CARDIOVASCULAR PHYSIOLOGY - PDF Free Download

CARDIOVASCULAR PHYSIOLOGY LECTURE 4 Cardiac cycle Polygram - analysis of cardiac activity Ana-Maria Zagrean MD, PhD

The Cardiac Cycle - definitions: the sequence of electrical and mechanical events that repeats with every heartbeat OR the period of time from the beginning of one heartbeat to the beginning of the next one OR a sequence of filling and pumping - the duration of the cardiac cycle is the reciprocal of the heart rate: CC duration is dependent on HR =0.8 s for a HR=75 beats/min 1 s for a HR=60 beats/min

The Cardiac Cycle Note the valves (blue) which control the one way direction of blood flow; also, the tendons prevent the AV valves from turning inside-out. As the animation starts, the atria fill, then contract (atrial systole), pumping blood via the AV valves into the ventricles. Then the ventricles contract (ventricular systole), causing the AV valves to shut and the semicircular valves to open, allowing blood out of the heart (normally, A and V do not contract at the same time). This is followed by relaxation (diastole) of the ventricles, and the semilunar valves shut. The cycles then repeats itself

The Cardiac Cycle The closing and opening of the cardiac valves define 4 main phases of the CC 1. Inflow phase: the inlet valve is open and the outlet valve is closed; AV valve closure terminates phase 1 2. Isovolumetric contraction: both valves are closed, with no blood flow; Semilunar valve opening terminates phase 2. 3. Outflow phase: the outlet valve is open and the inlet valve is closed; Semilunar valve closing terminates phase 3 4. Isovolumetric relaxation: both valves are closed, with no blood flow; AV valve opening terminates phase 4 2+3 = systole (ventricles contract), about 0.3 sec for a HR =75 beats /min 4+1 = diastole (ventricles relax), about 0.5 sec from a CC of 0.8 sec, HT=75 beats/min

The Cardiac Cycle 1. AS: pumping the blood into V during the last part of the VD 2. VS: isovolumic contraction 3. VS: rapid ventricular ejection 4. VS: reduced ventricular ejection 5. VD: isovolumic ventricular relaxation 6. VD: rapid ventricular filling 7. VD: slow/reduced ventricular filling (diastasis) 8. AD: during all the VS and part of the VD A for atrial, V for ventricular, S for systole, D for diastole

The Cardiac Cycle

Changes in ventricular volumes, pressures and flow during the phases of the cardiac cycle The placement of catheters used for pressure measurements in the right heart.

Atrial Systole - immediately the P wave on the ECG - 0,1 sec at a HR of 75 bats/min - functional significance: Atrium = primer pump for the ventricle: contributes to, but is not essential for ventricular filling (<20% from stroke volume in a person at rest and up to 40% during heavy exercise) - causes the 4 th heart sound (phonocardiogram) - venous pulse: a wave (jugulogram)

Volume (ml) Presure (mmhg) Isovolumic Isovolumic Rapid inflow contraction Ejection relaxation Diastasis Atrial systole 120 Ao C 100 80 Aortic pressure 60 40 20 0 130 M C Ao O M O a c v Atrial pressure Ventricular pres. 90 50 Ventricular volume S 1 S 2 S 3 S 4 S 1 Electrocardiogram Phonocardiogram Polygram: events of the cardiac cycle for left ventricular function

Atrial Diastole - 0,7 sec for 75 beats/min - changes in diastolic intra-atrial pressure: - physiological changes: c and v waves - pathological changes (valves pathology)

Volume (ml) Presure (mmhg) Isovolumic Isovolumic Rapid inflow contraction Ejection relaxation Diastasis Atrial systole 120 Ao C 100 80 Aortic pressure 60 40 20 0 130 M C Ao O a c v M O a c v Atrial pressure Ventricular pres. 90 50 Ventricular volume S 1 S 2 S 3 S 4 S 1 Electrocardiogram Phonocardiogram Polygram: events of the cardiac cycle for left ventricular function

- 0,27 s; - phases: Ventriculare systole 1. isovolumic contraction AV valves close, V contracts with closed valves increase in intraventricular pressure that will cause opening of semilunar valves 2. rapid ejection; 70% ejection accelerated decrease in ventricular volume 3. decreased/slow ejection; 30% ejection slow decrease in ventricular volume decrease ventricular and aortic pressures - results in ejection of 70 ml of blood = stroke volume (leaving another 50 ml in the ventricle end systolic volume)

Isovolumic Contraction Ventricles are closed chambers

Ventricular ejection When P LV > 80 mmhg P RV > 8 mmhg Rapid (1/3; 70%) ejection Slow (2/3; 30%) ejection

Ventricular diastole - 0,53 s (decreases with increase in HR) - phases: - isovolumic relaxation (all valves closed, pressure falls rapidly in the ventricle) - rapid ventricular filling - slow ventricular filling (diastasis) - late ventricular filling determined by atrial systole

Isovolumic Relaxation

Ventricular filling

Comparison of the dynamics of the left and right ventricles

Mechanical, electrical, acoustic, and echocardiographic events in the cardiac cycle. Here the cardiac cycle begins with atrial contraction (AS) Phase 1 of the CC has three subparts: -rapid ventricular filling, -decreased ventricular filling, -atrial systole (last stage of ventricular filling); Phase 3 has two subparts: -rapid and decreased ventricular ejection

Polygram - Analysis of Cardiac activity Electrical activity measured by electrocardiography Mechanical activity evaluated by: 1. Atrial pressure curve and venous pressure: recorded at jugular vein level (jugulogram) 2. Aortic pressure curve: recorded at carotid artery level (carotidogram) 3. Phonocardiography: record of the heart sounds 4. Ventricular volume: evaluated by apexocardiogram

Pressure waves in veins systemic veins have pressure waves - venous pulse: (1) retrograde action of the heartbeat during the cardiac cycle, (2) the respiratory cycle (3) the contraction of skeletal muscles. Jugular vein, has a complex pulse wave synchronized to the cardiac cycle: 3 peaks, labeled a, c, and v 3 minima, labeled av, x, and y.

Pressure transients in the jugular vein pulse reflect events in the cardiac cycle: a peak - caused by the contraction of the right atrium. av minimum is due to relaxation of the right atrium and closure of the tricuspid valve. c peak reflects the pressure rise in the right ventricle early during systole and the resultant protruding of the tricuspid valve-which has just closed-into the right atrium. x minimum occurs as the ventricle contracts and shortens during the ejection phase, later in systole. The shortening heart-with tricuspid valve still closed-pulls on and therefore elongates the veins, lowering their pressure. v peak is related to filling of the right atrium against a closed tricuspid valve, which causes right atrial pressure to slowly rise. As the tricuspid valve opens, the v peak begins to decline. y minimum reflects a fall in right atrial pressure during rapid ventricular filling, as blood leaves the right atrium through an open tricuspid valve and enters the right ventricle. The increase in venous pressure after the y minimum occurs as venous return continues in the face of reduced ventricular filling.

Effect of the Respiratory Cycle During inspiration, the diaphragm descends, causing intrathoracic pressure (and therefore the pressure inside the thoracic vessels) to decrease and intra-abdominal pressure to increase the venous return from the head and upper extremities transiently increases, as low-pressure vessels literally draw blood into the thoracic cavity. Simultaneously, the venous flow decreases from the lower extremities because of the relatively high pressure of the abdominal veins during inspiration. Therefore, during inspiration, pressure in the jugular vein falls while pressure in the femoral vein rises.

Cardiac Cycle causes flow waves in aorta and peripheral vessels With the closing & opening of pulmonary and aortic valves, blood flow and blood velocity across these valves oscillate from near zero, when the valves are closed, to high values, when the valves are open. Blood flow in the aortic arch actually oscillates between slightly negative and highly positive values. Flow (A) and pressure (B) profiles in the aorta and smaller vessels. Pressure in the aortic arch typically oscillates between ~ 80-120 mm Hg. Phasic changes in pressure and flow also occur in the peripheral arteries. Arterial pressure is usually measured in a large artery, such as the brachial artery the measured systolic and diastolic arterial pressures, as well as the pulse pressure and mean arterial pressure, closely approximate the corresponding aortic pressures.

Heart sounds and phonocardiography Heart sounds are relatively brief, discrete auditory vibrations of varying intensity (loudness), frequency (pitch), and quality (timbre). The first heart sound identifies the onset of ventricular systole, and the second heart sound identifies the onset of diastole. These two auscultatory events establish a framework within which other heart sounds and murmurs can be placed and timed. Listening to the sounds of the body with the aid of a stethoscope is called auscultation. The stethoscope can detect leaks in the valves that permit jets of blood to flow backward across the valvular orifice (i.e., regurgitation) as well as stenotic lesions that narrow the valve opening, forcing the blood to pass through a narrower space (i.e., stenosis). During certain parts of the cardiac cycle, blood passing through either regurgitant or stenotic lesions makes characteristic sounds that are called murmurs. Phonocardiogram: the recording of the auscultatory cardiac activity, using a transducer placed on the thorax. The movement of the valve leaflets can be detected by echocardiography.

Chest Surface Areas for Auscultation of Normal Heart Sounds The primary aortic area: 2 nd right intercostal space, adjacent to the sternum. The secondary aortic area: 3 rd left intercostal space, adjacent to the sternum (known as Erb area). The pulmonary area: 2 nd left intercostal space The tricuspid area: 4 th & 5 th intercostal spaces, adjacent to the left sternal border. The mitral area at the cardiac apex: 5 th left intercostal space, on the medioclavicular line.

The first heart sound (S1) systolic sound the lub appears at 0.02 0.04 sec after the beginning of the QRS complex vibrations are low in pitch and relatively long-lasting - lasts ~ 0.12-0.15 sec; frequency ~ 30-100 Hz; produced, in this order, by: closing of the mitral valve closing of the tricuspid valve opening of the pulmonar valve opening of the aortic valve.

The second heart sound (S2) diastolic sound the dub appears in the terminal period of the T wave lasts 0.08 0.12s produced, in this order, by: closing of the aortic valve, closing of the pulmonic valve, opening of the tricuspid valve, opening of the mitral valve. heard like a rapid snap because these valves close rapidly, and the surroundings vibrate for a short period physiologic splitting that varies with respiration (wider splitting with inspiration) Split S2 Inspiration Expiration Normal or physiologic

Split S2 Audible respiratory splitting means > 30 msec difference in the timing of the aortic (A 2 ) and pulmonic (P 2 ) components of the second heart sound. Splitting of S 2 is best heard over the 2 nd left intercostal space The normal P 2 is often softer than A 2 and rarely audible at apex Inspiration accentuates the splitting of S 2. Split S2 Inspiration Expiration Normal or physiologic

The third heart sound (S3) occurs in early diastole (at the beginning of the middle third of diastole) when rapid filling of the ventricles results in recoil of ventricular walls that have a limited distensibility lasts 0.02-0.04 sec protodiastolic sound or gallop A gallop rhythm is a grouping of three heart sounds that together sound like hoofs of a galloping horse. The addition of an S3 to the physiological S1 and S2 creates a three-sound sequence, S1-S2-S3, that is termed a protodiastolic gallop or ventricular gallop. it is normal in children and individuals with a thin thoracic wall occasionally heard as a weak, rumbling sound

The fourth heart sound (S4) presystolic sound: appears at 0.04 s after the P wave (late diastolic) lasts 0.04-0.10 s caused by the blood flow that hits the ventricular wall during the atrial systole. physiological only in small children, if heard in other conditions it is a sign of reduced ventricular compliance. addition of an S 4 produces another three-sound sequence, S 4 - S 1 -S 2, which is a presystolic gallop rhythm or atrial gallop during tachycardia S4-S1 can fuse, producing a summation gallop

EC=ejection click: most common early systolic sound; Results from abrupt halting of semilunar valves OS=opening snap: high-frequency early diastolic sound (occurs 50-100 msec after A2) associated with mitral stenosis (stiffening of the mitral valve); sound due to abrupt deceleration of mitral leaflets sound with associated murmur.

Phonocardiogram The duration of S1, S2 is slightly more than 0.10 sec. S1 ~ 0.14 sec S2 ~ 0.11 sec. (the semilunar valves are more taut than the A-V valves, so that they vibrate for a shorter time than do the A-V valves). The audible range of frequency (pitch) in the first and second heart sounds: ~ 40 cycles/sec up above 500 cycles/sec.

Polygram - Analysis of Cardiac activity Electrical activity measured by electrocardiography Mechanical activity evaluated by: 1. Phonocardiography: record of the heart sounds 2. Atrial pressure curve: recorded at jugular vein level (jugulogram) 3. Ventricular volume: evaluated by apexocardiogram 4. Aortic pressure curve: recorded at carotid artery level (carotidogram)

Volume (ml) Presure (mmhg) Isovolumic Isovolumic Rapid inflow contraction Ejection relaxation Diastasis Atrial systole 120 100 80 AoC Aortic pressure 60 40 20 0 130 MC Ao O MO a c v Atrial pressure Ventricular pres. 90 50 Ventricular volume S 1 S 2 S 3 S 4 S 1 Electrocardiogram Phonocardiogram Polygram: events of the cardiac cycle for left ventricular function

ATRIAL SYSTOLE (The end of ventricular diastole) Heart: During atrial systole the atrium contracts and tops off the volume in the ventricle with only a small amount of blood. Atrial contraction is complete before the ventricle begins to contract. Atrial pressure: The "a" wave occurs when the atrium contracts, increasing atrial pressure (yellow). Blood arriving at the heart cannot enter the atrium so it flows back up the jugular vein, causing the first discernible wave in the jugular venous pulse. Atrial pressure drops when the atria stop contracting. ECG: An impulse arising from the SA node results in depolarization and contraction of the atria. The P wave is due to this atrial depolarization. The PR segment is electrically quiet as the depolarization proceeds to the AV node. This brief pause before contraction allows the ventricles to fill completely with blood. Heart sounds: A fourth heart sound (S4) is abnormal and is associated with the end of atrial emptying after atrial contraction. It occurs with hypertrophic congestive heart failure, massive pulmonary embolism or tricuspid incompetence.

ISOVOLUMETRIC CONTRACTION The beginning of systole Heart: The atrioventricular (AV) valves close at the beginning of this phase. Electrically, ventricular systole is defined as the interval between the QRS complex and the end of the T wave (the Q-T interval). Mechanically, ventricular systole is defined as the interval between the closing of the AV valves and the opening of the semilunar valves (aortic and pulmonary valves). Pressures & Volume: The AV valves close when the pressure in the ventricles (red) exceeds the pressure in the atria (yellow). As the ventricles contract isovolumetrically - - their volume does not change (white ) -- the pressure inside increases, approaching the pressure in the aorta and pulmonary arteries (green). ECG: The electrical impulse propagates from the AV node through the His bundle and Purkinje system to allow the ventricles to contract from the apex of the heart towards the base. The QRS complex is due to ventricular depolarization, and it marks the beginning of ventricular systole. It is so large that it masks the underlying atrial repolarization signal. Heart sounds: The first heart sound (S1, "lub") is due to the closing AV valves and associated blood turbulence.

RAPID EJECTION Heart: The semilunar (aortic and pulmonary) valves open at the beginning of this phase. Pressures & Volume: While the ventricles continue contracting, the pressure in the ventricles (red) exceeds the pressure in the aorta and pulmonary arteries (green); the semilunar valves open, blood exits the ventricles, and the volume in the ventricles decreases rapidly ( white). As more blood enters the arteries, pressure there builds until the flow of blood reaches a peak. The "c" wave of atrial pressure is not normally discernible in the jugular venous pulse. Right ventricular contraction pushes the tricuspid valve into the atrium and increases atrial pressure, creating a small wave into the jugular vein. It is normally simultaneous with the carotid pulse. ECG: Heart sounds:

REDUCED EJECTION The end of systole Heart: At the end of this phase the semilunar (aortic and pulmonary) valves close. Pressures & Volume: After the peak in ventricular and arterial pressures (red and green), blood flow out of the ventricles decreases and ventricular volume decreases more slowly (white ). When the pressure in the ventricles falls below the pressure in the arteries, blood in the arteries begins to flow back toward the ventricles and causes the semilunar valves to close. This marks the end of ventricular systole mechanically. ECG: The T wave is due to ventricular repolarization. The end of the T wave marks the end of ventricular systole electrically. Heart sounds:

ISOVOLUMETRIC RELAXATION The beginning of diastole Heart: At the beginning of this phase the AV valves are closed. Pressures & Volume: Throughout this and the previous two phases, the atrium in diastole has been filling with blood on top of the closed AV valve, causing atrial pressure to rise gradually (yellow). The "v" wave is due to the back flow of blood after it hits the closed AV valve. It is the second discernible wave of the jugular venous pulse. The pressure in the ventricles (red) continues to drop. Ventricular volume (white ) is at a minimum and is ready to be filled again with blood. ECG: Heart sounds: The second heart sound (S2, "dup") occurs when the semilunar (aortic and pulmonary) valves close. S2 is normally split because the aortic valve closes slightly earlier than the pulmonary valve.

RAPID VENTRICULAR FILLING Heart: Once the AV valves open, blood that has accumulated in the atria flows rapidly into the ventricles. Pressures & Volume: Ventricular volume ( white white) increases rapidly as blood flows from the atria into the ventricles. ECG: Heart sounds: A third heart sound (S3) is usually abnormal and is due to rapid passive ventricular filling. It occurs in dilated congestive heart failure, myocardial infarction, or mitral incompetence.

REDUCED VENTRICULAR FILLING (DIASTASIS) Heart: Pressures & Volume: Ventricular volume ( white ) increases more slowly now. The ventricles continue to fill with blood until they are nearly full. ECG: Heart sounds: