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Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Nonsurgical Hodge, 2005 Evid Rep Technol Assess (Summ). 2005 Jul;(117):1-6. Effects of omega- 3 fatty acids on eye health. Prevention Mathew Milan, 2012 Jun 13;6:CD004567. Antioxidant vitamin supplementation for preventing and slowing the progression of age- related cataract. Prevention Zhao, 2014 Surgical Indications for Surgery Contraindications to Surgery Preoperative Medical Evaluation Indications for Surgery Contraindications to Surgery Preoperative Medical Evaluation Keay, 2012 Nutrients. 2014 Feb 28;6(3):931-49. Mar 14;3:CD007293. Biometry and Intraocular Lens Power Calculation Anesthesia Friedman, 2001 Ophthalmology. 2001 Mar;108(3):519-29. The effect of multivitamin/mineral supplements on age- related cataracts: a systematic review and meta- analysis. Routine preoperative medical testing for cataract surgery. Synthesis of the literature on the effectiveness of regional anesthesia for cataract surgery. 1 Prevention; - Surgical - Socioeconomic Considerations- Cost Considerations; Socioeconomic Considerations- Cost- effectiveness of Surgery; - Surgical - Complications of Surgery Complications of Surgery; - Surgical -

Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Davison, 2007 Cochrane Database Syst Rev. 2007 Jul 18;(3):CD006291. Sub- Tenon's anaesthesia versus topical anaesthesia for cataract surgery. Complications of Surgery; - Surgical - Ezra, 2007 Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005276. Topical anaesthesia alone versus topical anaesthesia with intracameral lidocaine for phacoemulsification. Complications of Surgery; - Surgical - Ezra, 2008 Ophthalmology. 2008 Mar;115(3):455-87. Supplementary intracameral lidocaine for phacoemulsification under topical anesthesia. A meta- analysis of randomized controlled trials. Complications of Surgery; - Surgical - Alhassan, 2008 Cochrane Database Syst Rev. 2008 Jul 16;(3):CD004083. Peribulbar versus retrobulbar anaesthesia for cataract surgery. Complications of Surgery; - Surgical - Alhassan, 2015 Cochrane Database Syst Rev. 2015 Jul 2;7:CD004083. Peribulbar versus retrobulbar anaesthesia for cataract surgery. Complications of Surgery; - Surgical - Guay, 2015 Cochrane Database Syst Rev. 2015 Aug 27;8:CD006291. Sub- Tenon's anaesthesia versus topical anaesthesia for cataract surgery. Lesin, 2015 Surv Ophthalmol. 2015 May- Jun;60(3):196-203. Factors associated with postoperative pain and analgesic consumption in ophthalmic surgery: a systematic review Postoperative Infection Prophylaxis Toxic Anterior Segment Syndrome Surgery Checklist Surgical Techniques Riaz, 2006 Cochrane Database Syst Rev. 2006 Oct 18;(4):CD001323. Surgical interventions for age- related cataract Complications of Surgery 2

Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Ang, 2012 Yu, 2012 Apr 18;4:CD008811. J Refract Surg. 2012 May;38(5):894-901. Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age- related cataract. Biaxial microincision cataract surgery versus conventional coaxial cataract surgery: meta- analysis of randomized controlled trials. Socioeconomic Considerations- Cost- effectiveness of Surgery management- surgical management- outcomes; cataract management- surgical management- complications of cataract surgery Riaz, 2013 Cochrane Database Syst Rev. 2013 Oct 10;10:CD008813. Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus phacoemulsification with posterior chamber intraocular lens for age- related cataract. Cost Considerations Quinones, 2013 Washington (DC): Department of Veterans Affairs; 2013 Dec. VA Evidence- based Synthesis Program Reports. Benefits and harms of femtosecond laser assisted cataract surgery: a systematic review Complications of Surgery de Silva, 2014 Intraocular Lenses Cochrane Database Syst Rev. 2014 Jan 29;1:CD008812. Ang, 2014 Cochrane Database Syst Rev. 2014 Nov 18;11:CD008811. Li, 2008 Medical Advisory Secretariat, Ontario Ministry of Health, 2009 Ophthalmology. 2008 May;115(5):830-8. Ont Health Technol Assess Ser. 2009;9(15):1-62. Phacoemulsification with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age- related cataract. Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age- related cataract Effect of AcrySof versus silicone or polymethyl methacrylate intraocular lens on posterior capsule opacification. Intraocular lenses for the treatment of age- related cataracts: an evidence- based analysis. Complications of Surgery Socioeconomic Considerations- Cost- effectiveness of Surgery Complications of Surgery; - Surgical - Posterior Capsular Opacification; Optical and Refractive Considerations; - Surgical - Optical and Refractive Considerations; - Surgical - Complications of Surgery; Socioeconomic Considerations- Cost- effectiveness of Surgery 3

Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Takakura, 2010 J Refract Surg. 2010 Mar;36(3):380-8. Functional assessment of accommodating intraocular lenses versus monofocal intraocular lenses in cataract surgery: metaanalysis. Optical and Refractive Considerations; - Surgical - Complications of Surgery; - Surgical - Posterior Capsular Opacification Calladine, 2012 Sep 12;9:CD003169. Multifocal versus monofocal intraocular lenses after cataract extraction. Optical and Refractive Considerations; - Surgical - Complications of Surgery; Visual Function and Quality of Life Zhu, 2012 PLoS One. 2012;7(3):e33013. Comparison of blue light- filtering IOLs and UV light- filtering IOLs for cataract surgery: a meta- analysis. Surgical Techniques; ; Optical and Refractive Considerations Schuster, 2013 Ophthalmology. 2013 Nov;120(11):2166-75. The impact on vision of aspheric to spherical monofocal intraocular lenses in cataract surgery: a systematic review with meta- analysis. Optical and Refractive Considerations Leung, 2014 Cochrane Database Syst Rev. 2014 Mar 4;3:CD007284. Types of intraocular lenses for cataract surgery in eyes with uveitis Ocular Comorbidities; - Surgical - Ong Hon, 2014 Cochrane Database Syst Rev. 2014 May 1;5:CD009667. Accommodative intraocular lens versus standard monofocal intraocular lens implantation in cataract surgery. Optical and Refractive Considerations Xu, 2014 Optical and Refractive Considerations J Refract Surg. 2014 Sep;30(9):634-44. Refractive versus diffractive multifocal intraocular lenses in cataract surgery: a meta- analysis of randomized controlled trials Optical and Refractive Considerations Conner- Spady, 2007 Can J Ophthalmol. 2007 Aug;42(4):543-51. A systematic literature review of the evidence on benchmarks for cataract surgery waiting time. Visual Function and Quality of Life 4

Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Fedorowicz, 2011 Song, 2014 Lawrenece, 2015 Complications for Surgery Cochrane Database Syst Rev. 2011 Jul 6;(7):CD004242. PLoS One. 2014 Nov 4;9(11):e112054. Cochrane Database Syst Rev. 2015 Nov 2;11:CD004242. Day care versus in- patient surgery for age- related cataract. Age- related cataract, cataract surgery and subsequent mortality: a systematic review and meta- analysis Day care versus in- patient surgery for age- related cataract. Provider and Setting; - Cost- effectiveness of Surgery; - Complications of Surgery; - Surgical - Postoperative Natural History Provider and Setting; - Cost- effectiveness of Surgery; - Complications of Surgery; - Surgical - Postoperative Rossetti, 1998 Ophthalmology. 1998 Mar;105(3):397-405. Medical prophylaxis and treatment of cystoid macular edema after cataract surgery. The results of a meta- analysis. Hodge, 2007 CMAJ. 2007 Apr 24;176(9):1285-90. The consequences of waiting for cataract surgery: a systematic review. Buehl, 2008 J Refract Surg. 2008 Nov;34(11):1976-85. Effect of intraocular lens design on posterior capsule opacification. Posterior Capsular Opacification; - Surgical - Intraocular Lenses; - Surgical - Findl, 2010 Cochrane Database Syst Rev. 2010 Feb 17;(2):CD003738. Interventions for preventing posterior capsule opacification. Surgical Techniques; Intraocular Lenses; - Surgical - Posterior Capsular Opacification Yilmaz, 2012 Eye (Lond). 2012 Feb;26(2):252-8. Ketorolac therapy for the prevention of acute pseudophakic cystoid macular edema: a systematic review. Sivaprasad, 2012 Feb 15;2:CD004239. Non- steroidal anti- inflammatory agents for treating cystoid macular oedema following cataract surgery. Postoperative Gower, 2013 Cochrane Database Syst Rev. 2013 Jul 15;7:CD006364. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Infection Prophylaxis; 5

Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Linertova, 2014 Wielders, 2015 Clin Ophthalmol. 2014 Aug 14;8:1515-22. Am J Ophthalmol. 2015 Nov;160(5):968-981.e33. Intracameral cefuroxime and moxifloxacin used as endophthalmitis prophylaxis after cataract surgery: systematic review of effectiveness and cost- effectiveness Prevention of Cystoid Macular Edema After Surgery in Nondiabetic and Diabetic Patients: A Systematic Review and Meta- Analysis Cost Consideration; - Surgical - Postoperative ; - Surgical - Infection Prophylaxis Postoperative Mousavi, 2015 Adv Pharmacol Sci. 2015;2015:507151. Complications for Intraocular Lenses Ocular comorbidities Allen, 2011 Clinical Evidence 2011;02:708 Clin Evid (Online): Zhang, 2015 Cochrane Database Syst Rev. 2015 Jul 14;7:CD008671. Systemic comorbidities Combined Surgery and Special Circumstances Friedman, 2002 Ophthalmology. 2002 Oct;109(10):1902-13. Jampel, 2002 Do Diana, 2008 Casparis, 2012 Thomas, 2014 Second Eye Surgery Ophthalmology. 2002 Dec;109(12):2215-24; quiz 2225, 2231. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD006366. Jun 13;6:CD006757. Cochrane Database Syst Rev. 2014 Jul 28 Anti- Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma Surgical strategies for coexisting glaucoma and cataract: an evidence- based update. Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence- based review. Surgery for post- vitrectomy cataract Surgery for cataracts in people with age- related macular degeneration. Antimetabolites in cataract surgery to prevent failure of a previous trabeculectomy Combined Surgery and Special Circumstances Surgical technique; Surgical technique; Surgical technique; Ocular Comorbidities 6

Table 1. American Academy for Ophthalmology s (AAO) Preferred Practice Patterns (PPP) Immediate Sequential (Same Day) Bilateral Surgery Long, 2006 Discharge from Surgical Facility Postoperative Postoperative Follow- up Posterior Capsule Opacification Cochrane Database Syst Rev. 2006 Jul 19;(3):CD003171. Surgical interventions for bilateral congenital cataract. Second- Eye Surgery; Surgical Techniques; - Surgical - 7