Chemicals in Surgical Periodontal Therapy von Alexandrina L. Dumitrescu 1. Auflage Chemicals in Surgical Periodontal Therapy Dumitrescu schnell und portofrei erhältlich bei beck-shop.de DIE FACHBUCHHANDLUNG Thematische Gliederung: Zahnmedizin Springer 2011 Verlag C.H. Beck im Internet: www.beck.de ISBN 978 3 642 18224 2
Contents 1 Guided Tissue Regeneration Barriers... 1 1.1 Biologic Basis of Guided Tissue Regeneration (GTR)... 1 1.2 Summary of Studies Evaluating the Efficacy of GTR in the Treatment of Infrabony Defects... 1 1.2.1 Histological Studies... 2 1.2.2 Clinical Studies... 2 1.3 Summary of Studies Evaluating the Efficacy of GTR in the Treatment of Furcation Lesions... 7 1.3.1 Histological Studies... 9 1.3.2 Clinical Studies... 9 1.4 Summary of Studies Evaluating the Efficacy of GTR in the Treatment of Gingival Recession... 14 1.4.1 Histological Studies... 14 1.4.2 Clinical Studies... 14 1.5 Adjunctive Use of Antibiotics in GTR Treatment... 22 1.6 Advantages and Disadvantages of the Use of GTR Treatment... 23 1.7 GTR Barriers for Periodontal Regeneration... 24 1.7.1 The Qualities of an Optimal GTR Barrier for Periodontal Regeneration... 24 1.7.2 Nonresorbable Membranes... 25 1.7.3 Bioresorbable Membranes... 31 1.7.4 New Trends in Guided Tissue Regeneration Barriers Development... 52 References... 58 2 Bone Grafts and Bone Graft Substitutes in Periodontal Therapy... 73 2.1 Autogenous Grafts... 73 2.1.1 Intraoral Autografts... 74 2.1.2 Extraoral Autografts... 75 2.2 Allografts... 77 2.2.1 Freeze-Dried Bone Allografts (FDBA)... 81 2.2.2 Demineralized Freeze-Dried Bone Allografts (DFDBA)... 81 2.3 Xenografts... 85 2.3.1 Anorganic Bovine-Derived Bone Xenograft (BDX)... 86 2.3.2 Anorganic Porcine-Derived Bone Xenograft... 90 2.3.3 Coralline Calcium Carbonate... 92 vii
viii Contents 2.4 Alloplasts (Alloplastic Synthetic Grafts)... 94 2.4.1 Polymethylmethacrylate and Polyhydroxylethylmethacrylate (PMMA-PHEMA) Polymers... 94 2.4.2 Demineralized Dentin Matrix (DDM)... 95 2.4.3 Hydroxylapatite (HA)... 95 2.4.4 Calcium Phosphate Cement (CPC)... 103 2.4.5 b-tricalcium Phosphate (TCP)... 107 2.4.6 Calcium Sulfate... 114 2.4.7 Bioactive Glasses (BG)... 116 2.4.8 Oily CaOH 2 Suspension... 121 2.4.9 Porous Titanium Granules... 123 2.5 Composite Grafts... 123 2.6 Factors Impacting Treatment Outcome... 125 2.6.1 Criteria for Evaluation of Graft Success for Periodontal Regeneration... 125 2.6.2 Factors Influencing Graft Success... 126 References... 127 3 Enamel Matrix Derivative for Periodontal Tissue Regeneration... 145 3.1 EMD Formulation... 145 3.2 Clinical Safety of EMD... 146 3.3 Biomimicry... 146 3.4 Mechanisms Underlying the Supportive Effects of EMD... 146 3.4.1 In Vitro and In Vivo Experiments... 146 3.4.2 Animal Experiments... 147 3.4.3 Human Histological Studies... 147 3.5 Summary of Studies Evaluating the Efficacy of Emdogain in the Treatment of Infrabony Pockets (Vertical Bone Loss)... 171 3.5.1 Nonsurgical Periodontal Therapy... 171 3.5.2 Surgical Periodontal Therapy... 171 3.5.3 Hard Tissue Response After Emdogain Treatment of Intrabony Pockets... 189 3.5.4 Factors That Determine Emdogain Outcomes in the Treatment of Infrabony Defects... 192 3.6 Summary of Studies Evaluating the Efficacy of Emdogain in the Treatment of Furcation Lesions... 195 3.7 Summary of Studies Evaluating the Efficacy of Emdogain in the Treatment of supra-alveolar-type defects... 197 3.8 Summary of Studies Evaluating the Efficacy of EMD in the Treatment of Gingival Recession... 198 3.9 Clinical Studies Evaluating the Effect of EMD on Early Wound Healing... 208 3.10 Clinical Studies Evaluating the Effect of EMD on Periodontal Healing of Replanted Teeth... 208 3.11 Advantages of the Use of Emdogain Gel... 209 References... 209
Contents ix 4 Chemical Root Surface Modifiers in the Treatment of Periodontal Disease... 217 4.1 Citric Acid... 217 4.2 Tetracycline HCl... 220 4.3 EDTA... 221 References... 224 5 The Use of Biologic Mediators for Periodontal Regeneration... 227 5.1 Growth Factor Delivery for Oral and Periodontal Tissue Engineering... 227 5.1.1 Biomaterials for Growth Factor Delivery... 230 5.1.2 Configurations of Growth Factor Delivery Carriers... 234 5.2 The Use of Platelet-Rich Plasma (PRP) for Periodontal Regeneration... 235 5.2.1 Preparation of Platelet-Rich Plasma... 238 5.2.2 Handling and Application of Platelet-Rich Plasma... 239 5.2.3 Safety... 241 5.2.4 Human Studies on Platelet-Rich Plasma... 241 5.2.5 Potential Advantages and Limitations of PRP... 243 5.3 Human Platelet Derived Growth Factor-BB (PDGF)... 243 5.4 Peptide P-15... 246 5.5 Insulin-Like Growth Factors... 249 5.6 Fibroblast Growth Factor-2... 250 5.7 Transforming Growth Factor-b... 254 5.8 Bone Morphogenetic Proteins... 262 5.9 Growth Factor Combinations... 292 References... 293 Index... 305
http://www.springer.com/978-3-642-18224-2