America, Hershey, PA Australia, Melbourne, VIC Europe, Munich info@vivopharm.com www.vivopharm.com Tissue Bladder Species Tumor Type Comment for in vivo work Lead Time for in vivo studies [weeks] MB-49-luc- Mouse urinary bladder carcinoma C57BL/6 KU-7-luc- GFP Brain Mouse urinary bladder carcinoma dual labeled:ex vivo cell isolation using U87MG glioblastoma; astrocytoma also available for U87MG-luc 6 U-87 MGluc glioblastoma; astrocytoma GL61-luc Murine glioblastoma multiforme extremely bright like 4T1-luc imaging from day 0 1 Breast 4 T1 Mouse breast carcinoma Balb/C Mice
Breast 4 T1-luc Mouse breast carcinoma 4t1-luc- tdtomato single cell detection in vivo Mouse breast carcinoma invasion with IHC. Ex vivo cell isolation using BT-474 breast carcinoma Oestrogen dependent, hormone pellets, HER pos -4 CCL-51 Mouse breast carcinoma lung mets 4 EMT6 Mouse breast carcinoma lung mets HCC1954 breast carcinoma slow growing, SCID CB17 Mice, HER pos 6 MCF-7 breast carcinoma Estrogen dependent, hormone pellets 4 MCF-7-luc- F5 breast adenocarcinoma Estrogen dependent, hormone pellets Lung/thoracic metastasis in nude beige (Harlan) MDA-MB-31 breast adenocarcinoma, Pleural also available: MDA-MB31-luc (vp cell line) -3
Breast MDA- MB-31-luc- D3-H1 breast adenocarcinoma, Pleural -3 MDA- MB-31-luc- D3HLN breast adenocarcinoma, Pleural, A spontaneous lymph node metastasis from a D3H1 mammary fat pad tumor more prone to methastise -3 MDA- MB-31-luctdTomato breast adenocarcinoma, Pleural invasion with IHC. Ex vivo cell isolation using -3 MDA- MB-31-luc- GFP breast adenocarcinoma, Pleural invasion with IHC -3 MDA-MB-468 breast adenocarcinoma slow growing 60 days lead time 4 Colon Colo-05 carcinoma,colorectal induction of cachexia 3-4 Colo05-luc carcinoma,colorectal. 3-4
Colon CT-6 Mouse carcinoma, colorectal HCT 116 carcinoma, colorectal also available for HCT 116-luc -4 HCT 116 luc carcinoma, colorectal. -4 HT-9 adenocarcinoma, colorectal HT-9-luc-D6 adenocarcinoma; colorectal. SCID-bg: subcutaneous metastasis to lymph node and lung. Long model up to 7 weeks LoVo-6-luc-1 adenocarcinoma; colorectal. secum wall in SCID-bg (CR) MC-38 Mouse adenocarinoma SW60 carcinoma, colorectal resistant 4 Leukemia Daudi B lymphoblast, Burkitt s lymphoma (NHL) iv injection in SCID mice 4 EL4-luc Murine Lymphoma. K-56-luc chronic myelogenous leukemia (CML).
Leukemia LP-1 Plasmacytoma, multiple myeloma (MM) NCI-H99 Plasmacytoma, multiple myeloma (MM) bone lytic when injected in bone marrow of tibia 4 bone lytic when injected in bone marrow of tibia 4 MOLT-4-luc acute lymphoblastic leukemia Perkin- Elmer, i.p and s.c. inoculation 1- MV(4)11 acute biphenotypic B monpcytic leukemia (AML) RPMI 86 Plasmacytoma, multiple myeloma (MM) i.v. injection in NOD SCID mice 4 bone lytic when injected in bone marrow of tibia 4 Ramos Burkitt s Lymphoma iv injection in SCID- C.B-17, survival model Raji B lymphoblast, Burkitt s lymphoma (NHL) Liver iv injection in SCID mice, also available for Rajiluc clone 4 Hep 3B.1-7 hepatocellular carinoma subcutaneous and orthotopic, >90% take rate 3 HepG-luc hepatocellular carinoma HUH-7 carcinoma very variable and fast growing 3 SK-HEP-1 adenocarcinoma 4
Lung Carcinoma A549-luc-C8 NSCLS carcinoma, lung. SCID-bg (CR): subcutaneous, intravenous lung colonization LL/ luc Mouse Lewis Lung (C57BL6) -3 LL/-luc-M38 Mouse Lung Cancer Perkin i.v. multiple metastasis in several mouse strains, short model 5 days 1.5 NCI-H09 SCLC, Small Cell Carcinoma NCI-H460 NSCLC, pleural effusion high variability 3 also available for NCI-H460-luc -4 Melanoma Skin B16-F0 Mouse melanoa C57 Black 6 mouse B16-F10 Mouse melanoma C57 Black 6 mouse B16-F10-luc-G5 Mouse melanoma Perkin C57BL/6 Albino (Jackson Lab) iv. multiple meths. short model 13 days 1 B16-F10-luc Mouse melanoma 40 fold brighter than luc version 1 C8161 malignant melanoma metastatic clone 3
Melanoma Skin CHL-1 melanoma fast growing G361 malignant melanoma lung and liver metastasis, induction of cachexia 4 Pancreas L3.6pL carcinoma pancectomy in preparation -4 Pan0 Mouse carcinoma C57B16 5 MIA PaCa- carcinoma in Athymic Foxn1 nude -4 PANC-1 epithelioid carcinoma SCID mice 3-6 BxPC3-luc pancreas adenocarcinoma Perkin Prostate DU 145 prostate carcinoma slow growth rate 4 LNCaP-luc-M6 prostate carcinoma Perkin hormone sensitive SCID-bg mice, pulmonary metastases LNCaP-luc-M6 prostate carcinoma Perkin 5 fold brighter than luc version -3-3
Prostate PC3 prostate adenocarcinoma also as PC3 luc (vp cell line) -3 PC-3M-luc-C6 PC-3M-luc PC-3-luc prostate adenocarcinoma Perkin also as intracardiac tumor models -3 PC-3-luc-GFP prostate adenocarcinoma Thyroid SW579 squamous cell carcinoma Gastrics Perkin invasion with IHC, Ex vivo cell isolation using -3 NCI-N87-luc- GFP stomach; derived from metastatic site liver invasion with IHC, Ex vivo cell isolation using
Tumor vascularisation hvegf-luc/ PC3M prostate cancer Oncology/Angiogenesis reporter cell line -3 other HT1080-luc Fibrosarcoma