Pushkar Mehra, BDS, DMD Formerly,Fellow Oral and Maxillofacial Currently, Assistant Professor Oral and Maxillofacial Boston University School of Dental Medicine Director Boston Medical Center Boston, Massachusetts Larry M. Wolford, DMD Clinical Professor of Oral and Maxillofacial Private Practice Joel K. Hopkin, DMD, MD Formerly, Resident Currently, Private Practice Salem, Oregon Vanessa Castro, DDS Formerly,Visiting Research Fellow Currently, Private Practice Brazil Rogerio Frietas, DDS Formerly,Fellow Currently, Private Practice Brasilia, Brazil Reprint requests: Dr Larry M. Wolford 3409 Worth Street, Suite 400 Sammons Tower Dallas, TX 75246 Fax: +214-828-1714 E-mail: lwolford@swbell.net Int J Adult Orthod Orthognath Surg Vol. 16, No. 3, 2001 Stability of maxillary advancement using rigid fixation and porous-block hydroxyapatite grafting: Cleft palate versus non-cleft patients This study was undertaken to evaluate the stability of maxillary advancement using bone plates for skeletal stabilization and porous block hydroxyapatite (PBHA) as a bone graft substitute for interpositional grafting in cleft and non-cleft patients. The records of 74 patients (41 females, 33 males) who underwent Le Fort I maxillary advancement using rigid fixation and PBHA interpositional grafting were evaluated retrospectively. All patients also underwent simultaneous sagittal split mandibular ramus osteotomies. Patients were divided into 2 groups for study purposes: group 1 consisted of 17 cleft palate patients and group 2 consisted of 57 non-cleft patients. Each group was further subdivided into 2 subgroups based on the concurrent vertical positioning of the maxillary incisors: groups 1a and 2a, where the maxilla underwent 3 mm or more of inferior repositioning, and groups 1b and 2b, where the maxilla underwent minimal vertical change ( 1 mm). Presurgery, immediate postsurgery, and longest follow-up lateral cephalometric tracings were superimposed and analyzed to calculate surgical change and long-term stability of results by assessing horizontal and vertical changes at point A, incisor superius, and the mesial cusp tip of maxillary first molar. The average follow-up time in group 1 was 37.9 months (range 12 to 136) and in group 2 was 28.77 months (range 17 to 88). Average maxillary advancement at point A was: group 1a, 5.4 mm; group 1b, 5.25 mm; group 2a, 5.48 mm; group 2b, 5.46 mm. Average relapse at point A was: group 1a, 0.75 mm; group 1b, 1 mm; group 2a, 0.47 mm; group 2b, 0.48 mm. Average horizontal and/or vertical relapse at the central incisors and first molars was 1 mm or less in group 1 and less than 0.5 mm in group 2. Although there was a slightly greater relapse in group 1, no statistically significant difference was observed between the groups. Maxillary advancement with Le Fort 1 osteotomies using rigid fixation and interpositional PBHA grafting during bimaxillary surgery is a stable procedure with good predictability in cleft and non-cleft patients, regardless of the direction of vertical maxillary movement. (Int J Adult Orthod Orthognath Surg 2001;16:193 199) The stability of maxillary advancement with the Le Fort I level osteotomy has been studied extensively. Factors implicated in contributing to instability of this procedure include presurgical orthodontics, inadequate mobilization, inappropriate or lack of bone grafting, increased masticatory forces, inadequate methods of fixation, type and amount of movement, soft tissue tension, 193 and presence of clefts. 1 8 The cleft palate patient has scarred soft tissues from previous palatal/pharyngeal surgery, which restricts maxillary advancement and places posteriorly directed tension on the maxilla. These factors, combined with normal masticatory function, may be responsible for the marked skeletal and dental relapse seen after maxillary advancement in cleft patients. 6,9 11
194 Mehra et al Fig 1a Coralline PBHA blocks (Interpore 200, Interpore International). Although historically, various fixation techniques have been used for maxillary stabilization (transosseous and suspension wires, 8 threaded Steinmann pins, 12 and intraoral skeletal fixation appliances 13 ), the most popular contemporary method of fixation utilizes bone plates and screws for stabilizing the osteotomized segments. 14 16 Different grafting materials have been used to fill continuity defects, including autogenous rib, cranial bone, and iliac crest bone grafts 17 ;freeze-dried bone 18 ;proplast blocks 19 ;solid-block hydroxyapatite grafts 20 ; and porous-block hydroxyapatite grafts (PBHA). 3 Questions remain regarding the most predictable method for fixation, as most studies have been plagued by variable factors such as type and amount of maxillary movement, multiple surgeons involved, small sample size, length of time for followup, and different methods of fixation employed within the study sample. The aim of this retrospective study was to assess our experience with the stability of the Le Fort I maxillary advancement using rigid fixation for skeletal stabilization and porous-block hydroxyapatite (Interpore 200, Interpore International) as a bone graft substitute (Fig 1a) in cleft palate and non-cleft patients undergoing bimaxillary surgery. Patients and methods A retrospective analysis was performed on the records of 74 patients (41 females Fig 1b A graft is cut from a larger block using a #701 tapered fissure bur with copious irrigation. Final contouring of each graft is done with a #15 scalpel blade. and 33 males) with a presurgical diagnosis of anteroposterior (A-P) maxillary hypoplasia. Average age of the patient sample was 28.4 years (range 15 to 62 years). All patients were operated by one surgeon and underwent multiple-segment Le Fort I osteotomies using the maxillary step osteotomy modification in combination with bilateral mandibular ramus sagittal split osteotomies. Criteria for inclusion in the study included: (1) bimaxillary surgery with multiple segmental Le Fort I osteotomy for maxillary advancement, (2) minimum of 12 months postsurgery follow-up, (3) rigid internal fixation using 4 bone plates (2.0- mm-diameter screws), and (4) use of PBHA interpositional grafts (Fig 1b) along the lateral maxillary walls and at the maxillary step areas between the advanced maxilla and stable bones (Figs 2 and 3). The PBHA grafts were first shaped from larger blocks (15 50 6 mm) using a #701 tapered fissure bur (Fig 1b) and a #15 scalpel blade and were then wedged into position without direct fixation with screws or wires. For study purposes, the 74 patients were divided into 2 groups: group 1 (17 cleft palate patients) and group 2 (57 noncleft patients). Each group was further subdivided into 2 subgroups based on the concurrent vertical positioning of the maxillary incisors: groups 1a (10 patients) and 2a (27 patients), where the maxilla was advanced horizontally and repositioned inferiorly (3 mm or greater inferior
c repositioning), and groups 1b (7 patients) and 2b (30 patients), where the maxilla was advanced horizontally with minimal change in vertical position (1 mm or less change in vertical position). Standardized lateral cephalometric radiographs taken before surgery (T1), immediately postsurgery (T2), and at the longest follow-up (T3) were traced by an independent examiner who was not involved in any of the surgeries. The tracings were superimposed and assessed under magnification (6 ) to calculate surgical change (T2 T1) and long-term stability of results (T3 T2) at the following landmarks: point A (A), incisor superius (Is), and mesial cusp tip of the maxillary first molar (molar superius [Ms]). Postsurgical relapse was measured in a horizontal (A-P) and vertical direction using the same dental landmarks and in an A-P direction for the skeletal landmark (A). The 6 magnification was used to improve the accuracy of assessment, since many of the measurements were small in magnitude; the numeric values determined at magnification were then divided by a factor of 6 to determine the actual changes. The Student t test was used to determine the statistical significance of the data obtained, and a P value of less than.05 was considered to be statistically significant. b a Int J Adult Orthod Orthognath Surg Vol. 16, No. 3, 2001 195 Fig 2 (left) Maxillary advancement using the maxillary step osteotomy technique with rigid fixation with bone plates. The osteotomy areas (a, b, c) are filled with PBHA interpositional grafts. Fig 3 (below) Intraoperative photograph showing placement of PBHA interpositional grafts in the left maxillary osteotomy areas after advancement. Table 1 Results Horizontal surgical stability (means and ranges) at point A A-P change at point A (mm) Group advancement Relapse 1a (n = 10) 5.40 (5 to 9) 0.75 (0 to 2) 1b (n = 7) 5.25 (5 to 8) 1.00 (0 to 2) 2a (n = 27) 5.48 (5 to 9) 0.47 (0 to 2) 2b (n = 30) 5.46 (5 to 10) 0.48 (0 to 2) The average follow-up time in group 1 was 37.9 months (range 12 to 136 months) and in group 2 was 28.7 months (range 17 to 88 months). Anteroposterior skeletal stability (Table 1) The average A-P maxillary advancements measured at A for the 4 subgroups were: group 1a, 5.4 mm (range 5 to 9 mm); group 1b, 5.25 mm (range 5 to 8 mm); group 2a, 5.48 mm (range 5 to 9 mm); group 2b, 5.46 mm (range 5 to 10 mm). The average A-P relapse as measured at A was 1 mm or less in group 1 and less than 0.5
196 Mehra et al Table 2 Horizontal surgical stability (means and ranges) at the incisors and molars A-P change at incisor (mm) mm in group 2. Although the cleft group had slightly greater relapse, the difference in stability between the 2 groups was not statistically significant (P >.05). Anteroposterior dental stability (Table 2) The average A-P advancements measured at the dental landmarks for the 4 subgroups were: group 1a,4.7 mm (range 3.5 to 5 mm) at the incisors and 4.9 mm (range 3.5 to 5 mm) at the molars; group 1b, 5.1 mm (range 3.5 to 5.5 mm) at the incisors and 5.5 mm (range 3.5 to 6 mm) at the molars; group 2a, 6.57 mm (range 5 to 10 mm) at the incisors and 6.9 mm (range 5 to 11 mm) at the molars; and group 2b, 6.73 mm (range 5 to 11 mm) at the incisors and 6.7 mm (range 5 to 12 mm) at the molars. The average A-P relapse at the incisors or molars was 1 mm or less in group 1 and less than 0.5 mm in group 2. There were no statistically significant differences between the groups (P >.05). A-P change at molar (mm) Group advancement Relapse advancement Relapse 1a (n = 10) 4.7 (3.5 to 5) 1 (0 to 3) 4.9 (3.5 to 5) 1 (0 to 4) 1b (n = 7) 5.1 (3.5 to 5.5) 0.7 (0 to 1) 5.5 (3.5 to 6) 0.45 (0 to 1) 2a (n = 27) 6.57 (5 to 10) 0.48 (0 to 1.2) 6.9 (5 to 11) 0.44 (0 to 2) 2b (n = 30) 6.73 (5 to 11) 0.45 (0 to 1.5) 6.7 (5 to 12) 0.48 (0 to 3) Table 3 Vertical surgical stability (means and ranges) at the incisors and molars Vertical change at incisor (mm) Vertical change at molar (mm) Group change Relapse change Relapse 1a (n = 10) 3.76 (3 to 5) 0.8 (0 to 2) 3.1 (3 to 3.5) 0.5 (0 to 1.5) 1b (n = 7) 0.75 (0 to 1) 0.5 (0 to 1) 0.75 (0 to 1) 0.45 (0 to 1) 2a (n = 27) 4.06 (3 to 7) 0.35 (0 to 1.2) 3.92 (3 to 10.5) 0.44 (0 to 1.5) 2b (n = 30) 0.18 ( 1 to 1) 0.04 (0 to 0.5) 0.6 (0 to 1) 0.11 (0 to 0.5) Vertical dental stability (Table 3) The average vertical surgical change for the 4 subgroups (positive numbers indicate inferior repositioning and negative numbers indicate superior repositioning) were as follows: group 1a, 3.76 mm (range 3 to 5 mm) at the incisors and 3.1 mm (range 3 to 3.5 mm) at the molars; group 1b, 0.75 mm (range 0 to 1 mm) at the incisors and 0.75 mm (range 0 to 1 mm) at the molars; group 2a, 4.06 mm (range 3 to 7 mm) at the incisors and 3.92 mm (range 3 to 10.5 mm) at the molars; group 2b, 0.18 mm (range 1 to 1 mm) at the incisors and 0.6 mm (range 0 to 1 mm) at the molars. The average postsurgical vertical relapse was 0.8 mm or less in group 1 and 0.35 mm or less in group 2. There were no statistically significant long-term differences between the groups (P >.05).
Discussion Int J Adult Orthod Orthognath Surg Vol. 16, No. 3, 2001 197 The Le Fort I osteotomy of the maxilla is the most commonly performed surgical procedure for correction of maxillary and midfacial deformities. Stability of the Le Fort I osteotomy is considered essential for a stable and predictable postsurgical result. The etiology of relapse after Le Fort I maxillary advancement is considered to be multifactorial, and conditions such as soft tissue mobilization, approximation of osteotomized bony walls, bone quality, dental occlusion/orthodontics, masticatory and respiratory function, use of interpositional grafts, presence of clefts, previous surgical procedures, and type of fixation are considered to be important. 1 8 It is generally agreed that superior repositioning of the maxilla with the Le Fort I osteotomy is stable, provided bone contact and stabilization are adequate. 21 However, contrasting results have been reported with inferior repositioning, superior repositioning when bone contact is poor or thin, and with advancement of the maxilla. 21 Stability of the maxilla after bimaxillary surgery has been reported to be equivalent to that seen following single-jaw (maxilla-only) surgery. 1,22 Although both non-rigid fixation (wire fixation) and rigid internal fixation (bone plates and screws) can be used for stabilization of the Le Fort I osteotomy, the latter technique is currently more popular. Use of rigid internal fixation eliminates the need for maxillomandibular fixation, thereby leading to increased patient comfort, improved oral hygiene, improved dietary considerations, faster healing, and increased stability of postsurgical results. Satrom et al 23 and Mogavoro et al 24 demonstrated significantly better stability using bone plate stabilization as compared to wire fixation in bimaxillary surgery. All patients in our study had rigid internal fixation with 4 bone plates (one plate each at the lateral pyriform rim and zygomatic buttress bilaterally) stabilized with screws 2.0 mm in diameter and 5.0 mm in length. For each bone plate, 2 screws were placed above and at least 2 screws were placed below the osteotomy level. The need for interpositional grafting in maxillary osteotomies has also been a subject of debate, with studies reporting contrasting results. 10,25 Interpositional grafting may be indicated in maxillary orthognathic surgery where bony continuity defects exist for several reasons 26 :to provide bony continuity, to improve bone healing, to decrease postsurgical relapse, and to provide surgical stability in traditionally unfavorable orthognathic movements. Various materials have been utilized for interpositional grafting, including autogenous bone, freeze-dried bone, silastic, proplast, solid-block HA, and PBHA. 3,17 20,26,27 Although autogenous bone grafts are the most popular material used for interpositional grafting in maxillary surgery, they have significant disadvantages, including the requirement for a second surgical site with associated harvest morbidity, difficulty in shaping the grafts, and the physiologic process of remodeling and resorption that occurs during healing, which could result in unpredictable relapse. Freeze-dried bone undergoes even greater resorption and remodeling, takes longer to heal, and has the problems associated with being a homograft. Solid-block HA does not allow bone ingrowth, is very difficult to shape, and does not get intimately incorporated into the host bony matrix. Coralline PBHA (Fig 1) is approved by the United States Food and Drug Administration specifically for use in orthognathic surgery and is a very attractive alternative for use as an interpositional grafting material in cases where grafting is indicated. It is porous and osteoconductive, allowing for intimate bony ingrowth through it. The pore size is similar to normal osteon size in bone (190 µm). Advantages of the use of PBHA as an alloplastic implant material include 26 : (1) no donor site morbidity, (2) no resorption, (3) no known hypersensitivity or immune response, (4) ease of manipulation, (5) no constraints on working time, (6) shorter overall surgical time compared with bone grafting, (7) shorter recovery time, and (8) unlimited volume availability. Wolford et al 27 introduced the use of PBHA as a bone graft substitute in orthognathic surgery in 1987 and reported a high success rate in 92 consecutive patients. In a subsequent study, Wardrop and Wolford reported 1 mm or less of horizontal relapse in 14 patients after
198 Mehra et al maxillary advancement using rigid fixation and PBHA grafting, and recommended that grafting be used in cases where the advancement is 5 mm or greater in magnitude. 3 The successful use of PBHA grafting for maxillary downgrafting and advancement has been demonstrated. 3,28,29 Cottrell and Wolford 26 presented 5- to 10-year follow-up data on 110 patients with 403 PBHA implants placed in the maxilla and found that lateral maxillary wall grafting had a 95.7% long-term success rate. Holmes et al 30 conducted a histologic analysis of 17 human biopsy specimens of PBHA implants used in orthognathic surgery and showed an average composition of 48.5% hydroxyapatite matrix, 18% bone, and 33.5% soft tissue/vascular space in healed PBHA grafts. They also showed that bone growth through the PBHA graft was essentially complete at 4 months postsurgery, and subsequent changes involved maturation of the ingrown bone. Ayers et al 31 demonstrated that the human body establishes a near balance between the PBHA graft and surrounding maxillary bone relative to long-term bone ingrowth and microhardness of grafts placed during maxillary orthognathic surgery. Rigid fixation of the maxilla is critical for success when using PBHA, as it provides for stress-shielding of the graft material and minimizes micromovement during the initial healing phase. An important factor is that PBHA is brittle to handle, and like any new technique, there is a learning curve for the clinician when first using it. Once the practitioner is experienced, it should take him or her only 10 to 15 minutes to appropriately contour and place the HA grafts in position. Although our study has the disadvantage of being retrospective in nature and lacking a control group (non-grafted group), it shows that rigid fixation with PBHA grafting is a very effective way to minimize postsurgical relapse following maxillary advancements in bimaxillary surgery for cleft palate and non-cleft patients. Interpositional grafting was used on all patients included in this study because of 1 or more of the following factors that predispose to greater relapse: presence of clefts (group 1), more than 5 mm of advancement (groups 1 and 2), and inferior repositioning of the maxilla (groups 1a and 2a). Cleft palate patients are known to relapse more (up to 68%) than non-cleft patients after surgical correction of maxillary hypoplasia, and some authors advocate significant overcorrection to compensate for this relapse tendency. 9,32 In our study also, as expected, a greater skeletal relapse tendency was seen in the cleft group (approximately 25% of the A-P advancement) as compared to the non-cleft group (approximately 10% of the A-P advancement). The molars were generally seen to advance a greater amount than the incisors because of surgical maxillary expansion, which moves the molars forward relative to the incisors. It is possible that some of the dental changes reported may be a result of postsurgical dental/orthodontic changes. All patients had segmental maxillary surgery, and the maxillary and mandibular teeth were placed into the best occlusion possible at the time of surgery, thereby avoiding final occlusal coverage splints (some patients had palatal splints but without any occlusal coverage). No maxillomandibular fixation was used postsurgery, but light-force interarch elastics were usually applied to help control the occlusal relationships. This is the first reported study that has compared cleft and non-cleft patients for long-term stability of Le Fort I maxillary advancement (with the use of rigid fixation and PBHA grafting) during bimaxillary surgery. The use of rigid internal fixation and interpositional PBHA grafting provides for stable and predictable postsurgical outcomes after maxillary advancement in both cleft and non-cleft patients. References 1. Bothur S, Blomquist JE, Isakson S. Stability of Le Fort I osteotomy with advancement: A comparison of single maxillary surgery and a two-jaw procedure. J Oral Maxillofac Surg 1998;56: 1029 1033. 2. Schendel SA. Stability of Le Fort I osteotomy with advancement: A comparison of single maxillary surgery and a two-jaw procedure [discussion]. J Oral Maxillofac Surg 1998;56:1033 1034. 3. Wardrop RW, Wolford LM. Maxillary stability following downgraft and/or advancement procedures with stabilization using rigid fixation and porous block hydroxyapatite implants. J Oral Maxillofac Surg 1989;47:336 342.
4. Posnick JC, Dagys AP. Skeletal stability and relapse patterns after Le Fort I maxillary osteotomy fixed with miniplates: The unilateral cleft lip and palate deformity. Plast Reconstr Surg 1994;94(7): 924 932. 5. Freihofer HP Jr. Results of osteotomies of the facial skeleton in adolescence. J Maxillofac Surg 1977;5:267 297. 6. Eskenazi LB, Schendel SA. An analysis of Le Fort I maxillary advancement in cleft lip and palate patients. Plast Reconstr Surg 1992;5:779 786. 7. Louise PJ, Waite PD, Austin RB. Long-term skeletal stability after rigid fixation of Le Fort I osteotomies with advancement. Int J Oral Maxillofac Surg 1993;22:82 86. 8. Egbert M, Hepworth B, Myall, West R. Stability of Le Fort I osteotomy with maxillary advancement: A comparison of combined wire fixation and rigid fixation. J Oral Maxillofac Surg 1995;53: 243 248. 9. Bertolini F, De Rui G, Blasio AD, Sesenna E. Skeletal relapse of maxillary osteotomies in unilateral cleft lip and palate patients. Int J Adult Orthod Orthognath Surg 2000;15:30 36. 10. Wilmar K. On the Le Fort I osteotomy. Scand J Plast Reconstr Surg 1974;12:1 68. 11. Epker BN, Wolford LM. Middle-third facial osteotomies: Their use in the correction of congenital dentofacial and craniofacial deformities. J Oral Surg 1976;34:324 329. 12. Bennett MA, Wolford LM. The maxillary step osteotomy and Steinmann pin stabilization. J Oral Maxillofac Surg 1985;43:307 311. 13. Wessberg GA, Epker BN. Intraoral skeletal fixation appliance. J Maxillofac Surg 1981;9:237 239. 14. Schilli W, Niederdellman H, Harle F. Stable osteosynthesis in treatment of dentofacial deformity. In: Bell WH (ed). Correction of Dentofacial Deformities, vol 3. Philadelphia: Saunders, 1985:490 511. 15. Harsha BC, Terry BC. Stabilization of Le Fort I osteotomies utilizing small bone plates. Int J Adult Orthod Orthognath Surg 1986;1:69 77. 16. Steinhauser EW. Bone screws and plates in orthognathic surgery. Int J Oral Surg 1982;11: 209 213. 17. Bloomquist DS, Turvey TA. Bone grafting in dentofacial defects. In: Bell WH (ed). Correction of Dentofacial Deformities, vol 2. Philadelphia: Saunders, 1992:831 853. 18. Epker BN, Friedlaender G, Wolford LM, West RA. The use of freeze-dried bone in middle third face advancements. Oral Surg Oral Med Oral Pathol 1976;42:278 289. Int J Adult Orthod Orthognath Surg Vol. 16, No. 3, 2001 199 19. Burton DM, Berarducci JP, Scheffer RB. Proplast grafting: A new method for stabilization of maxillary advancements. Oral Surg 1980;50:387 389. 20. Kent JN, Zide MF, Kay JF, Jorcho M. Hydroxyapatite blocks and particles as bone graft substitutes in orthognathic and reconstructive surgery. J Oral Maxillofac Surg 1986;44:597 605. 21. Rotter BE, Zeitler DL. Stability of the Le Fort I osteotomy after rigid internal fixation. J Oral Maxillofac Surg 1999;57:1080 1088. 22. Carlotti AK, Schendel SA. An analysis of factors influencing stability of surgical advancement of the maxilla by Le Fort I osteotomy. J Oral Maxillofac Surg 1987;45:924 928. 23. Satrom KD, Sinclair PM, Wolford LM. The stability of double-jaw surgery: A comparison of rigid versus wire fixation. Am J Orthod 1991;6:550 563. 24. Mogavoro FJ, Buschang PH, Wolford LM. Orthognathic surgery effects on maxillary growth in patients with vertical maxillary excess. Am J Orthod Dentofac Orthop 1997;111:288 296. 25. Aurujo A, Schendel SA, Wolford LM. Total maxillary advancement with and without bone grafting. J Oral Surg 1978;36:849 858. 26. Cottrell DA, Wolford LM. Long-term evaluation of the use of coralline hydroxyapatite in orthognathic surgery. J Oral Maxillofac Surg 1998; 56:935 941. 27. Wolford LM, Wardrop RW, Hartog JM. Coralline porous hydroxyapatite as a bone graft substitute in orthognathic surgery. J Oral Maxillofac Surg 1987;45:1034 1042. 28. Pitta MC, Castro V, Wolford LM, Freitas RZ. Stability of maxillary downgraft procedures using rigid fixation and porous block hydroxyapatite grafts. J Oral Maxillofac Surg 1999;57:97 98. 29. Wolford LM, Castro V, Freitas RZ. Stability of maxillary advancement procedures using rigid fixation and porous block hydroxyapatite grafts. J Oral Maxillofac Surg 1999;57:95. 30. Holmes RE, Wardrop RW, Wolford LM. Hydroxyapatite as a bone graft substitute in orthognathic surgery: Histologic and histometric findings. J Oral Maxillofac Surg 1988;46:661 671 31. Ayers RA, Simske SJ, Nunes CR, Wolford LM. Longterm bone ingrowth and residual microhardness of porous block hydroxyapatite implants in humans. J Oral Maxillofac Surg 1998;56:1297 1301. 32. Hochban W, Ganb C, Austermann KH. Long-term results after maxillary advancement in patients with clefts. Cleft Palate J 1993;30(2):237 243.