Cours Pasteur. Molecular Cancer Genetics. September 24 October 5, Directors Jean-Pierre VARTANIAN Institut Pasteur. Sarah WATSON Institut Curie

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Cours Pasteur Molecular Cancer Genetics September 24 October 5, 2018 Directors Jean-Pierre VARTANIAN Institut Pasteur Sarah WATSON Institut Curie PROGRAM 2018-2019

Molecular Cancer Genetics Room 4 & Laboratory ground floor (Building 09, Education center), Institut Pasteur, Paris - Week 1-24 - 28 September 2018 Monday, September 24 9h15-10h00 Course presentation Education Center 10h30-12h00 Cancer-causing genes: understanding the functions of oncogenes and tumor suppressor genes 14h10-17h00 Practical Work (PW) presentation: Tuesday, September 25 9h00-10h30 Molecular cancer: pillars and keystones 11h00-12h30 Endogenous DNA mutator enzymes 14h00-17h00 PW: Wednesday, September 26 9h00-10h30 Regulation of Cell Cycle progression and diseases 11h00-12h30 Oncogenic viruses and the origin of molecular cancer biology 14h00-17h00 PW: Jean-Pierre Vartanian (Institut Pasteur) Chloé Journo (ENS, Lyon) Jean-Christophe Pagès (EFS) Jean-Pierre Vartanian (Institut Pasteur) Florence Margottin-Goguet (Institut Cochin) Moshe Yaniv (Institut Pasteur)

Thursday, September 27 9h30-12h00 PW: 14h00-17h00 Free Friday, September 28 9h00-10h30 Mechanisms of genome maintenance during antigen receptor diversification 11h00-12h30 Genetic predisposition to cancer 14h00-17h00 PW: Analysis of APOBEC3A induced Ludovic Deriano (Institut Pasteur) Pascal Pineau (Institut Pasteur)

Molecular Cancer Genetics Institut Curie, Ecole Normale Supérieure (ENS) Paris - Week 2 1-5 October 2018 Monday, October 1st 9h00-10h30 Introduction Sarah Watson (Institut Curie, DOM, INSERM U830) 10h30-12h00 Initiation to diagnostic procedures Gaëlle Pierron in somatic genetics (Institut Curie, Génétique) 14h00-15h30 DNA repair and cancer Marc-Henri Stern (Institut Curie, INSERM U830) 15h30-17h00 Epigenetics and cancer Raphaël Margueron (Institut Curie, CNRS UMR3215) Tuesday, October 2nd 9H00-10h30 Genetics of malignant rhabdoid tumors Franck Bourdeaut (Institut Curie, DOPAJA, RTOP) 10h30-12h00 Genetics and ethics Guillermo Orsi (Institut Curie, CNRS UMR3664) 14h00-17h00 Free: articles to prepare for Journal Club Wednesday, October 3rd 9h00-10h30 Genetics and the metastatic process François Clément-Bidard (Institut Curie St Cloud, DOM lab. BTC) 10h30-12h00 Genetics of sarcoma Sarah Watson (Institut Curie, DOM, INSERM U830) 14h00-15h30 Genetics of acute myeloid leukemia Hugues de Thé (Collège de France/CNRS UMR 7212) 15h30-17h00 Genetics predisposition to breast cancer Dominique Stoppa-Lyonnet (Institut Curie, Génétique)

Thursday, October 4th 9h00-12h00 Journal Club Sarah Watson (Institut Curie, DOM, INSERM U830) Free afternoon Friday, October 5th 9h00-10h30 Genetics of uveal melanoma Manuel Rodrigues (Institut Curie, DOM) 10h30-12h00 Steps in biomarkers development François-Clément Bidard (Institut Curie Hospital) 14h00-16h00 Evaluation

DIRECTORS OF THE COURSE Jean-Pierre VARTANIAN jean-pierre.vartanian@pasteur.fr Institut Pasteur 28, rue du Docteur Roux 75725 Paris Cedex 15 - France Sarah WATSON sarah.watson@curie.fr Institut Curie 26 rue d'ulm 75248 Paris Cedex 05 - France

CONTACTS - INSTITUT PASTEUR Service de la Scolarité Sylvie MALOT Céline CORBIN (Assistante) Tel : +33 (0)1 40 61 33 62 Bâtiment 13 Salle Saint-Joseph de Cluny Email : enseignement@pasteur.fr Centre d Enseignement Sylvie GARNERO Tél : +33 (0)1 40 61 38 04 Module 4 (bâtiment 06) Email : cours@pasteur.fr