Influenza Surveillance Report Saint Louis County Department of Public Health Week Ending 01/20/2019 Week 3

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35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 **53 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 19 2 21 22 23 24 25 26 27 28 29 3 31 32 33 34 Percent of Total Visits Saint Louis County Department of Public Health Week Ending 1/2/219 Week 3 Influenza Surveillance The Saint Louis County Department of Public Health (DPH) conducts influenza surveillance using three methods passive surveillance, active surveillance, and syndromic surveillance. Each surveillance method contributes unique information, allowing DPH to gain a fuller picture of influenza activity in Saint Louis County. Although influenza illness occurs yearround, DPH s seasonal influenza reporting begins in week 4 of one year (e.g., 218) and continues through week 2 of the following year (e.g., 219) in order to capture data throughout a typical flu season. For additional information on the three types of influenza surveillance, please see the notes at the end of the report. Syndromic Surveillance for Influenza-Like-Illness (ILI) As determined by ESSENCE, ILI accounted for.42% to 1.69% of daily visits to Saint Louis County hospital emergency departments (EDs) during the week ending 1/2/219. The number of visits to local hospital EDs for ILI ranged from 5 to 26 per day during the week ending 1/2/219. 5 ILI as Weekly Percent of Total Emergency Department (ED) Visits Saint Louis County Hospital EDs 218-219 compared to previous 4 seasons 4.5 4 3.5 3 *High 2.5 2 1.5 1.5 CDC Week of Visit 14-15 15-16 16-17 17-18 18-19 *High: Average (mean) weekly ILI percent of visits from previous four seasons plus three (3) standard deviations. **For previous seasons with a week 53, the week 53 data point for these seasons is an average of week 52 and week 1.. ILI as a weekly percentage of all visits in Saint Louis County hospital EDs was 1.2%, compared to 3.86% in 218 and 1.44% in 217, for week 3.

Active Influenza Surveillance Saint Louis County Department of Public Health, Week Ending 1/2/219 Surveillance sites reported 155 cases of influenza A and one case of influenza B for the week ending 1/2/219. Influenza A accounted for 99.4% (vs..6% for influenza B) of total influenza cases for the week ending 1/2/219. For the week ending 1/13/219, influenza A accounted for 98.2% of total influenza cases. Overall for the 218-219 influenza season, influenza A has accounted for 96.8% of total influenza cases. Influenza by Report Week and Type Saint Louis County Residents Only For Cases Reported between 9/24/218 and 1/2/219 Week Ending Type A Type B Unk Type Total 9/3/218 1 1 2 1/7/218 5 1 6 1/14/218 2 2 1/21/218 4 1 5 1/28/218 11 1 12 11/4/218 11 2 13 11/11/218 5 2 7 11/18/218 11 1 12 11/25/218 17 1 18 12/2/218 7 2 9 12/9/218 19 1 2 12/16/218 68 2 7 12/23/218 8 3 83 12/3/218 182 4 186 1/6/219 168 2 17 1/13/219 164 3 167 1/2/219 155 1 156 Total 98 3 938 Influenza by Age and Type Saint Louis County Residents Only For Cases Reported between 9/24/218 and 1/2/219 Age Group Type A Type B Unk Type Total n (% of total) n (% of total) n (% of total) n (%) to <2 89 (9) 1 () () 9 (1) 2 to 4 158 (17) 1 () () 159 (17) 5 to 14 197 (21) 3 () () 2 (21) 15 to 24 83 (9) 2 () () 85 (9) 25 to 49 193 (21) 11 (1) () 24 (22) 5 to 64 18 (12) 5 (1) () 113 (12) 65+ 8 (9) 7 (1) () 87 (9) Total 98 (97) 3 (3) () 938 (1) Page 2 of 6

Number of cases Number of cases Saint Louis County Department of Public Health, Week Ending 1/2/219 Influenza A Cases by CDC Report Week, 218-219 Compared to the Previous Four Seasons 14 12 Influenza A by Report Week Saint Louis County, MO 218-219 compared to previous 4 seasons 14-15: n = 2782 15-16: n = 1932 16-17: n = 3485 17-18: n = 6879 18-19 YTD: n = 98 1 8 6 4 2 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 5253* 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 19 2 CDC Report week 14-15 15-16 16-17 17-18 18-19 *For previous seasons with a week 53, the week 53 data point for these seasons is an average of week 52 and week 1. Influenza B Cases by CDC Report Week, 218-219 Compared to the Previous Four Seasons 5 45 4 Influenza B by Report Week Saint Louis County, MO 218-219 compared to previous 4 seasons 14-15: n = 1117 15-16: n = 355 16-17: n = 2338 17-18: n = 3274 18-19 YTD: n = 3 35 3 25 2 15 1 5 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 5253* 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 19 2 CDC Report week 14-15 15-16 16-17 17-18 18-19 *For previous seasons with a week 53, the week 53 data point for these seasons is an average of week 52 and week 1. Page 3 of 6

Number of cases Number of cases Influenza A Cases by Age Saint Louis County Department of Public Health, Week Ending 1/2/219 6 Influenza A Cases by Age 218-219 Season through 1/2/219, Saint Louis County, MO n = 98 Median = 18 yrs 5 4 3 2 1 4 8 12 16 2 24 28 32 36 4 44 48 52 56 6 64 68 72 76 8 84 88 92 96 1 14 Age (in years) Influenza B Cases by Age 5 Influenza B Cases by Age 218-219 Season through 1/2/219, Saint Louis County, MO n = 3 Median = 43 years 4 3 2 1 4 8 12 16 2 24 28 32 36 4 44 48 52 56 6 64 68 72 76 8 84 88 92 96 1 14 Age (in years) Page 4 of 6

Passive Influenza Surveillance Saint Louis County Department of Public Health, Week Ending 1/2/219 Two-hundred twenty-two total cases of influenza A and eight cases of influenza B were reported to DPH during the week ending 1/2/219. Influenza A accounted for 96.5% of total flu cases reported to DPH (vs. 3.5% for influenza B) for the week ending 1/2/219. For the week ending 1/13/219, influenza A accounted for 96.6% of total reported influenza cases. Overall for the 218-219 influenza season, influenza A has accounted for 91.4% of total reported influenza cases. Influenza by Report Week and Type Saint Louis County Residents Only For Cases Reported between 9/24/218 and 1/2/219 Week Ending Type A Type B Unk Type Total 9/3/218 4 5 9 1/7/218 7 1 8 1/14/218 8 5 13 1/21/218 7 8 15 1/28/218 13 5 18 11/4/218 15 5 2 11/11/218 14 7 21 11/18/218 2 6 26 11/25/218 21 7 28 12/2/218 11 4 15 12/9/218 28 4 32 12/16/218 77 8 85 12/23/218 14 9 113 12/3/218 226 12 238 1/6/219 229 13 242 1/13/219 224 8 232 1/2/219 222 8 23 Total 123 115 1345 Page 5 of 6

Saint Louis County Department of Public Health, Week Ending 1/2/219 Saint Louis County Influenza Outbreaks: As of the week ending 1/2/219, there have been no outbreaks of influenza reported to DPH. Weekly Virus/Microbiology Update, St. Louis Children s Hospital*: http://slchlabtestguide.bjc.org/default.aspx?url=8534fcd8-8b87-4952-b174-288d38b943 *courtesy of Gregory Storch, MD, and the St. Louis Children s Hospital Clinical Laboratory For additional information on national influenza surveillance, please visit the Centers for Disease Control and Prevention website: https://www.cdc.gov/flu/weekly/ For additional information on statewide influenza surveillance, please visit the Missouri Department of Health and Senior Services website: http://health.mo.gov/living/healthcondiseases/communicable/influenza/reports.php Active, Passive, and Syndromic Influenza Surveillance Passive surveillance Influenza is a reportable condition in the state of Missouri; positive influenza tests are reported to DPH year-round. DPH conducts passive influenza surveillance by collecting and aggregating data on all positive influenza tests in Saint Louis County residents. Passive surveillance provides information on the true burden of influenza illness in Saint Louis County, but is limited by variations in testing and reporting practices. If diagnostic tests are not conducted on patients presenting to health care providers with influenza-like-illness, or if test results (e.g., of rapid influenza tests) are not reported to DPH, those persons will not be included in the passive surveillance data. Thus, passive surveillance is likely an underestimate of the true burden of influenza illness in Saint Louis County. Active surveillance DPH conducts active influenza surveillance through a network of sentinel providers. This network is geographically distributed throughout the county, comprised of a wide range of care providers, and designed to capture a representative sample of provider types. Although active influenza surveillance does not capture the true magnitude of disease burden, it allows for year-to-year comparisons of influenza data. DPH can then assess trends in influenza data, as well as the relative magnitude of disease burden with respect to previous influenza seasons. Further, DPH works closely with sentinel sites throughout the influenza season, making the active surveillance data less susceptible to bias arising from testing or reporting variation. Because of these advantages, active surveillance using a network of sentinel providers is the primary method of influenza surveillance utilized by DPH. Syndromic surveillance DPH uses the ESSENCE system to conduct syndromic surveillance for ILI at Saint Louis County hospital EDs. ESSENCE captures data on all ED visits in persons with chief complaints (rather than final diagnoses or positive laboratory tests) of ILI. ILI chief complaints are those which include the word influenza or those that the ESSENCE system parses to [fever and (cough or sore throat)]. The syndromic surveillance data presented above include all visits for ILI (regardless of county of residence) to the ten Saint Louis County hospital EDs that contribute data to the ESSENCE system. Data from private physicians, clinics, or urgent care centers are not included in ESSENCE. Syndromic surveillance contributes to our understanding of the burden of influenza experienced by the health care system, as well as demonstrating the relative impact over time of influenza with respect to other illnesses. Page 6 of 6