BUPIVACAINE LIPOSOME (EXPAREL): Adjunct to Regional Anesthesia NEBRASKA ASSOCIATION OF NURSE ANESTHETISTS Spring Meeting: April 27-29, 2018 Sallie Poepsel, PhD, MSN, CRNA, APRN Director, AANA Region IV No Financial interests to disclose OBJECTIVES Describe the pharmacokinetics and pharmacodynamics of Exparel. List the indications for use of Exparel in post-op pain management. Identify the benefits and risks associated with Exparel use. Using case reports, delineate the post-op pain management outcomes associated with the use of Exparel 1
DepoFoam Encapsulated Bupivacaine DepoFoam drug delivery system composed of multivesicular liposomes Extended release of bupivacaine for long-acting pain relief Analgesic effect localized to injection site BUPIVACAINE Multivesicular Liposome In 2011:. 2 positive Phase 3, randomized, double-blind, placebocontrolled trials Demonstrated efficacy in 2 representative acute pain models 1) Hemorrhoidectomy 2) Bunionectomy 2
Clinical Studies: Exparel Study Clinical Setting Region Nerve Block 322 Thoracotomy Thoracic Intercostal 323 TKA Lower Femoral Multimodal Management Recommended to Manage Acute Postsurgical Pain Combines 2 analgesic agents or techniques that act by different mechanisms to provide better pain relief with fewer opioids Usually includes systemic analgesics with local anesthetics Post-Op Surgical Pain: What we know unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage is as subjective and variable as the perception of pain surgeons interpret and manage pain differently 3
Post-Op Surgical Pain: What we know the treatment of post-surgical pain varies so greatly Pharmacological agents remain the mainstay of the management of acute perioperative and postoperative pain Treatment requires a combination of multiple pharmacotherapies and routes of delivery Bupivacaine Liposome Injectable Suspension Intended Response single-dose administration into the surgical site to produce postsurgical analgesia blocks the generation and the conduction of nerve impulses * increasing the threshold for electrical excitation in the nerve, * slowing the propagation of the nerve impulse, * reducing the rate of rise of the action potential. 4
Pharmacokinetics Absorption - The rate of systemic absorption of bupivacaine is dependent upon the total dose of drug administered, the route of administration, and the vascularity of the administration site Distribution - appear to cross the placenta by passive diffusion Metabolism - are metabolized primarily in the liver via conjugation with glucuronic acid Excretion - kidney is the main excretory organ for most local anesthetics and their metabolites Interactions with other Drugs: EXPAREL should not be admixed with lidocaine or other nonbupivacaine-based local anesthetics. EXPAREL may be administered after at least 20 minutes or more have elapsed following local administration of lidocaine Side Effects Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal local anesthetics can produce central nervous system stimulation, depression, or both 5
EXPAREL FDA approved, opioid-free, bupivacaine-based, long-acting local anesthetic Bupivacaine used for nearly 50 years WHO essential medication EXPAREL used more than 3,000x per day via infiltration / field block for safe and effective, long-lasting analgesia EXPAREL can reduce postsurgical use of opioids Data support broad nerve block indication DOSAGE & ADMINISTRATION intended for single-dose administration only. Recommended dose of EXPAREL based on the following factors: Size of the surgical site Volume required to cover the area Individual patient factors that may impact the safety of an amide local anesthetic Maximum dose of 266 mg (20 ml) As general guidance in selecting the proper dosing for the planned surgical INJECTION GUIDELINES EXPAREL should be injected slowly into soft tissues of the surgical site with frequent aspiration to check for blood and minimize the risk of intravascular injection. EXPAREL is single-dose administration only. EXPAREL should be administered with a 25 gauge or larger bore needle. The maximum dosage of EXPAREL should not exceed 266 mg (20 ml, 1.3% of undiluted drug). EXPAREL can be administered undiluted or diluted to increase volume up to a final concentration of 0.89 mg/ml (i.e. 1:14 dilution by volume) with normal (0.9%) saline or lactated Ringer s solution. 6
DOSAGE & ADMINISTRATION As general guidance in selecting the proper dosing for the planned surgical site: a) Example bunionectomy A total of 8 ml (106 mg) was administered 7 ml of EXPAREL infiltrated into the tissues surrounding the osteotomy, and 1 ml infiltrated into the subcutaneous b) Example hemmorhoidectomy A total of 20 ml (266 mg=13.3mg/ml) of EXPAREL diluted with 10 ml of saline, for a total of 30 ml (8.86 mg/ml), divided into six 5 ml aliquots, injected by visualizing the anal sphincter as a clock face and slowly infiltrating one aliquot to each of the even numbers to produce a field block COMPATIBILITY CONSIDERATIONS The administration of EXPAREL may follow the administration of lidocaine after a delay of 20 minutes or more. When a topical antiseptic such as povidone iodine (e.g., Betadine ) is applied, the site should be allowed to dry before EXPAREL is administered into the surgical site. Bupivacaine HCl administered together with EXPAREL may impact the pharmacokinetic and/or physicochemical properties of EXPAREL, and this effect is concentration dependent. Hernia Repair (inguinal) DRUG ONSET PEAK DURATION Bupivacaine HCL 100 mg 5 min 0-1 hr 8 Exparel 266 mg 5 min P1: 0-2 hrs. P2: 12-24 72 hrs. 7
Journal of Pain, Vol. 17, No.2 (February 2016) pp.13-157 www.jpain.org or www.sciencedirect.com Chou et al. J Pain 2016;17:131-57. Application to the Practice Setting There were studies done on the effect of Exparel on patients Exparel dose demonstrated a significant reduction in pain intensity compared to placebo for up to 24 hours The findings from these studies would be helpful when applied in practice should help practitioner to properly administer and handle the medication Dosing: (following regional blocks: IS or ankle block) 1) added 10 ml of saline to 20 ml vial (266 mg) Exparel (total of 30 ml = 8.86 mg/ml); 5-10 ml injected each layer from the incision line in a fan fashion) 2) 266 mg (20 ml) diluted with 10 ml; injected 15 ml total (half volume = 133 mg) to (20 ml =177 mg) 3) all tissue injections done before closure 8
Dosing: (for hemorrhoidectomy) 1) added 10 ml of saline to 20 ml vial (266 mg) Exparel (total of 30 ml (8.86 mg/ml) 2) divided into six 5 ml aliquots -produce a field block injected in a clockwise fashion by slowly infiltrating one aliquot to each of the even numbers (in the clock) to a total of 30 ml (266 mg) CASE REPORTS:Pain Scale (IS Block + Exparel) PROCEDU RE Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 RCR (L) 0.5 0.5 1 1 2 2.5 RCR (R) 0 1 1 1 1.5-2 2 RCR (R) 0 0.5 1 1.5 1.5-2 2 RCR (L) 0 0.5 0.5 1 1-1.5 1.5-2.0 Post-Op Pain Progression 2.5 Progression 2 PainScale 1.5 1 0.5 0 1 2 3 4 5 6 Days Post-Op 9
CASE REPORTS: Opioids/NSAIDS Use Case Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 RCR (R) none none none none NSAID NSAID RCR (R) none none none none NSAID Opioid x1 RCR (R) none none none NSAID NSAID NSAID RCR (R) none none none none Opioid x1/ns AID NSAID Summary Decreases pain Single timepoint Over time Multiple surgical models Simple to use: Single intra-op administration Easy to inject Fine gauge needle Decreases opioids: Amount used & Time to first use Excellent safety No need for external device No long-term impact Summary: con t The benefits of Exparel extend well beyond effective pain control other recovery-related outcomes opioid burden, hospital stay time to rehabilitation, Collectively impact not only institutional costs, but also patient satisfaction (Pacira, 2015) 10
References Apfelbaum JL, Chen C, Mehta SS, Gan T. J. (2005, October). Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesthesiology, 103(4):681-3. Retrieved from http:// www.ncbi.nlm.nih.gov/pmc/articles/pmc3073562/ Arcangelo, V. & Peterson, A. (2013). Pharmacotherapeutics for advanced practice. Philadelphia, PA: Lippincott, Williams, & Wilkins. ISBN 978-1-4511-1197-2. ASA Task Force on Pain Management. (1995). Practice guidelines for acute pain management in the perioperative setting. Anesthesiology, 82(1071). Retrieved from http://medind.nic.in/iad/t06/i5/iadt06i5p340.pdf Brennan, T. J., M.D., Ph.D. (2011, January). Pathophysiology of postoperative pain. Pain. 152(3): S33 S40. Doi: 10.1016/j.pain.2010.11.005. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3073562/ Krenzischek, D. A. MAS, RN, CPAN, Dunwoody, C. J., MS, RN-BC, Polomano, R. C., PhD,RN, FAAN, and Rathmell, J. P., M.D. (2008, February). Pharmacotherapy for acute pain: implications for practice. Journal of PeriAnesthesia Nursing 23(1). Retrieve from http://www.sciencedirect.com/ science/article/pii/s1089947207003267 References Pacira Pharmaceuticals, Inc. (2014). Prescribing information for Exparel. Retrieved from the Exparel Website: http://www.exparel.com/hcp/pdf/ EXPAREL_Prescribing_Information.pdf Pacira Pharmaceuticals, Inc. (2015). New study finds decreased opioid use, hospital stay and readmission rates with Exparel Following Knee Replacement Surgery. Retrieved from http://investor.pacira.com/phoenix.zhtml? c=220759&p=irolnewsarticle&id=2108128 Rao, M., M.D. (2006, October). Acute post-operative pain. Indian Journal of Anesthesia (5): 340 344. Retrieved from http://medind.nic.in/iad/t06/i5/iadt06i5p340.pdf Yu, S.BS; Szulc, A. MA; Walton, S. L. MD; Bosco III, J.A MD; Iorio, R. M.D. (2015, November) Liposomal Bupivacaine versus femoral nerve block for pain control in total knee arthroplasty. Retrieved from https://aahks.apprisor.org/ epsabstractaahks.cfm?id=2 Questions 11
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