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CURRICULUM VITAE NAME: PRESENT TITLE: Didier Demesmin, MD CEO and Medical Director, University Pain Medicine Center OFFICE ADDRESS: 59 Veronica Avenue, Somerset, NJ 08873 TELEPHONE NUMBER/FAX NUMBER: (732) 873-6868 / (732) 873-6869 CITIZENSHIP: USA EDUCATION: Undergraduate Education Rutgers University New Brunswick, NJ BA Psychology Secondary Field Biological Sciences May 1994 Medical Education University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School Piscataway, NJ Medical Degree May 2000 POST GRADUATE EDUCATION: Internships and Residencies St. Vincent s Hospital and Medical Center New York, NY Internship Obstetrics and Gynecology July 2000 July 2001 SUNY Downstate Medical Center Brooklyn, NY Resident in Anesthesia Dept. of Anesthesiology July 2001 July 2004 Interventional Pain Fellowship Columbia University College of Physicians and Surgeons St. Luke s Roosevelt Hospital Center The Manhattan Center for Pain Management New York, NY August 2004 July 2005 ACADEMIC APPOINTMENTS Multidisciplinary Interventional Pain Medicine Fellowship JFK Johnson Rehabilitation Institute Fellowship Program Director November 2013 Present Physical Medicine and Rehabilitation and Sports Medicine Institute St. Peter s University Hospital Medical Director December 2013 - Present Page 1

Department of Physical Medicine and Rehabilitation Rutgers Robert Wood Johnson Medical School Clinical Assistant Professor July 2013 - Present Department of Medicine Rutgers Robert Wood Johnson Medical School Clinical Instructor August 2006 Present HOSPITAL APPOINTMENTS: CERTIFICATIONS: Saint Barnabas Hospital November 2013 - Present Somerset Medical Center February 23, 2009 Present Robert Wood Johnson University Hospital January 8, 2008 Present JFK Medical Center March 1,2007 - Present St. Peter s University Hospital Director of Pain Medicine Department March 2006 Present American Board of Anesthesiology: Anesthesiology American Board of Anesthesiology Sub-specialty: Pain Medicine MEMBERSHIPS, OFFICES AND COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES: Advisory Council Rutgers School of Arts and Sciences March 2016 - Present American Academy of Pain Management June 2006 - Present American Medical Association May 2005 - Present American Society of Interventional Pain Physicians June 2008 Present American Society of Regional Anesthesia and Pain Medicine (ASRA) February 2014 - Present Page 2

Medical Society of New Jersey June 2006 - Present New Jersey Society of Interventional Pain Physicians May 2005 Present North American Neuromodulation Society (NANS) February 2014 - Present North American Spine Society (NASS) February 2014 - Present World Institute of Pain June 2008 Present International Spine Intervention Society June 2013 Present HONORS/AWARDS COMMUNITY SERVICE: Medical Honoree American Cancer Society 28 th Annual Night of Wine and Roses Gala May 2014 Honoree-For Community Service Home Sharing, Inc. 2013 Harvest Jubilee October 2013 New Jersey Top Doctors-Peer Selected New Jersey Monthly Magazine 2010-2018 Physician s Recognition Award in Continuing Medical Education American Medical Association December 2007-2009 Award for Academic Excellence in Anesthesiology Robert Wood Johnson Medical School May 2000 Academic Scholarship for Pre-Med Students Office for Diversity and Academic Success in the Sciences Rutgers, the State University of New Jersey September 2009- Present BOARD OF DIRECTORS/TRUSTEES POSITIONS: New Jersey Society of Interventional Pain Physicians Director at Large Board of Trustee September 2010 - Present Page 3

Middlesex County Medical Society of New Jersey Board of Trustee January 2010 - Present President Elect June 2011 June 2012 President June 2012 June 2014 TEACHING RESPONSIBILITIES: 1. Clinical Assistant Professor Robert Wood Johnson Medical School July 2013 - Present 2. Postdoctoral Fellow Training in Pain Medicine JFK Medical Center Program Director July 2010 - Present 3. Resident Non-Hospital Site Training in Pain Medicine St. Peter s University Hospital July 2009 - Present 4. Clinical Instructor to Pre-Medical Students Rutgers, the State University of New Jersey August 2006 Present RESEARCH: 1. Principal Investigator: NIH sponsored study to evaluate the effects of physical therapy on post-mastectomy patients that are experiencing pain (September 2014 - June 2015 Phase III). 2. Principal Investigator: A randomized, double-blind, placebo-controlled study evaluating the efficacy, tolerability and safety of IV Neridronic Acid in the treatment of Complex Regional Pain Syndrome (June 2015 - February 2017 Phase III). 3. Principal Investigator: A multi-center, randomized trial evaluating Spinal Cord Stimulator Trial feedback (September 2014 - August 2015 Phase III). 4. Principal Investigator: A multi-center, quality of life study; pre- and post-stem cell injection of knee (October 2014 - March 2015 Phase III). 5. Principal Investigator: A multi-center, observational study to evaluate the clinical utility of pharmacogenomic testing (October 2014 - September 2015 Phase III). 6. Principal Investigator: A multi-center, observational study to evaluate the efficacy of topical compounded cream on chronic pain (Closed October 2015 Phase III). 7. Principal Investigator: Pharmacokinetic pediatric evaluation of once a day Hydromorphone Extended release for pediatric population with chronic pain (Closed 2014 Phase III). 8. Principal Investigator: A prospective, multi-center, randomized, controlled, double-blind study evaluating the Vertiflex Totalis Direct Decompression System for patients with spinal stenosis (May 15, 2015 October 2017 Phase III). 9. Principal Investigator: A multi-center, randomized, multi-phase, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of a monotherapy in subjects with signs and symptoms of osteoarthritis of the hip or knee (April 2015 June 2016 Phase III). Page 4

10. Principal Investigator: A multi-center, randomized withdrawal, double-blind, placebo-controlled trial to evaluate the efficacy and safety of guardian technology Oxycodone tablet in patients with moderate-to-severe chronic low back pain (December 2015 January 2017 Phase III). 11. Principal Investigator: A multi-center, randomized, double-blind, placebo and active-controlled, parallel-group study to evaluate the analgesic efficacy and safety of a monoclonal antibody in adult subjects with chronic low back pain (May 2016 August 2017 Phase III). 12. Principal Investigator: A prospective, multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of a single injection of stem cell alone or combined with hyaluronic acid in subjects with chronic low back pain (July 2017 ongoing Phase III). 13. Principal Investigator: A prospective, multi-center, post-market registry for evaluation of a spinal spacer for patients with moderate degenerative lumbar spinal stenosis (June 2018 ongoing Phase IV). PUBLICATIONS: Demesmin, Didier, MD., et al, Interventional Skills Competency in Pain Management in Pain Medicine Fellows ; American Journal of Physical Medicine and Rehabilitation, Submitted: June 2013. Demesmin, Didier, MD.; Parikh, Sagar, MD.; Hydrodiscectomy Chapter 34, In: Atlas of Pain Management Procedures, Editor Sudhir Diwan; McGraw Hill, New York, NY; Published February 2015. Liang, J., Williams, K., Lee, J., Ra, M., Demesmin, D. Pain Medicine. Physical Medicine and Rehabilitation Board Review 3 rd Edition. Cuccurullo (submitted and accepted for publication 2014) Parikh, Sagar, MD.; Demesmin, Didier, MD.; Spinal Cord Stimulation in the Setting of Brachial Plexopathy: A Case Report: Poster presented at the 13 th Annual Meeting of the American Society of Interventional Pain Physicians, Washington, DC; June 25-29, 2011-Abstract. Demesmin, Didier, MD.; Percutaneous Lumbar Disc Decompression Using SpineJet Microresector, Presented at the International Intradiscal Therapy Society, Poster, Toulouse, France, June 2007-Abstract. PRESENTATIONS: 1. Interim Analysis of Prospective, Multi-Center Outcome Observational Cohort Registry of Amniotic Fluid Treatment for Osteoarthritis of the Knee The 2015 Annual Scientific Meeting, Lake Buena Vista, Orlando, Florida, June 26-28 th, 2015. 2. Interim Analysis of Prospective, Multi-Center Outcome Observational Cohort Registry of Amniotic Fluid Treatment for Osteoarthritis of the Knee TOBI, June11-15 th 2015. 3. Spinal Cord Stimulation Device, Instructor/Lecturer, Saluda Medical Facility, Pennsylvania, October 25, 2014. 4. Interventional Pain Treatment for Cancer Pain, Tumor Board/Cancer Registry, St. Peter s University Hospital, New Brunswick, NJ, May 2014. 5. Mechanisms and Pathophysiology of Pain, Grand Rounds, St. Peter s University Hospital, New Brunswick, NJ, March 2014. 6. Latest Advances in Pain Medicine, Pain Management Lecture Series, Robert Wood Johnson University Hospital, New Brunswick, N.J., March 2014. 7. Minimally Invasive Discectomy Techniques, Course Director, Hydrocision Faculty, Tampa, FL, June 2009. 8. Overview of Interventional Pain Medicine, Grand Rounds, Robert Wood Johnson University Hospital, New Brunswick, NJ. April 2009. Page 5

9. Minimally Invasive Discectomy, Brazilian Conference on Minimally Invasive Spine Surgery, Sao Palo, Brazil, March 2009 (Phase III study). 10. Interventional Pain Management for Ischemic Pain, Grand Rounds, St. Peter s University Hospital, New Brunswick, NJ. October 2008. 11. Latest Advances in Pain Medicine, CME Lecture, Central New York Academy of Medicine, Utica, NY, November 2007. 12. Latest Advances in Pain Medicine, CME Grand Rounds, JFK Medical Center, Edison, NJ, October 2007. 13. Pain Management Principles: Lecture Series, St. Peter s University Hospital, New Brunswick, NJ, April 2007. 14. Overview of Opioid Pharmacology, Lecture Series, St. Peter s University Hospital, New Brunswick, NJ, March 2007. 15. Percutaneous Disc Decompression Workshop, Instructor, The Center for Ambulatory Resources (CARES), St. Peter s University Hospital, New Brunswick, NJ., February 2007. 16. Percutaneous Disc Decompression Techniques, Lecture, Italian Conference on Minimally Invasive Spine Treatment, Rome, Italy, November 2006. 17. Overview of Cancer Pain Management, Grand Rounds, St. Peter s University Hospital, New Brunswick, NJ, October 2006. 18. Interventional Pain Medicine Cadaver Workshop, Instructor/Lecturer, The Center for Ambulatory Resources (CARES), St. Peter s University Hospital, New Brunswick, NJ., August 2006. 19. Update in Interventional Pain Medicine, Grand Rounds, St. Peter s University Hospital, New Brunswick, NJ, August 2006. 20. Latest Advances in Pain Medicine, Grand Rounds, St. Peter s University Hospital, New Brunswick, NJ, July 2006. 21. Percutaneous Disc Decompression Cadaver Workshop Using the Spine Jet Microresector, Instructor/Lecturer, SUNY Syracuse School of Medicine, Syracuse, NY, March 2006. 22. Percutaneous HydroDiscectomy: Preliminary Results, Hydrocision Faculty, NY, November 2005. 23. Evaluation and Management of Chronic Pelvic Pain, Grand Rounds, Columbia College of Physicians and Surgeons/St. Luke s Roosevelt Hospital, New York, NY. March 2005. 24. Selective Topics in Pediatric Pain Management, Grand Rounds, SUNY Downstate Medical Center, Brooklyn, NY, December 2003. 25. Anesthetic Considerations for Premature Infants with Necrotizing Enterocolitis, Grand Rounds, SUNY Downstate Medical Center, Brooklyn, NY, October 2002. Page 6