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International Neuromodulation Society 14th World Congress May 25-30, 2019, Preliminary Scientific Program* *Subject to change Pre-Conference Days May 25-26 May 25 - Pre-Conference: Noninvasive Brain Stimulation Click here for more information May 26 - Pre-Conference: Innovations in Neuromodulation. Disruptive Innovation: The Driving Force of Progress in Neuromodulation. Not included in the main event CME/CPD credit. Click here for more information. May 26-2019 NSANZ and INS Cadaver Workshop Click here for more information.

18:00-19:30 Sunday, May 26 2019 INS Opening Reception in the Exhibition Area 08:00-11:30 Opening Plenary Session 08:00-08:30 08:30-08:50 08:50-09:15 Monday, May 27 2019 Welcome and INS Leadership Message Novel Model of Brain Function Non-Surgical Deep Brain Stimulation 09:15-09:40 09:40-10:00 A Critical Analysis of Clinical Trials in Neuromodulation Closed-loop Spinal Cord Stimulation: Evoke Study Results 10:00-10:25 Break, Posters & Exhibits

Blinded Randomized Controlled Trial On Waveforms: The SURF Study 10:30-10:50 10:50-11:10 11:10-11:30 Multifidis Peripheral Nerve Stimulation Randomized Controlled Trial Anatomic vs. Targeted Lead Placement in Dorsal Column Stimulation: Results from a Prospective, Multi-Center, International, Single-Blinded Randomized Controlled Trial 11:30-12:20 Oral Poster Presentations Five Best Abstracts 11:30-11:40 1 11:40-11:50 2 11:50-12:00 3 12:00-12:10 4 12:10-12:20 5 12:30-14:30 Lunch, Posters & Exhibits Lunch Symposium (12.30-13:30)

Monday, May 27 2019 14:30-16:00 Improving Delivery of Neuromodulation 14:30-14:45 14:45-15:00 What is on the Horizon for Stimulation Patterning? Adding Objective Markers to Spinal Cord Stimulation Assessments Brain Neuromodulation Adaptive Stimulation in Deep Brain Stimulation Rhythms of the Brain Cardiovascular Neuromodulation What s Hot and What s not in Neuromodulation for Cardiac Diseases Basic Mechanisms of Vagal Modulation in Cardiac Diseases 15:00-15:15 15:15-15:30 15:30-15:45 Common Research Questions for SCS Research and How to Answer them Systematic Troubleshooting Intrathecal Delivery Systems: Emerging Tools Animal models of Paresthesia based- SCS and Sub-perception-SCS and clinical correlates Deep Brain Stimulation for Obesity Deep Brain Stimulation for Eating Disorders Deep Brain Stimulation for Addiction Basic Mechanisms of Spinal Cord Stimulation in Cardiac Diseases Anesthetic Considerations and Perioperative Management of SCS Clinical Outcomes of Neuromodulation for Angina 15:45-16:00 Discussion Discussion Discussion 16:00-16:30 Break, Posters & Exhibits

16:30-18:20 Monday, May 27 2019 Oral Poster Presentations 16:30-16:40 1 1 1 16:40-16:50 2 2 2 16:50-17:00 3 3 3 17:00-17:10 4 4 4 17:10-17:20 5 5 5 17:20-17:30 6 6 6 17:30-17:40 7 7 7 17:40-17:50 8 8 8 17:50-18:00 9 9 9 18:00-18:10 10 10 10 18:10-18:20 11 11 11 18:20-18:30 18:30-19:30 Short Break to Change Halls Young Neuromodulators' Reception

07:30-08:30 Breakfast Symposium 08:30-11:30 08:30-09:00 Plenary Session Neuromodulation Centers of Excellence Tuesday, May 28 2019 Allied Health Workshop on Neuromodulation Nurses, psychologists, physiotherapists 09:00-09:30 09:30-10:00 Progress in Brain Machine Interface Intraspinal Stimulation 10:00-10:25 Break, Posters & Exhibits 10:30-11:00 11:00-11:30 11:50-12:30 Neuromodulation for Visceral Pain Perspectives of Gastrointestinal Neuromodulation INS General Assembly of Members 12:30-14:30 Lunch, Posters & Exhibits Lunch Symposium (12:30-13:30)

Tuesday, May 28 2019 14:30-16:00 14:30-14:45 14:45-15:00 15:00-15:15 Basal or Non-Basal: Intrathecal Regimens for 2019 Tailoring Intrathecal Therapy to Match Your Patient's Needs Deep Brain Stimulation for Pain Stimulation of the Accumbens Region New Developments in Neuromodulation for Gastrointestinal Conditions New Methods and Applications Using the Science Underlying GI Neuromodulation: Low and High Resolution Mapping Challenges for Bolus only Therapy Cingulate Stimulation Electroceuticals for Mapping and Modulating Gut Activity: Towards Closed-loop Management of Gastroparesis Functional Improvement with Continuous Intrathecal Morphine Infusion in Chronic Non-Cancer pain Deep Brain Stimulation for Pain: Pro and Con Neuromodulation for Inflammatory Bowel Disease 15:15-15:30 15:30-15:45 Are Side Effects Associated with the Long-Term Usage of Intrathecal Drug Delivery so Frightful? The Economics of Cancer Related Pain: New Data to Support use of Targeted Drug Delivery for Both Short Term and Long Term Survivors Motor Cortex Stimulation for Pain and Related Conditions: Pro and Con New Applications for Mid Gut Stimulation for Metabolic Disorders: GI Stimulation for Diabetes and Obesity New Neuromodulation Therapies for Colonic Disorders 15:45-16:00 Novel Intrathecal Analgesics in Cancer Pain Discussion Discussion 16:00-16:30 Break, Posters & Exhibits

16:30-18:20 16:30-16:40 1 1 1 16:40-16:50 2 2 2 16:50-17:00 3 3 3 17:00-17:10 4 4 4 17:10-17:20 5 5 5 17:20-17:30 6 6 6 17:30-17:40 7 7 7 17:40-17:50 8 8 8 17:50-18:00 9 9 9 18:00-18:10 10 10 10 18:10-18:20 11 11 11 18:20-18:30 18:30-19:30 Tuesday, May 28 2019 Oral Poster Presentations Short Break to Change Halls International Women in Neuromodulation Reception

07:30-08:30 Breakfast Symposium 08:30-11:30 08:30-09:00 Plenary Session Sources of Bias in Randomized Controlled Trials of Neuromodulation and Advice on Mitigation Wednesday, May 29 2019 09:00-09:30 Current Concepts and Evidence in Neuromodulation for Headache 09:30-10:00 Prospective 12 Month Outcomes of Multi-Center Trials of 10 khz Spinal Cord Stimulation in the Treatment of Arm and Neck Pain (Australian & North American Centers) 10:00-10:25 Break, Posters & Exhibits 11:00-11:30 Recommendations of the Joint INS, IoN and IMMPACT Group Giant of Neuromodulation Award 11:30-12:20 12:30-14:30 Lunch, Posters & Exhibits Lunch Symposium (12:30-13:30)

Wednesday, May 29 2019 14:30-16:00 Neuromodulation for Pain: Sensing and Feedback What Should a Neuromodulation Device Measure? 14:30-14:45 14:45-15:00 Using Wearable Sensors and Implantable Neuromodulation Devices to Measure Function Neuromodulation for Neuro- Rehabilitation and Stroke Neuromodulation for Neurorehabilitation of Motor Disorders for Stroke and Spinal Cord Injury: An Overview Noninvasive Brain Stimulation for Stroke Under the Hood: Mechanisms of Action Aspects Beyond the Gate Burst and High Frequency Stimulation: Mechanisms of Action 15:00-15:15 Physiological Sensing in Deep Brain Stimulation Invasive Brain Stimulation for Stroke Role of ECAPS in Understanding Spinal Cord Stimulation Action 15:15-15:30 Feedback Stimulation of the Dorsal Columns Spinal Cord Stimulation for Spinal Cord Injury Microglial Modulation in Neural Stimulation 15:30-15:45 Long-term Outcomes from the Noninvasive Brain Stimulation for Avalon Study: A prospective Spinal Cord Injury Multicenter Study Evaluating Closed- Loop SCS in the Treatment of Chronic Back and Leg Pain Deep Brain Stimulation Mechanism of Action Review 15:45-16:00 Discussion Discussion Discussion 16:00-16:30 Break, Posters & Exhibits

16:30-18:20 Wednesday, May 29 2019 Oral Poster Presentations 16:30-16:40 1 1 1 16:40-16:50 2 2 2 16:50-17:00 3 3 3 17:00-17:10 4 4 4 17:10-17:20 5 5 5 17:20-17:30 6 6 6 17:30-17:40 7 7 7 17:40-17:50 8 8 8 17:50-18:00 9 9 9 18:00-18:10 10 10 10 18:10-18:20 11 11 11

Mandarin English, English Mandarin (Simultaneous Translation) 08:00-10:00 Pyrmont Theatre Meeting Room C4.4 Meeting Room C4.5 Meeting Room C2.6 New Targets, New Diseases Thursday, May 30 2019 Advances in Neuromodulation for Refractory Epilepsy Neuromodulation for Pelvic Organ Motility Disorders Special Session Neuromodulation in Asia 08:00-08:15 The Case for Cordotomy vs. Neuromodulation for Cancer Pain Neurobiology of Neuromodulation of Epilepsy Sacral Neuromodulation for the Treatment of Urinary Bladder Dysfunction: Mechanism of Action 08:15-08:30 Sphenopalatine Ganglion Stimulation Therapy: Procedural Challenges Neuro-Anatomy Relevant to Neuromodulation for Epilepsy Indications and Clinical Results of Pelvic Floor Neuromodulation 08:30-08:45 08:45-09:00 Treatment of Refractory Chronic Migraine: Results from a Feasibility Study The Approaches in Peripheral Nerve Stimulation of Brachial Plexus Responsive Vagal Nerve Stimulation Responsive Deep Brain Stimulation Standardization in Sacral Neuromodulation Technique Complications Associated with Sacral Neuromodulation 09:00-09:15 Mechanisms of Action of Dorsal Root Ganglion Stimulation for Pain Hippocampal Deep Brain Stimulation Sacral Neuromodulation for Pelvic Pain and Pelvic Organ Dysfunction 09:15-09:30 State of the Art Review of Dorsal Root Ganglion Stimulation Targeting in Deep Brain Stimulation for Epilepsy Updates in Percutaneous Tibial Neuromodulation 09:30-09:45 New Indications for Dorsal Root Ganglion Stimulation Experience of Deep Brain Stimulation for Epilepsy Pudendal Stimulation 09:45-10:00 Discussion Discussion Discussion Discussion 10:00-10:25 Break, Posters & Exhibits

Thursday, May 30 2019 Pyrmont Theatre Meeting Room C4.4 Meeting Room C4.5 Meeting Room C2.3 10:30-11:20 Oral Poster Presentations Special Session Neuromodulation in Asia 10:30-10:40 1 1 1 10:40-10: 50 2 2 2 10:50-11:00 3 3 3 11:00-11:10 4 4 4 11:10-11:20 5 5 5 Discussion 11:20-11:30 Short Break to Change Halls 11:30-13:20 11:30-12:00 Closing Plenary Session: The Future? Why Optimizing your Vagal Nerve will Become Routine Big Data Use in Neuromodulation 12:00-12:30 12:30-13:00 Transcranial Stimulation for a Smarter You Cyber Security in Neuromodulation 13:00-13:30 13:30 Congress Adjourns