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World s most advanced PCR-CBD Made from 100% Organic Full-Spectrum Phytocannabinoid Rich (PCR) CBD oil from speciallybred, premium source cultivars that are blended for a superior therapeutic entourage effect. Extracted using subzero winterization and molecular distillation. Measured/metered 50mg dose tablet = consistency, discreet use and best value (no waste). Engineered with ONLY-of-its-kind dual-tier-release-delivery-system (matched to the innate capacity of CB1 and CB2 Receptors to take in CBD) for optimal bioavailability and absorption. Less-than-point-zero-three (<.03%) THC so non-psychoactive. EVERY Path of Purity ingredient contributes therapeutic or absorption value. PoP s mixture of Omega 3, 6 and 9 is in perfect balance to help reverse the dietary and other imbalances that can contribute to inflammation. EVERY ingredient choice is premium: e.g. use of stevia leaves for flavor and collateral therapeutic value. $.10 cents per mg so unparalleled value to end users. Practitioner ONLY Model rewards participants for time/effort in leading the way. Join with us now: http://www.pathofpurity.com/pop/register.php?invite=3798721

Why that matters? The Human Endocannabinoid System (ECS) is our body s most complex, comprehensive and advanced signalling and neurotransmitter network. Using EXTERNAL Cannabinoids (CBDs) boosts performance and efficiency of our ECS and raises baseline of INTERNAL ENDO-Cannabinoids (those our body makes on demand). Phytocannabinoid Rich (PCR) Extracts, which contain all 110+ Cannabinoids - and thereby contribute a sum of the whole is greater than the sum of the parts synergy in the form of an entourage effect, are proven to offer greatest therapeutic value to Endocannabinoid System performance Path of Purity has been created from the ground-up to be the best of the best.

Endocannabinoid System (ECS) Promotes and regulates homeostasis Manages and regulates: Mood, Cognition, Memory, Motor Control, Motor Coordination, Sleep, Appetite, Temperature, Reproduction, Bone Development. Pain Perception, Immune Response. Bridge between mind and body Helps us maintain a stable internal environment in the face of a changing external environment. A healthier ECS is a healthier US PERIOD! ECS performance is a foundation of wellness, fitness and athletic performance. Diminished ECS is a precursor to diminished health, reduced vitality and ultimately disease.

Endocannabinoid System (ECS) Most complex signalling and neurotransmitter system Two (2) specialized types of Receptors: CB1 receptors in brain, nervous system, connective tissues, gonads, glands, and organs, CB2 receptors in the immune system as well as the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs. Acts like the Conductor of an Orchestra ECS releases Endocannabinoids that act unlock CB1 or CB2 receptors causing them to adjust to (even) subtle changes in biochemical cues in fluids surrounding each cell. When unlocked by Endocannabinoids, CB1/CB2 receptors activate powerful physiologic processes to manage/regulate many of our body s most important functions. Different types of cells collaborate and do different tasks to achieve a common purpose.

CB1 & CB2 Receptors: VITAL sites!

Endocannabinoid System (ECS) BAND CONDUCTOR: uses baton to signal members to use different instruments and different movements toward common goal of producing best harmonized sound. ECS: makes Endocannabinoids on demand in order to signal different cell types to perform different actions toward common goal of producing our body s best harmonized outcome. Endocannabinoids simultaneously communicate with/coordinate the actions of different cell types - causing them to work collaboratively. Endocannabinoids only Neurotransmitter that can communicate backwards. Normally flow from presynaptic neurons to postsynaptic neurons. Going in opposite direction enables Endocannabinoids to deliver feedback to a presynaptic cell. This is CRUCIAL to homeostasis: if a neuron is firing messages too quickly, Endocannabinoids instruct it to slow down by traveling upstream and activating presynaptic CB1 receptors.

Example of ECS at work: injury These unique ECS capabilities are crucial to injury response: When we are injured our body's best outcome is to minimize pain and damage caused by the injury while facilitating full recovery as promptly as possible. ECS releases Endocannabinoids to facilitate this outcome by signaling 3 different cell types to take 3 different actions: 1. injured tissue told to reduce release of activators and sensitizers; 2. nerve cells are told to stabilize to prevent excessive firing, and 3. nearby immune cells are told to calm to prevent release of proinflammatory substances.

ECS Research Studies The Endocannabinoid System as an Emerging Target of Pharmacotherapy by Dr. Pal Pacher published in 2006. Among Dr. Pacher's conclusions was the following: In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. Modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few. (PAL PACHER, SANDOR BATKAI, and GEORGE KUNOS Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, Pharmacol Rev. 2006 September ; 58(3): 389-462)

ECS Research Studies cont d Dr. Pacher then went on to provide a template of the potential health challenges that improved ECS performance could positively affect, as follows: Energy Metabolism: Appetite Regulation, Peripheral Energy Metabolism, Obesity and Metabolic Abnormalities, Cachexia and Anorexia Pain and Inflammation Central Nervous System Disorders: Neurotoxicity and Neuro-trauma; Stroke; Multiple Sclerosis and Spinal Cord Injury; Movement Disorders (Basal Ganglia Disorders - Parkinson's Disease, Huntington's Disease, Tourette's Syndrome); Amyotrophic Lateral Sclerosis (ALS); Alzheimer's; Epilepsy; Mental Disorders (Schizophrenia, Anxiety and Depression); Insomnia; Nausea and Emesis (Vomiting); Drug addiction and Alcohol Disorders (Opiates, Nicotine, Cocaine, Alcohol, Psychostimulants) Cardiovascular and Respiratory Disorders: Hypertension; Circulatory Shock (Hemorrhagic, Cardiogenic, Endotoxic); Myocardial Reperfusion Injury; Atherosclerosis; Asthma Eye Disorders (Glaucoma and Retinopathy) Cancer Gastrointestinal and Liver: Inflammatory Bowel Syndrome; Acute and Chronic Liver Disease (Hepatitis and Liver Cirrhosis) Musculoskeletal Disorders: Arthritis; Osteoporosis Reproduction (PAL PACHER, Pharmacol Rev. 2006 September ; 58(3): 389-462); See the complete article, as well as an NIH update of the conditions template Dr. Pacher suggested at: www.popreplenishingpcr-cbd.com; Sections Two and Section Four.

Striking up the ECS Band Endocannabinoids are made INTERNALLY on demand. Nature has given us EXTERNAL source of Cannabinoids in form of 110+ compounds found in the Cannabis Sativa Plant: NOTE: if the Plant has less-than-point-three-percent (<.3%) Tetrahydrocannabinol (THC) content it is non-psychoactive and called Hemp. Research shows: Taking (external) Cannabinoids support/bolsters our (internal) Endocannabinoid System by signaling body to (both) manufacture more endocannabinoids and build more CB1 and CB2 receptors. Having more receptors increases our body s efficiency in using Cannabinoids and enhances baseline Endocannabinoid activity. The greatest therapeutic contributions result from Full-Spectrum Hemp Oil Extracts containing ALL 110+ Cannabinoids - because the compounds work synergistically in a sum of the whole is greater than the sum of the parts way.

Wide-ranging benefits of CBDs

Raising the CBD Bar from the ground-up

CB1 & CB2 Receptors: VITAL sites!

Urine test September 21, 2018 53 year-old male who has been ingesting one (1) Path of Purity tablet for 3+ months 09/21/2018 ingested eleven (11) Path of Purity Tablets Please see NEXT slide: Individual followed instructions of test instrument: Waited one hour from taking Path of Purity Emptied bladder Then tested proceeds of next urination THC test results shown in column to left Test negative

Urine test September 21, 2018 THC measurement in bottom left corner

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