University of Groningen Left ventricular diastolic function and cardiac disease Muntinga, Harm Jans IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2000 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Muntinga, H. J. (2000). Left ventricular diastolic function and cardiac disease: a radionuclide angiography study Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 19-01-2019
Left ventricular diastolic function and cardiac diasease A radionuclide angiography study
Rijksuniversiteit Groningen LEFT VENTRICULAR DIASTOLIC FUNCTION AND CARDIAC DISEASE A radionuclide angiography study PROEFSCHRIFT ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, Dr. D.F.J. Bosscher in het openbaar te verdedigen op woensdag 10 mei 2000 om 14.15 uur door HARM JANS MUNTINGA geboren op 17 mei 1965 te Groningen
Promotores: Co-promotor: Referent: Beoordelingscommissie: Prof. Dr. H.J.G.M. Crijns Prof. Dr. E.E. van der Wall Dr. P.K. Blanksma Dr. M.G. Niemeyer Prof. Dr. W.H. Van Gilst Prof. Dr. F.L. Meijler Prof. Dr. T. Van der Werf
Paranimfen: G.T. Bult-Muntinga A.E. Tuinenburg The work described in this thesis has been carried out at the departments of Cardiology and Nuclear Medicine of the Martini Hospital and the department of Cardiology of the University Hospital in Groningen.
Copyright 2000 by H.J. Muntinga. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronically, mechanically, by photocopying, recording, or otherwise, without the written permission of the author. ISBN 90-367-1178-9 Druk: Drukkerij van Denderen B.V., Groningen, NL Design and Layout: H.J. Muntinga Front cover showing a heart threatened with thistles by stupidity, with thorns by genius and with blossoms by love (reproduced from Alfons Mucha) on a background of RNA derived pictures of the heart showing one cardiac cycle. Financial support for the publication and realisation of this thesis by WCN (Working Group on Cardiovascular Research The Netherlands), Martini Ziekenhuis, Stichting Edu Cardio Groningen, Roche Nederland B.V., Sanofi~Synthelabo, Byk nederland B.V., Merck Sharp & Dohme B.V., AstraZeneca, Servier Nederland B.V., and Novartis Pharma B.V. is gratefully acknowledged.
Ter nagedachtenis aan mijn vader Aan mijn moeder Aan Monique, Sanne en Jacco
Contents Chapter 1 General introduction and aim of the thesis 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Diastolic function: physiology, methods and clinical significance. Background of the present thesis Normal values and reproducibility of left ventricular filling parameters by radionuclide angiography International Journal of Cardiac Imaging 1997;13:165-171 Editorial comment by M. Pillay International Journal of Cardiac Imaging 1997;13:173 Quantification of the atrial contribution to diastolic filling during radionuclide angiography Nuclear Medicine Communications 1997;18:642-647 Circadian rhythm in left ventricular relaxation of patients with congestive heart failure: diagnostic and therapeutic implications European Journal of Internal Medicine 1998;9:91-97 Effect of mibefradil on left ventricular diastolic function in patients with congestive heart failure Journal of Cardiovascular Pharmacology 1996;27:652-656 Left ventricular beat-to-beat performance in atrial fibrillation: dependence on contractility, preload and afterload Heart 1999;82:575-580 Letter to the editor by Professor Mark I.M. Noble and response Accepted for publication in Heart Left ventricular diastolic function after cardioversion of chronic atrial fibrillation Submitted Summary and conclusions Samenvatting en conclusies 5 30 39 41 50 60 69 83 87 10 0