University of Groningen Serotonin, cortisol, and stress-related psychopathology Tanke, Marit Aline Christine IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2009 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Tanke, M. A. C. (2009). Serotonin, cortisol, and stress-related psychopathology: from bench to bed s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
Serotonin, Cortisol & Stress-Related Psychopathology from bench to bed MaritTanke
Studies presented in this thesis were performed at the University Center Psychiatry, the Department of Medical Oncology and the department of Pathology and Laboratory Medicin, Umiversity Medical Center Groningen., Groningen the Netherlands, and the department of Psychosocial Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands. Publication of this thesis was financially supported by Graduate School of Behavioral and Cognitive Neurosciences, the University of Groningen, University Medical Center Groningen, Astra Zeneca BV, Eli Lilly Nederland BV, Servier Nederland Farma BV, Wyeth Pharmaceuticals BV. Cover by: Gerard Tanke Printed by: PrintPartners Ipskamp BV, Enschede, The Netherlands ISBN printed version: 978-90-367-3715-9 ISBN electronic version: 978-90-367-3716-6 Marit Tanke, 2008
RIJKSUNIVERSITEITGRONINGEN Serotonin, cortisol and stress-related psychopathology from bench to bed Proefschrift terverkrijgingvanhetdoctoraatinde MedischeWetenschappen aanderijksuniversiteitgroningen opgezagvande RectorMagnificus,dr.F.Zwarts, inhetopenbaarteverdedigenop woensdag18maart2009 om16.15uur door MaritAlineChristineTanke geborenop12mei1981 teenschede
Promotores: Prof.dr.J.Korf Prof.dr.P.deJonge Prof.dr.I.P.Kema Copromotor: dr.f.j.bosker Beoordelingscommissie: Prof.dr.G.C.G.Dehue Prof.dr.P.G.M.Luiten Prof.dr.B.W.J.H.Penninx
Contents Chapter1 Introduction/7 Chapter2 Lowtryptophandietincreasesstresssensitivity,butdoesnotaffect habituationinrats/19 Chapter3 Oppositeeffectsofa5HT1Aanda5HT2Creceptoragonistonthe acousticstartleresponseinratsonalowtryptophandiet,preliminary results/37 Chapter4 1.LongtermadministrationofanSSRIdepletesserotoninstoresinthe ratbrain/49 2.Increasedstartlereflexandserotoninmetabolismfollowing citalopramdiscontinuationinrats/55 Chapter5 Sustainedreleaseofcorticosteroneinratsaffectsreactivity,butdoes notaffecthabituationtoimmobilizationandacousticstimuli/65 Chapter6 Lowplasmatryptophanincarcinoidpatientsisassociatedwith increasedurinarycortisolexcretion/79 Chapter7 Socialinteraction,ratherthandistressorsomaticcomplaints,is associatedwithlowtryptophanandconsequentlylowbrainserotonin, duringinterferonalphatreatment/87 Chapter8 Psychopathologyincarcinoidpatientsisaffectedbytheinteractionof 5HTTLPRandplasmatryptophanlevels/97 Chapter9 Lymphocyteglucocorticoidreceptorresistanceanddepressive symptomseverity:apreliminaryreport/109 Chapter10 Summaryandgeneraldiscussion/119 References/127 Nederlandsesamenvatting/151 Dankwoord/161 Publicationlist/167 CurriculumVitae/168