The Sunshine Sharing Hour With Steven Horne, RH(AHG) Tuesday, January 22, 2019 Rejuvenate Your Health with Nitric Oxide (NO) Nitric Oxide (NO) A simple molecule composed of one atom of nitrogen and one atom of oxygen Highly reactive Lasts a few seconds in the body In 1998, the Nobel Peace Prize for Physiology or Medicine was awarded to three researchers for their discoveries concerning nitric oxide as a signaling molecule to relax blood vessels and perform other tasks There is now a growing body of research showing the health benefits of adequate levels of NO 1
Endothelium or Endothelial Lining A layer of cells, just one cell thick, lining the arteries It produces nitric oxide to signal the artery muscles to relax and increase blood flow It plays a vital role in managing oxygen and nutrient distribution to every other cell of the body Endothelial Dysfunction Occurs when the endothelial lining is damaged and inflammation is present Endothelial mitochondria shift production of NO to energy production to compensate for the inflammatory process This is a an underlying factor in chronic and degenerative disease because tissue health cannot be maintained without adequate blood flow Nitroglycerine and NO The NO research explains why nitroglycerine works as a treatment for angina Nitroglycerine is transformed into nitrite, which is then converted to NO NO signals blood vessels to relax, lower blood pressure and reducing angina 2
NO and Blood Pressure Declining levels of NO may be the primary cause of essential hypertension (high blood pressure from unknown causes) Millions of people have essential hypertension It is a risk factor for strokes and heart attacks and causes kidney damage NO and Heart Disease Increasing NO levels can help prevent, slow or even reverse arterial plaque Increased NO also help prevent thrombosis, the formation of blood clots in the circulatory system that cause heart attacks, strokes and other problems. Erectile Dysfunction and NO Low levels of NO can also contribute to erectile dysfunction (ED) In fact, many drugs for ED (including Vigara and Cialis work by increasing NO levels Increased NO also helps female arousal 3
Interconnections Endothelial Dysfunction is linked to chronic inflammation and mitochondrial dysfunction The more inflammation present in the body, the lower the levels of NO produced by the endothelium Poor mitochondrial function also reduces NO production and increases free radical production NO and Inflammation Higher levels of inflammation = lower levels of NO Increased NO reduces inflammation Specifically, NO production may help relieve the chronic inflammation involved in asthma and arthritis. NO and Diabetes Increased NO levels have also been shown to increase cellular sensitivity to insulin, making it helpful for people with diabetes Increased NO also reduces diabetic complications such as blindness, foot and leg ulcers and kidney disease 4
Saying Yes to NO Have greater energy and feel better overall Clearer mind, better mood Reduce aging Help every part of the body to heal by aiding blood flow Decrease risk of degenerative diseases Exercise and NO Exercising is one of the best ways to enhances NO production Thirty to sixty minutes a day of moderate exercise greatly increases NO levels You can t sustain NO production without exercise Exercise helps prevent cardiovascular disease, reduces your risk of stroke, helps low blood pressure, balances blood fats and triglycerides, reduces inflammation, eases leg pain and helps you lose weight NO Aids Exercise The relationship between exercise and NO levels is reciprocal Exercise increases NO and NO enhances the ability to exercise Several studies have shown that increasing blood levels of nitrates, a precursor to NO production, results in greater efficiency in energy production and oxygen utilization in the muscles during exercise.. Increasing NO can help you exercise longer and with less fatigue Iif you are overweight, asthmatic, diabetic, already have heart disease or any other condition that makes exercise difficult, enhancing NO, you can jump start your exercise program 5
Avoid Sugar Sugar is a major factor in damaging the endothelium and high sugar consumption reduces NO production It is also pro-inflammatory and highly addictive If you have problems with blood sugar start limiting your intake of starchy Take a Blood Sugar Balancing Formula containing herbs like cinnamon, nopal, fenugreek and gymnema. Don t Smoke Smoking or inhaling airborne contaminants results in toxic substances being readily diffused straight into the blood stream These irritants set up a cascade of inflammatory reactions, beginning with the damage they do to the endothelial lining This lays the foundation for low levels of NO and cardiovascular disease Nitric Oxide Synthesis 6
L-Arginine Pathway Nitric Oxide Sythases are enzymes that convert l- arginine to nitric oxide in the presence of oxygen 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 2 citrulline +2 NO + 4 H2O + 3 NADP+ NOS Enzymes There are three forms of NOS enzymes Neuronal nitric oxide synthase (nnos or NOS I) which is found in the brain Aids blood flow in the brain Helps brain and nerve development Immune nitric oxide synthase (inos or NOS II) Signals immune defenses to help the body fight infection Also participates in the regulation of chronic inflammation Endothelial nitric oxide synthase (enos or NOS III) Dilates arteries and enhance blood flow. L-Arginine Supplements May Help Cardiovascular disease Angina Intermittent claudication (leg pain) Dementia Erectile dysfunction Immune function Athletic performance L-citrilline can help to recycle l-arginine and make it more effective 7
Nitrates and Nitrites The body makes NO is from nitrate (NO3) and nitrite (NO2) Nitrates are naturally found in many common vegetables, including lettuce, arugula, spinach, parsley, cabbage and turnips Nitrites produce NO without oxygen, which means they can help enhance NO when oxygen levels are low Beets are one of the best sources for nitrates They are also rich in: Folate a methyl donor Boron an important trace mineral Betaine another methyl donor Betalains antioxidants that give beets their color and aid liver detoxification Beets Nitrate- Nitrite- NO 8
Are Nitrates Safe? Nitrates have been used for thousands of years as a food preservative, a way of curing meats They work in several ways: They delay rancidity Control growth of certain harmful bacteria Develop the flavor and color of meat Preserves the flavor of smoke and spice Starting in the 1950s and through the 1970s concerns arose that nitrates were carcinogenic Many people continue to believe they are harmful because studies show increased cancer risk from eating processed meats Yes, Dietary Nitrates are Safe The correlation between processed meats and cancer is weak There are other compounds in processed meats that are more likely suspects for increasing cancer than nitrates Vegetables are rich in nitrates and research shows they lower cancer risk Nitrates and nitrites are in breast milk Saliva is high in nitrates because the body concentrates them in saliva Tibetans have 100 times higher levels of nitrates and nitrites in their blood but don t have a high cancer risk Other Nutrients for NO Production 9
Vitamin D3 An antioxidant that helps protect the endothelial lining from damage A cofactor in the activation of nitric oxide synthetase Low levels of vitamin D3 contribute to reduced levels of nitric oxide Experts suggest that upwards of 90% of the population may be deficient in vitamin D3 Magnesium Experts suggest that magnesium deficiency may affect as high as 70% It is essential in mitochondrial energy production and therefore in the synthesis of nitric oxide in endothelial cells Magnesium also aids muscle relaxation and can help reduce blood pressure and increase blood flow. Vitamin K2 A vitamin involved in blood clotting Assists vitamin D3 in maintaining the health of the endothelium Helps to mobilize calcium and keep it from depositing in the artery walls, thus preventing hardening of the arteries 10
Other Vitamins Vitamin C has a protective effect on the endothelial cells B vitamins, such as B1 (thiamine), B3 (niacin), B6 (pyridoxine) and B9 (folic acid) are absolutely critical to energy production within all mitochondria Niacin, taken as a single is helpful for opening up blood flow Omega-3 Fatty Acids Omega-3 Essential Fatty Acids reduce inflammatory reactions and cardiovascular risk They help to reduce blood triglycerides, decrease arterial inflammation and reduce the risk of thrombosis The omega-3 fatty acid DHA is also important in aiding mitochondrial function Why You Should Say Yes to More NO 11
Circulatory Benefits Vasodilation, improving blood flow, reducing blood pressure Triglyceride reduction Regulation of C-Reactive Protein (CRP), a proinflammatory compound Increases microvascular permeability, delivering oxygen and nutrients to cells Helps prevent, and possibly reverse, arterial plaque Brain and Nerve Benefits Helps muscles relax, helps modulate stress May help reduce depression Aids sleep Aids learning and memory, may inhibit dementia Respiratory Benefits Aids bronchial dilation, increasing oxygen flow into the lungs, may help ease asthma and improve lung function in COPD Helps with oxygen utilization, reduces altitude sickness, aids oxygen uptake during exercise 12
Structural Benefits Enhances pain medications to relieve arthritic pain, helps reduce arthritic pain directly Enhances exercise, reducing fatigue and increasing stamina There is also evidence that higher levels of NO can improve bone density Immune Benefits NO may help the body fight bacterial infections, including E. coli and Staphylococcus aureus (staph), including MRSA, the antibiotic resistant form of staph Other Benefits Increases sensitivity to insulin to manage blood sugar and reduces complications of diabetes May helps with bladder infections, urinary incontinence and improving kidney filtration in chronic kidney disease Aids eye health by enhancing circulation in the eyes, may help reduce glaucoma 13
Action Plan 1. Start by creating a program of regular moderate exercise 2. Avoid eating refined carbohydrates and take supplements to balance your blood sugar if high. 3. If you smoke, work on quitting. 4. Take a Dual Pathway Nitric Oxide Enhancing Supplement containing both l-arginine and beet root, along with l-citrilline, magnesium, and vitamins B1, B9, C and D. 5. Take an Omega-3 Essential Fatty Acid Supplement and/or a Krill Oil Supplement with vitamin K2 You should notice improvements in energy and overall health within a couple of weeks. Upcoming Education Upcoming Member Webinars New Webinar Series: Sunshine Product Training Tuesday February 12, 6:00 MT: Circulatory System Products Sunshine Sharing Hour (Tue, Feb 26) Purify Your GI Tract Other Classes and Events 2019 Healthy Perspective Webinar Series https://events.genndi.com/channel/healthyperspective 2019 Seeking Light and Truth Webinar series: https://events.genndi.com/channel/seekinglight Comments, Questions and Answers Type your questions about tonight s topic into the chat box Product presentation to follow this Q&A 14