Risk factors of gestational diabetes mellitus among the re-birth pregnant women in Xiamen City in

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46 6 2017 11 JOURNAL OF HYGIENE RESEARCH Vol. 46 No. 6 Nov. 2017 925 1000-8020 2017 06-0925-05 檾檾檾檾 DANONE INSTITUTE CHINA Young Scientists' Forum 檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾 2015 2016 1 361003 gestational diabetes mellitus GDM 2015 2016 393 GDM 1 1 393 1 GDM 24 9. 11 ± 3. 09 kg vs 7. 54 ± 2. 95 kg t = 2. 121 P = 0. 004 64 /393 vs 38 /393 χ 2 = 7. 616 P = 0. 006 GDM Z = - 4. 060 P = 0. 001 χ 2 = 14. 297 P = 0. 001 χ 2 = 12. 938 P = 0. 001 2 χ 2 = 7. 078 P = 0. 010 GDM GDM 3. 8 kg OR = 3. 467 2 Logistic GDM 24 10 kg OR = 1. 875 P = 0. 001 2 24 10 kg GDM 3. 8 kg GDM R715. 3 R714. 147 A Risk factors of gestational diabetes mellitus among the re-birth pregnant women in Xiamen City in 2015-2016 Fan Yanfeng Xu Rongxian Cai Lili Cai Liqian Maternal and Child Health Hospital Xiamen 361003 China Abstract Objective GDM among the re-birth pregnant women. Methods No. 2014-2-76 E-mail fyf8011@ 163. com 1 E-mail rong1963cn@ aliyun. com To discuss the risk factors of the gestational diabetes mellitus A total of 393 pregnant women with GDM were collected randomly according to the number of the antenatal care manual in the Maternal and Child Health Hospital in Xiamen City. Meanwhile 393 pregnant women with normal glucose tolerance were chosen to be the control group matching with

926 46 age of the GDM group. Their basic data would be analyzed including the BMI before pregnancy the degree of the education the times of the abortion the body weight gain during the pregnancy their parental diabetes history the birth weight of the last fetal the history of GDM and so on. The two groups of people were re-birth pregnant women. Results Single factor analysis showed that among the GDM group the total body weight gain before the 24th week 9. 11 ± 3. 09 kg and the proportion of their mothers with the DM 64 /393 were both higher than the control group 7. 54 ± 2. 95 kg and 38 /393 however the degree of the education was lower than the control group. Paired chi-square analysis showed that the history of macrosomia delivery χ 2 = 14. 297 P = 0. 001 the history of GDM χ 2 = 12. 938 P = 0. 001 and abortion history more than 2 times χ 2 = 7. 078 P = 0. 010 were the risk factors of GDM for those women. Meanwhile with the increasing of the fetal birth weight the risk of being the GDM during the second pregnancy was also increasing. When the fetal birth weight reached 3. 8 kg OR = 3. 467 the risk value reached a strong correlation. Multiple factors Logistic regression analysis showed those factors of GDM also had statistically significant differences especially the bodyweight gain before the 24th week over 10 kg played the most important role during the pregnancy OR = 1. 875 P = 0. 001. Conclusion The risk factors of the GDM for the re-birth pregnant women concluded the history of GDM the history of macrosomia the times of the abortion over twice the bodyweight gain before the 24th week over 10 kg the low degree of the education the pregnant women s mother had the DM. For those pregnant women with fetal birth weight above 3. 8 kg they should be included in the high risk population of GDM during the next pregnancy. Key words re-birth gestational diabetes mellitus risk factors gestational diabetes mellitus GDM 1 1 393 3 1 2 1. 2 3 GDM GDM 393 body mass index BMI = 1 kg / m 2 BMI < 18. 5 18. 5 ~ 1. 1 23. 9 24. 0 GDM 2015 2 2016 5 24 ~ 28 75 g 24 ~ 28 5. 1 mmol /L 1 h 10. 0

6. 2015 2016 927 mmol /L 2 h 8. 5 mmol /L 2. 1 GDM 5-6 1. 3 SPSS 17. 0 24 t χ 2 Logistic 2 1 1 GDM Z = - 4. 060 P = 0. 001 2015 2016 n = 393 n = 393 t /χ 2 /Z P / 29. 52 ± 4. 99 29. 86 ± 5. 11 t = - 0. 939 0. 348 24 /kg 9. 11 ± 3. 09 7. 54 ± 2. 95 t = 2. 121 0. 004 20. 93 ± 2. 78 20. 59 ± 2. 85 t = 1. 660 0. 098 41 47 χ 2 = 0. 461 0. 497 352 346 64 38 χ 2 = 7. 616 0. 006 329 355 11 12 Z = - 4. 060 0. 001 227 168 / 21 21 134 192 364. 06 422. 94 2. 2 GDM 2 2 P < 0. 05 OR 2 2 2015 2016 χ 2 1 P OR 95% CI 1 7 14. 297 0. 001 4. 286 2. 017 ~ 9. 109 30 355 2 14 38 7. 078 0. 010 1. 710 1. 152 ~ 2. 539 65 276 4 33 1. 571 0. 254 1. 333 0. 850 ~ 2. 089 44 312 12 18 12. 938 0. 001 2. 611 1. 548 ~ 4. 405 47 316 1 McNema 2. 3 2. 4 Logistic 3 Logistic 4 5 2 24 3. 8 kg OR = 3. 467 P = 0. 001 10 kg OR GDM 24 1. 0 ~ 1. 1 10 kg OR = 1. 875 P = 0. 001 1. 2 ~ 1. 4 1. 5 ~ 2. 9 3 7 GDM OR = 1. 241 P = 0. 001

928 46 3 1 2015 2016 /kg a b c d χ 2 P OR 95% CI 3. 1 37 97 75 184 2. 814 0. 109 1. 293 0. 958 ~ 1. 747 3. 2 62 113 85 133 3. 960 0. 055 1. 329 1. 004 ~ 1. 760 3. 3 125 112 82 74 4. 639 0. 037 1. 366 1. 028 ~ 1. 814 3. 4 173 106 79 35 3. 941 0. 048 1. 342 1. 004 ~ 1. 794 3. 5 223 87 56 27 6. 720 0. 012 1. 554 1. 113 ~ 2. 168 3. 6 258 77 43 15 9. 633 0. 002 1. 790 1. 239 ~ 2. 587 3. 7 290 68 28 7 16. 667 0. 001 2. 429 1. 586 ~ 3. 718 3. 8 321 52 15 5 20. 433 0. 001 3. 467 2. 022 ~ 5. 943 3. 9 340 40 10 3 18. 000 0. 001 4. 000 2. 108 ~ 7. 589 1 a < b < c < d 4 Logistic = 0 = 1 < 2 = 0 2 = 1 24 < 10 kg = 0 10 kg = 1 = 0 = 1 1 = 2 = 3 = 4 = < 3. 5 kg = 1 3. 5 kg 3. 6 kg = 2 3. 6 kg 3. 7 kg = 3 3. 7 kg 3. 8 kg = 4 3. 8 kg 3. 9 kg = 5 3. 9 kg 4. 0 kg = 6 4. 0 = 7 5 2015 2016 Logistic B SE Wald OR 95% CI P 0. 449 0. 203 4. 902 1. 567 1. 053 ~ 2. 333 0. 027 0. 609 0. 252 5. 860 1. 839 1. 123 ~ 3. 012 0. 015 24 0. 629 0. 170 13. 640 1. 875 1. 343 ~ 2. 618 0. 001-0. 248 0. 075 10. 987 0. 780 0. 674 ~ 0. 904 0. 001 0. 513 0. 228 5. 051 1. 670 1. 068 ~ 2. 613 0. 001 0. 216 0. 048 20. 069 1. 241 1. 129 ~ 1. 364 0. 001 3 6 ~ 12 GDM 8 GDM GDM GDM 9 GDM 1 1 GDM 2 OR = 1. 567 P = 0. 027 1. 839 OR = 1. 839 P = 0. 015 GDM 10 χ 2 = 7. 616 P = 0. 006 BATTISTA 11 GDM GDM GDM GDM GDM GDM

6. 2015 2016 929 12 24 Study Groups Consensus Panel. International GDM association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy J. Diabetes Care 24 10 kg 2010 33 3 676-682. GDM Logistic 6. OR OR = 1. 875 P = J. 2011 46 2 0. 001 24 150-153. 7. M. 2003 75-76. 3. 8 kg OR = 3. 4678. OR = 4. 286 J. GDM OR 2011 14 4 204-209. 9. TCF7L2 J. GDM 2011 27 1 32-35. GDM 10 NOLAN C J DAMM P PRENTKI M. Type-2 diabetes across generations from pathophysiology to 1. 9786 169-181. J. 11 BATTISTA M C HIVERT M F DUVAL K et al. 2011 14 4 210-214. 2. J. 2015 27 11 1157-1159. 2011 20 11 596-600. 3. J. 12. 2014 10 2 126-130. J. 2013 11 9 4. 1374-1375. M. 2008 445-446. 5 International Association of Diabetes and Pregnancy prevention and management J. Lancet 2011 378 Intergenerational cycle of obesity and diabetes how can we reduce the burdens of these conditions on the health of future generations J. Exp Diabetes Res 2016-09-26 924 9. 2002 J 2005 26 2 77-83. 10 MACFARLANE D J LEE C C HO E Y et al. 13 SHORT K R VITTONE J L BIGELOW M L et al. Impact of aerobic exercise training on age-related. changes in insulin sensitivity and muscle oxidative capacity J. Diabetes 2003 52 8 1888-1896. 14 MARQUES-VIDAL P VOLLENWEIDER P Reliability and validity of the Chinese version of IPAQ short last 7days J. Sci Med Sport 2007 10 1 45-51. 11 FUNG T T CHIUVE S E MCCULLOGUH M L et WAEBER G. Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study J. Nutr Metab Cardiovasc Dis 2015 25 1 75-84. 15 HILDING A ERIKSSON A K AGARDH E E et al. al. Adherence to a DASH-style diet and risk of The impact of family history of diabetes and lifestyle coronary heart disease and stroke in women J. Arch Int Med 2008 168 7 713-720. 12 HEIANZA Y ARASE Y SAITO K et al. Role of factors on abnormal glucose regulation in middle-aged Swedish men and women J. Diabetologia 2006 49 11 2589-2598. alcohol drinking pattern in type 2 diabetes in 16. Japanese men the toranomon hospital health 2 J. management center study 11 J. Am J Clin Nutr 2013 97 3 561-568. 2015 7 5 297-301. 2016-10-10