Varian and BrainLAB this historically strong relationship has evolved and is set to unlock infinite possibilities Varian Medical Systems, the world s leading manufacturer of radiotherapy and radiosurgery solutions, and BrainLAB, a global leader in the development and manufacture of software-driven medical technology, have teamed up to create Novalis Tx, the most powerful radiosurgery system available. This historically strong relationship has evolved and is set to unlock infinite possibilities for more innovative and effective treatment options. A revolutionary combination of advanced technologies, Novalis Tx offers a full spectrum of features putting the power of clinical excellence in your hands and powering hope in your patients.

Varian the world s leading manufacturer of medical devices and software for treating cancer and other medical conditions Varian Medical Systems, Inc., of Palo Alto, CA, is the world s leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, proton therapy, and brachytherapy. The company supplies informatics software for managing comprehensive cancer clinics, radiotherapy centers and medical oncology practices. Varian is a premier supplier of tubes and digital detectors for X-ray imaging in medical, scientific, and industrial applications and also supplies X-ray imaging products for cargo screening and industrial inspection. Varian Medical Systems employs approximately 4,400 people who are located at manufacturing sites in North America and Europe and in its 60 sales and support offices around the world. In Europe, the company operates manufacturing and engineering centers in Baden (Switzerland), Crawley (England), Haan (Germany), Helsinki (Finland) and Toulouse (France) and has headquarters for Europe, Middle East, India and Africa (EMEA) based in Zug, Switzerland. varian.com

BrainLAB a pioneer in the field of radiosurgery, BrainLAB develops, manufactures and markets software-driven medical technology, enabling more precise, less invasive procedures A pioneer in the field of radiosurgery, BrainLAB develops, manufactures and markets softwaredriven medical technology, enabling more precise, less invasive procedures. Among the core products are image-guided systems and software that provide highly accurate real-time information used for surgical navigation and radiosurgical planning and delivery. BrainLAB systems and software are leveraged to provide clinicians with an information portal to more effectively access and interpret diagnostic scans and other digital medical information for better informed decisions. BrainLAB solutions allow for expansion from a single system to operating suites to digitally integrated hospitals, covering all subspecialties from neurosurgery, orthopedics, ENT, CMF to spine & trauma and oncology. With more than 2,650 systems installed in more than 65 countries, BrainLAB is a market leader in image-guided technology. The privately held BrainLAB group, founded in 1989, is headquartered in Munich, Germany, and today employs more than 950 people in 15 offices across Europe, Asia, Australia, and North and South America. brainlab.com

Novalis Tx: Powerful Treatment Minutes are faster than hours. Novalis Tx offers one of the highest dose rates available, automated beam shaping, and frameless patient positioning for fast treatment often in just minutes. When every moment counts, an hour is too long. We ve Got Your Back and Front. Some radiosurgery systems only deliver anterior and lateral treatments. Novalis Tx treats your patients from every approach, including posteriorly. Approachability is a great quality. Get Connected. Novalis Tx brings patient data to you. Before you select a device, make sure it connects to a system that delivers patient information you need. Now that s service. A Healthy Dose. Novalis Tx delivers a high-intensity shaped beam of radiation to precisely paint the lesion with dose, while sparing critical structures. What s healthy about dot-matrix style dose delivery? Breathe Easy. Lesions are moving targets when your patients shift and breathe during treatment. Novalis Tx strobes the beam in real time, using imageguidance to adapt treatment during typical patient movement. Motors and gears over adaptations in milliseconds? Don t hold your breath. Form and function go together. Some new form factors may not address existing needs and can limit performance. Novalis Tx provides an optimal balance of form and functionality. When looking for a system, make sure you get the form and functionality you need. A Whole New Dimension. Planar radiography gives you a pretty good snapshot of some abnormalities. Novalis Tx combines 2D imaging with built-in volumetric cone-beam CT scanning to precisely define the target in 3D. New dimension, new perspective. Seeing is Believing. Novalis Tx, with Portal Vision and ExacTrac X-Ray 6D, images patients anytime during treatment the key to image-guidance. Imaging only once before treatment can impact accuracy. It s never good to make assumptions. Clean Cut The Novalis Tx multiple energy system (6 MV to 20 MV) produces more energy and penetrates deeper with greater conformality. Treat deep-seated tumors and keep adjacent organs and tissue safe. Doing it any other way just doesn t cut it.

Novalis Tx Performs The Beam Shaper The 2.5 mm HD120 high-definition beam shaper offers the smallest leaves available for highly precise conformality around the tumor. Tighter margins can result in superior dose escalation to the tumor, while reducing the risk of complications. Highest Dose rate Offering a dose rate of 1,000 MU per minute, Novalis Tx is the most powerful radiosurgery system available, penetrating deeper to treat tumors previously considered inoperable. IGRT & Patient Positioning On-Board Imager (OBI) and ExacTrac X-Ray 6D offer fast, highly accurate image-guidance and automatic positioning for initial setup and snap verification during treatment. OBI is mounted to Novalis Tx, rotating robotic arms along three axes of motion for the best possible view of the tumor. OBI cone-beam CT scanning also allows for 3D imaging of soft tissue. Intelligent Software With Eclipse and iplan, Novalis Tx provides a powerful treatment planning platform integrating advanced diagnostic information for more informed treatment decisions. Intelligent INTegration ARIA combines all patient records into one solution images, administrative, clinical and financial information linking medical, radiation and surgical oncology processes. iplan Net provides a flexible network-based infrastructure, integrating entire surgery and radiotherapy departments for increased cooperation, productivity and efficiency. Versatile, non-invasive Treatment Novalis Tx offers one of the most versatile treatment platforms available for radiosurgery and radiotherapy from frameless and frame-based treatment of cranial indications to extra-cranial treatment of spine, lung, liver and prostate lesions.

Versatility Drives Performance

Infinite Possibilities Novalis Tx provides diversified treatment possibilities, giving you the power to provide personalized treatment for each patient Impressive versatility, Fast Treatment Novalis Tx offers a wide range of treatment options for a large number of indications malignant and benign lesions, brain metastases, arteriovascular malformations, and functional lesions. During a typical day, a site can perform dozens of fractionated treatments and two to four single-fraction treatments. With highly flexible treatment modalities, Novalis Tx enables single stage, hypo- and hyper-fractionated treatments, as well as treatment with circular beams, conformal beams, dynamic conformal arcs, and IMRT. Novalis Tx provides diversified treatment possibilities, giving you the power to provide personalized treatment for each patient.

Impressive Versatility Metastasis Other Extra-Cranial Prostate Liver Lung Spine Craniopharyngioma Pituitary Adenoma Functional Schwannoma Head & Neck Other AVM Meningioma Glioma Estimated distribution of indications treated at Novalis Tx Centers

Industry-Leading Treatment Times 200 200 180 160 140 120 120 100 90 90 90 80 60 60 60 40 45 45 20 20 20 0 N/A Arteriovenous Malformation Acoustic Neuroma (single stage) Trigeminal Neuralgia (single stage) Spine Tumor (Stage IV) Competitor 1 Competitor 2 Novalis Tx Graph reflects total time in treatment room, including actual treatment. Source: Surgical Neurology 66 (2006) 559-564

Investing in Clinical Excellence Novalis Circle provides Novalis Tx and Novalis users with a network for communication, collaboration and development of new ideas and treatment techniques NOVALIS Circle Novalis Circle is a global network of clinicians dedicated to the advancement of radiosurgery. Novalis Tx users are leaders in their field. Through Novalis Circle, they demonstrate their strong commitment to providing one of the most clinically advanced treatment options for patients. Novalis Circle provides Novalis Tx and Novalis users with a network for communication, collaboration and development of new ideas and treatment techniques that will continue to change the face of radiosurgery. TOOLS FOR SUCCESS Novalis academy offers comprehensive, customized instruction for clinicians. Qualified personnel and experienced professionals present detailed training to enhance and develop user skills. Courses consist of theoretical and hands-on training sessions at various sites, including Varian and BrainLAB offices worldwide and partner facilities. Together with the post-sale support spectrum, Novalis academy gives your team the tools necessary to become more confident, strengthen existing skills, maximize Novalis Tx performance, and improve treatment outcomes. GLOBAL SUPPORT 24/7/365 Novalis Tx Support works to meet and exceed your needs throughout planning, installation and training phases of Novalis Tx integration, and beyond. Highly trained specialists provide customized support solutions, ensuring your clinical needs are addressed. Our proactive service offerings mean your Novalis Tx can perform at the highest level. Novalis Tx Support is an extension of your team, helping you realize clinical excellence.

Novalis Tx Marketing Customized marketing materials Strategic PR campaign B-roll video Grand opening event Consumer TV, print, radio and outdoor ad campaign Patient education brochure and video Referring physician ad and direct mail campaigns Referring physician event Patient advocacy group outreach Website content, images and animation Link to Novalis Tx website One-on-one customized service Generate demand. Increase your competitive edge. Offering treatment with Novalis Tx positions your facility as a leading provider of advanced technology demonstrating your commitment to clinical excellence. Novalis Tx Marketing works closely with you to develop a customized marketing plan targeting referring physicians, patients and consumers, to generate demand and increase your competitive edge. From tailored marketing materials and PR to a strategic direct marketing and advertising campaign, Novalis Tx Marketing is your roadmap to success. Simply Get On with Life Developed to inform patients and consumers of one of the most clinically advanced radiosurgery treatments available, the Novalis Tx consumer advertising campaign communicates your facility s commitment to, and track record of, treatment success. The campaign targets women decision-makers through depiction of three key relationships in their lives child, parent and significant other creating an emotional connection. The campaign conveys the key message that your loved one can be treated with Novalis Tx, return home the same day and get on with life. While the copy touches on traditional values, the visual language of the campaign is innovative and atypical of many health- or hospital-related ads, leading to greater visual impact and recall by target audiences.

Referring Physician Campaign

Consumer Print Campaign

Consumer Television Campaign

Consumer Billboard Campaign

Registered trademark of Varian Medical Systems, Inc. 2007, Registered trademark of BrainLAB AG in Germany and/or the US 2007