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THURSDAY 11 TH APRIL 2019 SCHEDULE PAGE 1 08.00 08.45 Registration 08.45 09.00 Introduction Dr Peter Spronk KEYNOTE ADDRESS 09.00 09.30 On the other side of the stethoscope: when the intensivist becomes sick Dr Don Chalfin SEPSIS - BASICS Chairpersons: Dr Peter Spronk & 09.30 09.45 Biology of vascular responsiveness in sepsis - lessons from ADRENAL Prof Bala Venkatesh 09.45 10.00 Microcirculation is the motor of organ failure 10.00 10.15 Chronic alcohol and sepsis 10.15 10.30 Sepsis 3 - three years on 10.30 10.50 Questions 10.50 11.10 Coffee Break TUTORIALS / WORKSHOPS / ROUND TABLE CARDIOVASCULAR Chairpersons: & Dr Ravi Kumar 11.10 11.30 SESAME protocol: a focused whole-body approach to cardiac arrest 11.30 11.45 Use of adrenaline in out of hospital cardiac arrest Dr Michael Kuiper 11.45 12.00 ECMO - CPR Dr Tim Hayes 12.00 12.15 Deep dive into diastolic heart failure: why nothing works? CONTROVERSIES Chairpersons: Dr Francesca Rubulotta & Dr Antonios Liolios 11.10 11.25 Vit C / steroids / thiamine in sepsis 11.25 11.40 Gender equality means that conferences should not name speakers Dr Adrian Wong 11.40 11.55 Permissive anaemia 11.55 12.10 Hypovolaemia does not exist in ICU Dr Ashley Miller 12.10 12.25 Personalised care is just an excuse for people to ignore guidelines and best practice Dr Adrian Wong PRACTICAL ASPECTS IN ICU 1 Chairpersons: Dr Tony Thomas & Dr Tony Whitehouse 11.10 11.25 Abdominal emergencies in ICU Dr Deepak Govil 11.25 11.40 Mechanical insufflation-exsufflation (cough assist) Ms Raechel Moses 11.40 11.55 Emergency front of the neck access - another victory for ultrasound Dr Justin Kirk-Bailey 11.55 12.10 Extubation in ICU 12.10 12.25 Clinical frailty - what is it, why do we need to know? 11.10 13.00 Round Table Sepsis - the challenge Moderator: Prof Tim Buchman Prof Rui Moreno Prof Ruth Kleinpell Prof Kathy Rowan 12.00 13.00 12.15 12.30 Questions Round Table Tracheostomy - all you need to know Moderator: Dr Jose Chacko Ms Rachael Moses 12.25 12.50 Questions 12.50 13.50 Lunch 12.25 12.50 Questions 12.50 13.50 Lunch Small Meeting Room: Workshop

THURSDAY 11 TH APRIL 2019 SCHEDULE PAGE 2 TUTORIALS / WORKSHOPS / ROUND TABLE Chairperson: Prof Paolo Pelosi Steriods in ICU 12.30 12.45 PRO 12.45 13.00 CON Dr Jean-Louis Vincent 13.00 13.10 Questions 13.10 14.00 Lunch NEURO CRITICAL CARE Chairpersons: Dr Michael Kuiper & Prof Fang Gao Smith 14.00 14.15 Early brain injury in ICU: too little too late Dr Matthew Rowland 14.15 14.30 ICP - more than a number Prof Rui Moreno 14.30 14.45 Intracranial haemorrhage: emerging research in minimally invasive options for intensivists to know Associate Prof Aarti Sarwal 14.45 15.00 Ketones as neuro protective agents Prof Bala Ventakesh 15.00 15.20 Questions 15.20 15.50 Coffee Break SEPSIS - MANAGEMENT Chairpersons: Dr Rob MacSweeney & 13.50 14.05 10 elements that can improve outcome in sepsis 14.05 14.20 How we optimized vasopressor use in sepsis 14.20 14.35 Beta blockers in septic shock Dr Tony Whitehouse 14.35 14.50 Quality improvement in sepsis management Prof Tim Buchman 14.50 15.05 Questions 15.05 15.30 Coffee Break ICU ISSUES 1 Chairpersons: Dr Ruth Kleinpell & 15.30 15.45 How bed availability drives care 15.45 16.00 WHO s in Critical Care Dr Tony Thomas 16.00 16.15 Quality improvement and evidence based practice 16.15 16.30 SLT in critical care 16.30 16.45 Addressing burnout in critical care providers Prof Ruth Kleinpell COMMUNICATIONS / ETHICS / HEALTH ECONOMICS Chairpersons: Associate Prof Leslie Whetstine & Dr Niels Van Regenmortal 13.50 14.05 Basic concepts and philosophy of health economics: why is it relevant for clinicians? Dr Don Chalfin 14.05 14.20 Cost of preventable cardiac arrests Dr Francesca Rubulotta 14.20 14.35 Current controversies in ethics Associate Prof Leslie Whetstine 14.35 14.50 Communications in the ICU 14.50 15.05 Questions 15.05 15.30 Coffee Break NUTRITION Chairpersons: & Dr Matthew Rowland 15.30 15.45 Topic to be arranged 15.45 16.00 Muscle mass and physical recovery in ICU: innovations for targeting nutrition and exercise 16.00 16.15 Monitoring a medical nutrition intervention in ICU Dr Alex Katanakis 16.15 16.30 Questions 14.00 15.00 Round Table Rehabilitation in ICU Moderator: Dr Peter Spronk Ms Rachael Moses Tutorial ICU rounds with Frank-Starling Small Meeting Room: Tutorial Haemostatis - all you need to know 16.00 17.00 Round Table Research: Practical aspects Writing a grant / fellowship application Designing a trial / reporting results Moderator: Prof Bala Venkatesh Prof Fang Gao Smith Prof Kathy Rowan

THURSDAY 11 TH APRIL 2019 SCHEDULE PAGE 3 TUTORIALS / WORKSHOPS / ROUND TABLE TOPICS 2 Chairpersons: & 15.50 16.05 Lactate metabolism Dr Marek Nalos 16.05 16.20 EPIC 3: how our ICU world has changed 16.20 16.35 The gut-brain connection and the psychobiome ICU ISSUES 1 (continued) Chairpersons: Dr Ruth Kleinpell & 16.45 17.00 Safety profiles of the ACCP and their contributions to ICU Mr Gavin Denton 17.00 17.30 Questions UPDATES IN INTENSIVE CARE Chairpersons: Prof Rui Moreno & 16.30 17.10 Updates on the latest literature and landmark papers Dr Rob MacSweeney 17.10 17.25 Updates on rehabilitation 17.25 17.30 Questions 16.00 17.00 Tutorial Acid-base Stewart approach Dr Niels Van Regenmortal Small Meeting Room: Workshop 16.35 16.50 Sepsis registry in Wales 16.50 17.05 Lessons we can learn from history 17.05 17.30 Questions 19.00 for 19.30 Foster & Robinson Room Crowne Plaza Manchester Oxford Road 55 Booth Street West Mancheser M15 6PQ SYMPOSIUM DINNER Admission by pre-booked ticket only AFTER DINNER SPEECH: Tracheostomy in critically ill patients: patients and families will never walk alone Prof Paolo Pelosi

FRIDAY 12 TH APRIL 2019 SCHEDULE PAGE 1 08.15 09.00 Registration KEYNOTE ADDRESS Chairpersons: Dr Don Chalfin & Dr Antonios Liolios 09.00 09.30 The ICU in Europe: the mismatch between demand and supply Prof Rui Moreno TUTORIALS / WORKSHOPS HAEMODYNAMICS Chairpersons: Dr Don Chalfin & Dr Antonios Liolios 09.30 09.45 The cardiovascular response to ECMO, CRRT and cardiac assist devices 09.45 10.00 Limits of fluid responsiveness parameters Prof Michel Slama 10.00 10.15 Ivabradine: a new tool to control tachycardia without affecting inotropism Prof Bernard Cholley 10.15 10.30 Questions 10.30 11.00 Coffee Break Chairperson: Mervyn Singer is wrong: whatever it is I am against it? 11.00 11.15 PRO 11.25 11.30 CON 11.30 11.45 Questions ARDS Chairpersons: Prof Paolo Pelosi & Dr Francesca Rubulotta 09.35 09.50 Mechanisms of ARDS To be announced 09.50 10.05 Impact of BALTI trial Prof Fang Gao Smith 10.05 10.20 Extracorporeal CO2 removal - respiratory dialysis: future of hypercapnic respiratory failure Dr Deepak Govil 10.20 10.35 Recruitment maneuver in ARDS: effect on haemodynamics and on the heart Prof Michel Slama 10.35 10.50 Questions 10.50 11.15 Coffee Break Chairperson: Prof Tim Buckman Deteriorating patient in the ward: the need for monitoring 11.15 11.30 PRO Dr Francesca Rubulotta 11.30 11.45 CON TOPICS 2 Chairpersons: Associate Prof Leslie Whetstine & Dr Ravi Kumar 09.35 09.50 Trauma haemorrhage - management and beyond 09.50 10.05 Conscientious objection Associate Prof Leslie Whetstine 10.05 10.20 Choice of IV fluids: a pragmatic approach 10.20 10.30 Questions 10.30 10.50 Coffee Break ULTRASOUND IN CRITICAL CARE Chairpersons: Associate Prof Aarti Sarwal & 10.50 11.10 From pocket to POCUS Dr Jonathan Wilkinson 11.10 11.25 Pushing POCUS further - beyond heart and lungs Dr Justin Kirk-Bailey 11.25 11.40 All the misconceptions surrounding lung ultrasound 09.35 10.35 Journal Matters: writing, reviewing, associate editing and editor in chief Prof Tim Buchman Crew resource management (CRM) in ICU Dr Alex Katanakis Small Meeting Room: 11.00 12.00 Physiological basis of fluids Interpreting abnormal haematology and coagulation profiles in acutely ill patients 11.45 12.00 Questions

FRIDAY 12 TH APRIL 2019 SCHEDULE PAGE 2 TUTORIALS / WORKSHOPS Chairperson: Prof Rui Moreno PA catheter is still the best option in the 21 st Century 11.45 12.00 PRO 12.00 12.15 CON Prof Michel Slama 12.15 12.30 Questions 12.30 13.30 Lunch INFECTIONS AND ANTIBIOTICS Chairpersons: Dr Tony Thomas & Dr Ravi Kumar 13.30 13.45 Inhaled antibiotics Dr Deepak Govil 13.45 14.00 Early antibiotics in sepsis - do they work 14.00 14.15 Antibiotic stewardship Dr Niels Van Regenmortal 14.15 14.30 Faecal transplant for C. difficile and potential other uses in ICU 14.30 14.50 Questions 14.50 15.20 Coffee Break FUTURE ICU Chairpersons: Dr Michael Kuiper & 12.00 12.15 Transfer of ventilated patients in the future Mr Gavin Denton 12.15 12.30 Suspended animation - a reality 12.30 12.45 Precision medicine in sepsis 12.45 13.00 Tailoring nutrition therapy to illness and recovery: the future 13.00 13.15 Questions 13.15 14.15 Lunch Chairperson: Prof Fang Gao Smith Closing the lungs is better than keeping them open 14.15 14.30 PRO Prof Paolo Pelosi 14.30 14.45 CON Dr Rob MacSweeney 14.45 15.00 Questions 15.00 15.20 Coffee Break ULTRASOUND IN CRITICAL CARE (continued) Chairpersons: Associate Prof Aarti Sarwal & 11.40 11.55 Point of care cranial ultrasound and transcranial Doppler in critical care Associate Prof Aarti Sarwal 11.55 12.10 Ventilator induced diaphragm dysfunction Associate Prof Aarti Sarwal 12.10 12.45 Questions 12.45 13.45 Lunch TOPICS 3 Chairpersons: Mr Gavin Denton & 13.45 14.00 Mechanical ventilation in non-ards patients Prof Paolo Pelosi 14.00 14.15 Results from the POPPI (Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients) trial Prof Kathy Rowan 14.15 14.35 Shock induced endotheliopathy in critical illness: a new disease entity 14.35 14.50 Questions 14.50 15.20 Coffee Break 12.00 13.00 Social media and knowledge dissemination Moderator: Dr Rob MacSweeney Dr Jonathan Wilkinson Dr Antonios Liolios Dr Adrian Wong Dr Segun Olusanya Airway assessment to wean patients with tracheostomy Ms Rachael Moses Small Meeting Room: 14.00 15.00 Interesting cases in ICU Workshop: Determination of death for organ donation Dr Michael Kuiper Associate Prof Leslie Whetstine

FRIDAY 12 TH APRIL 2019 SCHEDULE PAGE 3 ICU ISSUES 2 Chairpersons: Dr Peter Spronk & Prof Ruth Kleinpell 15.20 15.35 Promoting family engagement in ICU: lessons learned Prof Ruth Kleinpell from an international study 15.35 15.50 Unplanned removal of medical devices Dr Tony Thomas 15.50 16.15 Managing an ICU team in crisis - is weakness an option Dr Adrian Wong 16.15 16.30 Questions CLOSING LECTURE Chairpersons: Dr Peter Spronk & Prof Ruth Kleinpell 16.30 16.50 Bigger science 16.50 17.00 Closing remarks Dr Peter Spronk ENDORSED BY ICU MANAGEMENT & PRACTICE