University of Groningen Premature atherosclerosis in systemic autoimmune diseases de Leeuw, Karina IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2008 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Leeuw, K. D. (2008). Premature atherosclerosis in systemic autoimmune diseases s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
PREMATURE ATHEROSCLEROSIS IN SYSTEMIC AUTOIMMUNE DISEASES Karina de Leeuw
Studies presented in this thesis were financially supported by De Cock Stichting, Junior Scientic Masterclass, Groningen University Institute for Drug Exploration (GUIDE) Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. Further financial support was generously provided by Abbot BV, AstraZeneca BV, DiagnOptics, Dutch Arthritis Association, Menarini Farma Nederland, Novartis Pharma BV, Perimed AB Stockholm, Pfizer BV, Sanofi-Aventis Netherlands BV, Servier Nederland Farma BV, Schering-Plough BV, University of Groningen, University Medical Center Groningen Copyright 2008 Karina de Leeuw ISBN-number: 978-90-367-3375-5 (printed version) ISBN-number: 978-90-367-3374-8 (digital version) Printed by Doorn drukkerij, Groningen Cover illustration by Erika Bijzet (Ten Boer, The Netherlands)
RIJKSUNIVERSITEIT GRONINGEN Premature atherosclerosis in systemic autoimmune diseases Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniveriteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op maandag 9 juni 2008 om 16.15 uur door Karina de Leeuw geboren op 30 juni 1982 te Leiderdorp
Promotor: Prof. dr. C.G.M. Kallenberg Copromotores: Dr. M. Bijl Dr. A.J. Smit Beoordelingscommissie: Prof. dr. J.W. Cohen Tervaert Prof. dr. W.H. van Gilst Prof. dr. T.W.J. Huizinga
Premature atherosclerosis in systemic autoimmune diseases Karina de Leeuw CONTENTS page Chapter 1. Accelerated atherosclerosis in patients with systemic autoimmune diseases Ann N Y Acad Sci 2005, 1051: 362-371 7 Aim and outline of the thesis 19 Chapter 2. Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus Lupus 2006, 15: 675-682 21 Chapter 3. Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus Submitted 37 Chapter 4. Vascular responsiveness in the microcirculation of patients with systemic lupus erythematosus is not impaired Accepted to Lupus 51 Chapter 5. Accumulation of advanced glycation endproducts in patients with systemic lupus erythematosus Rheumatology 2007, 46: 1551-1156 65 Chapter 6. Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus Arthritis Res Ther 2007, 9: R84 81
Chapter 7. Accelerated atherosclerosis in patients with Wegener s granulomatosis Ann Rheum Dis 2005, 64: 753-759 99 Chapter 8. Progression of atherosclerosis in patients with Wegener's granulomatosis: a long-tem follow-up study Submitted 115 Chapter 9. Enhanced endothelium-dependent microvascular responses in patients with Wegener s granulomatosis J Rheum 2007, 34: 1875-1881 127 Chapter 10. Summary, discussion, and future perspectives 143 Nederlandse samenvatting 157 Dankwoord 169 List of abbreviations 175