University of Groningen Prevention and care of chemotherapy-induced gastrointestinal mucositis Kuiken, Nicoline IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Kuiken, N. S. S. (2017). Prevention and care of chemotherapy-induced gastrointestinal mucositis [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 17-01-2019
Prevention and care of chemotherapyinduced gastrointestinal mucositis Nicoline Kuiken
The research described in this thesis was performed at the Department of Pediatrics, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. The research described in this thesis was funded by the Dutch Cancer Society (KWF) and a small part was funded by Stichting Scoren tegen Kanker. The author gratefully acknowledges the financial support for printing this thesis by: Groningen University Institute for Drug Exploration (GUIDE) University Medical Center Groningen (UMCG) University of Groningen (RUG) Cover design: Rietkraag, 80 x 180 cm, olieverf op doek; Artist cover design: Annemiki Bok www.annemikibok.nl Lay-out: J.A. Grunnekemeijer Printed by: Ridderprint BV, Ridderkerk, The Netherlands ISBN: 978-90-367-9750-4 (printed) 978-90-367-9749-8 (digital) N.S.S. Kuiken, 2017. All rights reserved. No part of this thesis may be reproduced, distributed, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
Prevention and care of chemotherapyinduced gastrointestinal mucositis Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op maandag 8 mei 2017 om 14.30 uur door Nicoline Sipkje Sophia Kuiken geboren op 2 januari 1988 te Huizen
Promotores Prof. dr. E.H.H.M. Rings Prof. dr. A.K. Groen Copromotor Dr. W.J.E. Tissing Beoordelingscommissie Prof. dr. E.S.J.M. de Bont Prof. dr. G. Dijkstra Prof. dr. N.M.A. Blijlevens
Someone is sitting in the shade today, because someone planted a tree a long time ago. Warren Buffet
Paranimfen Anke Heida Laura Aggenbach
CONTENTS Chapter 1 General introduction, aims and outline 9 Prevention and treatment 23 Chapter 2 Chapter 3 Chapter 4 Effect of oral insulin on severity and recovery of methotrexateinduced gastrointestinal mucositis in the rat 25 Tumor Necrosis Factor-alpha inhibitor Etanercept does not alter methotrexate-induced gastrointestinal mucositis in rats 39 Farnesoid X Receptor activation aggravates methotrexate-induced gastrointestinal mucositis 57 Clinical care 79 Chapter 5 Risk analysis, diagnosis and management of gastrointestinal mucositis in pediatric cancer patients 81 Chapter 6 Biomarkers and non-invasive tests for gastrointestinal mucositis 103 Chapter 7 Chapter 8 Effect of minimal enteral feeding on recovery in a methotrexateinduced gastrointestinal mucositis rat model 121 Feeding strategies in pediatric cancer patients with gastrointestinal mucositis: a multicenter prospective observational study and international survey 137 Discussion / Appendices 157 Chapter 9 Summary, discussion and future perspectives 159 Appendices Nederlandse samenvatting 177 Dankwoord 185 Biografie/Biography 193 List of publications 197