PARIS Cedex 15 Paris Date submitted to OIE 04/01/2016

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Follow-up report No.5 Report reference:, Reference OIE : 19449, Report Date : 04/01/2016, Country : France Report Summary Name of sender of the report Dr Loic Evain Telephone (33) 1 49 55 81 77 Position Directeur Général adjoint, CVO Fax (33) 1 49 55 55 91 Address 251, rue de Vaugirard Email loic.evain@agriculture.gouv.fr 75732 PARIS Cedex 15 Paris Date to OIE 04/01/2016 Animal type Terrestrial Date of report 04/01/2016 Disease Highly pathogenic avian influenza Date of start of the event 10/11/2015 Causal Agent Highly pathogenic avian influenza virus Date of confirmation of the event 24/11/2015 Serotype(s) H5N1 Date of last occurrence 2007 Reason Reoccurrence of a listed disease Diagnosis Clinical, Laboratory (advanced) Country or zone a zone or compartment Clinical signs Yes Number of reported outbreaks = 15, Draft= 0 Outbreak details DORDOGNE-other - Saint-Paul la Roche Farm Saint-Paul la Roche 45.4978253 0.9818008 10/11/2015 01/12/2015 Birds Animals 14000 7 0 14000 0 Affected Population Samples taken in a duck farm with a gavage unit as part of the scheduled national surveillance with isolation of a H5N1 virus. Following additional samples, a H5N9 strain virus was also identified in the farm. DORDOGNE-other - Backyard Biras 45.288611 0.639444 14/11/2015 20/11/2015 Birds Animals 32 22 22 10 0 Affected Population A backyard (non-commercial farm) consisting of 32 broiler chickens and layer hens showing acute mortalities leading to testing and preventive slaughter. DORDOGNE-other - MONTIGNAC Farm MONTIGNAC 45.066667 1.161389 27/11/2015 08/12/2015 Birds Animals 30 9 9 21 0 Affected Population A backyard consisting of 25 hens, 3 ducks and 2 geese showed mortality. Sampling carried out under clinical suspicion isolated a highly pathogenic H5N1 virus. HAUTE-VIENNE-other - LES BILLANGES Farm LES BILLANGES 45.9805066 1.5406258 03/12/2015 10/12/2015 Birds Animals 250 3 3 247 0 Affected Population The death of three animals in a poultry farm led to take samples following a clinical suspicion. The results from the National Reference Laboratory on 8 December 2015 confirm H5N1 serotype. DORDOGNE-other - NANTHEUIL Farm NANTHEUIL 45.4237843 0.9612285 03/12/2015 08/12/2015 Birds Animals 1000... 0 1000 0 Affected Population Samples taken in order to leave the restriction zone. Printed on: Tue Jan 5 17:48:45 CET 2016 Page 1/5

DORDOGNE-other - SAINT ARMAND DE Farm SAINT ARMAND DE 45.049765 1.2768368 10/12/2015 18/12/2015 COLY COLY Birds Animals 1000... 0 1000 0 Affected Population Samples were taken in the frame of the analytical surveillance. LANDES-other report - - EYRES MONCUBE Farm EYRES MONCUBE 43.7175309-0.5451694 11/12/2015 14/12/2015 Birds Animals 910... 0 910 0 Affected Population Samples were taken in the framework of analytical surveillance. The National Reference Laboratory confirmed the presence of H5N1 virus on 22 December 2015. PYRÉNÉES-ATLANTIQ - CROUSEILLES Farm CROUSEILLES 43.5293617-0.0902759 12/12/2015 21/12/2015 UES-other report - Birds Animals 1810... 0 1810 0 Affected Population Ducks in a gavage unit showed mortality. The National Reference laboratory confirmed the presence of H5N1 virus. DORDOGNE-other - LE LARDIN SAINT Farm LE LARDIN SAINT 45.1364263 1.2275143 12/12/2015 21/12/2015 LAZARE LAZARE Birds Animals 480... 0 480 0 Affected Population Samples were taken in the frame of the analytical surveillance. DORDOGNE-other - Bosset Farm Bosset 45.035833 0.366389 13/12/2015 16/12/2015 Birds Animals 1070... 0 1070 0 Affected Population Farm with fattened ducks. Samples were taken in the framework of movements out of the zone of Bosset for slaughter. The slaughter of the flock is planned on 16 December 2015. LANDES-other report - - SERRES GASTON Farm SERRES GASTON 43.6770137-0.5271729 14/12/2015 04/01/2016 Birds Animals 10840... 0 10840 0 Affected Population Samples were taken in the frame of the analytical surveillance in a farm with 6,000 ducks in gavage process, 4,000 ducklings and 840 ducks at the end of the gavage process. The National Reference laboratory confirmed the presence of H5N1 virus on 21 December 2015. HAUTES-PYRÉNÉES-ot - BAZILLAC Farm BAZILLAC 43.3523109 0.1037034 18/12/2015 23/12/2015 her Birds Animals 5600 3 3 5597 0 Affected Population Samples were taken following a clinical suspicion in a farm with 3,000 ducks and 2,600 geese. The National Reference laboratory confirmed the presence of H5N1 virus on 23 December 2015. Printed on: Tue Jan 5 17:48:45 CET 2016 Page 2/5

GERS-other report - - MONTAUT Farm MONTAUT 43.405831 0.421362 20/12/2015 23/12/2015 Birds Animals 415 35 35 380 0 Affected Population Samples were taken following mortality in ducks in gavage process. The National Reference laboratory confirmed the presence of H5N1 virus on 23 December 2015. DORDOGNE- (this report - CELLES Farm CELLES 45.293999 0.4053409 20/12/2015 - ) Birds Animals 200 6 6...... Affected Population Out of the 30 hens of the holding, 6 died which lead to samples being taken in the frame of a clinical suspicion. The National Reference Laboratory confirmed the presence of H5N1 virus. Additionally the holding includes 150 pigeons, 4 peacocks and 16 geese. All of them will be destroyed. LOT- (this report - - MIERS Farm MIERS 44.8506442 1.7264083 24/12/2015 ) Birds Animals 1250 39 39...... Affected Population Out of a lot of 180 guinea fowls, 39 died, which lead to samples being taken in the frame of a clinical suspicion. The National Reference Laboratory confirmed the presence of H5N1 virus. There is another lot of 80 guinea fowls, 280 ducks, 650 broilers and 60 layers on the farm. All of them will be destroyed. Outbreak summary: Total outbreaks = 15 (Submitted) Species Susceptible Cases Deaths Destroyed Slaughtered Birds 38887 124 117 37365 0 Epidemiology Epidemiological comments Zoning: protection (3 km) and surveillance (10 km) zones around the farm. Source of the outbreak(s) or origin of infection Unknown or inconclusive Measures applied Applied To be applied stamping out control of wildlife reservoirs movement control inside the country screening zoning disinfection / disinfestation surveillance outside containment and/or protection zone official disposal of carcasses, by-products and waste surveillance within containment and/or protection zone traceability Animals treated Vaccination Prohibited No Yes Diagnostic test results Laboratory Type Name of Laboratory Species Test Type Date results provided Result National laboratory National Reference Laboratory for Avian Influenza and Newcastle Disease, ANSES Birds nucleotide sequencing 30/12/2015 Positive Printed on: Tue Jan 5 17:48:45 CET 2016 Page 3/5

Laboratory Type Name of Laboratory Species Test Type Date results provided Result National laboratory National Reference Laboratory Birds real-time reverse 30/12/2015 Positive for Avian Influenza and Newcastle Disease, ANSES transcriptase/polymerase chain reaction (RRT-PCR) Future Reporting The event is continuing. Weekly follow-up reports will be. Printed on: Tue Jan 5 17:48:45 CET 2016 Page 4/5

Outbreak maps Printed on: Tue Jan 5 17:48:45 CET 2016 Page 5/5