Endoplasmic Reticulum Stress in Health and Disease

Endoplasmic Reticulum Stress in Health and Disease

Patrizia Agostinis Afshin Samali (Eds.) Endoplasmic Reticulum Stress in Health and Disease 1 C

Editors Patrizia Agostinis Department of Cellular and Molecular Medicine K.U. Leuven Leuven, Belgium Afshin Samali School of Natural Sciences, Department of Biochemistry National University of Ireland Galway, Ireland ISBN 978-94-007-4350-2 ISBN 978-94-007-4351-9 (ebook) DOI 10.1007/978-94-007-4351-9 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012940268 Springer Science+Business Media Dordrecht 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control, and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ER stress. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contributes to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impacts therapeutic outcome. This book focuses on different aspects of ER stress. It starts with an introduction into the ER biology and the molecular bases of ER stress, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy, as well as cell death. The reader will find much emphasis on transitions between different cellular responses and communication between different organelles (including ER-Golgi, ER-mitochondria and ER-nucleus communication). The book focuses on physiological responses of ER stress in pancreatic β cells and on major pathologies or pathological conditions which have been linked with ER stress. The first topic consists of chapters delineating the emerging role of ER stress in metabolic disease, such as obesity, Type 2 diabetes and cardiovascular disease. Next, the role of ER stress in inflammatory-based diseases and neurodegeneration is covered. Furthermore, the double-edged function of ER stress pathways in carcinogenesis is discussed. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, these 19 chapters will provide the reader with the latest insights in the role of ER stress in pathophysiology. These chapters are presented by scientists at the forefront of scientific discovery. Their reviews will highlight the most exciting and innovative aspects of their particular areas of expertise in ER stress. Keywords: ER stress, Signal Transduction, Apoptosis, Autophagy, Carcinogenesis, Inflammation, Infection, Metabolic disease, Neurodegeneration, Therapy Related subjects: Biomedical Sciences, Cancer Research, Oncology, Metabolic disease, Inflammation v

Contents I Cellular Responses to ER Stress Biology of the Endoplasmic Reticulum.......................... 3 Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis and Afshin Samali A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Response............. 23 Jared Q Gerlach, Shashank Sharma, Kirk J Leister and Lokesh Joshi ER Stress Signaling Pathways in Cell Survival and Death......... 41 Tom Verfaillie, Richard Jäger, Afshin Samali and Patrizia Agostinis Endoplasmic Reticulum-Mitochondria Connections, Calcium Cross-Talk and Cell Fate: A Closer Inspection................... 75 Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo and Cristina Fasolato ER Stress and UPR Through Dysregulated ER Ca 2 + Homeostasis and Signaling.............................................. 107 Tim Vervliet, Santeri Kiviluoto and Geert Bultynck Regulation of ER Stress Responses by micrornas............... 143 Danielle E. Read, Ananya Gupta, Karen Cawley and Sanjeev Gupta ER Stress As Modulator of Autophagy Pathways................. 163 María Salazar, Sonia Hernández-Tiedra, Mar Lorente and Guillermo Velasco Physiological ER Stress: The Model of Insulin-Secreting Pancreatic β-cells.......................................... 185 Mohammed Bensellam, Patrick Gilon and Jean-Christophe Jonas vii

viii Contents II ER Stress in Physiological and Pathological Conditions Pathological ER Stress in β Cells.............................. 215 Bryan O Sullivan-Murphy and Fumihiko Urano Endoplasmic Reticulum Stress and the Unfolded Protein Response in Lipid Metabolism and Obesity..................... 231 Sana Basseri and Richard C. Austin ER Stress and Inflammation.................................. 257 Abhishek D. Garg, Agnieszka Kaczmarek, Dmitri V. Krysko and Peter Vandenabeele ER Stress in Intestinal Inflammatory Disease.................. 281 Michal F. Tomczak, Arthur Kaser and Richard S. Blumberg Role of ER Stress in Dysfunction of the Nervous System.......... 299 Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson and Fumihiko Urano Endoplasmic Reticulum (ER) Stress in Amyotrophic Lateral Sclerosis (ALS)............................................. 323 Han-Jou Chen and Jackie de Belleroche Cardiovascular Disease and Endoplasmic Reticulum Stress........ 339 Marek Michalak and Jody Groenendyk Signaling the Unfolded Protein Response in cancer............... 357 Stéphanie Lhomond and Eric Chevet UPR Activation in Cancer Cells: A Double-Edged Sword.......... 383 Ethel R. Pereira, Amanda M. Preston and Linda M. Hendershot Contribution of ER Stress to Immunogenic Cancer Cell Death..... 413 Abhishek D. Garg, Dmitri V. Krysko, Jakub Golab, Peter Vandenabeele and Patrizia Agostinis Current Advances in ER Stress Intervention Therapies........... 429 Laurence A. Booth, Nichola Cruickshanks, Yong Tang, M. Danielle Bareford, Hossein A. Hamed, Paul B. Fisher, Steven Grant and Paul Dent Index..................................................... 447