Regeneration Bone Grafting & Soft Tissue Management

Regeneration Bone Grafting & Soft Tissue Management

Human Histology OSTEON II 26.5 months

Regeneration Products information Table of contents Bone Graft Material OSTEON II OSTEON OSTEON II Collagen OSTEON Collagen 5 6 7 8 Membrane Collagen Graft Collagen Membrane HA Collagen Membrane 11 12 13 Products use guide 15

4 Regeneration Bone Grafting & Soft Tissue Management Bone Graft Material

Regeneration Bone Grafting & Soft Tissue Management 5 Application of OSTEON II Ridge augmentation Extraction site & osteotomy Cystic cavities Sinus lift Periodontal defect Composition of OSTEON II Osteoconductive biphasic calcium phosphate with higher β-tcp OSTEON II = HA 30% + β-tcp 70% Characteristics of OSTEON II Highly resorbable due to higher β-tcp content Easy manipulation Excellent wettability Osteoconductive synthetic bonegraft Pore size : 250μm Porosity : 70% Cell Adhesion Test In Vitro Dissolution Test Microsturcure 500 μm 100 μm X 1000 Animal Test 12-weeks follow up in rabbit calvaria model OSTEON OSTEON II

6 Regeneration Bone Grafting & Soft Tissue Management Application of OSTEON Ridge augmentation Extraction site Cystic cavities Sinus lift Periodontal defect Composition of OSTEON 100% Synthetic bone graft : HA scaffold coated with β-tcp OSTEON = HA 70% + β-tcp 30% Specification of OSTEON 100% synthetic bone graft Interconnected porous structure similar to that of human cancellous bone Osteoconductive material as a bone growth scaffold OSTEON Human bone Cell Adhesion Test Human ostelblast cell OSTEON X 1000 X 1000 X 5000 Osteoblast cell was well attached and spreaded on OSTEON surface. Human Histology OSTEON New bone OSTEON OSTEON New bone New bone 0.5mm 0.25mm 1.0mm 1.5mm 0.5mm 0.25mm 6.5 months after sinus graft surgery 10 months after sinus graft surgery 21 months after sinus graft surgery OSTEON area = 1.24mm 2 (17.1%) New bone area = 1.63mm 2 (22.7%) OSTEON area = 3.04mm 2 (35.5%) New bone area = 2.38mm 2 (27.7%) OSTEON area = 6.30mm 2 (40.4%) New bone area = 5.12mm 2 (33.0%)

Regeneration Bone Grafting & Soft Tissue Management 7 Application of OSTEON II Collagen Simple grafting (volume up) Ridge augmentation Extraction site & osteotomy Cystic cavities Periodontal defect Characteristics of OSTEON II Collagen Bone void filler composed of synthetic bonegraft(osteon II) and natural type I collagen Moldable to various defect shape after being wet Easy handling, thus shortened operation time OSTEON II is highly resorbable due to higher β-tcp content (HA:β-TCP=30:70) Collagen is absorbed over several weeks after helping the initial shaping Microstructure In Vitro Dissolution Test of OSTEON II Animal Test Animals : New zealand white rabbit Implantation area: Femur Period: 6 weeks CT image

8 Regeneration Bone Grafting & Soft Tissue Management Application of OSTEON Collagen Ridge augmentation Extraction site & osteotomy Cystic cavities Sinus lift Periodontal defect Description OSTEONTM Collagen is a bone void filler composed of synthetic bone(osteon ), and natural type I collagen. Characteristics of OSTEON Collagen Collagen coating enables easy handling, and thus shortened operation time Moldable to various defect shape after being wet Collagen dissolves after helping the initial handling Excellent new bone formation and space maintenance Hemostatic function Highly pure type I collagen derived from bovine tendon Cell Adhesion Test Osteoblasts spread well on the OSTEON Collagen X 1000 X 5000 Animal Test Animals: new zealand white rabbit Implantation area: calvaria Period: 8 weeks Staining method: goldner trichrome

Regeneration Bone Grafting & Soft Tissue Management 9 Bone Material Products Type REF Size (mm) Volume (cc) DT7G 0205 010 DT7G 0205 025 DT7G 0205 050 DT7G 0205 100 DT7G 0205 200 0.2~0.5 0.1 0.25 0.5 1.0 2.0 OSTEON II Vial type DT7G 0510 010 DT7G 0510 025 DT7G 0510 050 DT7G 0510 100 DT7G 0510 200 0.5~1.0 0.1 0.25 0.5 1.0 2.0 DT7G 1020 010 DT7G 1020 025 DT7G 1020 050 DT7G 1020 100 DT7G 1020 200 1.0~2.0 0.1 0.25 0.5 1.0 2.0 Sinus (Syringe type) DT7G 0510 050 SS DT7G 1020 050 SS 0.5~1.0 1.0~2.0 0.5 Lifting (Syringe type) DT7G 0205 025 LS DT7G 0510 025 LS 0.2~0.5 0.5~1.0 0.25 Type REF Size (mm) Volume (cc) GBG 0305 025 GBG 0305 050 GBG 0305 100 GBG 0305 200 0.3~0.5 0.25 0.5 1.0 2.0 OSTEON Vial type GBG0 510 025 GBG0 510 050 GBG0 510 100 GBG0 510 200 0.5~1.0 0.25 0.5 1.0 2.0 GBG 1020 025 GBG 1020 050 GBG 1020 100 GBG 1020 200 1.0~2.0 0.25 0.5 1.0 2.0 Sinus (Syringe type) GBG 0510 SS GBG 1020 SS 0.5~1.0 1.0~2.0 0.5 Lifting (Syringe type) GBG 0305 LS GBG 0510 LS 0.3~0.5 0.5~1.0 0.25 OSTEON TM II Collagen OSTEON TM Collagen Type REF Size (mm) Particle size (mm) OTCC 0605 M Ø6.0 x 5.0 Cylinder 0.2~1.0 OTCC 0610 M Ø6.0 x 10.0 Type REF Size (mm) Particle size (mm) GOCC 0605 Ø6.0 x 5.0 Cylinder 0.5~1.0 GOCC 0610 Ø6.0 x 10.0

10 Regeneration Bone Grafting & Soft Tissue Management Membrane Material

Regeneration Bone Grafting & Soft Tissue Management 11 Application of Collagen Graft Soft tissue regeneration Hemostasis & Stabilization blood clot Protect and heal the wound site Characteristics of Collagen Graft Provide stabilized environment of soft tissue regeneration Double structure with porous and dense layer Tensile Strength Degradation property 1.5 100 1.0 Competitor 80 60 0.5 40 20 Competitor 0 Dry Wet 0 0 2 4 6 8 Time (hr) Competitor MPa Dry Wet Dry Wet 0.62 0.15 1.22 0.08 Microstructure Porous Layer x50 x200 Dense Layer x50 x200

12 Regeneration Bone Grafting & Soft Tissue Management Application of Collagen Membrane Biodegradable barrier membrane for guided bone / tissue regeneration Periodontal / infrabony defects Ridge augmentation Extraction sites (implant preparation / placement) Sinus lift Characteristics of Collagen Membrane Easy manipulation Dual-sided usage Barrier function lasting for 6 months Highly pure type I collagen derived from bovine tendon Thinner membrane(300 μm ) with multiple layers for easy manipulation and sufficient mechanical strength in surgery. Resorption period of 6 months to provide enough time for stabilizing graft materials and supporting bone growth. Multiple-layered structure enables more effective bone regeneration by sparing enough space for hard tissue formation and facilitates proliferation of osteoblast. Microstructure X 1000 X 5000 Animal test In Vitro Dissolution Test Rabbit calvaria model, 6 weeks 12weeks

Regeneration Bone Grafting & Soft Tissue Management 13 Application of HA Collagen Membrane Resorbable collagen membrane containing hydroxyapatite (HA) particles Periodontal / Infrabony defects Ridge augmentation Extraction sites Guided Bone Regeneration(GBR) procedure Sinus lift Characteristics of HA Collagen Membrane Resorbable barrier membrane Osteoconductive due to HA particles New bone formation through the membrane Highly pure type I collagen derived from bovine tendon Cell adhesion test Microstructure X 1000 X 7000 MC3T3 / E1 (Osteoblast cell X500) Animal test Rabbit calvaria model, 12 weeks

14 Regeneration Bone Grafting & Soft Tissue Management Membrane Material Collagen graft Type Square type REF Size (mm) Thickness (mm) CSD 1010 CSD 1020 CSD 1520 CSD 2030 10 X 10 10 X 20 15 X 20 20 X 30 3 Round type CSD 10 C Ø10 3 Collagen Membrane Type Square type REF GCM 1020 GCM 1520 GCM 2030 Size (mm) 10 X 20 15 X 20 20 X 30 Thickness (mm) 0.3 HA Collagen Membrane Type Square type REF GCHM 1020 GCHM 1520 GCHM 2030 Size (mm) 10 X 20 15 X 20 20 X 30 Thickness (mm) 0.3

Regeneration Bone Grafting & Soft Tissue Management 15 The All-round Products in Bone Related Cases Dentium s regeneration products are covering all round of the bone related clinical cases. Each of OSTEON TM series has characteristic and own materials it made for. Dentium s regeneration products are applicable to a variety of surgical parts. Series of regeneration products will take big role in the treatment area of GBR and considering expanding to practitioners and patients. β-tcp content Convenient Operability Extraction socket with intact socket Soft tissue regeneration Sinus elevation Extraction socket with defective socket Peri-implantitis Major bone augmentation Minor bone augmentation Periodontal defects

16 Regeneration Bone Grafting & Soft Tissue Management Regeneration Bone Grafting & Soft Tissue Management

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Specifications are subject to change without prior notice. Some products to be launched in the market after necessary approvals are also listed in this catalog. CAT-B0401(REV.21, 1512) HEAD OFFICE 6F, 29, Teheran-ro 87-gil, Gangnam-gu, Seoul, 135-879 Korea Tel +82-2-555-3750 Fax +82-2-501-9560 MANUFACTURER 1F, Gyeonggi R&DB Center / 226, 2F, GSBC, 105 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-270 Korea 1F, 31, Deogyeong-daero 1499beon-gil, Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-400 Korea T +82-31-888-5100 F +82-31-888-5105 HOMEPAGE www.dentium.co.kr / www.genoss.co.kr