Nagoya Med. J., 199 Function of aquaporin in the brain and brain edema KAZUYA SOBUE Department of Anesthesiology and Medical crisis Management, Nagoya City University Graduate School of Medical Sciences AQP AQP AQP AQP Peter Agre Aquaporin: AQP Agre AQP AQP Agre AQP AQP CHIP channellike integral protein AQP AQP AQP AQP AQP AQP GLP aquaglyceroporin AQP AQP AQP AQP AQP AQP NPA Asn- Pro-Ala 199
200 AQP NPA CHIP GLP AQP AQP AQP AQP AQP AQP AQP AQP AQP Neuromyelitis optica NMO AQP NMO
201 AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP BBB AQP Nico BBB BBB AQP BBB AQP AQP Kir AQP α AQP AQP GFAP AQP AQP
202 AQP AQP AQP AQP AQP AQP AQP AQP protein kinase C PKC mitogenactivated protein kinase MAPK PKC AQP AQP AQP AQP MAPK p MAPK AQP AQP AQP AQP PDZ PSD -Discs large-zo AQP AQP reversion-induced LIM protein RIL PDZ AQP AQP AQP AQP AQP Klatzo cytotoxic edema vasogenic edema Cytotoxic edema vasogenic edema AQP AQP
203 AQP AQP cytotoxic edema cytotoxic edema AQP AQP AQP vasogenic edema AQP AQP IL- β AQP mrna AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP AQP Preston GM, Agre P: Isolation of the cdna for erythrocyte integral membrane protein of kilodaltons: Member of an ancient channel family. Proc Natl Acad Sci USA ; : -. Ishibashi K, Kuwahara M, Sasaki S: Molecular biology of aquaporins. Rev Physiol Biochem Pharmacol ; : -. Ishibashi K: Aquaporin superfamily with unusual npa boxes: S-aquaporins superfamily, sip-like and subcellular-aquaporins. Cell Mol Biol Noisy-legrand ; : -.
204 Murata K, Mitsuoka K, Hirai T, et al.: Structural determinants of water permeation through aquaporin-.nature ; : -. Nielsen S, Kwon TH, Frøkiaer J, Agre P: Regulation and dysregulation of aquaporins in water balance disorders. J Intern Med ; : -. Agre P, Kozono D: Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett ; : -. Lennon VA, Kryzer TJ, Pittock SJ, et al.: IgG marker of optic-spinal multiple sclerosis binds to the aquaporin- water channel. ; JExpMed : -. Yamamoto N, Yoneda K, Asai K et al.: Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation. Mol Brain Res ; : -. Venero JL, Vizuete ML, Machado A, et al.: Aquaporins in the central nervous system. Prog Neurobiol ; : -. Hasegawa H, Ma T, Skach W, et al.: Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem ; : -. Speake T, Freeman LJ, Brown PD: Expression of aquaporin and aquaporin water channels in rat choroids plexus. Biochim Biophys Acta ; : -. Sobue K, Yamamoto N, Yoneda K, et al.: Molecular cloning of two bovine aquaporin- cdna isoforms and their expression in brain endothelial cells. Biochim Biophys Acta ; : -. Guadagno E, Moukhles H: Laminin-induced aggregation of the inwardly rectifying potassium channel, Kir, and water-permeable cnannel, AQP, via a dystroglycan-containing complex in astrocytes. Glia ; : -. Amiry-Moghaddam M, Williamson A, Palomba M, et al.: Delayed K clearance associated with aquaporin- mislocalization: Phenotypic defects in brains of α-syntrophin-null mice. Proc Natl Acad Sci USA ; : -. Yamamoto N, Sobue K, Miyachi T, et al.: Differential regulation of aquaporin expression in astrocytes by protein kinase C. Brain Res Mol Brain Res ; : -. Arima H, Yamamoto N, Sobue K, et al.: Hyperosmotic mannitol stimulates expression of aquaporin and through a p mitogen activated kinasedependent pathway in rat astrocytes. J Biol Chem ; : -. Neely JD, Amiry-Moghaddam M, Ottersen OP, et al.: Syntrophin-dependent expression and localization of aquaporin- water channel protein. Proc Natl Acad Sci USA ; : -. Yokota T, Miyagoe Y, Hosaka K, et al.: Aquaporin- is absent at the sarcolemma and at perivascular astrocyte endfeet in -syntrophin knockout mice. Proc Japan Acad ; : -. Iida Y, Matsuzaki T, Morishima T, et al.: Localization of reversion-induced LIM protein RIL in the rat central nervous system. Acta Histochem Cytochem : -,. Yasui M, Hazama A, Kwon TH, et al.: Rapid gating and anion permeability of an intracellular aquaporin. Nature ; : -. Manley GT, Fujimura M, Ma T, et al.: Aquaporin- deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Med ; : -. Papadopoulos MC, Manley GT, Krishna S, et al.: Aquaporin- facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J ; : -. Arima H, Yamamoto N, Sobue K, et al: Hyperosmotic mannitol stimulates expression of aquaporin and through a p mitogen activated kinasedependent pathway in rat astrocytes. J Biol Chem ; : -. Ito H, Yamamoto N, Hirate H, et al: Interleukin- β induces the expression of aquaporin- through a NF-κB pathway in rat astrocytes. J Neurochem ; : -. Morishima T, Aoyama M, Iida Y, et al: Lactic acid
205 increases aquaporin expression on the cell membrane of cultured rat astrocytes. Neurosci Res ; : -.
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