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OUTCOMES DIVISION OF MEDICINE Department of Neurology

About Cleveland Clinic Florida Cleveland Clinic Florida s medical staff are dedicated physicians who have joined the clinic as salaried doctors to practice a different kind of medicine: Where commitment to patients, providing expert innovative care, and involvement in medical education are the goals. We work as a team, access the same electronic medical records, and cooperate to give our patients the best care. Providing excellent care to our patients is why we are here.

Department of Neurology TABLE OF CONTENTS: Chairman Introduction 4 Programs 5 Innovation 9 Excellence 10 Nestor Galvez-Jiminez, M.D Staff Maurice Hanson, M.D. Tarannum Khan, M.D. Adriana Rodriguez, M.D. Virgilio D. Salanga, M.D. Efrain Salgado, M.D.

Chair s Letter Established in 1986, the Department of Neurology at Cleveland Clinic Florida brings the tradition and care of the well-known Cleveland Clinic in Ohio. As the only Neurology service of its kind in Broward, Palm Beach and Collier counties, the department provides a multidisciplinary approach to the neurosciences, continuing neurological education and training of future neurologists and scientists. When education, training and state-of-the-art care meet, the results are phenomenal for patients and society. We are pleased to provide our referring physicians and patients alike with a quick overview of the services we provide and how we measure up to others. The Department of Neurology provides consultation in all areas of neurology but has exceeding expertise in stroke, neuromuscular diseases, headache medicine, movement disorders, epilepsy, and the dementias. Together with the Spine Institute, the Neurology Department actively cares, and diagnoses patients with degenerative spine disorders. With the Department of Neurosurgery innovative therapies such as Deep Brain Stimulation are offered. Brain tumors are addressed in a multidisciplinary fashion along with the Oncology, Radiotherapy and Neurosurgical departments. We believe reporting outcomes serves the needs of the referring physician, patients, donors and friends of the Clinic in making various decisions. We are pleased to share our data and hope you will find it useful and informative. Nestor Galvez-Jimenez, M.D., M.Sc., M.H.S.A., F.A.C.P. Chairman, Department of Neurology.

Programs Stroke Program According to the World Health Organization (WHO) stroke is the leading cause of neurological disability and death in the world. Many are due to embolic events from a diseased heart or arteries. During the period between January and December 2006, all such patients, treated at the Neurology Service of the Cleveland Clinic Hospital were discharged on preventative anticoagulation as required under the current guidelines of the American Heart and Stroke Association. When compared to hospitals around the country, we are above the expected standard nationwide in the treatment of acute ischemic stroke and use of blood clotting busting or thrombolytic agents. Percent of patients at risk for DVT who received DVT prophylaxis by the 2nd hospital day. Time Period: Q1 2006 - Q4 2006; Site: Cleveland Clinic Florida (13811) When compared to all Florida hospitals, we were above the norm in 2006 on prevention for blood clot formation in the legs. Treatment and prevention of abnormal cholesterol markers upon patients discharged continued to increase and were above the norm when compared to all Florida hospitals during 2006. Percent of ischemic stroke or TIA patients with atrial fibrillation who are discharged on anticoagulation therapy (warfarin/coumadin or heparin/heparinoids), unless an absolute or relative contraindication exists Time Period: Jan 2006 - Dec 2006; Site: Cleveland Clinic Florida (13811) Percent of ischemic stroke or TIA patients with LDL>100 mg/ dl OR on cholesterol reducer prior to admission who are discharged on cholesterol-reducing drugs. Time Period: Q1 2006 - Q4 2006; Site: Cleveland Clinic Florida (13811) Percent of acute ischemic stroke patients who arrive at the ED at CCFla within 120 minutes (2 hours) of onset of stroke symptoms who receive IV t-pa within 180 minutes (3 hours) of onset of stroke symptoms Time Period: Q1 2006 - Q4 2006; Site: Cleveland Clinic Florida (13811) For the calendar years 2006-, the stroke service treated or evaluated: o Stroke (infarcts)/transient ischemic attacks (TIA): 2,127. o Carotid stenosis: 230. o The stroke service performed above the national and state norms in all recognized areas of prevention and acute treatment of ischemic stroke.

Programs Neuromuscular Diseases The oldest of all programs within the department of neurology, the neuromuscular diseases program runs perhaps one of the busiest electro-diagnostic laboratories in Broward and Palm Beach counties. In a total of 2304 studies were performed of which 1466 were specifically requested for the diagnosis or evaluation of patients suffering with neuromuscular diseases. All electro-diagnosti cians are board certified or eligible in the field. The number of electro-diagnostic studies continues to trend upwards, reaching nearly 1466 in. (EDX: EMG/NCS, autonomic testing, pudendal nerve studies and SSEP (somatosensory evoked responses). In ; 1,141 EMG/NCS were performed, 37 autonomic studies, 192 pudendal nerve testing and 96 SSEP evaluations. A sample of the most common diagnosis seen at the neuromuscular program: neuromuscular junction disorders such as myasthenia gravis, Lambert Eaton myasthenic syndrome; motor neuron diseases such as ALS, primary lateral sclerosis, post polyo syndrome; peripheral neuropathies and myopathies such as diabetic, toxic, inflammatory and other metabolic neuropathies; genetic disorders such as Charcot Marie Tooth disease, Dejerine Sottas and other HSM neuropathies. Compressive neuropathies such as carpal tunnel syndrome; ulnar neuropathies; degenerative spine related conditions such as radiculopathies are commonly encountered in the laboratory. Neurodiagnostic Laboratory The neurodiagnostic laboratory provides comprehensive state-of-the-art neurodiagnostic evaluation for patients with a variety of neurological disorders, such as epilepsy, stroke, neuromuscular disorders, motor control, imbalance and vertigo, sensory complaints and multiple sclerosis. The studies performed at our laboratory include: Electroencephalography (EEG) Ambulatory EEG Visual Evoked Responses Somatosensory Evoked Responses Brainstem Evoked Responses Electrocochleography Transcranial Doppler Ultrasonography Autonomic Testing EMG/NCS (electromyography/nerve conduction studies) Pudendal EMG Botulinum toxin therapy Research studies/procedures Between 2003 and a total of 15,907 procedures have been performed at the laboratory making this one of the busiest laboratories of its type in Broward, Palm Beach and Collier counties. Many of these patients may have nerve and or muscle biopsies performed in cooperation with the neurosurgical or plastic surgery departments. Genetic testing is offered to those patients whose clinical history and examination support the need to perform such studies. Movement Disorders Program The Movement Disorders Program, established in 1996, is the only program of its type in Broward, Palm Beach and Collier Counties offering a multidisciplinary approach to the diagnosis and treatment of patients with all types of conditions affecting motor control. A total of 2533 consultations for the evaluation and diagnosis of patients with abnormal motor control were performed in. Most common conditions treated were:

Programs Parkinson s disease; Secondary forms of Parkinsonism such as PSP, OPCA, MSA; Mytochondrial cytopathies; Metabolic syndromes resulting in abnormal motor control such as Wilson s disease; Degenerative hereditary disorders such as Huntington disease. Cerebellar ataxias, Choreas, Tics, Tourrete syndrome, Restless Legs, Tremor Gait disorders and Falls and other associated conditions were continuously assessed at the program during 2006. Speech disturbances (dystonic/spastic) Over 1465 patients-injections have been administered over a 6-year period and the number of patients continues to grow. Neuromodulation and other surgical procedures (deep brain stimulation) in Movement Disorders. We performed our first Deep Brain Stimulation Surgery in 1998, then one of the few centers offering the procedure in the state of Florida. Since then this type of surgery has been performed in a very selected groups of patients suffering with Parkinson s disease, tremor and Dystonia. One of the largest dystonia clinic with botulinum toxin therapy and baclofen pumps in Broward and Palm Beach is housed at the Movement Disorders Program of Cleveland Clinic. Evaluation for both research studies on this condition, investigator initiated studies and patients undergoing deep brain stimulation for dystonia have all been performed at our center.

Programs Expert evaluation for programming of patient with deep brain stimulators is offered along with patients with baclofen pumps for a variety of conditions such as cerebral palsy, dystonia, primary lateral sclerosis, post stroke spasticity and others. Total patients undergoing care for DBS/ programming: 72 Total surgeries (DBS) in : 15 Bertrand procedure for medically intractable Cervical dystonia: 1 An active academic program, over 68 scientific publications, book chapters and books have been written by the movement disorders staff. A fellowship program for the training of neurologists wishing to become experts in the field have been in placed since 1999. * No activity reported for 2007 DBS surgeries over a three-year period. Epilepsy program The Epilepsy program within the Department of Neurology offers comprehensive diagnosis and treatment for patients with seizures and epilepsy. The epilepsy program actively collaborates with the renowned Epilepsy Center of the Cleveland Clinic in Cleveland, Ohio where patients requiring epilepsy surgery are referred. This allows Cleveland Clinic Florida Physicians and patients access to cutting edge medical and surgical therapies for those patients in most need for such treatments. Since 2001 a total of 420 patients have been evaluated at the epilepsy-monitoring unit (EMU) at the Cleveland Clinic Hospital. Over 250 EEGs studies are performed every year at Clinic outpatient services. Ambulatory EEG services are offered when required At the hospital in-patient services a total of 1,315 EEGs were performed over an eight-year period.

Innovation In education, research and patient care. Firsts: First report on the benefits of aspirin in combination with dypiridamole after 30 days in patients presenting with acute ischemic stroke. In 1987 among the first centers offering deep brain stimulation for patients with Parkinson s disease, tremor and dystonia. First observational and therapeutic studies on the relationship of cervical dystonia and chronic daily headaches. First report on the benefits of botulinum toxin therapy for the treatment of headaches associated with cervical dystonia. First depiction on the benefits of topiramate for the treatment of essential tremor First account on the benefits of zonizamide for the treatment of essential tremor First comparison study on the benefits of prami pexole vs. ropinirole for the treatment of restless legs syndrome First neurology residency training program north of Miami-Dade but south of Gainesville, Florida with full accreditation from the American Council of Graduate Medical Education. First in offering education in the subspecialties of Cerebrovascular diseases; Neuromuscular disorders and Electrodiagnostic Medicine; and Movement Disorders north of Miami-Dade but south of Gainesville, Florida. The only neurodiagnostic laboratory dedicated for the assessment of patients with colorectal and genitourinary systems disorders as it relates to the peripheral and central nervous system. The only autonomic nervous system laboratory in Broward and Palm Beach counties. Among the first reports on the use of electrodiagnostic studies in the diagnosis of severe constipation

Excellence We strive to provide the best care possible, one patient at a time. We ask our patients about their experience and satisfaction with the care received by our staff. Among 260 patients treated at our department, 80% reported very good to excellent care provided by the staff. In addition, over 90% will recommend our providers to others.