall 2 1.27 6.31 FCSRT delayed total recall 7-11 FCSRT index of sensitivity of cuing 0.52-0.9 Rey-Osterrieth figure copy recall 0/36 0 9.46 Executive Functions Raven s Progressive Matrices 25/36 27.5 18 Attentive Matrices 40/60 35.5 30 Social Cognition Abilities Ekman Global Score 41/60 43.97 37.46 Ekman Surprise Score 10/10-6 Ekman Happiness Score 10/10-9 Ekman Sadness Score 8/10-4 Ekman Anger Score 7/10-5 Ekman Fear Score 1/10-2 Ekman Disgust Score 5/10-4 Reading the Mind in the Eye Task 22/36 21.79 15 Story-based empathy (SET) Global Score 17/18 - SET Affective states attribution 6/6 - SET Cognitive states attribution 6/6 - SET Causal Inference 5/6 - FDG-PET SPM t-map
Emotion Recognition and attribution (ERA) index bvftd vs HC AUC : 0.909 Cut-off: 86.02 bvftd vs AD AUC : 0.768 Cut-off: 79.07