Organized by: Division of Hepatology and Gene Therapy

Organized by: Division of Hepatology and Gene Therapy

WELCOME MESSAGE Pamplona, June 2004 Dear colleagues, Welcome to Frontiers 2004! This new edition of Frontiers is an especial one since it coincides with the inauguration of the new Center for Applied Medical Research (CIMA) of the University of Navarra. This new center will represent a considerable impulse for different areas of biomedical research in our University including liver pathophysiology and therapy of liver diseases. Science nowdays, more than ever, will benefit for personal interchange of views, ideas, expertise and experience. And CIMA will offer an appropriate framework for interdisciplinar studies, cross fertilization of minds and inter-institutional collaborative studies. This year we will hear of advances in pathogenesis and therapy of liver diseases. Excellent lecturers and chairmen from Europe and America constitute the best guarantee for the scientific success of Frontiers 2004. We hope that this Symposium will not only enlarge our knowledge of liver science and liver medicine but also reinforce friendship among colleagues and stimulate collaboration between groups in the hepatology field. An extraordinary post-meeting event will take place this year: the lecture in Memoria of Prof. Ortiz de Landazuri which will be given by an exceptional immunologist, Prof. Rolf M. Zinkernagel, Nobel laurate 1996. This is a golden end for a Symposium which also commemorates the 50 th anniversary of the Medical School of the University of Navarra. J. Prieto Prof. of Medicine University of Navarra

SCIENTIFIC PROGRAMME SCIENTIFIC PROGRAMME FRIDAY - OCTOBER 08, 2004 08.25 h. Welcome and Overview Dr. Jesús Prieto (Pamplona - Spain). Dr. Francisco Errasti ( Pamplona - Spain ) Session I: Molecular Hepatology and Pathophysiology (1) Chairmen: Dr. F. Vilardell (Barcelona - Spain) Dr. R. Esteban (Barcelona - Spain) 08.35-09.00 New avenues in hepatitis C research Dr. Bruce Malcolm (USA) 09.00-09.30 Hepatocellular transporters and human liver disease. Dr. Ronald Oude-Elferink ( The Netherlands ) 09.30-10.00 Haemochromatosis : an update. Dr. Antonello Pietrangelo (Modena - Italy ) 10.00-10.30 Progress in the pathogenesis of cholangiopathies. Dr. Mario Strazzabosco (Bergamo - Italy) 10.30-11.00 Extrahepatic sites of HCV replication: clinical implications. Dr. Jorge Rakela (Arizona - USA) 11.00-11.30 h. Coffee Break Session II: Molecular Hepatology and Pathophysiology (2) Chairmen: Dr. M. Carneiro (Lisboa - Portugal) Dr. Jose Maria Mato (Spain) 11.30-12.00 Fibrogenesis: new developments Dr. David Brenner (New York - USA) 12.00-12.30 Disruption of intestinal barrier and spontaneous bacterial peritonitis in cirrhotic patients. Dr. Ramón Planas (Barcelona - Spain)

SCIENTIFIC PROGRAMME FRIDAY - OCTOBER 08, 2004 12.30-13.00 The molecular basis of hepatocarcinogenesis. Dr. Snorri Thorgeirsson (Maryland - USA) 13.00-13.30 Renal dysfunction in advanced liver disease Dr. Vicente Arroyo (Barcelona - Spain) 13.30-15.30 h. Lunch Session III: Pathogenesis and therapy Chairmen: Dr. Bioulac-Sage (Bordeaux-France) Dr. Jaume Bosch (Barcelona -Spain) 15.30-16.00 Progress in therapy of chronic HCV infection. Dr. Laurent Castera (Bordeaux - France) 16.00-16.30 Hepatic Encephalopathy: recent advances Dr. Andres Blei (Chicago - USA) 16.30-16.45 h. Coffee Break Session IV: Gene therapy in Liver Diseases Chairmen: Dr. Stefan Kochanek (Ulm-Germany) Dr. C. Balabaud (Bordeaux-France) 16.45-17.15 Therapeutic potential of lentiviral vectors Dr. Luigi Naldini (Turin - Italy) 17.15-17.45 Gene therapy of liver cancer : present and future Dr. Bruno Sangro (Pamplona - Spain) State of the Art Lecture 17.50 Presentation : Dr. Jaime Guardia (Barcelona - Spain) 18.00-18.30 Research in Liver diseases at the beginning of the 3 rd millenium Dr. Juan Rodes (Barcelona - Spain) Concluding Remarks Dr. Jesus Prieto (Pamplona - Spain) 19.00 Lecture in memoria Prof. Ortiz de Landazuri ( In the building of Medical Library ) " On natural and artificial vaccinations " Prof. Rolf M. Zinkernagel Nobel Laureate of Medicine in 1996

GENERAL INFORMATION Venue: Salón de Actos de la Facultad de Ciencias (Hexagono) University of Navarra Pamplona - Spain Organized by: Clínica Universitaria and Medical School University of Navarra Pamplona - Spain Date: October 08, 2004 Congress language: English Registration fee: Free of charge Registration fee includes: Course documentation Access to scientific sessions Coffee breaks Certificate of attendance Special Dinner Major Sponsor: With the special collaboration of : GILEAD SCIENCE FUJISAWA FERRING TERAKLIN Organizing Secretariat : C/ Sor Angela de la Cruz, 8 28020 Madrid (Spain) Phone: +34 91 555 11 19 Fax: +34 91 555 35 81 E-mail: congresos@viajesoasis.com Web: www.viajesoasis.com

REGISTRATION AND ACCOMMODATION FORM Please, send this bulletin together with the corresponding payment to the Organizing Secretariat: VIAJES OASIS C/ Sor Angela de la Cruz, 8 28020 Madrid - Spain Tel: +34 91 555 11 19 - Fax: +34 91 555 35 81 E-mail: congresos@viajesoasis.com Surname:... Name:... Address:... City/Country:... Zip Code:... Phone:... Fax:... E-mail:... Institution:... HOTEL ACCOMMODATION NH Iruña Park Hotel **** (or similar category) Single room: 126 Euros Double room: 140 Euros Prices include buffet breakfast and V.A.T. Arrival Date:... Departure Date:... Form of payment: by bank draft payable to VIAJES OASIS S.A. or Credit Card (VISA/AMEX) Number Expiry date

FACULTY ARROYO, Vicente ( Barcelona ) BALABAUD, Charles ( Bordeaux, France ) BIOULAC - SAGE Paulette ( Bordeaux, France ) BLEI, Andrés ( Chigago, USA ) BOSCH, Jaume ( Barcelona ) BRENNER, David ( New York, USA ) CARNEIRO DE MOURA, Miguel ( Lisboa ) CASTERA, Laurent ( Bordeaux, France ) ESTEBAN, Rafael ( Barcelona ) GUARDIA, Jaime ( Barcelona ) KOCHANEK, Stefan ( Ulm, Germany ) MALCOLM, Bruce (USA) MATO, Jose Mª ( Spain ) NALDINI, Luigi ( Turin, Italy ) OUDE-ELFERINK, Ronald ( Amsterdam ) PIETRANGELO, Antonello ( Modena, Italy ) PLANAS, Ramón ( Barcelona ) PRIETO, Jesus ( Pamplona ) RAKELA, Jorge ( Arizona, USA ) RODES, Juan ( Barcelona ) SANGRO, Bruno ( Pamplona ) STRAZZABOSCO, Mario ( Bergamo, Italy ) THORGEIRSSON, Snorri ( Maryland ) VILLARDEL, Francisco ( Barcelona )

ORGANIZING SECRETARIAT C/ Sor Angela de la Cruz, 8 28020 Madrid (Spain) Telephone: +34-91 555 11 19 Fax: +34-91 555 35 81 Web site: www.viajesoasis.com E-mail: congresos@viajesoasis.com