University of Groningen Apoptosis and colorectal cancer. Studies on pathogenesis and potential therapeutic targets Koornstra, Jan IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2006 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Koornstra, J. J. (2006). Apoptosis and colorectal cancer. Studies on pathogenesis and potential therapeutic targets s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
Apoptosis and colorectal cancer studies on pathogenesis and potential therapeutic targets
The studies presented in this thesis were supported by the Dutch Cancer Society, grant RUG 1998-1660 (Chapters 4, 5, 6 and 8), grant RUG 2000-2286 (Chapters 2, 3, 4, 6 and 8), a personal fellowship (Chapter 2) and by the Dutch Digestive Disease Foundation, grant WS 2001-31 (Chapters 3, 4, 5, 6 and 8). The printing of this thesis was supported by the Dutch Digestive Disease Foundation, AstraZeneca, AltanaPharma, Janssen-Cilag, Roche, Schering-Plough and Tramedico. CIP GEGEVENS KONINKLIJKE BIBLIOTHEEK DEN HAAG Koornstra, Jan Jacob Apoptosis and colorectal cancer studies on pathogenesis and potential therapeutic targets Proefschrift Groningen. ISBN: 90-367-2400-7 Copyright 2006, Jan Jacob Koornstra All rights reserved. No part of this publication may be reproduced, or transmitted in any form or by any means, without permission of the author. Schilderij cover: Jentsje Popma, verkaveld landschap, regio Oldambt Layout: Helga de Graaf, Groningen Printed by: Print Partners Ipskamp Enschede
RIJKSUNIVERSITEIT GRONINGEN Apoptosis and colorectal cancer studies on pathogenesis and potential therapeutic targets Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 11 januari 2006 om 16.15 uur door Jan Jacob Koornstra geboren op 25 juli 1969 te Alkmaar
Promotores: Copromotor: Prof. dr. J.H. Kleibeuker Prof. dr. E.G.E. de Vries Prof. dr. H. Hollema Dr. S. de Jong Beoordelingscommissie: Prof. dr. P.L.M. Jansen Prof. dr. G.J.A. Offerhaus Prof. dr. T. Wiggers
Paranimfen: Drs. Bart W. Schot Drs. Sjoerd Hovenga
voor mijn vader en mijn moeder
CONTENTS Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Introduction and outline of the thesis Changes in apoptosis during the development of colorectal cancer: a systematic review of the literature. Crit Rev Oncol Hematol 2003;45:37-53 Assessment of apoptosis by M30 immunoreactivity and the correlation with morphological criteria in normal colorectal mucosa, adenomas and carcinomas. Histopathology 2004;44:9-17 Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. J Pathol 2003;200:327-335 Expression of TRAIL receptors DR4 and DR5 in sporadic and hereditary colorectal tumours: potential targets for apoptosis induction. Eur J Cancer 2005;41:1195-1202 Prognostic significance of TRAIL, DR4 and DR5 expression in adjuvant treated stage III colon cancer patients. submitted Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas. Lancet 2003;362:230-232 Sulindac inhibits β-catenin expression in normalappearing colon of hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis patients. Cancer Epidemiol Biomarkers Prev 2005;14:1608-1612 Summary, conclusions and future perspectives Samenvatting, conclusies en toekomstperspectieven 11 17 47 61 77 91 105 115 129 141 List of publications Curriculum vitae Dankwoord Appendix 153 157 159 165