ARE YOU AT RISK OF A HEART ATTACK OR STROKE? Understand How Controlling Your Cholesterol Reduces Your Risk

ARE YOU AT RISK OF A HEART ATTACK OR STROKE? Understand How Controlling Your Cholesterol Reduces Your Risk

CONSIDER YOUR HEART HEALTH: REDUCE YOUR CHOLESTEROL Uncontrolled or continuous high cholesterol is a serious risk factor for cardiovascular disease and could lead to a heart attack or stroke. 1 You can t see or feel cholesterol, but it s there and could lead to an emergency. What is cholesterol? Cholesterol is a fatty substance in the blood. You need some cholesterol to be healthy, as it helps your body to generate new cell walls, hormones and bile acids. 2 However, too much can build up within your arteries, making them too narrow. 3 This can lead to a cardiovascular health emergency. It includes good and bad cholesterol, apart from other components: High-density lipoprotein (HDL), the good cholesterol 2 Low-density lipoprotein (LDL), the bad cholesterol 2 NORMAL ARTERY WITH NORMAL BLOODFLOW PLAQUE FORMATION WITH CHOLESTEROL DEPOSIT AND REDUCED BLOODFLOW RUPTURED PLAQUE WITH OBSTRUCTED BLOODFLOW 3,4

HIGH BAD CHOLESTEROL HIGH RISK OF HEART ATTACK OR STROKE 2 Every year, more than 30million people suffer from a heart attack or stroke 5 1 in 3 NEARLY WILL HAVE A SUBSEQUENT CARDIOVASCULAR EVENT. 6 HIGH LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C) If your patient has suffered previous MI or stroke and still has elevated LDL-C, despite use of high-intensity statins, HELP YOUR PATIENTS MANAGE THEIR CARDIOVASCULAR HEALTH

REDUCE THE RISK OF A HEART ATTACK OR STROKE Your cholesterol won t go down by itself. Reduce the risk of another heart attack or stroke by reducing your cholesterol. 1 Do all you can to lower cholesterol following a heart attack or stroke. Certain lifestyle changes can help, such as eating a healthy diet, quitting smoking and exercising more. 7 It s also important that you stay on therapy. Don t forget to take the medication prescribed by the doctor to reduce the risk of another heart attack or stroke. Immediately following your heart attack or stroke is the best time to take action. Reduce your concern by addressing the risk as soon as possible. Ask your doctor what steps you can take to address your high cholesterol and risk of having another heart attack or stroke.

RISK FACTORS INCLUDE: 7 LDL High LDL-C HDL Diabetes Hypertension Low HDL Inadequate fruit/vegetable intake Lack of exercise Obesity Consumption of alcohol Smoking Psychosocial factors

HAVE YOU ASKED YOUR DOCTOR AM I DOING ENOUGH? If you already suffer from high cholesterol it is likely that your doctor has prescribed a statin or other traditional lipid-lowering medication. However, this isn t always enough to lower bad cholesterol for some people. Even if you are taking a therapy such as a statin, the risk of a heart attack or stroke may still persist. 8,9 Talk to your doctor about innovative cholesterol treatment options that lower your cholesterol and your risk of an event.

YOU ARE NOT ALONE It s natural to worry after a heart attack or stroke. But you are not alone in this. Enlist the support of your family, friends, local patient group and care team. They are there to help you. IT S TIME TO TAKE CONTROL Take the right steps to put your health first. Don t wait. Schedule an appointment with your doctor to discuss your cholesterol. If your numbers are too high despite being on a cholesterol-lowering therapy, talk to your doctor about innovative treatments that can help reduce your risk of another heart attack or stroke. 10 Be in control of your health, fully engage in life and reduce the hidden risk of heart attack or stroke. LOWER BAD CHOLESTEROL LOWER RISK OF HEART ATTACK OR STROKE 2

Visit www.emergencycholesterol.com for more information Referencias 1. World Health Organization. Raised Cholesterol. Available at: http://www.who.int/gho/ncd/risk_factors/cholesterol_text/en/last accessed June 2018 2. Goldstein, J. L., & Brown, M. S. (2009). History of Discovery: The LDL Receptor. Arteriosclerosis, Thrombosis, and VascularBiology, 29(4), 431 438. http://doi.org/10.1161/atvbaha.108.179564 3. Hansson, G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352, 1685-1695 (2005). 4. Glaglov S. Compensatory Enlargement of Human Atherosclerotic Coronary Arteries. N Engl J Med 316,1371-1375 (1987). 5. World Health Organization. Prevention of Recurrences of Myocardial Infarction and Stroke Study The PREMISE programme: country projects. Available at: http://www.who.int/cardiovascular_diseases/priorities/secondary_prevention/country/en/index1.html Last accessed June 2018 6. Bhatt DL, Eagle KA, Ohman EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients atrisk of or with atherothrombosis. JAMA.2010;304:1350-1357. Available at: https://www.ncbi.nlm.nih.gov/pubmed/20805624 Last accessed June 2018 7. Yusuf S, Hawken S, Ôunpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937-952. 8. Sampson UK. et al. Residual Cardiovascular Risk Despite Optimal LDL-Cholesterol Reduction with Statins: The Evidence, Etiology, and Therapeutic Challenges. NIH. 14(1): 1 10. doi:10.1007/s11883-011-0219-7. (2012). 9. Wong ND, et al. Prevalence of the American College of Cardiology/American Heart Association statin eligibility groups, statin use, and low-density lipoprotein cholesterol control in US adults using the National Health and Nutrition Examination Survey 2011 2012. Journal of Clinical Lipidology 10, 1109 1118. (2016). 10. Sabatine et al. Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels - A Meta-analysis; JAMA Cardiol. doi: 10.1001/jamacardio.2018.2258 Amgen Middle East FZ-LLC Business Central Tower A, 2007 P.O Box 502607, Dubai, UAE PR-NA-ARE-000016 Sep 18