LEVEL OF THE COURSE and ELIGIBILITY: PhD students, or other qualified candidates

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CALL FOR APPLICATION for Institut Pasteur International Network Course 2017 «Infectious diseases pathogenesis in Asia/Pacific» at the Institut Pasteur of Shanghai COURSE DATE: 4 th May 2017 20 th May 2017 LOCATION: Shanghai, CHINA TOPIC: The TAPPIN 2017 course will focus on infectious diseases caused by major pathogens including viruses, bacteria, parasites and fungi, relevant to the East Asia and Southeast Asia regions. The teaching will cover essential molecular mechanisms of pathogen life cycle and host responses, epidemiology of infections and functional genetics, novel technologies of pathogen diagnostics and discovery, and systems biology of pathogen infections. This 2-week course will consist of seminars in the morning and practical learning/workshop in the afternoon. The course encourages close interactions and dialogue between students and teaching staffs. Round-table discussions steered by professors will be devoted to review and discuss topics developed during the courses. Workshops will introduce students to the challenge imposed to public health systems by endemic and pandemic infectious disease outbreaks. Practical learning will be conducted to provide essential knowledge on cutting edge technologies and methodological approaches devoted to the study of infectious diseases. The panel of professors is composed by world-leader scientists from France (, French Academy of Sciences, College de France, INSERM), Germany (EMBL Heidelberg), China (IPS, Fudan University, Tsinghua University, Hong-Kong University), Senegal (Institut Pasteur Dakar) and Cambodia (Institut Pasteur of Cambodia). All traveling costs (air ticket, accommodation) of the accepted students will be funded. LEVEL OF THE COURSE and ELIGIBILITY: PhD students, or other qualified candidates LIMITED NUMBER OF STUDENTS: 24 REGISTRATION: Please complete and return the application form (see below), including two letters of recommendation, a personal statement, and a copy of passport face page to Caroline Wu (nwu@ips.ac.cn) and Emilie Carlot (emilie.carlot@ips.ac.cn). DEADLINE FOR APPLICATION: 15 th February 2017 For more information, please contact: Scientific matters: Fernando Arenzana: farenzan@ips.ac.cn China matters: Caroline Wu nwu@ips.ac.cn International matters: Emilie Carlot emilie.carlot@ips.ac.cn

About IPS-CAS:, Chinese Academy of Sciences (IPS-CAS) is an independent, nonprofit life sciences research institute dedicated to address public health issues in China, other Asian region, and the world. IPS creates synergies between the Institut Pasteur Networks and CAS institutions, leveraging all the assets of Shanghai as one of Asia s leading business and technology hubs. IPS scientists are engaged in a broad range of basic infectious disease research ranging from viral hepatitis, HIV, respiratory viral infections, emerging viral infections, oncogenic viruses, and other non-viral pathogens. Together with its academic and industry partners, IPS also has a strategic goal to develop prototype product in the field of pathogen diagnostics, vaccines and other forms of therapeutics. For more information: http://english.shanghaipasteur.cas.cn/ About IPIN: The Institut Pasteur International Network (IPIN), a consortium of 33 institutes around the world is linked by the same missions and values. The foundation of IPIN resides in the sustainability of its infrastructures, the involvement of its researchers and the strength of its human resources. The IPIN allows scientists to become involved in research at the heart of endemic areas, to share their knowledge and expertise, and to develop a research group within 4 years. For more information: http://www.pasteur.fr/en/international/institut-pasteur-international-network

1. Personal information APPLICATION FORM for Institut Pasteur International Network Course 2017 «Infectious diseases pathogenesis in Asia/Pacific» at the Institut Pasteur of Shanghai Present Position Surname Post-doc PhD student other (please specify): Given name Nationality Gender Female Male Postal Address Telephone Email 2. Professional Affiliation University/Institute/Organization Faculty/Department/Division Country Director/Supervisor Subject of Current Research Degree/Diploma/Certificate pursued Expected Date of Termination Language of Instruction

3. Academic qualifications: (most recent first) 1. Title of Degree Date Obtained: Major Subject Honors/Grade (if applicable) Institution (Country) Language of Instruction 2. Title of Degree Date Obtained: Major Subject Honors/Grade (if applicable) Institution (Country) Language of Instruction 3. Title of Degree Date Obtained: Major Subject Honors/Grade (if applicable) Institution (Country) Language of Instruction 4. Awards and honors (add if necessary) Type of Award Awarding Institution Date of Award

5. Research/professional experience (add if necessary) Institution Position Topic Mode Full-time Employment Period From To Part-time Month / Year Month / Year Full-time Part-time Month / Year Month / Year Full-time Part-time Month / Year Month / Year 6. General outline of current research project (max. 200 words) 7. What do you expect from this course? (max. 200 words)

8. List of publications 1. 2. 3. 4. 5. 9. Recommendation letters Applicants should arrange for 2 recommendation letters, including current supervisor. Please list below the names of the 2 referees. Name Position Organization E-mail Name Position Organization E-mail Please return the completed application form, including two letters of recommendation, a personal statement and a copy of passport face page to Caroline Wu (nwu@ips.ac.cn) and Emilie Carlot (emilie.carlot@ips.ac.cn). Deadline for application: 15 th February 2017 Date: Signature of applicant:

TENTATIVE PROGRAM Institut Pasteur International Network Course 2017 «Infectious diseases pathogenesis in Asia/Pacific» at the Institut Pasteur of Shanghai Thursday 4 th May: Overview of host/pathogen interactions 8:30 Homeostasis of immune responses 9:45 Innate responses 11:00 Coffee break 11:15 Adaptive responses (humoral and cell responses) 14:00 Acute and chronic responses, the damageable aspects of host response 15:15 Coffee break 15:30 Immunodeficiencies and susceptibility to pathogen infections Sebastian Amigorena Institut Curie, Paris French Academy of Sciences Guangxun Meng Brigitte Autran La Pitié Salpétrière Hospital, Paris Hong Tang Alain Fischer Necker Enfants Malades Hospital, French Academy of Sciences, Collège de France Friday 5 th May: Introduction to virology 8:30 Virus taxonomy and virus life cycle 9:45 Evolution and structure of viruses 11:00 Coffee break 11:15 Variability of RNA viruses 14:00 Introduction to pandemic and epidemic diseases - Zoonosis 15:15 Coffee break 15:30 WORKSHOP: Functional genetics of infectious diseases Noël Tordo Institut Pasteur Guinea Félix Rey, French Academy of Sciences Marco Vignuzzi Amadou Sall Institut Pasteur Dakar Anavaj Sakuntabhai University of Kyoto Monday 8 th May: Viral pathogenesis 8:30 Viruses and vectors Didier Fontenille Institut Pasteur Cambodia

9:45 Arboviruses (Bunyaviridae family) 11:00 Coffee break 11:15 Arboviruses (Flaviviridae & Togaviridae families) 14:00 WORKSHOP: Infectious diseases - Emergency preparedness and responses Pierre-Yves Lozach EMBL, Germany Dimitri Lavillette Jean-Claude Manuguerra Zhiming YUAN Wuhan Institute of Virology Tuesday 9 th May: Viral pathogenesis/malaria 8:30 Highly pathogenic hemorrhagic viruses 10:30 Coffee break 10:45 Rabies 14:00 WORKSHOP: Malaria 15:30 WORKSHOP: Malaria - Drug resistance Sylvain Baize Institut Pasteur Lyon, BSL4 Hervé Bourhy Lubin Jiang (IPS) Didier Ménard Institut Pasteur Cambodia Wednesday 10 th May: Viral pathogenesis 8:30 Orthomyxovirus, coronaviruses and other respiratory viruses 10:30 Coffee break 10:45 Enteroviruses 14:00 WORKSHOP: Oncogenic viruses Malik Peiris Hong Kong University Francis Delpeyroux Lan Ke Thursday 11 th May: Viral pathogenesis 8:30 Hepatotropic viruses 10:30 Coffe break 10:45 Hepatotropic viruses 14:00 WORKSHOP: Introduction to systems biology: from high-content screening technologies to computational biology Jin Zhong Yu WEI Marc Windisch, Institut Pasteur Korea Hao Pei

Friday 12 th May: Viral pathogenesis 8:30 HIV infection, AIDS pathogenesis 10:30 Coffee break 10:45 HIV infection, AIDS pathogenesis 14:00-17:00 WORKSHOP: Prophylaxis & treatment of viral infections Linqi ZHANG University of Edinburgh Lisa Chakrabarti Xia /Huang Zhong Monday 15 th May: Bacteria, parasite 8:30 Tuberculosis/Resistances 9:45 Tuberculosis/Resistances 11:00 Coffee break 11:15 Leptospirosis 14:00- PRACTICAL LEARNING: Starting with cell culture adherent/non 17:00 adherent cells Brigitte Gicquel Gao Qian Fudan University, Shanghai Gerald Spaeth Qibin Leng Tuesday 16 th May: Fungus, viral vectors 8:30 Fungal infections 10:30 Coffee break 10:45 Viral vectors 14:00-17:00 PRACTICAL TEACHING: Cell phenotyping, flow cytometry Changbin Chen Dongming Zhou Xiaoming Zhang Wednesday 17 th May (whole day) Thursday 18 th May (8:30-12:30): Practical teaching PRACTICAL TEACHING: Virus inoculation/titration PRACTICAL TEACHING: Imaging viral infection PRACTICAL TEACHING: Molecular diagnostics of viral infections PRACTICAL TEACHING: Bioinformatics: comparative genomics of viruses Zhikang qian Gang Long Chiyu Zhang Pei Hao Thursday 18 th May (14:00-16:00): Evaluation