PROSTAGLANDIN ABSTRACTS A Guide to the Literature Volume 1: m06-m70

PROSTAGLANDIN ABSTRACTS A Guide to the Literature Volume 1: m06-m70

PROSTAGLANDIN ABSTRACTS A Guide to the Literature Volume 1: 1906-1970 Richard M. Sparks Population Information Program Department of Medical and Public Affairs Science Communication Division The George Washington University Medical Center Washington, D. C. IFIIPLENUM NEW YORK-WASHINGTON-LONDON

Sparks, Richard M Prostaglandin abstracts. Library of Congress Cataloging in Publication Data Abstracts prepared by authors of articles or members of the Science Communication Division staff, George Washington University Medical Center. CONTENTS: v. 1. 1906-1970. 1. Prostaglandin-Abstracts. 2. Prostaglandin-Bibliography. I. George Washington University, Washington, D.C. Medical Center. Science Communication Division. II. Title. [DNLM: 1. Prostaglandins-Abstracts. ZQU90 S736p) QPS01.P6SS65 574.1'9247 73-217S0 ISBN 978-1-4684-6155-8 ISBN 978-1-4684-6155-8 ISBN 978-1-4684-6153-4 (ebook) DOI 10.1007/978-1-4684-6153-4 The preparation of this volume was supported by the United States Agency for International Development through contracts with the Worcester Foundation for Experimental Biology and the George Washington University. Softcover reprint of the hardcover 15t edition 1970 IFI/Plenum Data Corporation is a subsidiary of Plenum Publishing Corporation 227 West 17th Street, New York, N. Y. 10011 United Kingdom edition published by Plenum Press, London A Division of Plenum Publishing Company, Ltd. Davis House (4th Floor), 8 Scrubs Lane, Harlesden, London, NWIO 6SE, England All rights reserved No part of this publication may be reproduced in any form without written permission from the publisher

CONTENTS Ack nowledgements Foreword.... Explanatory Note. VII ix xi Abstracts... Subject Index Author Index Journal Index Appendix.. I. Directory of Prostaglandins Research II. Secondary Sources of Information in Prostaglandin Research 441 451 469 475 477 483 v

ACKNOWLEDGEMENTS The editor wishes to thank the many organizations and individuals who have contributed to the success of this project, especially the Upjohn Company of Kalamazoo, Michigan, Drs. J. R. Weeks, J. C. Babcock, G. E. Underwood and the late Dr. L. E. Rhuland; the Worcester Foundation for Experimental Biology of Shrewsbury, Massachusetts, Ms. Julia Lobotsky and Ms. Gerry Seward; and staff personnel who prepared and edited much of the material in this volume, James R. Heath III and Nancy E. Stillerman. VII

FOREWORD This volume contains abstracts of most of the significant scientific literature dealing with prostaglandins published between 1906~when certain biologically active tissue extracts first stimulated the speculation of researchers~and 1970~when the use of prostaglandins for experimental control of fertility and induction of labor had been reported from six countries. Of the more than 4000 articles now identified which were published between 1906 and 1972, approximately half had appeared in print by the end of 1970. A second volume will cover the material printed in 1971 and 1972 with special emphasis on the role of prostaglandins in reproductive physiology. The reasons for publishing this considerable compilation of data are twofold. On the one hand, prosta glandins, a family of fatty acid derivatives first identified in human semen, have been shown to have great and varied effects on all aspects of human physiology due to activity at the cellular level as mediators in the formation of cyclic AMP. The study of prostaglandins is considered today one of the most promising fields in the biological sciences. Secondly, as is now recognized, prostaglandins play an important role in reproduction, influencing both male and female fertility. It is hoped that this volume will make the results of early prostaglandin research available to investigators throughout the world, including especially those in developing coun tries who may not have easy access to such material. At a time of increasing world concern over rapid population growth and excess or unwanted pregnancies, researchers throughout the world are seeking new or improved methods for the voluntary control of fertility. Prostaglandins hold great promise in this field, and have already been used clinically in 15 countries to induce menstruation, or terminate first and second trimester pregnancies. So far, side effects such as nausea, vomiting, and diarrhea have limited the usefulness of the presently available prosta glandin compounds and/or delivery systems under most circumstances. But the search for better means of birth control continues. It seems likely that prostaglandins, which are the natural mediators of reproductive functions, or some new prostaglandin analogs administered in the form of a medicated vaginal tampon, intrauterine injection, or possibly in combination with other drugs will eventually play an important role in fertility control. At the time of this writing, the United States Food and Drug Administration is expected to license prostaglandin F 2 c< for sale In the United States within the next two months for use in the termination of second trimester pregnancy. The Upjohn Company of Kalamazoo, Michigan hopes to begin marketing immediately. The Office of Population, United States Agency for International Development, has supported applied research in prostaglandins with special reference to use in developing countries. USAID seeks specifically to identify or improve present birth control technologies so that they can be effectively and con veniently used by men and women in developing countries. This volume is designed above all to assist researchers in the developed and developing countries who share th is objective. We hope that th is increase in the availability of scientific information about prostaglandins will hasten the day when what the United Nations has called "the basic right of every person to determine the number and spacing of their offspring" is not only a basic human right but also a genuine reality throughout the world. November 1, 1973 R. T. Ravenholt, M.D., M.P.H. Director J. Joseph Speidel, M.D., M.P.H. Chief, Research Division Office of Population United States Agency for I nternational Development ix

EXPLANATORY NOTE Every citation in this bibliography was verified with a copy on file in the library of the Population I nformation Program of the George Washington University Medical Center. If a satisfactory author's or prepared abstract accompanied the article, it was used and credit was given. Otherwise, abstracts were prepared by members of the Science Communication Division staff. Those individuals, identified by their initials at the end of the abstracts are: Frank D. Bradley, Mary Ellen Hashmall, James R. Health III, John W. Johnston, Irvin C. Mohler, R. Allen Pierce, Paul Richmond, CharlesW. Shilling, Richard M. Sparks, Nancy E. Stillerman, George Wolfhard, Michael Towers, and Arthur R. Turner. If a prepared abstract was used, but the format was changed without alteration of the content regarding prostaglandins, it has been identified as "Author modified." If no informative abstract accompanied the article, and none could be prepared, as, for instance, when a translation could not be readily obtained, the citation has been included without an abstract. Since this bibliography is a guide to the literature, citations and abstracts have been prepared for all the types of literature-journal articles, reviews, books, book chapters, newspaper articles, abstracts, symposia-in which prostaglandins have been discussed. In the preparation of abstracts, however, primary consideration has been given to the research significance of the article, that is to the amount of new information contained in it. For example, most editorials and reviews are not abstracted in detail because the scientific information upon which they were based is not new or fully provided in the article. Furthermore, the original research is also included in this bibliography and can be readily identified through the subject and author indexes. Citations are grouped chronologically and alphabetically by the surname of the senior author. Editorials, notes, and materials with no author indicated are listed under Anonymous, alphabetically by title: XI