University of Groningen Role of multidrug resistance-associated protein 1 in airway epithelium van der Deen, Margaretha IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van der Deen, M. (2007). Role of multidrug resistance-associated protein 1 in airway epithelium s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
Role of multidrug resistance-associated protein 1 in airway epithelium Margaretha van der Deen
The studies described in this thesis were financially supported by: Nederlands Astma Fonds (NAF97.35) Stichting Astma Bestrijding (SAB) Spinoza premium (NWO) The printing of this thesis was financially supported by: Rijksuniversiteit Groningen, Faculteit der Medische Wetenschappen Stichting werkgroep Interne Oncologie Nederlands Astma Fonds (NAF) Stichting Astma Bestrijding (SAB) AstraZeneca BV Graduate School GUIDE Thesis University of Groningen ISBN: 978-90-367-3039-6 Cover: Jeroen en Margaretha Guikema-van der Deen This thesis was printed by: PrintPartners Ipskamp B.V., Enschede, the Netherlands
RIJKSUNIVERSITEIT GRONINGEN Role of Multidrug Resistance-associated Protein 1 in Airway Epithelium Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 16 mei 2007 om 13.15 uur door Margaretha van der Deen geboren op 21 december 1972 te Hoogeveen
Promotores : Prof. dr. E.G.E. de Vries : Prof. dr. D.S. Postma : Prof. dr. W. Timens Copromotor : Dr. H. Timmer-Bosscha Beoordelingscommissie : Prof. dr. H.A.M Kerstjens : Prof. dr. R.J. Scheper : Prof. dr. M. Müller ISBN: 978-90-367-3040-2
Paranimfen: Henriëtte Post Janine Nuver There must be a relationship between all events Isabel Allende
Contents Chapter one Chapter two Chapter three Chapter four Chapter five Chapter six Chapter seven Chapter eight Chapter nine General introduction ATP-binding cassette (ABC) transporters in normal and pathological lung Respiratory Research, 2005; 6: 59 Diminished expression of multidrug resistanceassociated protein 1 (MRP1) in bronchial epithelium of COPD patients Virchows Archiv, 2006; 449: 682-688 Multidrug resistance-associated protein 1 in transplant and native bronchus in emphysema Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells Effect of COPD treatments on MRP1 mediated transport in bronchial epithelial cells Indomethacin induces apoptosis in an MRP1- dependent mechanism in MRP1 overexpressing, doxorubicin resistant SCLC cells Summary and future perpectives 9 17 53 67 75 91 107 121 137 Nederlandse samenvatting (Dutch summary) Dankwoord (Acknowledgments) 149 163